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Liver transplantation as an alternative for the treatment of neuroendocrine liver metastasis: Appraisal of the current evidence

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hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 146-153页

作者： Philip C.Muller Matthias Pfister Dilmurodjon Eshmuminov kuno lehmann Department of Surgery and Transplantation University Hospital ZurichRämistrasse 100Zurich CH-8091Switzerland

Background:Liver transplantation(LT)for neuroendocrine liver metastases(NELM)is still in *** comparing LT with liver resection(LR)for NELM are scarce,as patient selection is heterogeneous and experience is *** goal of this review was to provide a critical analysis of the evidence on LT versus LR in the treatment of *** sources:A scoping literature search on LT and LR for NELM was performed with PubMed,including English articles up to March ***:International guidelines recommend LR for NELM in resectable,well-differentiated tumors in the absence of extrahepatic metastatic disease with superior results of LR compared to systemic or liver-directed *** liver surgery has extended resectability criteria whilst entailing increased perioperative risk and short disease-free *** highly selected patients(based on the Milan criteria)with unresectable NELM,oncologic results of LT are *** factors include tumor biology(G1/G2)and burden,waiting time for LT,patient age and extrahepatic *** on low-level evi-dence,LT for low-grade NELM within the Milan criteria resulted in improved disease-free survival and overall survival compared to *** benefits of LT were lost in patients beyond the Milan ***:With adherence to strict selection criteria especially tumor biology,LT for NELM is becoming a valuable option providing oncologic benefits compared to *** evidence suggests even stricter selection criteria with regard to tumor biology.

关键词： Liver transplantation Neuroendocrine liver metastases Liver resection Selection criteria Tumor biology

Fish-on-Chips:unveiling neural processing of chemicals in small animals through precise fluidic control

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Neural Regeneration Research 2024年第11期19卷 2351-2353页

作者： Samuel k.h.Sy ho ko Division of Neurology Department of Medicine and TherapeuticsFaculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Li ka Shing Institute of health Sciences Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Department of Electrical and Electronic Engineering Faculty of EngineeringThe University of Hong KongPok Fu LamHong Kong IslandHong Kong Special Administrative RegionChina Advanced Biomedical Instrumentation Center Hong Kong Science ParkPak Shek KokNew TerritoriesHong Kong Special Administrative RegionChina Margaret k.L.Cheung Research Center for Management of Parkinsonism Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Lau Tat-chuen Research Center of Brain Degenerative Diseases in Chinese Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Gerald Choa Neuroscience Institute The Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina

Precise chemical cue presentation alongside advanced brainwide imaging techniques is important to the study of chemosensory processing in ***,the dynamic nature of chemical-carrying media,such as water or air,poses a significant challenge for delivering highly-controlled chemical flow to an animal ***,contact-based cue manipulation and delivery easily shift the position of the animal subject,which is often undesirable for high-quality brain ***,more advanced interfacing tools that align with the diverse range of body part sizes of an animal,ranging from micrometer-scale neurons to meter-long limbs,are much *** is particularly crucial when dealing with dimensions that are beyond the reach of conventional experimental tools.

关键词： dealing precise sizes

Long Term X-Ray Spectral Variations of the Seyfert-1 Galaxy Mrk 279

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Research in Astronomy and Astrophysics 2024年第6期24卷 307-314页

作者： k.Akhila Ranjeev Misra Savithri h.Ezhikode k.Jeena Department of Physics Providence Women’s CollegeUniversity of CalicutKerala 673009India Inter-University Centre for Astronomy and Astrophysics(IUCAA) PB No.4GaneshkhindPune 411007India Department of Physics and Electronics CHRIST(Deemed to be University)Hosur Main RoadBangalore 560029India

We present the results from a long term X-ray analysis of Mrk 279 during the period 2018–*** use data from multiple missions–AstroSat,NuSTAR and XMM-Newton,for the *** X-ray spectrum can be modeled as a double Comptonization along with the presence of neutral Fe kαline emission,at all *** determined the source’s X-ray flux and luminosity at these different *** find significant variations in the source’s flux *** also investigate the variations in the source’s spectral components during the observation *** find that the photon index and hence the spectral shape follow the variations only over longer time *** probe the correlations between fluxes of different bands and their photon indices,and found no significant correlations between the parameters.

