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Advancement in utilization of magnetic resonance imaging and biomarkers in the understanding of schizophrenia

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World Journal of Clinical Cases 2025年第1期13卷 11-15页

作者： Aidan k Tirpack danyaal g Buttar Mandeep kaur department of Psychiatry Campbell University School of Osteopathic MedicineBuies CreekNC 27506United States department of Psychiatry and Behavioral Health Mercyhealth Hospital and Trauma CenterJanesvilleWI 53548United States

Historically,psychiatric diagnoses have been made based on patient’s reported symptoms applying the criteria from diagnostic and statistical manual of mental *** utilization of neuroimaging or biomarkers to make the diagnosis and manage psychiatric disorders remains a distant *** have been several studies that examine brain imaging in psychiatric disorders,but more work is needed to elucidate the complexities of the human *** this editorial,we examine two articles by Xu et al and Stoyanov et al,that show developments in the direction of using neuroimaging to examine the brains of people with schizo-phrenia and *** et al used magnetic resonance imaging to examine the brain structure of patients with schizophrenia,in addition to examining neurotransmitter levels as *** et al used functional magnetic resonance imaging to look at modulation of different neural circuits by diagnostic-specific scales in patients with schizophrenia and *** two studies provide crucial evidence in advancing our understanding of the brain in prevalent psychiatric disorders.

关键词： Schizophrenia Magnetic resonance imaging Biomarkers Neurotransmitters Psychiatric disorders

Quality assessment between calibrated highway safety manual safety performance functions and calibration functions for predicting crashes on freeway facilities

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第1期7卷 76-87页

作者： imalka C.Matarage Sunanda dissanayake department of Civil Engineering Kansas State UniuersityManhattanKS 66502USA

Crash prediction models are commonly used for network screening in highway safety management process,where potential impacts of highway safety treatments are *** Highway Safety Manual(HSM)provides crash prediction models for various types of highway facilities that are often referred to as safety performance functions(SPFs).Freeway facility SPFs in the HSM were developed using data gathered from the states of California,Maine,and *** applying these HSM-default SPFs to a local jurisdiction,the HSM recommends calibration of HSM-default SPFs or development of jurisdiction-specific SPFs to improve the accuracy of crash *** study first calibrated the HSM-default freeway SPFs and for further accuracy and comparison purposes calibration functions were developed using kansas freeway *** performance of calibrated HSM-default SPFs was then compared with developed calibration functions concerning the accuracy in crash *** facility calibration dataset included521 freeway segments,351 entrance-related speed-change lanes,and 366 exit-related speed-change *** residual plots and several other goodness-of-fit measures were used to assess the quality of calibrated HSM-default SPFs and calibration *** functions fitted better compared to calibrated HSM-default SPFs for kansas freeway *** methodology used in this study could be beneficial and practiced to any *** functions could be used as an alternative to jurisdiction-specific SPFs or a replacement for HSM-default SPFs,which are frequently used in comparing alternatives,in calculating economic benefits of project improvements,and in estimating economic effectiveness of crash reduction in highway safety-related decision making.

关键词： Transportation Freeway segments Speed-change lanes Crash prediction models goodness-of-fit measures Calibration factor

Chyle leak following root of mesentery dissection in pancreaticoduodenectomy with inferior infracolic superior mesenteric artery first approach

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World Journal of Clinical Cases 2025年第8期13卷 8-14页

作者： Prabir Maharjan Sujan Regmee Spandan d Adhikari Rabin Pahari Roshan ghimire dhiresh k Maharjan Suman k Shrestha Prabin B Thapa department of gastrointestinal and general Surgery Kathmandu Medical College and Teaching HospitalKathmandu 44600Nepal

