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Advancements in nanotechnology for the delivery of phytochemicals

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Journal of Integrative Medicine 2024年第4期22卷 385-398页

作者： Divya Chauhan Pavan k.Yadav Nazneen Sultana Arun Agarwal Saurabh Verma Manish k.Chourasia Jiaur R.Gayen Division of Pharmaceutics and Pharmacokinetics Central Drug Research InstituteCouncil of Scientific and Industrial ResearchLucknow 226031Uttar PradeshIndia Academy of Scientific and Innovative Research Ghaziabad 201002Uttar PradeshIndia

Phytosomes(phytophospholipid complex) are dosage forms that have recently been introduced to increase the stability and therapeutic effect of herbal medicine. Currently, bioactive herbs and the phytochemicals they contain are considered to be the best remedies for chronic diseases. One promising approach to increase the efficacy of plant-based therapies is to improve the stability and bioavailability of their bio-active ingredients. Phytosomes employ phospholipids as their active ingredients, and use their amphiphilic properties to solubilize and protect herbal extracts. The unique properties of phospholipids in drug delivery and their use in herbal medicines to improve bioavailability results in significantly enhanced health benefits. The introduction of phytosome nanotechnology can alter and revolutionize the current state of drug delivery. The goal of this review is to explain the application of phytosomes, their future prospects in drug delivery, and their advantages over conventional formulations.

关键词： Phytochemical Bioavailability Drug delivery system Phytosome Plant extracts

Physical properties and maximum allowable mass-radius relation of complexity-free compact stellar objects within modified f(R,T)gravity formalism

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Chinese Physics C 2024年第7期48卷 273-288页

作者： M.k.Jasim S.k.Maurya Abdelghani Errehymy Ali khalid Jassim kottakkaran Sooppy Nisar Abdel-Haleem Abdel-Aty Department of Mathematical and Physical Sciences College of Arts and SciencesUniversity of NizwaNizwa 616Sultanate of Oman Astrophysics Research Centre School of MathematicsStatistics and Computer ScienceUniversity of KwaZulu-NatalPrivate Bag X54001Durban 4000South Africa Electrical Engineering Department College of EngineeringMustansiriyah UniversityBaghdadIraq Department of Mathematics College of Science and Humanities in AlkharjPrince Sattam bin Abdulaziz UniversityAl KharjSaudi Arabia Department of Physics College of SciencesUniversity of BishaP.O.Box 344Bisha 61922Saudi Arabia

This paper investigates the physical properties and predicted radii of compact stars generated by the Tolman-IV complexity-free model within the background of modified gravity theory,particularly the f(R,T)-gravity theory,under complexity formalism for a spherically symmetric spacetime proposed by ***[Phys Rev D 97:044010,2018].By solving the resulting set of differential equations,we obtain the explicit forms of the energy-momentum(EM)tensor components,including the density,radial pressure,and tangential *** influence of the parameterχon various physical properties of the star is thoroughly *** model undergoes a series of rigorous tests to determine its physical *** findings indicate that the model exhibits regularity,stability,and a surface with vanishing *** boundary of this surface is determined by carefully selecting the parameter *** complexity method employed in f(R,T)gravity offers an interesting approach for developing astrophysical models that are consistent with observable events as demonstrated by recent *** this regard,we use observational data from the GW190814 event,detected by the LIGO and Virgo observatories,to investigate the validity of the Tolman-IV model in f(R,T)*** analysis includes comparing the model's predictions with the observed characteristics of the compact object involved in the *** addition,data from two-millisecond pulsars,PSR J1614-2230 and PSR J0952-0607,are incorporated to further constrain the theoretical ***,we present a diagram depicting the relationship between the total mass and radius of the compact object candidates for different values ofχ.

关键词： complexity modified gravity compact Stars

Juxtapose of System Performance for Food Calorie Estimation Using IoT and Web-based Indagation

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Journal of Harbin Institute of Technology(New Series) 2024年第1期31卷 54-63页

作者： Anusuya S Sharmila k Department of Computer Science VISTASChennai 600117India Department of Computer Science Dr.MGR Janaki College for WomenChennai 600028India

A rudimentary aspect of human life is the health of an individual,and most commonly the wellbeing is impacted in a colossal manner through the consumption of food. The intake of calories therefore is a crucial aspect that must be meticulously monitored. Various health gremlins can be largely circumvented when there is a substantial balance in the number of calories ingested versus the quantity of calories *** food calorie estimation is a popular domain of research in recent times and is meticulously analyzed through various image processing and machine learning techniques. However,the need to scrutinize and evaluate the calorie estimation through various platforms and algorithmic approaches aids in providing a deeper insight on the bottlenecks involved,and in improvising the bariatric health of an individual. This paper pivots on comprehending a juxtaposed approach of food calorie estimation through the use of employing Convolution Neural Network(CNN)incorporated in Internet of Things(IoT),and using the Django framework in Python,along with query rule-based training to analyze the subsequent actions to be followed post the consumption of food calories in the constructed webpage. The comparative analysis of the food calorie estimate implemented in both platforms is analyzed for the swiftness of identification,error rate and classification accuracy to appropriately determine the optimal method of use. The simulation results for IoT are carried out using the Raspberry Pi4B model,while the Anaconda prompt is used to run the server holding the web page.

