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NeCAB family of neuronal calcium-binding proteins in health and disease

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael k.e.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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COVID-19病人出院后3个月和1年后的CT肺部异常

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国际医学放射学杂志 2022年第4期 480-480页

作者： B.Vijayakumar j.Tonkin A.Devaraj k.e.j.philip C.M.Orton S.R.Desai P.L.Shah 刘雪丹

摘要目的在长达1年的随访中，评估出院新型冠状病毒肺炎（COVID-19）病人的症状、功能损害和在连续胸部CT扫描中显示的残余肺异常。资料与方法作为一项针对

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Risk of Tropical Cyclones and Floods to Power Grids in Southeast and east Asia

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International journal of Disaster Risk Science 2024年第4期15卷 494-507页

作者： Mengqi Ye philip j.Ward Nadia Bloemendaal Sadhana Nirandjan elco e.koks Institute for environmental Studies Vrije Universiteit Amsterdam1081 HV AmsterdamThe Netherlands Deltares 2629 HV DelftThe Netherlands Royal Netherlands Meteorological Institute(kNMI) 3731 GA De BiltThe Netherlands

Power grids play a critical role in modern society, serving as the lifeline of a well-functioning economy. This article presents a first large-scale study on the risk estimation of tropical cyclone(TC)-induced winds and coastal floods, which can widely impact power grids in Southeast and east Asia. Our comprehensive risk model incorporates detailed infrastructure data from OpenStreetMap(OSM) and government power grid maps, along with global hazard maps and vulnerability curves. The results reveal that the estimated expected annual damages from TCs and coastal floods to OSM-mapped assets account for approximately 0.07%(0.00–0.38%) and 0.02%(0.00–0.02%) of the total GDP of the study area, respectively. We analyzed the main sources of uncertainty in the risk model and emphasized the importance of understanding asset *** results highlight the urgent need to strengthen power infrastructure to withstand the impacts of natural hazards, and the significance of reliable risk information for improving power grid design and planning. Focusing on developing more region-specific infrastructure data and vulnerability curves will improve the accuracy of risk estimation and provide valuable insights not only for the electricity sector but also for customers of other infrastructure systems that heavily rely on a stable supply of electricity.

关键词： Asset level Coastal foods Power grids Risk analysis Tropical cyclones Vulnerability curves

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Predicting june Mean Rainfall in the Middle/Lower Yangtze River Basin

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Advances in Atmospheric Sciences 2020年第1期37卷 29-41页

作者： Gill M.MARTIN Nick j.DUNSTONe Adam A.SCAIFe philip e.BeTT Met Office exeter

We demonstrate that there is significant skill in the GloSea5 operational seasonal forecasting system for predicting june mean rainfall in the middle/lower Yangtze River basin up to four months in *** of the rainfall in this region during june is contributed by the mei-yu rain *** find that similar skill exists for predicting the east Asian summer monsoon index(eASMI)on monthly time scales,and that the latter could be used as a proxy to predict the regional ***,there appears to be little to be gained from using the predicted eASMI as a proxy for regional rainfall on monthly time scales compared with predicting the rainfall *** interannual variability of the june mean rainfall is affected by synoptic and intraseasonal variations,which may be inherently unpredictable on the seasonal forecasting time scale,the major influence of equatorial Pacific sea surface temperatures from the preceding winter on the june mean rainfall is captured by the model through their influence on the western North Pacific subtropical *** ability to predict the june mean rainfall in the middle and lower Yangtze River basin at a lead time of up to 4 months suggests the potential for providing early information to contingency planners on the availability of water during the summer season.

关键词： forecast skill eASMI monthly mean rainfall east Asian summer monsoon Yangtze River basin

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Semi-Relativistic Reflection and Transmission Coefficients for Two Spinless Particles Separated by a Rectangular-Shaped Potential Barrier

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Communications in Theoretical Physics 2016年第10期65卷 389-395页

作者： k.e.Thylwe O.j.Oluwadare k.j.Oyewumi kTH-Mechanics Royal institute of Technology Department of Physics Federal University Oye-Ekiti Theoretical Physics Section Department of PhysicsUniversity of Ilorin

A generalized Schr¨odinger approximation,due to Ikhdair & Sever,of the semi-relativistic two-body problem with a rectangular barrier in(1+1) dimensions is compared with exact *** and approximate transmission and reflection coefficients are obtained in terms of local wave *** approximate transmission and reflection coefficients turn out to be surprisingly accurate in an energy range |∈-V0| ere μ is the reduced mass,∈ the scattering energy,and V_0 the barrier top *** approximate wave numbers are less accurate.

