检索结果-南通市图书馆

Storylines of family medicine Ⅸ:people and places—diverse populations and locations of care

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Family Medicine and Community Health 2024年第S3期12卷 79-88页

作者： William B Ventres Leslie A Stone emad R Abou-Arab Julio Meza David S Buck Jerome W Crowder Jennifer Y C edgoose Alexander Brown ellen J Plumb Amber k Norris Jay J Allen Lauren e giammar John e Wood Scott M Dickson g Austin Brown Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine University of Michigan Medical SchoolAnn ArborMichiganUSA Family Medicine University of California Los AngelesDavid Geffen School of MedicineLos AngelesCaliforniaUSA Community Medicine University of HoustonTilman J Fertitta Family College of MedicineHoustonTexasUSA Social and Behavioral Sciences University of HoustonTilman J Fertitta Family College of MedicineHoustonTexasUSA Family Medicine and Community Health University of Wisconsin-Madison School of Medicine and Public HealthMadisonWisconsinUSA NH Dartmouth Family Medicine Residency ConcordNew HampshireUSA San Francisco VA Medical Center San FranciscoCaliforniaUSA Duluth Family Medicine Residency Program University of Minnesota Medical School Duluth CampusDuluthMinnesotaUSA UAMS Northeast Regional Campus Family Medicine Residency Program JonesboroArkansasUSA Cascades east Family Medicine Residency Program Oregon Health&Science University School of MedicineKlamath FallsOregonUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅸ:people and places—diverse populations and locations of care’,authors address the following themes:‘LgBTQIA+health in family medicine’,‘A family medicine approach to substance use disorders’,‘Shameless medicine for people experiencing homelessness’,“Difficult”encounters—finding the person behind the patient’,‘Attending to patients with medically unexplained symptoms’,‘Making house calls and home visits’,‘Family physicians in the procedure room’,‘Robust rural family medicine’and‘Full-spectrum family medicine’.May readers appreciate the breadth of family medicine in these essays.

关键词： illustration family dimensions

elucidating regulatory processes of intense physical activity by multi-omics analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Military Medical Research 2024年第4期11卷 479-499页

作者： ernesto S.Nakayasu Marina A.gritsenko Young-Mo kim Jennifer e.kyle kelly g.Stratton Carrie D.Nicora Nathalie Munoz kathleen M.Navarro Daniel Claborne Yuqian gao karl k.Weitz Vanessa L.Paurus kent J.Bloodsworth kelsey A.Allen Lisa M.Bramer Fernando Montes kathleen A.Clark grant Tietje Justin Teeguarden kristin e.Burnum-Johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA environmental and Molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA environmental and Molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： Multi-omics analysis Intense exercise Human performance Biofluids Metabolism Immunity

维普期刊数据库

LkB1 depletion-mediated epithelial-mesenchymal transition induces fibroblast activation in lung fibrosis

在线全文

学校读者我要写书评

暂无评论

genes & Diseases 2024年第3期11卷 417-426页

作者： Zijian Xu elizabeth R.Davies Liudi Yao Yilu Zhou Juanjuan Li Aiman Alzetani Ben g.Marshall David Hancock Tim Wallis Julian Downward Rob M.ewing Donna e.Davies Mark g.Jones Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and experimental Sciences Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biomedical Research Centre University Hospital SouthamptonSouthampton SO166YDUK University Hospital Southampton Southampton SO166YDUK Oncogene Biology The Francis Crick InstituteLondon NW11ATUK

The factors that determine fibrosis progression or normal tissue repair are largely *** previously demonstrated that autophagy inhibition-mediated epithelial-mesenchymal transition(eMT)in human alveolar epithelial type Il(ATIl)cells augments local myofibroblast differentiation in pulmonary fibrosis by paracrine ***,we report that liver kinase B1(LkB1)inactivation in ATIl cells inhibits autophagy and induces eMT as a *** IPF lungs,this is caused by the down-regulation of CAB39L,a key subunit within the LkB1 complex.3D co-cultures of ATIl cells and MRC5 lung fibroblasts coupled with RNA sequencing(RNA-seq)confirmed that paracrine signaling between LkB1-depleted ATIl cells and fibroblasts augmented myofibroblast ***,these data suggest that reduced autophagy caused by LkB1 inhibition can induce eMT in ATIl cells and contribute to fibrosis via aberrant epithelial-fibroblast crosstalk.

