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Asian Pacific Journal of Tropical Biomedicine 2024年第9期14卷 401-409页

作者： B.Prathap V.Satyanarayanan k.duraipandian P.Subashree Department of Pharmacology Karpaga Vinayaga Institute of Medical Sciences and Research CenterMaduranthakam 603308Tamil NaduIndia Department of Pharmacology SRM Medical College Hospital and Research CenterKattankulathur 603211Tamil NaduIndia Department of Anatomy Karpaga Vinayaga Institute of Medical Sciences and Research CenterMaduranthakam 603308Tamil NaduIndia Department of Ophthalmology Karpaga Vinayaga Institute of Medical Sciences and Research CenterMaduranthakam 603308Tamil NaduIndia

Objective:To evaluate the effect of asiaticoside on streptozotocin(STZ)and nicotinamide(NAD)-induced carbohydrate metabolism abnormalities and deregulated insulin signaling pathways in ***:Asiaticoside(50 and 100 mg/kg body weight)was administered to STZ-NAD-induced diabetic rats for 45 days,and its effects on hyperglycaemic,carbohydrate metabolic,and insulin signaling pathway markers were ***:Asiaticoside increased insulin production,lowered blood glucose levels,and enhanced glycolysis by improving hexokinase activity and suppressing glucose-6-phosphatase and fructose-1,6-bisphosphatase *** in glycogen metabolism were mitigated by increasing glycogen synthase activity and gluconeogenesis was decreased by decreasing glycogen phosphorylase ***,asiaticoside upregulated the mRNA expressions of IRS-1,IRS-2,and GLUT4 in STZ-NAD-induced diabetic rats and restored the beta cell morphology to ***:Asiaticoside has the potential to ameliorate type 2 diabetes by improving glycolysis,gluconeogenesis,and insulin signaling pathways.

关键词： Asiaticoside Type 2 diabetes mellitus Metabolic disorders Carbohydrate metabolism Insulin signaling

A Novel Optimizer in Deep Neural Network for Diabetic Retinopathy Classification

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Computer Systems Science & Engineering 2022年第12期43卷 1099-1110页

作者： Pranamita Nanda N.duraipandian Department of Computer Science and Engineering Velammal Institute of TechnologyChennai601204TamilnaduIndia Department of Computer Science and Engineering Saveetha Engineering CollegeChennai602105TamilnaduIndia

In severe cases, diabetic retinopathy can lead to blindness. For decades,automatic classification of diabetic retinopathy images has been a challenge. Medical image processing has benefited from advances in deep learning systems. Toenhance the accuracy of image classification driven by Convolutional Neural Network (CNN), balanced dataset is generated by data augmentation method followed by an optimized algorithm. Deep neural networks (DNN) are frequentlyoptimized using gradient (GD) based techniques. Vanishing gradient is the maindrawback of GD algorithms. In this paper, we suggest an innovative algorithm, tosolve the above problem, Hypergradient Descent learning rate based Quasi hyperbolic (HDQH) gradient descent to optimize the weights and biases. The algorithms only use first order gradients, which reduces computation time andstorage space requirements. The algorithms do not require more tuning of thelearning rates as the learning rate tunes itself by means of gradients. We presentempirical evaluation of our algorithm on two public retinal image datasets such asMessidor and DDR by using Resnet18 and Inception V3 architectures. The findings of the experiment show that the efficiency and accuracy of our algorithm outperforms the other cutting-edge algorithms. HDQHAdam shows the highestaccuracy of 97.5 on Resnet18 and 95.7 on Inception V3 models respectively.

关键词： CNN diabetic retinopathy data augmentation gradient descent deep learning optimization

Secured Data Storage Using Deduplication in Cloud Computing Based on Elliptic Curve Cryptography

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Computer Systems Science & Engineering 2022年第4期41卷 83-94页

作者： N.Niyaz Ahamed N.duraipandian Department of Computer Science and Engineering Velammal Engineering CollegeChennai600066India

The tremendous development of cloud computing with related technol-ogies is an unexpected ***,centralized cloud storage faces few chal-lenges such as latency,storage,and packet drop in the *** storage gets more attention due to its huge data storage and ensures the security of secret *** of the developments in cloud storage have been positive except better cost model and effectiveness,but still data leakage in security are billion-dollar questions to *** data security techniques are usually based on cryptographic methods,but these approaches may not be able to with-stand an attack from the cloud server's ***,we suggest a model called multi-layer storage(MLS)based on security using elliptical curve cryptography(ECC).The suggested model focuses on the signiﬁcance of cloud storage along with data protection and removing duplicates at the initial *** on divide and combine methodologies,the data are divided into three ***,theﬁrst two portions of data are stored in the local system and fog nodes to secure the data using the encoding and decoding *** other part of the encrypted data is saved in the *** viability of our model has been tested by research in terms of safety measures and test evaluation,and it is truly a powerful comple-ment to existing methods in cloud storage.