关键词： two-body relativistic equation rectangular barrier transmission 1+1D relativistic scattering semi-relativistic approximation spinless Salpeter equation

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Non-Relativistic Phase Shifts for Scattering on Generalized Radial Yukawa Potentials

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Communications in Theoretical Physics 2016年第4期65卷 434-440页

作者： O.j.Oluwadare k.e.Thylwe k.j.Oyewumi Department of Physics Federal University Oye-Ekiti kTH-Mechanics Royal institute of Technology Theoretical Physics Section Department of PhysicsUniversity of Ilorin

Non-relativistic phase shifts for a generalized Yukawa potential V(r) =-V_0( e^(-αr)/r)-V_1( e^(-2αr)/r^2) are studied by the amplitude-phase method and by a frequently used analytic method based on a Pekeris-type approximation of power-law potential *** variations of V_1 seem to have marginal effects on the effective potential and on exact phase ***,as pointed out in this study,a Pekeris-type approximation in scattering applications often implies serious distortions of both effective potentials and phase *** Pekeris-type based analytic approximation in this study seems to give low-quality scattering results for this model potential at low energies.

关键词： quantum mechanics scattering partial waves resonances

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Nanoscale viscoelastic properties and adhesion of polydimethylsiloxane for tissue engineering

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Acta Mechanica Sinica 2014年第1期30卷 2-6页

作者： j.Chen k.e.Wright M.A.Birch School of Mechanical & Systems engineering Newcastle University Arthritis Research Uk (ARUk) Tissue engineering Centre Institute of Cellular MedicineNewcastle UniversityUK Research Uk (ARUk) Tissue engineering Centre Institute of Cellular MedicineNewcastle UniversityUK St james’ University Hospital University of Leeds UK

It has shown that altering crosslink density of biopolymers will regulate the morphology of Mesenchymal Stem Cells （MSCs） and the subsequent MSCs differentia- tion. These observations have been found in a wide range of biopolymers. However, a recent work published in Nature Materials has revealed that MSCs morphology and differen- tiation was unaffected by crosslink density of polydimethyl- siloxane （PDMS）, which remains elusive. To understand such unusual behaviour, we use nanoindentation tests and modelling to characterize viscoelastic properties and sur- face adhesion of PDMS with different base：crosslink ratio varied from 50：1 （50D） to 10：1 （10D）. It has shown that lower crosslink density leads to lower elastic moduli. De- spite lower nanoindentation elastic moduli, PDMS with lowest crosslink density has higher local surface adhesion which would affect cell-biomaterials interactions. This work suggests that surface adhesion is likely another important physical cue to regulate cell-biomaterials interactions.

关键词： Bioploymer- Nanoindentation- Viscoelasticity Surface adhesion

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Biomimetic Leukocyte Adhesion: A Review of Microfluidic and Computational Approaches and Applications

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journal of Bionic engineering 2008年第4期5卷 317-327页

作者： j. Hanzlik e. Cretekos k. A. Lamkin-kennard Department of Mechanical engineering Rochester Institute of Technology Rochester

Leukocyte rolling and adhesion are complex physiological processes that have received a great deal of attention over the past decade. Significant increases in the knowledge base related to how leukocytes adhere in shear flows have occurred as a result of the development of novel experimental and computational techniques. Micro- and nano-fabrication techniques have enabled the development of novel flow devices for studying leukocyte adhesion in simple and complex geometries. Improvements in computer technology have enabled simulations of complex flow processes to be developed. As a result of these advances in knowledge related to leukocyte adhesion, numerous novel devices have been developed that mimic the leukocyte rolling and adhesion process. examples of these devices include cell separation and enrichment devices and targeted ultrasound contrast agents. Future advances related to leukocyte rolling and adhesion processes hold great promise for advancing our knowledge of disease processes as well as development of novel therapeutic devices.