关键词： CAB39L Crosstalk eMT LkB1 Pulmonary fibrosis

Neuroimaging in atypical normal tension glaucoma:debating routine implementation in the absence of classic neurological findings

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(english edition) 2024年第3期17卷 509-517页

作者： Umay güvenç gülizar Demirok güner Üney Selma Uzman Ophthalmology Department Ankara Training and Research HospitalAnkara 06230Turkey

●AIM:To assess the necessity of neuroimaging in patients with neurological or atypical findings of normal tension glaucoma(NTg)who do not exhibit typical glaucoma manifestations.●MeTHODS:A retrospective analysis was conducted on 90 atypical NTg patients who underwent cranial magnetic resonance imaging(MRI)due to atypical *** demographic characteristics,clinical parameters,and radiological findings were recorded.●ReSULTS:Among the patients,66.7%had abnormal radiology results,with the most common findings being gliosis(34.4%),sequelae of cerebrovascular events and vascular malformations(14.4%),and benign intracranial mass lesions(11%).Non-glaucomatous visual field defects were more frequently observed in patients with abnormal neuroimaging ***,there were no significant differences in intraocular pressure,optic disc parameters,retinal nerve fiber layer thickness,and visual field indices between patients with normal and abnormal radiological *** mean age of the patients was ***,there was a significant age difference,with the abnormal radiology group having a higher median age(P=0.021).●CONCLUSION:The study highlights the importance of cranial imaging in older NTg patients to detect underlying pathologies and prevent *** suggests that neuroimaging may be warranted in NTg patients with atypical visual field defects incompatible with ***,routine neuroimaging in all NTg patients without classic neurological signs may not be necessary.

关键词： normal tension glaucoma neuroimaging atypical visual field defects

Combustion characteristics of low-quality lignite for different bed material sphericities in a circulating fluidized bed boiler:A numerical study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第7期90卷 364-382页

作者： Barış gürel gülşah karaca Dolgun Osman İpek Ali keçebaş Department of Mechanical engineering Engineering FacultySüleyman Demirel UniversityÇünürIspartaTurkey Department of energy Systems engineering Technology FacultyMuğla SıtkıKoçman UniversityKötekliMenteşeMuğlaTurkey

This study delves into the combustion behavior of various lignite types within a circulating fluidized bed boiler(CFBB),with a primary focus on the impact of different bed material sphericity ratios(0.5,0.7,and 0.9).Utilizing bed material with a sphericity ratio of 0.9 sourced from theÇan power plant and verified through experimentation,the research reveals several key ***,furnace temperatures tended to rise with higher sphericity ratios,albeit with variations between lignite types,particularly highlighting the complexity of this relationship in the case of gLI-Tunçbilek *** levels in the combustion chamber remained consistent across different sphericity ratios,indicating minimal influence on pressure *** combustion efficiency,especially at the bottom of the boiler,was observed at lower sphericity levels(0.5 and 0.7)forÇan lignite,as reflected in CO_(2) mole *** NO_(x) emissions generally decreased with lower sphericity,the sensitivity to sphericity varied by lignite type,with Ilgın lignite showcasing low NO_(x) but high SO_(2) emissions,underscoring the intricate interplay between lignite properties,sphericity,and ***,this study advances our understanding of CFBB combustion dynamics,offering insights valuable for optimizing performance and emissions control,particularly in lignite-based power.

关键词： Circulating fluidized bed boiler Computational particle fluid dynamics method Particle sphericity ratios NO_(x)and SO_(2)emissions energy production efficiency

effect of biochar on the metabolome of soybean seedlings

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oil Crop Science 2024年第1期9卷 60-68页

作者： Nathalia e.Silva Mariana g.Aguilar Osania e.Ferreira gleicia M.Paulino Jaqueline C.L.Carvalho Lúcia P.S.Pimenta Alan R.T.Machado Programa de Pos-graduaçao em Ciencias Ambientais Universidade do Estado de Minas GeraisFrutalMinas Gerais38202-436Brazil Departamento de Química Universidade Federal de Minas GeraisMinas GeraisBelo Horizonte31270-901Brazil Departamento de engenharia Aplicada e Tecnologias Ambientais Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil Departamento de Ciencias exatas Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil

The use of biochar can have several effects on plant germination,depending on raw material,preparation method and application ***,the molecular mechanisms that lead to those results have yet to be *** aim of this research was to improve the understanding of these mechanisms by characterizing the metabolic effects of sugarcane bagasse biochar on soybean *** types of biochars were prepared by pyrolysis at 300℃(SCB300),400℃(SCB400)and 600℃(SCB600).Then,each one was mixed into sand at 1%,3%,5%(w/w)dose,*** experiment was performed in 8 days of incubation,when the number of germinated seeds and the average radicle length were *** evaluate the metabolome,the dry biomass(DB)was subjected to extraction with a mixture of methanol-d4 and D2O(1:1 v/v).The extracts were submitted to metabolomics analysis by Proton Nuclear Magnetic *** Relative germination,Relative Average Radicle growth and germination Index increased in all treatments compared to *** the other hand,the DB increased in all treatments,except for SCB300,at doses of 1%and 3%w/*** metabolites(alanine,asparagine,acetic acid,citric acid,glycerol,fatty acids and sucrose)were identified and quantified in DB extracts as the most influential finding for the separation of *** together,these results strongly suggested that biochars accelerated the catabolism of triacylglycerols to sucrose and induced a slight osmotic stress.

