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枯草芽孢杆菌用于外源蛋白质生产和分泌的可能性

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生物技术通报 1987年第4期 1-5页

作者： RoyH.doi 刘阳

成功地利用枯草芽孢杆菌分泌外源基因产物,需要一个缺失胞外蛋白酶的寄主,需要创造遗传调控外源基因在生长期间表达的因子和营养条件,还需要进一步了解寄主的分泌机制以提高其分泌效率。

关键词：蛋白质真核生物真核体外源基因芽抱杆菌末端序列

Tetraquark and Pentaquark Systems in Lattice QCD

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Journal of Modern Physics 2016年第8期7卷 774-789页

作者： Fumiko Okiharu Takumi doi Hiroko Ichie Hideaki Iida Noriyoshi Ishii Makoto Oka Hideo Suganuma Toru T. Takahashi Faculty of Education Niigata University Niigata Japan Theoretical Research Division Nishina Center RIKEN Wako Japan Department of Physics Tokyo Institute of Technology Tokyo Japan Research and Education Center for Natural Sciences Keio University Kanagawa Japan Research Center for Nuclear Physics (RCNP) Osaka University Ibaraki Japan Department of Physics Graduate School of Science Kyoto University Kyoto Japan Gunma National College of Technology Maebashi Japan

We study multi-quark systems in lattice QCD. First, we revisit and summarize our accurate mass measurements of low-lying 5Q states with J = 1/2 and I = 0 in both positive- and negative-parity channels in anisotropic lattice QCD. The lowest positive-parity 5Q state is found to have a large mass of about 2.24 GeV after the chiral extrapolation. To single out the compact 5Q state from Nk scattering states, we use the hybrid boundary condition (HBC), and find no evidence of the compact 5Q state below 1.75 GeV in the negative-parity channel. Second, we study the multi-quark potential in lattice QCD to clarify the inter-quark interaction in multi-quark systems. The 5Q potential V5Q for the QQ--QQ system is found to be well described by the “OGE Coulomb plus multi-Y Ansatz”: The sum of the one-gluon-exchange (OGE) Coulomb term and the multi-Y-type linear term based on the flux-tube picture. The 4Q potential V4Q for the QQ- system is also described by the OGE Coulomb plus multi-Y Ansatz, when QQ and are well separated. The 4Q system is described as a “two-meson” state with disconnected flux tubes, when the nearest quark and antiquark pair are spatially close. We observe a lattice-QCD evidence for the “flip-flop”, i.e., the fluxtube recombination between the connected 4Q state and the “two-meson” state. On the confinement mechanism, the lattice QCD results indicate the flux-tube-type linear confinement in multi-quark hadrons. Finally, we propose a proper quark-model Hamiltonian based on the lattice QCD results.

关键词： Lattice QCD Multi-Quarks Quark Confinement Exotic Hadrons

Conversion hepatectomy for hepatocellular carcinoma with main portal vein tumour thrombus after lenvatinib treatment: A case report

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World Journal of Hepatology 2021年第3期13卷 384-392页

作者： kazuhiro Takahashi Jaejeong kim Amane Takahashi Shinji Hashimoto Manami doi kinji Furuya Ryosuke Hashimoto Yohei Owada koichi Ogawa Yusuke Ohara Yoshimasa Akashi katsuji Hisakura Tsuyoshi Enomoto Osamu Shimomura Masayuki Noguchi Tatsuya Oda Department of Gastrointestinal and Hepatobiliary Pancreatic Surgery University of TsukubaTsukuba 3058575IbarakiJapan Department of Gastroenterological Surgery Saitama Cancer CenterSaitama 3620806SaitamaJapan Department of Diagnostic Pathology University of TsukubaTsukuba 3058575IbarakiJapan