关键词： leukocyte microfluidics hydrodynamics

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Critical parameters near the ferromagnetic-paramagnetic phase transition in La_(0.67–x)Y_xBa_(0.23)Ca_(0.1)MnO_3 compounds(x=0.10 and x=0.15)

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journal of Rare earths 2015年第3期33卷 263-270页

作者： Mounira Abassi N.Dhahri j.Dhahri k.Taibi e.k.Hlil Laboratory of Condensed Matter and Nanosciences University of Monastir 5019 Tunisia Institut Néel CNRS and Joseph Fourier university B.P.166 38042 Grenoble France Institut Néel CNRS et Université Joseph Fourier BP 166 F-38042 Grenoble cedex 9 France

The critical properties of the mixed manganite La0.67–x Y x Ba0.23Ca0.1Mn O3 with x=0.10 and x=0.15 around the paramagnetic（PM）-ferromagnetic（FM） phase transition were investigated through various techniques. These involved modified Arrott plots, kouvel-Fisher method and Widom scaling relation. Magnetic data, analyzed in the critical region, using the above methods, yielded the critical exponents for（x=0.10） La0.57Y0.10Ba0.23Ca0.1Mn O3（β=0.312±0.002 and γ=1.147±0.003 at T C=299.23±0.05 k）. Moreover, the estimated critical exponents of（x=0.15） La0.52Y0.15Ba0.23Ca0.1Mn O3 were β=0.286±0.004 and γ=0.943±0.002 at T C=289.53±0.06 k. The critical exponents＇ values were close to the theoretical values of 3D-Ising model and tricritical mean-field model. These results suggested that the present composition should be close to a tricritical point in the La0.67–x Y x Ba0.23Ca0.1Mn O3 phase diagram. expressing the field dependence as ΔS M∝H n allowed us to establish a relationship between the exponent n and the critical exponents of the material and to propose a phenomenological universal curve for the field dependence of ΔS M.

关键词： perovskite manganites phase transition entropy critical properties rare earths

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Dryland agriculture and rangeland restoration priorities in Afghanistan

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journal of Arid Land 2015年第3期7卷 391-402页

作者： Michael j jACOBS Catherine A SCHLOeDeR philip D TANIMOTO Texas Agri Life Research Department of Ecosystem Science & Management2138TAMUCollege StationTX 77843-2138USA Oikos Services LLCFortineMT 59918USA Conservation Imaging Inc.AuburndaleMassachusetts 02466USA

Afghanistan is threatened by rangeland degradation.A quantitative visual analysis of Google earth Imagery was used to systematically locate,characterize and quantify the current extent of rangelands in Afghanistan degraded as a consequence of dryland *** data were used in conjunction with dryland agriculture locations to establish a climate envelope comprised by temperature and mean annual precipitation to create a geographical mask known to contain dryland *** this mask we created a grid of 100 km2 cells that we analyzed individually to access dryland agriculture *** limits to sustainable dryland agriculture and areas of high restoration priority were also assessed as was the distribution of rain-fed agriculture with respect to the location of traditional migration routes for extensive livestock *** extents of agriculture in Afghanistan,at both upper and lower elevations,correlated most closely with mean annual temperature（MAT） at the upper elevation limits,and with mean annual precipitation（MAP） at the lower elevation *** total,dryland agriculture comprised 38,980 km2 of former native *** was highest in the northwestern,northern and northeastern provinces of Herat,Badghis,Faryab,jawzjan,Sar-e-Pul,Samangan,Balkh,Baghlan,kunduz,Takhar and Badakhshan,with the highest percentage of conversion occurring in *** MAP value of 〈400 mm is perceived by farmers as the current climatic limit to sustainable dryland agriculture across the northern regions of the *** this MAP value,approximately 27,677 km2 of converted rangeland met the need for restoration *** projections indicate that Afghanistan will become warmer and drier in the coming *** consequence of this trend is that the MAP threshold of 〈400 mm to sustainable dryland agriculture will become obsolete in the coming *** of currently converted rangelands is needed to restore critical grazing area

关键词： degradation climatic trends extensive livestock production dryland agriculture rangeland restoration

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