关键词： food calorie estimation convolution neural network Django framework internet of things raspberry Pi

5G Resource Allocation Using Feature Selection and Greylag Goose Optimization Algorithm

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Computers, Materials & Continua 2024年第7期80卷 1179-1201页

作者： Amel Ali Alhussan S.k.Towfek Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Computer Science and Intelligent Systems Research Center BlacksburgVA 24060USA

In the contemporary world of highly efficient technological development,fifth-generation technology(5G)is seen as a vital step forward with theoretical maximum download speeds of up to twenty gigabits per second(Gbps).As far as the current implementations are concerned,they are at the level of slightly below 1 Gbps,but this allowed a great leap forward from fourth generation technology(4G),as well as enabling significantly reduced latency,making 5G an absolute necessity for applications such as gaming,virtual conferencing,and other interactive electronic *** of this change are not limited to connectivity alone;it urges operators to refine their business strategies and offers users better and improved digital *** essential factor is optimization and the application of artificial intelligence throughout the general arrangement of intricate and detailed 5G *** Binary Greylag Goose Optimization(bGGO)to achieve a significant reduction in the feature set while maintaining or improving model performance,leading to more efficient and effective 5G network management,and Greylag Goose Optimization(GGO)increases the efficiency of the machine ***,the model performs and yields more accurate *** work proposes a new method to schedule the resources in the next generation,5G,based on a feature selection using GGO and a regression model that is an ensemble of k-Nearest Neighbors(kNN),Gradient Boosting,and Extra Trees *** ensemble model shows better prediction performance with the coefficient of determination R squared value equal *** proposed framework is supported by several Statistical analyses,such as theWilcoxon signed-rank *** of the benefits of this study are the introduction of new efficient optimization algorithms,the selection of features and more reliable ensemble models which improve the efficiency of 5G technology.

关键词： Optimization ensemble learning 5G technology artificial intelligence greylag goose optimization ANOVA test

Gastric cystica profunda:Another indication for minimally invasive endoscopic resection techniques?

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World Journal of Gastroenterology 2024年第27期30卷 3278-3283页

作者： Harjot k Bedi Douglas Motomura Neal Shahidi Department of Medicine University of British ColumbiaVancouver V6Z 2K5BCCanada

Gastric cancer presents a significant global health burden,as it is the fifth most common malignancy and fourth leading cause of cancer mortality *** in incidence rates across regions underscores the multifactorial etiology of this *** overall 5-year survival rate remains low despite advances in its diagnosis and *** surgical gastrectomy was previously standard-of-care,endoscopic resection techniques,including endoscopic mucosal resection and endoscopic submucosal dissection(ESD)have emerged as effective alternatives for early *** to surgical resection,endoscopic resection techniques have comparable 5-year survival rates,reduced treatment-related adverse events,shorter hospital stays and lower *** also enables en bloc resection,thus affording organ-sparing curative endoscopic resection for early *** this editorial,we comment on the recent publication by Geng et al regarding gastric cystica profunda(GCP).GCP is a rare gastric pseudotumour with the potential for malignant *** presents a diagnostic challenge due to its nonspecific clinical manifestations and varied endoscopic *** are several gaps in the literature regarding the diagnosis and management of GCP which warrants further research to standardize patient *** in endoscopic resection techniques offer promising avenues for GCP and early gastric cancers.

关键词： Early gastric cancer Endoscopy Endoscopic submucosal dissection Gastric cystica profunda

Enhancing Healthcare Data Security and Disease Detection Using Crossover-Based Multilayer Perceptron in Smart Healthcare Systems

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 977-997页

作者： Mustufa Haider Abidi Hisham Alkhalefah Mohamed k.Aboudaif Department of Industrial Engineering College of EngineeringKing Saud UniversityP.O.Box-800Riyadh11421Saudi Arabia

The healthcare data requires accurate disease detection analysis,real-timemonitoring,and advancements to ensure proper treatment for ***,Machine Learning methods are widely utilized in Smart Healthcare Systems(SHS)to extract valuable features fromheterogeneous and high-dimensional healthcare data for predicting various diseases and monitoring patient *** methods are employed across different domains that are susceptible to adversarial attacks,necessitating careful ***,this paper proposes a crossover-based Multilayer Perceptron(CMLP)*** collected samples are pre-processed and fed into the crossover-based multilayer perceptron neural network to detect adversarial attacks on themedical records of *** an attack is detected,healthcare professionals are promptly alerted to prevent data *** paper utilizes two datasets,namely the synthetic dataset and the University of Queensland Vital Signs(UQVS)dataset,from which numerous samples are *** results are conducted to evaluate the performance of the proposed CMLP model,utilizing various performancemeasures such as Recall,Precision,Accuracy,and F1-score to predict patient *** the proposed method with existing approaches,it achieves the highest accuracy,precision,recall,and ***,the proposedmethod achieves a precision of 93%,an accuracy of 97%,an F1-score of 92%,and a recall of 92%.