关键词： Cloud storage deduplication fog computing and elliptic curve cryptography

Modeling of Optimal Deep Learning Based Flood Forecasting Model Using Twitter Data

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Intelligent Automation & Soft Computing 2023年第2期35卷 1455-1470页

作者： G.Indra N.duraipandian Department of Computer Science and Engineering RMK College of Engineering and TechnologyChennai601206India Department of Computer Science and Engineering Saveetha Engineering CollegeChennai602106India

Aﬂood is a signiﬁcant damaging natural calamity that causes loss of life and *** work on the construction ofﬂood prediction models intended to reduce risks,suggest policies,reduce mortality,and limit property damage caused byﬂ*** massive amount of data generated by social media platforms such as Twitter opens the door toﬂood *** of the real-time nature of Twitter data,some government agencies and authorities have used it to track natural catastrophe events in order to build a more rapid rescue ***,due to the shorter duration of Tweets,it is difﬁcult to construct a perfect prediction model for determiningﬂ*** learning(ML)and deep learning(DL)approaches can be used to statistically developﬂood prediction *** the same time,the vast amount of Tweets necessitates the use of a big data analytics(BDA)tool forﬂood *** this regard,this work provides an optimal deep learning-basedﬂood forecasting model with big data analytics(ODLFF-BDA)based on Twitter *** suggested ODLFF-BDA technique intends to anticipate the existence ofﬂoods using tweets in a big data *** ODLFF-BDA technique comprises data pre-processing to convert the input tweets into a usable *** addition,a Bidirectional Encoder Representations from Transformers(BERT)model is used to generate emotive contextual embed-ding from ***,a gated recurrent unit(GRU)with a Multilayer Convolutional Neural Network(MLCNN)is used to extract local data and predict theﬂ***,an Equilibrium Optimizer(EO)is used toﬁne-tune the hyper-parameters of the GRU and MLCNN models in order to increase prediction *** memory usage is pull down lesser than 3.5 MB,if its compared with the other algorithm *** ODLFF-BDA technique’s performance was validated using a benchmark kaggle dataset,and theﬁndings showed that it outperformed other recent approaches signiﬁcantly.

关键词： Big data analytics predictive models deep learning ﬂood prediction twitter data hyperparameter tuning

Optimal Adaptive Genetic Algorithm Based Hybrid Signcryption Algorithm for Information Security

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Computer Modeling in Engineering & Sciences 2015年第5期105卷 47-68页

作者： R.Sujatha M.Ramakrishnan N.duraipandian B.Ramakrishnan Velammal Engineering College Anna UniversityIndia School of Computer Applications Madurai Kamarajar UniversityIndia Department of Computer Science and Research Centre S.T.Hindu CollegeMadurai Kamarajar UniversityIndia

The functions of digital signature and public key encryption are simultaneously fulfilled by signcryption,which is a cryptographic *** securely communicate very large messages,the cryptographic primitive called signcryption efficiently implements the same and while most of the public key based systems are suitable for small messages,hybrid encryption(kEM-DEM)provides a competent and practical *** this paper,we develop a hybrid signcryption *** hybrid signcryption is based on the kEM and DEM *** kEM algorithm utilizes the kDF technique to encapsulate the symmetric *** DEM algorithm utilizes the Adaptive Genetic Algorithm based Elliptic curve cryptography algorithm to encrypt the original ***,for the security purpose,we introduce the three games and we proved the attackers fail to find the security attributes of our proposed signcryption *** proposed algorithm is analyzed with Daniel of Service(DOS),Brute Force attack and Man In Middle(MIM)attacks to ensure the secure data transaction.

关键词： Hybrid Signcryption kEM DEM Adaptive Genetic Algorithm EllipticCurve Cryptography