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Neural Regeneration Research 2025年第2期20卷 366-377页

作者： samuel Abokyi Dennis Yan-yin Tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their *** comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing *** vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and *** retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering pro

关键词： age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma neuromodulation phagocytosis photoreceptor outer segment degradation retinal aging transcription factor EB

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris k.Salgado Jose M.Santiago samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/gLAST EAAT-2/gLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Formal verification with HiLLS-specified models:A further step in multi-analysis modeling of complex systems

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International Journal of Modeling, Simulation, and Scientific Computing 2019年第5期10卷 82-107页

作者： kehinde g.samuel Oumar Maiga Mamadou k.Traor′e frican University of Science&Technology AbujaNigeria Universit´e des Sciences des Techniques et des Technologies Bamako Mali University of Bordeaux IMS CNRS UMR 5218 France

The multi-analysis modeling of a complex system is the act of building a family of models which allows to cover a large spectrum of analysis methods(such as simulation,formal methods,enactment,...)that can be performed to derive various properties of this *** High-Level Language for Systems Specification(HiLLS)has recently been introduced as a graphical language for discrete event simulation,with potential for other types of analysis,like enactment for rapid system *** defines an automata language that also opens the way to formal *** paper provides the building blocks for such a *** way,a unique model can be used not only to perform both simulation and enactment experiments but also to allow the logical analysis of properties without running any ***,it saves from the effort of building three different analysis-specific models and the need to align them semantically.

关键词： Discrete Event System Specification(DEVS) High Level Language for Systems Specification(HiLLS) multi-analysis modeling discrete event simulation model checking

Fish-on-Chips:unveiling neural processing of chemicals in small animals through precise fluidic control

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Neural Regeneration Research 2024年第11期19卷 2351-2353页

作者： samuel k.H.Sy Ho ko Division of Neurology Department of Medicine and TherapeuticsFaculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Li ka Shing Institute of Health Sciences Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Department of Electrical and Electronic Engineering Faculty of EngineeringThe University of Hong KongPok Fu LamHong Kong IslandHong Kong Special Administrative RegionChina Advanced Biomedical Instrumentation Center Hong Kong Science ParkPak Shek KokNew TerritoriesHong Kong Special Administrative RegionChina Margaret k.L.Cheung Research Center for Management of Parkinsonism Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina Lau Tat-chuen Research Center of Brain Degenerative Diseases in Chinese Faculty of MedicineThe Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina gerald Choa Neuroscience Institute The Chinese University of Hong KongShatinNew TerritoriesHong Kong Special Administrative RegionChina

Precise chemical cue presentation alongside advanced brainwide imaging techniques is important to the study of chemosensory processing in ***,the dynamic nature of chemical-carrying media,such as water or air,poses a significant challenge for delivering highly-controlled chemical flow to an animal ***,contact-based cue manipulation and delivery easily shift the position of the animal subject,which is often undesirable for high-quality brain ***,more advanced interfacing tools that align with the diverse range of body part sizes of an animal,ranging from micrometer-scale neurons to meter-long limbs,are much *** is particularly crucial when dealing with dimensions that are beyond the reach of conventional experimental tools.

关键词： dealing precise sizes

TRS Scheduling for Improved QoS Performance in Cloud System

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Computers, Materials & Continua 2023年第4期75卷 1547-1559页

作者： g.John samuel Babu M.Baskar Department of Computer Science and Engineering School of ComputingCollege of Engineering and TechnologySRM Institute of Science and TechnologyKattankulathurChengalpattuTamilnadu603203India Department of Computing Technologies School of ComputingCollege of Engineering andTechnologySRM Institute of Science and TechnologyKattankulathurChengalpattuTamilnadu603203India

