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参考相似影像对乳腺钼靶摄影中簇状微钙化灶鉴别诊断的潜在价值

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国际医学放射学杂志 2010年第1期 77-77页

作者： R.Nakayama H.Abe J.Shiraishi k.doi 余华君 kurt Rossmann Laboratories for Radiologic Image Research Department of RadiologyUniversity of Chicago

目的通过筛除数据库中罕见病例,评估与未知疾病病灶影像相似的已知疾病病灶影像在鉴别乳腺钼靶良恶性簇状微钙化中的潜在价值。材料与方法制度评审委员会批准这次从公用数据库中获取影像并且遵从HIPAA法案的回顾性研究。从数据库中筛除... 详细信息

目的通过筛除数据库中罕见病例,评估与未知疾病病灶影像相似的已知疾病病灶影像在鉴别乳腺钼靶良恶性簇状微钙化中的潜在价值。材料与方法制度评审委员会批准这次从公用数据库中获取影像并且遵从HIPAA法案的回顾性研究。从数据库中筛除罕见病灶,如恶性表现的良性病灶和良性表现的恶性病灶

关键词：微钙化灶恶性病灶良性病灶鉴别诊断影像学潜在价值

1997年—2006年Radiology发表论文中实验设计和资料分析的受试者工作特征(ROC)研究

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国际医学放射学杂志 2010年第1期 85-85页

作者： J.Shiraishi L.L.Pesce C.E.Metz k.doi 何健 kurt Rossmann Laboratories for Radiologic Image Research Department of RadiologyUniversity of Chicago

目的通过回顾1997年—2006年间发表在Ra-diology上的使用受试者工作特征(receiver operating charac-teristic,ROC)研究手段的论文(主要是有关实验设计、成像方法、医疗状况和ROC范例方面),对近年来在医学成像中使用ROC的状况进行广视... 详细信息

目的通过回顾1997年—2006年间发表在Ra-diology上的使用受试者工作特征(receiver operating charac-teristic,ROC)研究手段的论文(主要是有关实验设计、成像方法、医疗状况和ROC范例方面),对近年来在医学成像中使用ROC的状况进行广视野的分析。材料与方法使用2条判断标准,得到295

关键词： ROC 受试者 Radiology 实验设计试验设计

应用超声微血流成像分析慢性肝病肝内血管形态学改变以评估肝纤维化分级:初步研究

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国际医学放射学杂志 2011年第1期34卷 94-页

作者： k.Sugimoto J.Shiraishi F.Moriyasu S.Ichimura R.Metoki k.doi 程悦 Department of Gastroenterology and Hepatology Tokyo Medical University

目的应用超声微血流成像(MFI)评价由于肝纤维化程度增加导致的血管形态学改变。方法 47例接受肝活检的病人及10例正常人行MFI检查。

关键词：超声对比剂微血流成像技术肝纤维化血管形态学

Preoperative albumin-bilirubin score and liver resection percentage determine postoperative liver regeneration after partial hepatectomy

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World Journal of Gastroenterology 2024年第14期30卷 2006-2017页

作者： kazuhiro Takahashi Masahiko Gosho Yoshihiro Miyazaki Hiromitsu Nakahashi Osamu Shimomura kinji Furuya Manami doi Yohei Owada koichi Ogawa Yusuke Ohara Yoshimasa Akashi Tsuyoshi Enomoto Shinji Hashimoto Tatsuya Oda Department of Gastrointestinal and Hepatobiliary-Pancreatic Surgery University of TsukubaTsukuba 3058-575IbarakiJapan Department of Biostatistics University of TsukubaTsukuba 3058-575IbarakiJapan

BACkGROUND The success of liver resection relies on the ability of the remnant liver to *** of the knowledge regarding the pathophysiological basis of liver regeneration comes from rodent studies,and data on humans are ***,there is limited knowledge about the preoperative factors that influence postoperative *** To quantify postoperative remnant liver volume by the latest volumetric software and investigate perioperative factors that affect posthepatectomy liver *** A total of 268 patients who received partial hepatectomy were *** were grouped into right hepatectomy/trisegmentectomy(RH/Tri),left hepa-tectomy(LH),segmentectomy(Seg),and subsegmentectomy/nonanatomical hepatectomy(Sub/Non)*** regeneration index(RI)and late rege-neration rate were defined as(postoperative liver volume)/[total functional liver volume(TFLV)]×100 and(RI at 6-months-RI at 3-months)/RI at 6-months,*** lower 25th percentile of RI and the higher 25th percentile of late regeneration rate in each group were defined as“low regeneration”and“delayed regeneration”.“Restoration to the original size”was defined as regeneration of the liver volume by more than 90%of the TFLV at 12 months *** The numbers of patients in the RH/Tri,LH,Seg,and Sub/Non groups were 41,53,99 and 75,*** RI plateaued at 3 months in the LH,Seg,and Sub/Non groups,whereas the RI increased until 12 months in the RH/Tri *** to our multivariate analysis,the preoperative albumin-bilirubin(ALBI)score was an independent factor for low regeneration at 3 months[odds ratio(OR)95%CI=2.80(1.17-6.69),P=0.02;per 1.0 up]and 12 months[OR=2.27(1.01-5.09),P=0.04;per 1.0 up].Multivariate analysis revealed that only liver resection percentage[OR=1.03(1.00-1.05),P=0.04]was associated with delayed ***,multivariate analysis demonstrated that the preoperative ALBI score[OR=2.63(1.00-1.05),P=0.02;per 1.