关键词： galaxies:Seyfert galaxies:individual(Mrk 335) X-rays:galaxies

Net effect of air pollution controls on health risk in the Beijing-Tianjin-hebei region during the 2022 winter Olympics and Paralympics

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Journal of Environmental Sciences 2024年第1期135卷 560-569页

作者： Changqing Lin Peter k.k.Louie Alexis k.h.Lau Jimmy C.h.Fung Zibing Yuan Minghui Tao Xuguo Zhang Md.Shakhaoat hossain Chengcai Li Xiang Qian Lao Division of Environment and Sustainability The Hong Kong University of Science and TechnologyHong KongChina Environmental Protection Department Hong Kong Government SARHong KongChina Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina Guangdong-hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality The Hong Kong University of Science and TechnologyHong KongChina Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina School of Environment and Energy South China University of TechnologyGuangzhou 510006China hubei key Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Department of Public health and Informatics Jahangirnagar UniversityDhaka 1342Bangladesh Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Jockey Club School of Public health and Primary Care The Chinese University of Hong KongHong KongChina

Due to the non-linearity in ozone(O_(3))formation,reducing the emission of nitrogen oxides(NO_(x))may increase O_(3) *** the counteractive O_(3) response to NO_(x) reduction,overall impact of air pollution controls can be ambiguous when the assessments focus on the changes in pollutant *** this study,a risk-based method was used to gauge the net effect of air pollution controls on mortality risk in the Beijing–Tianjin–hebei(BTh)region during the 2022 Winter Olympics and Paralympics(WOP).This mega-event presents a unique opportunity to investigate the efficacy of deep cuts in pollutant *** show that O_(3) concentrations greatly increased as nitrogen dioxide(NO_(2))concentrations decreased in the *** to the active photochemical formations,O_(3) became the dominant pollutant that affected human health during the *** the substantial O_(3) increases,the health benefits of NO_(2) reductions overwhelmed the adverse health effects of O_(3) increases in most regions of the BTh(at 81 out of 112 stations).After considering the impacts of particulate matter,the integrated health risk of air pollution mixtures declined almost everywhere in the *** results underscore the great necessity of changing the assessment paradigm of pollution control from using concentration-based methods to using risk-based *** with the carbon neutrality policy,stringent control of NO_(x)emission from combustion sources is a promising way to achieve synergistic control solutions for air pollution and climate change.

关键词： Ozone Nitrogen dioxide health risk Carbon neutrality Mega-events

Single-pilot operations in commercial flight:Effects on neural activity and visual behaviour under abnormalities and emergencies

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Chinese Journal of Aeronautics 2024年第8期37卷 277-292页

作者： Qinbiao LI Chun-hsien ChEN kam k.h.NG Xin YUAN Cho Yin YIU human Factors and Ergonomics Laboratory Department of Aeronautical and Aviation EngineeringThe Hong Kong Polytechnic UniversityHong Kong Special Administrative Region 100872China School of Mechanical&Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

With cutting-edge technologies and considering airline human-resource-saving,a single pilot in commercial jets could be technically *** changes in captains’natural behaviours are initially required to comprehend the specific safe human performance envelope for safeguarding single-pilot flight,particularly in high-risk *** paper investigates how captains’performance transforms for fixing emergencies when operating from Dual-Pilot Operations(DPO)to Single-Pilot Operations(SPO)through a physiological-based *** pilots flew an emergency-included flight with/without first officers’*** neural activities and scanning behaviours were recorded using a 32-channel Electroencephalogram(EEG)and glasses-based eye tracker,with the observation and post-experiment questionnaires to evaluate the flight operations and pilots’*** alone,there was a significantly increased cortical activity in h and b waves over the frontal,parietal,and temporal lobes during the more complicated emergencies,and pilots focused less on the primary flight display while spending significantly more time scanning the other *** physiological fluctuating patterns associated with risky operations in SPO were highlighted by cross-correlating multimodal *** experimental-based noteworthy insights may wish to inform commercial SPO measures to lessen the persistent physiological fluctuation,assisting airlines in creating SPO-oriented intelligent flight systems to give captains adequate support for assuring safer air transportation.