BACkGROUND Hepatocellular carcinoma(HCC)accompanied by portal vein tumour thrombus(PVTT)presents an aggressive disease course,worsening liver function reserve,and a high recurrence *** practice guidelines recommend systemic therapy as the first-line option for HCC with portal ***,to achieve longer survival in these patients,the treatment strategy should be concluded with removal of the tumour by locoregional *** experienced a case of initially unresectable HCC with main PVTT converted to radical hepatectomy after lenvatinib *** SUMMARY A 59-year-old male with chronic hepatitis C infection visited our clinic as a regular post-surgery ***-enhanced abdominal computed tomography revealed a liver mass diffusely located at the lateral segment with a massive PVTT extending from the umbilical portion to the main and contralateral third-order portal *** the diagnosis of unresectable HCC with Vp4(main trunk/contralateral branch)PVTT,lenvatinib was started at 12 mg/*** computed tomography taken 3 mo after starting lenvatinib showed regression of the PVTT,which had retreated to the contralateral first-order portal *** tolerated the full dose without major adverse *** cessation of lenvatinib for 7 d,radical left lobectomy and PVTT thrombectomy were *** patient’s postoperative course was ***,the primary lesion showed fibrotic changes,with moderately to poorly differentiated tumour cells surrounded by granulation tissues in some *** majority of the PVTT showed *** was alive without recurrence for 8 *** This is the first case of HCC with Vp4 PVTT in which radical conversion hepatectomy was succeeded after lenvatinib treatment.

关键词： Hepatocellular carcinoma Lenvatinib Portal vein tumour thrombus Conversion hepatectomy Case report

Predicting Delivery Error Using a DICOM-RT Plan for Volumetric Modulated Arc Therapy

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2014年第2期3卷 82-87页

作者： Hideharu Miura Masao Tanooka Masayuki Fujiwara Yasuhiro Takada Hiroshi doi Soichi Odawara kengo kosaka Norihiko kamikonya Shozo Hirota Department of Radiological Technology Hyogo College of Medicine College Hospital Hyogo Mukogawa-cho Nishinomiya City Hyogo Japan Department of Radiology Hyogo College of Medicine 1-1 Mukogawa-cho Nishinomiya City Hyogo Japan

The purpose of this study was to investigate the prediction of mechanical error using DICOM-RT plan parameters for volumetric modulated arc therapy (VMAT). We created plans for gantry rotation arcs of 360° and 180° (full-arc and half-arc VMAT) for six maxillary sinus cancer cases using a Monaco treatment planning system, and delivered the doses with a linear accelerator. We calculated DICOM-RT plan parameters, including gantry, multileaf collimator (MLC) positions and Monitor Units (MU). We compared plans with regard to gantry angle per MU (degrees/MU) and MLC travel per MU (mm/MU) for each segment. Calculated gantry angle/MLC position speeds and errors were evaluated by comparison with the log file. On average, the half-arc VMAT plan resulted in 47% and 35% fewer degrees/MU and mm/MU than the full-arc VMAT plan, respectively. The root mean square (r.m.s.) gantry and MLC speeds showed a linear relationship with calculated degrees/MU and mm/MU, with coefficients of determination (R2) of 0.86 and 0.72, respectively. The r.m.s. gantry angle and MLC position errors showed a linear relationship with calculated degrees/MU and mm/MU with R2 of 0.63 and 0.76, respectively. Deviations from plan parameters were related to mechanical error for VMAT, and provided quantitative information without the need for VMAT delivery. These parameters can be used in the selection of treatment planning.

关键词： Volumetric-Modulated Arc Therapy DICOM-RT Plan Patient-Specific QA Radiotherapy Planning Computer-Assisted

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高纯钨和化学气相沉积钨的特性和应用

中国钨业 1995年第5期10卷 21-23页

作者： Yoshihiko doi 刘光俊东京钨股份有限公司

一、绪言采用传统的还原方法能够生产5个九纯度的钨粉.该纯度的钨粉主要用于制取高质量的 Ti-W 和 WSi2合金,这些合金是半导体溅射靶的不可缺少的原材料。大规模集成电路（LSI）上的沉积电极和屏蔽所用的溅射靶是采用热压合金粉末和机... 详细信息

一、绪言采用传统的还原方法能够生产5个九纯度的钨粉.该纯度的钨粉主要用于制取高质量的 Ti-W 和 WSi2合金,这些合金是半导体溅射靶的不可缺少的原材料。大规模集成电路（LSI）上的沉积电极和屏蔽所用的溅射靶是采用热压合金粉末和机加工压制品制造的。

关键词：化学气相沉积法高纯钨粉末冶金超大规模集成电路溅射靶高质量沉积速度纯度钨粉沉积电极

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电刺激听神经诱发小鼠脑干神经元活动的光信号特征(英文)

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中国临床康复 2005年第29期9卷 219-221,i0003页

作者：蔡竖平沈静土井直解放军总医院老年医学研究所北京市100853 日本关西医科大学耳鼻喉科

背景:光学记录技术是以电压敏感染料为介质,以硅光电二极管转换技术为特点的新型电生理检测方法,有助于分析复杂的神经结构中膜电位变化的时间-空间分布。目的:使用光学记录的方法观察小鼠脑干听神经电刺激诱发冲动的时间-空间分布,并... 详细信息