关键词： Liver regeneration Albumin-bilirubin score Liver resection percentage Partial hepatectomy Human Regeneration index

胸部影像学小肺癌:使用骨抑制成像提高检出——与双能量减影胸部成像的对比

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国际医学放射学杂志 2012年第1期 88-88页

作者： R.Engelmann L.L.Pesce k.doi C.E.Metz H.MacMahon 于寰 Department of Radiology MC-2026University of Chicago5841 S Maryland AveChicagoIL 60637

目的明确骨抑制成像结合标准的胸片是否比单纯的标准胸片可提高放射学医师对小肺癌检测的能力,以及骨抑制成像的准确性是否与双能量减影片相当。材料与方法研究获机构审查委员会批准并符合HIPAA,无需知情同意。

关键词：小肺癌图像双能量减影胸片

Inverse relationship between platelet Akt activity and hippocampal atrophy:A pilot case-control study in patients with diabetes mellitus

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World Journal of Clinical Cases 2024年第2期12卷 302-313页

作者： Haruhiko Tokuda Takamitsu Hori Daisuke Mizutani Tomoyuki Hioki kumi kojima Takashi Onuma Yukiko Enomoto Tomoaki doi Rie Matsushima-Nishiwaki Shinji Ogura Hiroki Iida Toru Iwama Takashi Sakurai Osamu kozawa Department of Metabolic Research Research InstituteNational Center for Geriatrics and GerontologyObu 474-8511Japan Department of Clinical Laboratory National Center for Geriatrics and GerontologyObu 474-8511Japan Department of Pharmacology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Neurosurgery Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Dermatology Central Japan International Medical CenterMinokamo 505-8510Japan Department of Anesthesiology and Pain Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Emergency Medicine Faculty of MedicineUniversity of ToyamaToyama 930-0194Japan Department of Emergency and Disaster Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Research Institute National Center for Geriatrics and GerontologyObu 474-8511Japan

BACkGROUND Akt plays diverse roles in *** is involved in the pathogenesis of type 2 diabetes mellitus(T2DM),which is caused by insulin *** also plays a vital role in human platelet ***,the hippocampus is closely associated with memory and learning,and a decrease in hippocampal volume is reportedly associated with an insulin-resistant phenotype in T2DM patients without *** To investigate the relationship between Akt phosphorylation in unstimulated platelets and the hippocampal volume in T2DM *** Platelet-rich plasma(PRP)was prepared from the venous blood of patients with T2DM or age-matched *** pellet lysate of the centrifuged PRP was subjected to western blotting to analyse the phosphorylation of Akt,p38 mitogen-activated protein(MAP)kinase and glyceraldehyde 3-phosphate dehydrogenase(GAPDH).Phosphorylation levels were quantified by densitometric *** volume was analysed using a voxel-based specific regional analysis system for Alzheimer’s disease on magnetic resonance imaging,which proposes the Z-score as a parameter that reflects hippocampal *** The levels of phosphorylated Akt corrected with phosphorylated p38 MAP kinase were inversely correlated with the Z-scores in the T2DM subjects,whereas the levels of phosphorylated Akt corrected with GAPDH were ***,this relationship was not observed in the control *** These results suggest that an inverse relationship may exist between platelet Akt activation and hippocampal atrophy in T2DM *** findings provide insight into the molecular mechanisms underlying T2DM hippocampal atrophy.

关键词： Akt Platelet Hippocampal atrophy Magnetic resonance imaging Diabetes mellitus

Onsager principle as a tool for approximation

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Chinese Physics B 2015年第2期24卷 1-6页

作者： Masao doi Center of Soft Matter Physics and Its Applications Beihang University

Onsager principle is the variational principle proposed by Onsager in his celebrated paper on the reciprocal *** principle has been shown to be useful in deriving many evolution equations in soft matter *** the principle is shown to be useful in solving such equations *** examples are discussed：the diffusion dynamics and gel *** examples show that the present method is novel and gives new results which capture the essential dynamics in the system.