关键词： Aviation engineering Single pilot operations Behaviour changes Eye tracker Electroencephalogram

Crystal structure and luminescence dynamics of highly pure LiM(PO_(3))_(3):Eu^(3+)(M=Sr,Ca) red phosphors for white light emitting diodes

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Journal of Rare Earths 2024年第8期42卷 1470-1478,I0002页

作者： Payal khajuria M.Manhas A.k.Bedyal Ankush Vij h.C.Swart Vinay kumar Department of Physics and Astronomical Sciences Central University of JammuRahy-Suchani.Samba1143J&KIndia Department of Physics School of SciencesCluster University of JammuCanal RoadJammu180001India Department of Physics University of Petroleum and Energy StudiesDehradunUttarakhand248007India Department of Physics University of the Free StateP.O.Box 339BloemfonteinZA 9300South Africa

highly pure red phosphors LiM(PO_(3))_(3):Eu^(3+)(M=Sr,Ca) doped with Eu^(3+)(1 mol%) were synthesized via solution combustion method and their crystal structure and luminescence dynamics were studied to explore its suitability in white light emitting *** Rietveld refinement analysis of the powder Xray diffraction patterns reveals that the phosphors belong to the pure triclinic phase of LiSr(PO_(3))_(3) and LiCa(PO_(3)) with space group P-1(2).The scanning electron microscopy images showed the agglomerated *** photoluminescence emission spectra under 393 nm show an orange band at 594 nm and a red band at 613 nm ascribed to ^(5)D_(0)→^(7)F_(1).^(5)D_(0)→^(7)F_(2) transitions of Eu^(3+)ion in both the ***,the spectroscopic properties such as luminescence behaviour,and Stark splitting were used to examine the symmetry of Eu^(3+)ions in LiM(PO_(3))_(3):Es^(3+)(M=Sr,Ca) phosphors in terms of distortion induced upon *** Stark splitting shows that the actual site symmetry for Eu^(3+)ion was estimated to be D_(2) type for both *** photometric properties of LiCa(PO_(3))_(3):Eu^(3+)such as Commission International de l'Eclairage coordinates(x=0.64,y=0.36) near to the standard one(red),high color purity(95%) and higher brightness reveal that the phosphor has the capability of acting as a red component in n-UV white light emitting diodes.

关键词： Photoluminescence Phosphate WLEDs Stark splitting Rare earths

Influence of erbium on structural,and charged particles,photons,and neutrons shielding properties of Ba_(1-x)Er_(x)SnO_(3) perovskite ceramics

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Journal of Rare Earths 2024年第4期42卷 724-732页

作者： M.k.h.hamad Nidal Dwaikat M.h.A.Mhareb M.I.Sayyed R.M.hamad Y.S.M.Alajerami M.A.Almessiere Gameel Saleh Ahmad hussein Alomari k.A.Ziq Department of Basic Sciences School of Social and Basics SciencesAl Hussein Technical UniversityKing Abdullah II St 242Amman11831Jordan Department of Physics College of Engineering and PhysicsInterdisciplinary Research Center for Advanced MaterialsKing Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Department of Physics College of ScienceImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam31441Saudi Arabia Basic and Applied Scientific Research Center Imam Abdulrahman Bin Faisal UniversityP0.Box 1982Dammam31441Saudi Arabia Department of Physics Faculty of ScienceIsra UniversityAmman11622Jordan Department of Nuclear Medicine Research Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityPo.Box 1982Dammam31441Saudi Arabia Medical Imaging Department Applied Medical Sciences FacultyAl Azhar University-Gaza CityPo.Box 1277Palestine Department of Biophysics Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityPo.Box1982Dammam 31441Saudi Arabia Department of Biomedical Engineering College of EngineeringImam Abdulrahman Bin Faisal UniversityPo.Box 1982Dammam31441Saudi Energy&Minerals Regulatory Commission Amman11821Jordan