Numerous methods are analysed in detail to improve task schedulingand data security performance in the cloud environment. The methodsinvolve scheduling according to the factors like makespan, waiting time,cost, deadline, and popularity. However, the methods are inappropriate forachieving higher scheduling performance. Regarding data security, existingmethods use various encryption schemes but introduce significant serviceinterruption. This article sketches a practical Real-time Application CentricTRS (Throughput-Resource utilization–Success) Scheduling with Data Security(RATRSDS) model by considering all these issues in task scheduling anddata security. The method identifies the required resource and their claim timeby receiving the service requests. Further, for the list of resources as services,the method computes throughput support (Thrs) according to the number ofstatements executed and the complete statements of the service. Similarly, themethod computes Resource utilization support (Ruts) according to the idletime on any duty cycle and total servicing time. Also, the method computesthe value of Success support (Sus) according to the number of completions forthe number of allocations. The method estimates the TRS score (ThroughputResource utilization Success) for different resources using all these supportmeasures. According to the value of the TRS score, the services are rankedand scheduled. On the other side, based on the requirement of service requests,the method computes Requirement Support (RS). The selection of service isperformed and allocated. Similarly, choosing the route according to the RouteSupport Measure (RSM) enforced route security. Finally, data security hasgets implemented with a service-based encryption technique. The RATRSDSscheme has claimed higher performance in data security and scheduling.

关键词： Cloud task scheduling TRS quality of service RSM route security data security SDE RATRSDS

Optimal load frequency control through combined state and control gain estimation for noisy measurements

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Protection and Control of Modern Power Systems 2020年第1期5卷 268-279页

作者： Anju g.Pillai Elizabeth Rita samuel A.Unnikrishnan Department of Electrical&Electronics Engineering Rajagiri School of Engineering&TechnologyErnakulamKerala 682037India APJ Abdul kalam Technological University ThiruvananthapuramKeralaIndia

Combined estimation of state and feed-back gain for optimal load frequency control is *** frequency control(LFC)addresses the problem of controlling system frequency in response to disturbance,and is one of main research areas in power system operation.A well acknowledged solution to this problem is feedback stabilization,where the Linear Quadratic Regulator(LQR)based controller computes the feedback gain k from the known system parameters and implements the control,assuming the availability of all the state ***,this approach restricts control to cases where the state variables are readily available and the system parameters are ***,by estimating the states continuously from available measurements of some of the states,it can accommodate dynamic changes in the system *** paper proposes the technique of augmenting the state variables with controller *** introduces a non-linearity to the augmented system and thereby the estimation is performed using an Extended kalman *** results in producing controller gains that are capable of controlling the system in response to changes in load demand,system parameter variation and measurement noise.

关键词： Load frequency control State feedback control Linear quadratic regulator Extended kalman filter Single area power system

Impact of indoor heat load and natural ventilation on thermal comfort of radiant cooling system:An experimental study

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Energy and Built Environment 2023年第5期4卷 543-556页

作者： k Dharmasastha D.g.Leo samuel S.M.Shiva Nagendr M.P.Maiya Department of Mechanical Engineering Indian Institute of Technology MadrasChennaiTamil Nadu 600036India Barghest Building Performance Pte.Ltd. 118535Singapore Department of Civil Engineering Indian Institute of Technology MadrasRefrigeration and Air ConditioningChennai 600036India Department of Building Enivironment and Energy Engineering The Hong Kong Polytechnic UniversityHong Kong

Construction and operation of buildings are responsible for about 20%of the global energy *** embodied energy of conventional buildings is high due to the utilization of energy-intensive construction mate-rials and traditional construction *** operational energy is attributed to the usage of power-consuming conventional air-conditioning ***,moving to an energy-efficient cooling technology and eco-friendly building material can lead to significant energy savings and CO 2 emission *** the present study,an energy-efficient thermally activated building system(TABS)is integrated with glass fiber rein-forced gypsum(gFRg),an eco-friendly building *** proposed hybrid system is termed the thermally activated glass fiber reinforced gypsum(TAgFRg)*** system is not only energy-efficient and eco-friendly but also provides better thermal *** experimental room with a TAgFRg roof is constructed on the premises of the Indian Institute of Technology Madras(IITM),Chennai,located in a tropical wet and dry climate *** influence of indoor sensible heat load and the impact of natural ventilation on the thermal comfort of the TAgFRg system are *** increase in internal heat load from 400 to 700 W deteriorates the thermal comfort of the indoor *** is evident from the increases in operative temperatures from 29.8 to 31.5℃ and the predicted percentage of dissatisfaction from 44.5%to 80.9%.Natural ventilation increases the diurnal fluctuation of indoor air temperature by 1.6 and 1.9℃ for with and without cooling cases,*** reduces the maximum indoor CO 2 concentration from 912 to 393 ppm.