BACkgROUNd The root of mesentery dissection is one of the critical maneuvers,especially in borderline resectable pancreatic head ***-abdominal chyle leak(CL)including chylous ascites may ensue in up to 10%of patients after pancreatic *** recognized superior mesenteric artery(SMA)first approaches are invariably *** mesenteric dissection through the inferior infracolic approach has been discussed in this study emphasizing its post-operative impact on CL which is the cornerstone of this *** To assess incidence,risk factors,clinical impact of CL following root of mesentery dissection,and the different treatment *** This is a retrospective study incorporating the patients who underwent dissection of the root of mesentery with inferior infracolic SMA first approach pancreat-oduodenectomy for the ventral body and uncinate mass of pancreas in the department of gastrointestinal and general Surgery of kathmandu Medical College and Teaching Hospital from January 1,2021 to February 28,***-erative findings and postoperative outcomes were *** In three years,ten patients underwent root of mesentery dissection with inferior infracolic SMA first approach *** mean age was 67.6 years with a male-to-female ratio of 4:*** was seen in four *** virtue of CL,Clavien-dindo grade Ⅱ or higher morbidity was observed in four *** patients had a hospital stay of more than 20 days with the former having a delayed gastric emptying and the latter with long-term total parenteral nutrition *** mean operative time was 330 *** resection was achieved in 100%of the *** mean duration of the intensive care unit and hospital stay were 2.55±1.45 days and 15.7±5.32 days,*** Root of mesentery dissection with lymphadenectomy and vascular resection correlated with occurrence of *** complete curative resection,these were managed with tota

关键词： Chyle leak Chylous ascites Clavien-dindo Pancreatoduodenectomy Root of mesentery dissection Superior mesenteric artery first approach Total parenteral nutrition Uncinate mass Vascular resection Ventral body mass

Sexual Morph of Furcasterigmium furcatum (Plectosphaerellaceae) from Magnolia liliifera Collected in Northern Thailand

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Phyton-International Journal of Experimental Botany 2020年第3期89卷 765-777页

作者： Jutamart Monkai Ruvishika S.jayawardena Sajeewa S.N.Maharachchikumbura kevin d.Hyde Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai57100Thailand School of Science Mae Fah Luang UniversityChiang Rai57100Thailand School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu611731China

We isolated an interesting fungus from dead leaves of Magnolia liliifera collected from Chiang Mai,*** novel strain is related to Plectosphaer-ellaceae based on the morphology of its asexual morph and the analysis of sequence *** analyses using a combined gene analysis of LSU and ITS sequence data showed that this strain is clustered in the same clade with Furcasterigmium furcatum with high statistical *** new strains produced the asexual morph in culture which is morphologically similar to ***,we identified this strain as the sexual morph of *** is the first record of sexual morph for the monotypic genus Furcasterigmium and the first record of this genus on Magnolia.

关键词： Acremonium phylogeny sexual morph sordariomycetes taxonomy

Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecomte department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Role of marine natural products in the development of antiviral agents against SARS‑CoV‑2:potential and prospects

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Marine Life Science & Technology 2024年第2期6卷 280-297页

作者： d.P.Nagahawatta N.M.Liyanage Thilina U.jayawardena H.H.A.C.k.Jayawardhana Seong‑Hun Jeong Hyung‑Jun kwon You‑Jin Jeon department of Marine Life Sciences Jeju National UniversityJeju 690-756Republic of Korea department of Chemistry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada Marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Functional Biomaterial Research Center Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel coronavirus,known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has surfaced and caused global concern owing to its ***-CoV-2 is the causative agent of coronavirus disease 2019;however,it was only discovered at the end of the year and was considered a pandemic by the World Health ***,the develop-ment of novel potent inhibitors against SARS-CoV-2 and future outbreaks is urgently *** naturally occurring bioactive substances have been studied in the clinical setting for diverse *** intricate infection and replication mechanism of SARS-CoV-2 offers diverse therapeutic drug targets for developing antiviral medicines by employing natural products that are safer than synthetic *** natural products(MNPs)have received increased attention in the development of novel drugs owing to their high diversity and ***,this review article investigates the infection and replication mechanisms,including the function of the SARS-CoV-2 genome and ***,we highlighted anti-SARS-CoV-2 therapeutic intervention efforts utilizing MNPs and predicted SARS-CoV-2 inhibitor design.

关键词： SARS-CoV-2 Marine natural products drug targets Inhibitors

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru