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2011年全国压电和声波理论及器件应用研讨会

作者： k.kirk shung Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCA 90089-1111USA

＜正＞High frequency ultrasonic imaging（＞ 30 MHz） is considered by many to be the next frontier in ultrasonic imaging because higher frequencies yield much improved spatial *** consequence is a reduced depth of *** has many clinical applications ranging from visualizing internal and surface structures of the blood vessel wall and mapping anterior segments of the eye,to characterizing skin *** added significance is the recent intense interest in small animal imaging for the purpose of evaluating the efficacy of drugs and gene therapy. Combining high frequency ultrasound with optical imaging *** coherent tomography and photoacoustic imaging has opened new doors for intravascular imaging in diagnosing vascular *** development of ultrasonic transducers/arrays and imaging systems at such a high frequency will be reviewed in this talk.

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PZT FILM GENERATOR DRIVEN BY ULTRASONIC WAVE

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Journal of Advanced Dielectrics 2012年第3期2卷 1-5页

作者： QIFA ZHOU kWOk HO LAM BENPENG ZHU XIABING ZHANG k.kirk shung TONGQING YANG S.TAkEUCHI NIH Transducer Resource Center Department of Biomedical Engineering University of Southern California Los Angeles CA 90089 USA Department of Electronic Science and Technology Huazhong University of Science and Technology Wuhan 430072 China Functional Materials Research Laboratory Tongji University Siping Road 1239 ShanghaiChina Medical Engineering Course Graduate School of Engineering Toin University of Yokohama Yokohama 225-8501 Japan

Energy harvesting was demonstrated in hydrothermal PZT nanocrystal films driven by *** high temperature sintering and solution infiltration,PZT films with nanograin sizewas found to exhibit bulk-like properties such as large remnant polarization of 42μC/cm^(2).Withthe bulk-like properties,a packaged PZT film device was demonstrated to be capable of convertingmechanical energy carried by the ultrasonic wave into electrical energy in a reliable and efficient *** result suggests an alternative potential solution for energy harvesting application.

关键词： PZT film ultrasonic energy harvesting

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ecent Advances in the Science of Burst Wave Lithotripsy and Ultrasonic Propulsion

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Biomedical Engineering Frontiers 2022年第1期3卷 54-66页

作者： Xuejun Qian Gengxi Lu Biju B.Thomas Runze Li Xiaoyang Chen k.kirk shung Mark Humayun Qifa Zhou Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCA 90089USA Department of Ophthalmology University of Southern CaliforniaLos AngelesCA 90033USA USC Ginsburg Institute for Biomedical Therapeutics University of Southern CaliforniaLos AngelesCA 90033USA

*** degeneration involving progressive deterioration and loss of function of photoreceptors is a major cause of permanent vision loss *** to treat these incurable conditions incorporate retinal prostheses via electrically stimulating surviving retinal neurons with implanted devices in the eye,optogenetic therapy,and sonogenetic *** challenges of these strategies include invasive manner,complex implantation surgeries,and risky gene *** and ***,we show that direct ultrasound stimulation on the retina can evoke neuron activities from the visual centers including the superior colliculus and the primary visual cortex(V1),in either normal-sighted or retinal degenerated blind rats in *** neuron activities induced by the customized spherically focused 3.1 MHz ultrasound transducer have shown both good spatial resolution of 250μm and temporal resolution of 5 Hz in the rat visual *** additional customized 4.4 MHz helical transducer was further implemented to generate a static stimulation pattern of letter *** findings demonstrate that ultrasound stimulation of the retina in vivo is a safe and effective approach with high spatiotemporal resolution,indicating a promising future of ultrasound stimulation as a novel and noninvasive visual prosthesis for translational applications in blind patients.

关键词： stimulation implantation letter

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High-Frequency Plused-Wave Doppler System with 45 MHz PMN-PT Needle Transducers for Evaluating the Treatment of Retinal Vein Occlusion

High-Frequency Plused-Wave Doppler System with 45 MHz PMN-PT...

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第二届全国压电和声波理论及器件技术研讨会

作者： Hossein Ameri Emanuel J.Gottlieb Jesse T.Yen Jonathan M.Cannata Mark S.Humayun k.kirk shung Philips Medical Systems BothellWA 98041

Retinal vein occlusion is a common vascular eye disease,and it is the second disease causing visual loss in elder *** treatment procedures have been devised to surgically remove the obstruction and reestablish the blood *** quantitative analysis is needed to evaluate blood flow during the *** current fluorescein angiography and ultrasound color Doppler are not applicable for evaluating the treatment of retinal vein occlusion instantaneously.

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Investigation of cell mechanics using single-beam acoustic tweezers as a versatile tool for the diagnosis and treatment of highly invasive breast cancer cell lines: an in vitro study

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Microsystems & Nanoengineering 2020年第1期6卷 927-938页

作者： Hae Gyun Lim Hsiao-Chuan Liu Chi Woo Yoon Hayong Jung Min Gon kim Changhan Yoon Hyung Ham kim kkirk shung Department of Creative IT Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea NIH Resource Center for Medical Ultrasonic Transducer Technology and Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCA 90089USA Department of Biomedical Engineering Inje UniversityGimhaeGyeongnam 50834Republic of Korea

Advancements in diagnostic systems for metastatic cancer over the last few decades have played a significant role in providing patients with effective treatment by evaluating the characteristics of cancer *** the progress made in cancer prognosis,we still rely on the visual analysis of tissues or cells from histopathologists,where the subjectivity of traditional manual interpretation *** paper presents the development of a dual diagnosis and treatment tool using an in vitro acoustic tweezers platform with a 50MHz ultrasonic transducer for label-free trapping and bursting of human breast cancer *** cancer cell detection and classification,the mechanical properties of a single cancer cell were quantified by single-beam acoustic tweezers(SBAT),a noncontact assessment tool using a focused acoustic ***-mimicking phantoms and agarose hydrogel spheres(AHSs)served to standardize the biomechanical characteristics of the *** on the analytical comparison of deformability levels between the cells and the AHSs,the mechanical properties of the cells could be indirectly measured by interpolating the Young’s moduli of the *** a result,the calculated Young’s moduli,i.e.,1.527kPa for MDA-MB-231(highly invasive breast cancer cells),2.650kPa for MCF-7(weakly invasive breast cancer cells),and 2.772 kPa for SkBR-3(weakly invasive breast cancer cells),indicate that highly invasive cancer cells exhibited a lower Young’s moduli than weakly invasive cells,which indicates a higher deformability of highly invasive cancer cells,leading to a higher metastasis ***-cell treatment may also be carried out by bursting a highly invasive cell with high-intensity,focused ultrasound.

关键词： diagnosis treatment weakly

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