关键词： germination Metabolomics 1H NMR Pyrolysis Sugarcane bagasse

维普期刊数据库

MDCN:Modified Dense Convolution Network Based Disease Classification in Mango Leaves

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第2期78卷 2511-2533页

作者： Chirag Chandrashekar k.P.Vijayakumar k.Pradeep A.Balasundaram School of Computer Science and engineering Vellore Institute of Technology(VIT)ChennaiIndia Center for Cyber Physical Systems School of Computer Science and EngineeringVellore Institute of Technology(VIT)ChennaiIndia

The most widely farmed fruit in the world is *** the production and quality of the mangoes are hampered by many *** diseases need to be effectively controlled and ***,a quick and accurate diagnosis of the disorders is *** convolutional neural networks,renowned for their independence in feature extraction,have established their value in numerous detection and classification ***,it requires large training datasets and several parameters that need careful *** proposed Modified Dense Convolutional Network(MDCN)provides a successful classification scheme for plant diseases affecting mango *** model employs the strength of pre-trained networks and modifies them for the particular context of mango leaf diseases by incorporating transfer learning *** data loader also builds mini-batches for training the models to reduce training ***,optimization approaches help increase the overall model’s efficiency and lower computing *** employed on the MangoLeafBD Dataset consists of a total of 4,000 *** the experimental results,the proposed system is compared with existing techniques and it is clear that the proposed algorithm surpasses the existing algorithms by achieving high performance and overall throughput.

关键词： Leaf disease detection deep convolutional neural networks transfer learning optimization MangoLeafBD Dataset

FSCIL-eACA: Few-Shot Class-Incremental Learning Network Based on embedding Augmentation and Classifier Adaptation for Image Classification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of electronics 2024年第1期33卷 139-152页

作者： Ruru ZHANg Haihong e Meina SONg School of Computer Science Beijing University of Posts and Telecommunications education Department Information Network engineering Research Center Beijing University of Posts and Telecommunications

The ability to learn incrementally is critical to the long-term operation of AI systems. Benefiting from the power of few-shot class-incremental learning(FSCIL), deep learning models can continuously recognize new classes with only a few samples. The difficulty is that limited instances of new classes will lead to overfitting and exacerbate the catastrophic forgetting of the old classes. Most previous works alleviate the above problems by imposing strong constraints on the model structure or parameters, but ignoring embedding network transferability and classifier adaptation(CA), failing to guarantee the efficient utilization of visual features and establishing relationships between old and new classes. In this paper, we propose a simple and novel approach from two perspectives: embedding bias and classifier bias. The method learns an embedding augmented(eA) network with cross-class transfer and class-specific discriminative abilities based on self-supervised learning and modulated attention to alleviate embedding bias. Based on the adaptive incremental classifier learning scheme to realize incremental learning capability,guiding the adaptive update of prototypes and feature embeddings to alleviate classifier bias. We conduct extensive experiments on two popular natural image datasets and two medical datasets. The experiments show that our method is significantly better than the baseline and achieves state-of-the-art results.

关键词： Training Adaptation models Visualization Image recognition Prototypes Self-supervised learning Power capacitors

Understanding the corrosion and bio-corrosion behaviour of Magnesium composites – a critical review

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2024年第3期12卷 890-939页

作者： Prithivirajan Sekar S.k.Panigrahi Department of Mechanical engineering Indian Institute of Technology MadrasChennai600036India Applied Magnesium Research Center Center of Excellence in Materials and Manufacturing for Futuristic MobilityIndian Institute of Technology MadrasChennai600036India

Realising the potential of Magnesium(Mg),several globally leading ventures have invested in the Mg industry,but their relatively poor corrosion resistance is a never ending saga till *** corrosion and bio-corrosion behaviour of Mg has gained research attention and still remains a hot topic in the application of automobile,aerospace and biomedical *** intrinsic high electrochemical nature of Mg limits their utilization in diverse *** scenario has prompted the development of Mg composites with an aim to achieve superior corrosion and bio-corrosion *** present review enlightens the influence of grain size(gS),secondary phase,texture,type of matrix and reinforcement on the corrosion and bio-corrosion behaviour of Mg ***,the corrosion and bio-corrosion behaviour of Mg composites manufactured by primary and secondary processing routes are ***,the comprehensive corrosion and bio-corrosion mechanisms of these Mg composites are ***,the individual role of gS,texture and corrosive medium on corrosion and bio-corrosion behaviour of Mg composites are clarified and *** challenges encountered,unanswered issues in this field are explained in detail and accordingly the scope for future research is *** review is presented from basic concrete background to advanced corrosion mechanisms with an aim of creating interest among the readers like students,researchers and industry experts from various research ***,the corrosion and bio-corrosion behaviour of Mg composites are critically reviewed for the first time to:(i)contribute to the body of knowledge,(ii)foster research and development,(iii)make breakthrough,and(iv)create life changing innovations in the field of Mg composite corrosion.

关键词： Corrosion Bio corrosion Magnesium alloys Magnesium composites Magnesium implants.

维普期刊数据库