背景:光学记录技术是以电压敏感染料为介质,以硅光电二极管转换技术为特点的新型电生理检测方法,有助于分析复杂的神经结构中膜电位变化的时间-空间分布。目的:使用光学记录的方法观察小鼠脑干听神经电刺激诱发冲动的时间-空间分布,并分析抑制性神经递质γ-氨基丁酸和γ-氨基丁酸A受体拮抗剂荷包牡丹碱对听觉诱发冲动的影响。设计:随机对照实验。单位:解放军总医院老年医学研究所,日本关西医科大学耳鼻喉科。材料:实验于2002-05/11在日本关西医科大学耳鼻喉科实验室完成。选取出生后0～5d的ddy/ddy小鼠100只,清洁级,雌雄不拘。方法:将全部动物麻醉后断头处死,在冷冻条件下制作有活性的脑干切片。脑片一侧与无损伤的听神经根残端连接。将脑片置于硅胶铺底的有机玻璃平皿中,用直径30μm钨丝固定。用钨丝电极刺激脑片一侧的听神经根残端,在耳蜗核、前庭核记录诱发反应。对照情况下使用正常的人工脑脊液作为灌流液;灌流液中加入50μmol/Lγ-氨基丁酸的人工脑脊液代替正常人工脑脊液孵育脑片20min后,记录γ-氨基丁酸对脑干听觉通路诱发信号的影响;灌流液中加入50μmol/Lγ-氨基丁酸和200μmol/L荷包牡丹碱的人工脑脊液代替含50μmol/Lγ-氨基丁酸的人工脑脊液孵育脑片20min后,记录荷包牡丹碱对脑干听觉通路诱发信号的影响。刺激条件为正相矩形波脉冲,电流强度5mA,持续时间5ms,频率0.1Hz,电刺激起始时间被设置为89.9ms。脑片染色采用电压敏感染料Nk3041,使用16×16像素的硅光电二极管阵列设备记录刺激听神经所诱发的光学信号。主要观察指标:①主要结局;电刺激听神经诱发的脑干光学信号及其特点。②次要结局:γ-氨基丁酸和荷包牡丹碱光学反应记录结果。结果:实验纳入ddy/ddy小鼠100只,中途死亡56只,共44只进入结果分析。①电刺激听神经诱发的脑干光学信号及其特征:刺激听神经诱发的光学信号以时间-空间分布的形式被记录。在同侧耳蜗核,光学信号的潜伏期为(4.63±1.01)ms,前庭核的峰潜伏期为(6.00±0.89)ms。每一个光学信号分为两个成分:快的峰电位样反应及慢的长时程反应。快电位的起始相具有突触前性质,晚期相具有突触后性质;慢的长时程反应可能与多突触传递有关。②γ-氨基丁酸和荷包牡丹碱光学反应记录结果:灌流液中加入50μmol/Lγ-氨基丁酸可最大限度地降低听神经诱发的脑干神经元信号的幅度,快反应起始相的潜伏期没有延长,但幅度有所降低,晚期相以及慢反应的幅度被明显抑制;而灌流液中加入50μmol/Lγ-氨基丁酸、200μmol/L荷包牡丹碱后则可部分逆转γ-氨基丁酸对此信号的作用,快的峰电位样反应和慢反应的幅度有部分恢复。结论:多部位的光学记录系统可以收集电刺激听神经的诱发反应,光学信号显示了时间-空间分布的类型。γ-氨基丁酸能够使电刺激听神经诱发的脑干神经元信号的幅度明显降低,而γ-氨基丁酸A受体拮抗剂荷包牡丹碱可以竞争性地对抗部分而非全部的γ-氨基丁酸的抑制作用,提示γ-氨基丁酸能神经元对听神经诱发冲动的抑制作用除部分通过γ-氨基丁酸A受体实现外,还涉及其他亚型的γ-氨基丁酸受体。

关键词：电刺激 GABA 受体 GABA—A 脑干光转录

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Can Crossref Citations Replace Web of Science for Research Evaluation?The Share of Open Citations

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Journal of Data and Information Science 2020年第4期5卷 35-42页

作者： TomášChudlarský Jan Dvořák Czech Technical University in Prague Computing and Information CentreJugoslávských partyzánů3CZ-16000 Praha 6Czech Republic Charles University Institute of Information Studies and LibrarianshipNa Příkopě29CZ-11000 Praha 1Czech Republic