关键词： reciprocal relation dissipation function Rayleighian slow variable diffusion dynamics gel dynamics

Distinctive Precursory Air–Sea Signals between Regular and Super El Ni os

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Advances in Atmospheric Sciences 2016年第8期33卷 996-1004页

作者： Lin CHEN Tim LI Swadhin k.BEHERA Takeshi doi key Laboratory of Meteorological Disaster Joint International Research Laboratory of Climate and Environmental Changeand Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science and Technology International Pacific Research Center School of Ocean and Earth Science and Technology University of Hawaii Application Laboratory Japan Agency for Marine-Earth Science and Technology

Statistically different precursory air–sea signals between a super and a regular El Ni no group are investigated, using observed SST and rainfall data, and oceanic and atmospheric reanalysis data. The El Ni no events during 1958–2008 are first separated into two groups： a super El Ni no group（S-group） and a regular El Ni no group（R-group）. Composite analysis shows that a significantly larger SST anomaly（SSTA） tendency appears in S-group than in R-group during the onset phase[April–May（0）], when the positive SSTA is very small. A mixed-layer heat budget analysis indicates that the tendency difference arises primarily from the difference in zonal advective feedback and the associated zonal current anomaly（u）.This is attributed to the difference in the thermocline depth anomaly（D） over the off-equatorial western Pacific prior to the onset phase, as revealed by three ocean assimilation products. Such a difference in D is caused by the difference in the wind stress curl anomaly in situ, which is mainly regulated by the anomalous SST and precipitation over the Maritime Continent and equatorial Pacific.

关键词： super El Ni no precursory air–sea signals thermocline depth anomaly ENSO

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秦艽的化学成分及抗炎保肝活性研究

中草药 2024年第10期55卷 3238-3247页

作者：龚丽龚冰璐周啟秀金琼杨竹雅刘录云南中医药大学云南省教育厅民族药物质基准研究重点实验室云南昆明650500

目的研究秦艽Gentiana macrophylla干燥根部的化学成分及抗炎保肝活性。方法采用多种色谱学方法对秦艽正丁醇和水层萃取物进行系统的分离纯化;采用脂多糖(lipopolysaccharide,LPS)诱导的RAW 264.7巨噬细胞中炎症因子白细胞介素-6(interl... 详细信息

目的研究秦艽Gentiana macrophylla干燥根部的化学成分及抗炎保肝活性。方法采用多种色谱学方法对秦艽正丁醇和水层萃取物进行系统的分离纯化;采用脂多糖(lipopolysaccharide,LPS)诱导的RAW 264.7巨噬细胞中炎症因子白细胞介素-6(interleukin-6,IL-6)的表达为指标,评价各化合物的抗炎活性;采用对乙酰氨基酚(paracetamol,APAP)诱导人肝细胞(LO2)为模型,研究对APAP诱导LO2细胞损伤的抑制作用,以评价各化合物的保肝活性。结果从秦艽70%乙醇提取物中分离鉴定11个化合物,分别为(+)-秦艽酸甲(1a)、(−)-秦艽酸甲(1b)、gentiananoside A(2)、3′-O-β-D-葡萄糖基龙胆苦苷(3)、chinshanol A(4)、8-羟基-落叶松脂醇-4'-O-β-D-葡萄吡喃糖苷(5)、berchemol(6)、6-去甲氧基茵陈色原酮(7)、1-(β-D-ribofuranosyl)-1H-1,2,4-triazone(8)、尿嘧啶苷(9)、β-D-吡喃葡萄糖基苯甲酸酯(10)和2-苯乙基-βD-吡喃葡萄糖(11)。活性研究显示,化合物1b对IL-6的分泌抑制效果明显;化合物1、1a、1b、2、8可降低APAP诱导的LO2细胞损伤中的丙氨酸转氨酶(alanine transaminase,ALT)和天冬氨酸转氨酶(aspartate aminotransferase,AST)水平。结论化合物1a和1b为1对新的苯并二氢吡喃光学异构体,化合物2~3为环烯醚萜类化合物,化合物4~6为木脂素类化合物,还含有黄酮、苯环衍生物等,化合物4~5、8、10为首次从该属植物中分离得到,化合物9为首次从该植物中分离得到;部分化合物显示出良好的抗炎保肝作用前景。

关键词：秦艽抗炎活性保肝活性 (+)-秦艽酸甲 (−)-秦艽酸甲 8-羟基-落叶松脂醇-4'-O-β-D-葡萄吡喃糖苷 β-D-吡喃葡萄糖基苯甲酸酯