Five perovskite ceramics samples of Ba_(1-x)Er_(x)SnO_(3) with x=0.00,0.05,0.10,0.15,and 0.20 were synthesized using the conventional solid-state reaction *** prepared samples were characterized by X-ray diffraction(XRD),Fourier transforms infrared(FTIR),and UV-Vis *** shielding properties against ionizing radiation were also *** XRD analysis shows the perovskite cubic structure as the major phase in all *** FTIR reveals a distinctive band around 614-620 cm^(-1) ascribed to the antisymmetric O-Sn-O ***-Vis spectroscopy was used to determine the bandgap according to diffuse reflectance,and the results display a fixed enhancement in the bandgap from 3.2 to 3.3 eV for all ***-ray shielding properties of the synthesized samples were experimentally measured and compared with XCOM computational *** relative differences(Δ,%)between experimental and theo retical values are low and fall within the 0.446%-7.10%*** addition of Er leads to the enhanced density,neutron,and gamma shielding *** contrast,charged particles’shielding parameters gradually reduce with rising Er *** results suggest that Ba_(1-x)Er_(x)SnO_(3) samples can be used in different radiation shielding applications.

关键词： Perovskite Ceramics Gamma ray shielding Mass stopping power Rare earths

Reply to “Beyond microbial carbon use efficiency”

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National Science Review 2024年第4期11卷 35-37页

作者： Feng Tao Johannes lehmann Ying-Ping Wang Lifen Jiang Bernhard Ahrens kostiantyn Viatkin Stefano Manzoni Benjamin Z.houlton Yuanyuan huang Xiaomeng huang Yiqi Luo Department of Ecology and Evolutionary Biology Cornell University Soil and Crop Sciences Section School of Integrative Plant ScienceCornell University CSIRO Environment Max Planck Institute for Biogeochemistry Department of Physical Geography and Bolin Centre for Climate Research Stockholm University Department of Global Development Cornell University key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Department of Earth System Science Ministry of Education Key Laboratory for Earth System Modelling Institute for Global Change Studies Tsinghua University

In their commentary, Xiao et al.[1]cautioned that the conclusions on the critical role of microbial carbon use efficiency (CUE) in global soil organic carbon (SOC) storage in the paper by Tao et al.[2] might be too *** claimed that Tao et al.’s study lacked mechanistic consideration of SOC formation and excluded important data *** et al. brought up important points,which can be largely reconciled with our findings by understanding the differences in expressing processes in empirical studies and in models.

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hybrid-Vlasov simulation of soft X-ray emissions at the Earth’s dayside magnetospheric boundaries

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Earth and Planetary Physics 2024年第1期8卷 70-88页

作者： M.Grandin h.k.Connor S.hoilijoki M.Battarbee Y.Pfau-kempf U.Ganse k.Papadakis M.Palmroth Department of Physics University of HelsinkiHelsinkiFinland NASA Goddard Space Flight Center GreenbeltMD20771USA Space and Earth Observation Centre Finnish Meteorological InstituteHelsinkiFinland

Solar wind charge exchange produces emissions in the soft X-ray energy range which can enable the study of near-Earth space regions such as the magnetopause,the magnetosheath and the polar cusps by remote sensing *** Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)and Lunar Environment heliospheric X-ray Imager(LEXI)missions aim to obtain soft Xray images of near-Earth space thanks to their Soft X-ray Imager(SXI)*** earlier modeling works have already simulated soft X-ray images as might be obtained by SMILE SXI during its mission,the numerical models used so far are all based on the magnetohydrodynamics description of the space *** investigate the possible signatures of ion-kinetic-scale processes in soft Xray images,we use for the first time a global hybrid-Vlasov simulation of the geospace from the Vlasiator *** simulation is driven by fast and tenuous solar wind conditions and purely southward interplanetary magnetic *** first produce global X-ray images of the dayside near-Earth space by placing a virtual imaging satellite at two different locations,providing meridional and equatorial *** then analyze regional features present in the images and show that they correspond to signatures in soft X-ray emissions of mirrormode wave structures in the magnetosheath and flux transfer events(FTEs)at the *** results suggest that,although the time scales associated with the motion of those transient phenomena will likely be significantly smaller than the integration time of the SMILE and LEXI imagers,mirror-mode structures and FTEs can cumulatively produce detectable signatures in the soft X-ray *** instance,a local increase by 30%in the proton density at the dayside magnetopause resulting from the transit of multiple FTEs leads to a 12%enhancement in the line-of-sight-and time-integrated soft X-ray emissivity originating from this ***,a proton density increase by 14%in the magnetosheath

关键词： magnetosphere magnetosheath numerical simulation SMILE LEXI soft X-ray emissions hybrid-Vlasov model polar cusp flux transfer events mirror-mode waves