Purpose:We study the proportion of Web of Science(WoS)citation links that are represented in the Crossref Open Citation Index(COCI),with the possible aim of using COCI in research evaluation instead of the WoS,if the level of coverage was ***/methodology/approach:We calculate the proportion on citation links where both publications have a WoS accession number and a doi simultaneously,and where the cited publications have had at least one author from our institution,the Czech Technical University in *** attempt to look up each such citation link in ***:We find that 53.7%of WoS citation links are present in the *** proportion varies largely by *** total figures differ significantly from 40%in the large-scale study by Van Eck,Waltman,Larivière,and Sugimoto(blog 2018,https://***/blog?article=n-r2s234).Research limitations:The sample does not cover all science areas uniformly;it is heavily focused on Engineering and Technology,and only some disciplines of Natural Sciences are ***,this reflects the real scientific orientation and publication profile of our *** implications:The current level of coverage is not sufficient for the WoS to be replaced by COCI for research ***/value:The present study illustrates a COCI vs WoS comparison on the scale of a larger technical university in Central Europe.

关键词： Open citations Crossref Open Citation Index Web of Science Current Research Information System

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新杀菌剂—Basitac~(mepronil)

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农药译丛 1982年第4期 55-58页

作者： Shoji doi 马永文陈伟敏日本组合化学工业公司

商品名为 Basitac 的新杀菌剂,对担子菌具有优良的活性,由日本组合化学工业公司(简称组合化学)开发并生产。自1974年以来,该药剂以编号 B1-2459或 kCO-1进行了试验,证明喷雾使用时,对防治水稻纹枯病,小麦、梨、菊花等的锈病具有高效。... 详细信息

商品名为 Basitac 的新杀菌剂,对担子菌具有优良的活性,由日本组合化学工业公司(简称组合化学)开发并生产。自1974年以来,该药剂以编号 B1-2459或 kCO-1进行了试验,证明喷雾使用时,对防治水稻纹枯病,小麦、梨、菊花等的锈病具有高效。作为种子或土壤处理,对猝倒病和蔬菜白绢病亦有效。现正在研究 Basitac 与其它药剂的混用试验,以期扩大新的应用范围。

关键词：可湿性粉剂组合化学稻纹枯病锈病农药剂型 Basitac mepronil

Feasibility of Estimating Patient-Specific Dose Verification Results Directly from Linear Accelerator Log Files in Volumetric Modulated Arc Therapy

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2016年第4期5卷 317-328页

作者： kengo kosaka Masao Tanooka Hiroshi doi Hiroyuki Inoue kazuo Tarutani Hitomi Suzuki Yasuhiro Takada Masayuki Fujiwara Norihiko kamikonya Shozo Hirota Department of Radiology Hyogo College of Medicine Nishinomiya Japan Department of Radiological Technology Hyogo College of Medicine College Hospital Nishinomiya Japan

The feasibility of estimating patient-specific dose verification results directly from linear accelerator (linac) log files has been investigated for prostate cancer patients who undergo volumetric modulated arc therapy (VMAT). Twenty-six patients who underwent VMAT in our facility were consecutively selected. VMAT plans were created using Monaco treatment planning system and were transferred to an Elekta linac. During the beam delivery, dynamic machine parameters such as positions of the multi-leaf collimator and the gantry were recorded in the log files;subsequently, root mean square (rms) values of control errors, speeds and accelerations of the above machine parameters were calculated for each delivery. Dose verification was performed for all the plans using a cylindrical phantom with diodes placed in a spiral array. The gamma index pass rates were evaluated under 3%/3 mm and 2%/2 mm criteria with a dose threshold of 10%. Subsequently, the correlation coefficients between the gamma index pass rates and each of the above rms values were calculated. Under the 2%/2 mm criteria, significant negative correlations were found between the gamma index pass rates and the rms gantry angle errors (r = 0.64, p < 0.001) as well as the pass rates and the rms gantry accelerations (r = 0.68, p < 0.001). On the other hand, the rms values of the other dynamic machine parameters did not significantly correlate with the gamma index pass rates. We suggest that the VMAT quality assurance (QA) results can be directly estimated from the log file thereby providing potential to simplify patient-specific prostate VMAT QA procedure.

关键词： Radiotherapy VMAT Log File Patient Specific QA Correlation Gamma Index