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结构紧凑的分离器系列

石油石化节能与计量 2000年第8期 25-29页

作者： k.e.arnold,P.L.Ferguson,王晓凤,李太平河南油田设计院河南油田设计院

本文主要介绍了近十年来国外分离器的发展现状 ,对各种类型的分离设备作了评价 ,并进行了相互对比 ,指出轻型结构紧凑的分离器将是今后发展的方向。

关键词：气液分离油水分离三相分离分离设备紧凑结构

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结构紧凑的分离器系列

国外油田工程 2000年第8期16卷 25-25,29页

作者： k.e.arnold P.L.Ferguson 王晓凤李太平河南油田设计院

关键词：气液分离油水分离分离设备紧凑结构

NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael k.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

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Applied Mathematics and Mechanics(english edition) 2025年第1期46卷 193-208页

作者： k.MUHAMMAD M.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHeMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

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SYNTHeSIS AND CHARACTeRIZATION OF NOVeL OPTICALLY ACTIVe POLY(AMIDe-IMIDe)S AND POLY(eSTeR-IMIDe)S CONTAINING CALIX[4]AReNe AND AMINO ACID UNITS WITH BINDING ABILITY TOWARDS ALkALI MeTAL AND TOXIC HeAVY MeTAL CATIONS

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Chinese Journal of Polymer Science 2010年第5期28卷 731-743页

作者： Abdol-reza Hajipour Sakineh Habibi arnold e.Ruoho Dept.of Pharmacology University of WisconsinMedical SchoolMadison53706-1532WIUSA Pharmaceutical Research Laboratory College of ChemistryIsfahan University of TechnologyIsfahan 84156IR Iran

A novel calix[4]arene derivative 2 with amino functional groups at the lower rim was first prepared via introduction of nitro functional groups and amination of the dinitro derivative of calix[4]arene. The optically active monomers were synthesized by dehydration of L-leucine （and L-isoleucine） and 3,3＇,4,4＇-benzophenonetetracarboxylic- 3,3＇,4,4＇-dianhydride （3） followed by reaction with thionyl chloride to form 5a and 5b. Two methods, polymerization under microwave irradiation and solution polymerization in CH2Cl2/TeA, were then employed to carry out the condensation polymerization of 2 with the optically active monomers 5a and 5b, respectively. The polymerization conditions affected the kind of resulting polymers, poly（amide-imide）s （PAIs） 6a and 6b and poly（ester-imide）s （PeIs） 6a＇ and 6b＇ were obtained selectively in good yields and moderate inherent viscosities. Sorption-extraction experiments were carried out using cram picrate extraction method and verified good binding ability of the resulting calixarene-based polymers towards silver, alkali metal and toxic heavy metal cations. Also thermogravimetric analysis indicated that the resulting PAIs and PeIs were thermally stable.

关键词： Condensation polymerization Ionophores Optically active Toxic heavy metals Polymeric calixarenes Thermal stability.

effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Prevalence of transfusion transmissible infections among various donor groups:A comparative analysis

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World Journal of Virology 2025年第1期14卷 108-117页

作者： Sanjay k Thakur Anil k Sinha Santosh k Sharma Aarzoo Jahan Dinesh k Negi Ruchika Gupta Sompal Singh Regional Blood Transfusion Centre Hindu Rao Hospital and NDMC Medical CollegeNorth Delhi 110007DelhiIndia Department of Zoology Veer Kunwar Singh UniversityAra 802301BiharIndia Regional Blood Transfusion Centre and Pathology Hindu Rao Hospital and NDMC Medical CollegeNorth Delhi 110007DelhiIndia Department of Cytopathology ICMR-National Institute of Cancer Prevention and ResearchNoida 201301Uttar PradeshIndia