关键词： Smart healthcare systems multilayer perceptron cybersecurity adversarial attack detection Healthcare 4.0

Influence of curing conditions on the shrinkage behavior of three-dimensional printed concrete formwork

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Frontiers of Structural and Civil Engineering 2024年第8期18卷 1225-1236页

作者： M.BEkAERT k.van TITTELBOOM G.de SCHUTTER Magnel-Vandepitte Laboratory for structural Engineering and Building Materials Department of Structural Engineering and Building MaterialsFaculty of Engineering and ArchitectureGhent UniversityGhent 60 B-9052Belgium

The use of three-dimensional(3D)printed concrete as formwork is becoming more widely applied within the ***,the technology is still not optimized and there are many reports of preliminary cracking during the curing of cast *** is believed to result from differential shrinkage between the printed and cast *** cracks(in the printed concrete or at the interface between the infill and printed concrete)form a preferential path for aggressive substances and can reduce the durability of the combined concrete *** ensure the desired service life of the structure,it is important that the differential shrinkage between cast and printed concrete is *** study investigated the effect of curing conditions on the differential shrinkage behavior of 3D and cast *** influence of prewetting of the dry-cured 3D printed formwork was also *** the experimental program,a vibrated and self-compacting concrete were used as cast *** 3D printed formwork was produced and combined with cast concrete to simulate a concrete *** formwork was cured for 1,7,or 28 d exposed to the air(relative humidity:60%or 95%)or submerged in *** length change of the combined elements was observed over 56 d after concrete casting and throughout the thickness of the *** show that increasing the curing period in dry conditions of the printed concrete leads to an expansion of the formwork on the first day after *** expansion leads to a non-uniform strain evolution throughout the curing period of the combined *** concrete formwork stored in wet conditions does not expand after the casting process but tends to show a decreasing linear deformation within the whole elements.

关键词： 3D concrete printing formwork shrinkage curing

New evidence for the epigenetic regulation of skeletal stem cells

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Science Bulletin 2024年第13期69卷 2004-2006页

作者： Liming Zhao Jun Xiao Charles k.F.Chan Institute for Stem Cell Biology and Regenerative Medicine Stanford University School of MedicineStanford CA 94305USA Department of Surgery Division of Plastic and Reconstructive SurgeryStanford University School of MedicineStanford CA 94305USA Department of Orthopaedic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Skeletal stem cells(SSCs)are crucial for skeletal development and regeneration,yet the epigenetic regulation of these cells remains poorly *** studies have delineated the epigenetic landscape across the developmental trajectory of SSCs,highlighting the involvement of Ptip in regulating SSC *** skeletal system undergoes dynamic remodeling throughout *** stem cells(SSCs),residing within the skeleton and lineage-restricted,serve as a cellular reserve to foster development and maintain skeletal *** categorized within the broader mesenchymal stromal/stem cells(MSCs).

关键词： skeletal involvement maintain

Enhanced quantum resources via two distant atom-cavity systems under the influence of atomic dissipation

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Communications in Theoretical Physics 2024年第2期76卷 62-73页

作者： M Setodeh kheirabady M k Tavassoly M Rafeie E Ghasemian Laser and Optics Group Faculty of PhysicsYazd UniversityYazd 89195-741Iran Department of Electrical Engineering Faculty of Intelligent Systems Engineering and Data SciencePersian Gulf UniversityBushehrIran

Quantum resources such as entanglement and coherence are the holy grail for modern quantum technologies. Although the unwanted environmental effects tackle quantum information processing tasks, suprisingly these key quantum resources may be protected and even enhanced by the implementation of some special hybrid open quantum systems. Here, we aim to show how a dissipative atom-cavity-system can be accomplished to generate enhanced quantum *** do so, we consider a couple of dissipative cavities, where each one contains two effective two-level atoms interacting with a single-mode cavity field. In practical applications, a classical laser field may be applied to drive each atomic subsystem. After driving the system, a Bell-state measurement is performed on the output of the system to quantify the entanglement and coherence. The obtained results reveal that the remote entanglement and coherence between the atoms existing inside the two distant cavities are not only enhanced, but can be stabilized, even under the action of dissipation. In contrast, the local entanglement between two atoms inside each dissipative cavity attenuates due to the presence of unwanted environmental ***, the local coherence may show the same behavior as the remote ***, the system provides the steady state entanglement in various interaction regimes,particularly in the strong atom-cavity coupling and with relatively large detuning. More interestingly, our numerical analyses demonstrate that the system may show a memory effect due to the fact that the death and revival of the entanglement take place during the interaction. Our proposed model may find potential applications for the implementation of long distance quantum networks. In particular, it facilitates the distribution of quantum resources between the nodes of large-scale quantum networks for secure communication.

关键词： remote entanglement and coherence atomic dissipation steady state entanglement Bell-statemeasurement