关键词： Thermally activated building system Air-conditioning Natural ventilation Thermal comfort Indoor air quality

Disagreement between symptom-reflux association analysis parameters in pediatric gastroesophageal reflux disease investigation

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World Journal of gastroenterology 2010年第19期16卷 2401-2406页

作者： samuel C Lüthold Mascha k Rochat Peter Bhler Division of gastroenterology Departement of Pediatrics Hospital of Fribourg CH-1708 Fribourg Switzerland Asthma and Allergy Research group University of Munich Lindwurmstrasse 4 D 80337 Munich Germany

AIM: To assess the agreement within 3 commonly used symptom-reflux association analysis (SAA) parameters investigating gastroesophageal reflux disease (gERD) in infants. METHODS: Twenty three infants with suspected gERD were included in this study. Symptom index (SI), Symptom sensitivity index (SSI) and symptom association probability (SAP) related to cough and irritability were calculated after 24 h combined pH/multiple intraluminal impedance (MII) monitoring. Through defined cutoff values, SI, SSI and SAP values are differentiated in normal and abnormal, whereas abnormal values point towards gastroesophageal reflux (gER) as the origin of symptoms. We analyzed the correlation and the concordance of the diagnostic classification of these 3 SAA ***: Evaluating the gER-irritability association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 39.2% of the infants. When irritability was taken as a symptom, there was only a poor inter-parameter association between SI and SSI, and between SI and SAP (kendall’s tau b = 0.37, P kendall’s tau b = 0.36, P g the gER-cough association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 52.2% of the patients. When cough was taken as a symptom, only SI and SSI showed a poor inter-parameter association (kendall’s tau b = 0.33, P gated for suspected gERD with pH/MII-monitoring, SI, SSI and SAP showed a poor inter-parameter association and important dis-agreements in diagnostic classification. These limitations must be taken into consideration when interpreting the results of SAA in infants.

关键词： gastroesophageal reflux disease Infant Symptom-reflux association analysis Intraluminal impedance monitoring pH

Electrical and non-linear optical studies on electrospun ZnO/BaO composite nanofibers

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Frontiers of Materials Science 2012年第1期6卷 69-78页

作者： g.NIXON samuel VIJAYAkUMAR M.RATHNAkUMARI P.SURESHkUMAR Department of Physics R.M.K.Engineering CollegeR.S.M.NagarKavaraipettai 601206India Materiais Research Centre Department of PhysicsVelammal Engineering CollegeChennai 600066India

Nanocapacitors and nonvolatile ferroelectric random access memories require nanoscale thin film coatings with ferroelectric properties. One dimensional ferroelectric nanofibers are used in ferroelectric memory devices owing to the fact that decrease of the dimensionality of the memory device elements will reduce the addressing and appreciably increase the storage capacity, Novel ZnO/BaO nanocomposite fibers exhibiting ferroelectric properties have been prepared in the form of non-woven mesh by electrospinning the sol derived from the sol-gel route, Thin cylindrical nanofibers of average diameter 100 nm have been obtained and their morphology is confirmed by SEM and AFM images. In the electrospinning process, the effect of the working distance on the fiber morphology was studied and it showed that working distance between 11 and 15 cm can produce fibers without beads and the decrease in working distance in this range increases the fiber diameter. Powder XRD was used to identify the phases and EDX analysis confirmed the presence of ZnO/BaO. Dielectric and non-linear optical properties have also been studied. The dielectric studies showed that ZnO/BaO composite nanofibers undergo a phase transition from ferroelectric to paraelectric at 323 k.

关键词： nanocomposite fiber sol-gel process dielectric property non-linear opticalproperty ferroelectric property