BACkGROUND Transfusion transmissible infections(TTIs)are illnesses spread through contaminated blood or blood *** India,screening for TTIs such as hepatitis B virus(HBV),hepatitis C virus(HCV),human immunodeficiency virus(HIV)-I/II,malaria,and syphilis is mandatory before blood ***,HCV,HBV,and HIV are the leading viruses causing mortality,affecting millions of people globally,including those with co-infections of HIV/HCV and HIV/*** highlight the impact of TTIs on life expectancy and health risks,such as liver cirrhosis,cancer,and other diseases in individuals with chronic ***,millions of blood donations take place annually,emphasizing the importance of maintaining blood *** To study the prevalence of TTIs,viz.,HBV,HCV,HIV I/II,syphilis,and malaria parasite(MP),among different blood donor *** The study assessed the prevalence of TTIs among different blood donor groups in Delhi,*** included total donors,in-house donors,total camp donors,institutional camp donors,and community camp *** for HIV,HBV,and HCV were done using enzyme-linked immunosorbent assay,while syphilis was tested with rapid plasma reagins and MP rapid card *** prevalence of HBV,HCV,HIV,and syphilis,expressed as *** in infection rates between the groups were analyzed usingχ²tests and P-values(less than 0.05).ReSULTS The study evaluated TTIs among 42158 blood donors in *** overall cumulative frequency of TTIs in total blood donors was 2.071%,and the frequencies of HBV,HCV,HIV-I/II,venereal disease research laboratory,and MP were 1.048%,0.425%,0.221%,0.377%,and 0.0024%,***-house donors,representing 37656 donors,had the highest transfusion transmissible infection(TTI)prevalence at 2.167%.Among total camp donors(4502 donors),TTIs were identified in 1.266%of donors,while community camp donors(2439 donors)exhibited a prevalence of 1.558%.Institutional camp donors(2063 donors)had the l

关键词： Blood donors Transfusion transmissible infections Hepatitis B virus Human immunodeficiency virus Hepatitis C virus Malaria parasite Syphilis

New data sources for social indicators: the case study of contacting politicians by Twitter

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International Journal of Digital earth 2017年第8期10卷 829-845页

作者： Cristina Rosales Sánchez Massimo Craglia arnold k.Bregt european Commission–DG Joint Research Centre Digital Economy UnitIspraItaly Wageningen University and Research Centre Laboratory of Geo-information Science and Remote SensingWageningenThe Netherlands

Data availability is a persistent constraint in social policy *** 2.0 technologies could provide valuable new data sources,but first,their potentials and limitations need to be *** paper reports on a method using Twitter data for deriving indications of active citizenship,taken as an example of social *** citizenship is a dimension of social capital,empowering communities and reducing possibilities of social ***,classical measurements of active citizenship are generally costly and *** paper looks at one of such classic indicators,namely,responses to the survey question‘contacts to politicians’.It compares official survey results in Spain with findings from an analysis of Twitter *** method presents its own strengths and weakness,thus best results may be achieved by the combination of *** surveys have the clear advantage of being statistically robust and representative of a total ***,Twitter data offer more timely and less costly information,with higher spatial and temporal *** paper presents our full methodological workflow for analysing and comparing these two data *** research results advance the debate on how social media data could be mined for policy analysis.

关键词： Twitter active citizenship social media indicators data mining

Governance interactions of spatial data infrastructures: an agent-based modelling approach

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International Journal of Digital earth 2021年第6期14卷 696-713页

作者： Jaap-Willem Sjoukema Jalal Samia arnold k.Bregt Joep Crompvoets Laboratory of Geo-Information Science and Remote Sensing Wageningen University&ResearchWageningenThe Netherlands kU Leuven Public Governance Institute LeuvenBelgium Department of Geography and Urban Planning University of MazandaranBabolsarIran

In order to facilitate and coordinate spatial data sharing and exchange,many organisations have developed spatial data infrastructures(SDIs).SDI governance plays a pivotal role in the development and evolution of an SDI,but as SDIs are complex adaptive systems,governing is a *** research therefore proposes a complexity perspective to SDI governance by exploring the use of agent-based modelling to simulate and examine SDI governance *** this agent-based simulation,we examine interactions between SDI stakeholders,data availability and the effects of different governance styles(hierarchical,network and laissez-faire governance)and budget *** simulation shows that it is possible to mimic SDI governance dynamics through agent-based *** running different scenarios,it appears that a network approach is more successful compared to a hierarchical or laissez-faire *** validation shows that overall the results of the simulation are credible and insightful,although improvements can be made to make the model more *** agent-based modelling,SDI governance becomes more tangible and visible,which facilitates discussion and ***-based modelling therefore appears to be a helpful new approach in a better understanding of the complexities and dynamics of SDI governance.

关键词： Governance spatial data infrastructure(SDI) agentbased modelling funding models complex adaptive systems