检索结果-南通市图书馆

Rapid,simple and stability-indicating determination of polyhexamethylene biguanide in liquid and gel-like dosage forms by liquid chromatography with diode-array detection

引用

Journal of Pharmaceutical Analysis 2013年第6期3卷 408-414页

作者： Markus küsters Soren beyer Stephan kutscher Harald Schlesinger Michael Gerhartz Central Hospital of the German Federal Armed Forces koblenz Pharmacy Section Central Institute of the German Federal Armed Forces koblenz Laboratory Department of Food and Environmental Chemistry

A rapid and simple method for the determination of potyhexamethylene biguanide （polyhexanide, PHMB） in liquid and gel-like pharmaceutical formulations by means of high performance liquid chromatography coupled to diode-array detection （HPLC DAD） was devel- oped. Best separation was achieved using a cyanopropyl bonded phase （Agilent Zorbax Eclipse XDB-CN column 4.6mm x 75 mm with particle size of 3.5 μm） as well as gradient elution consisting of acetonitrile/deionized water at a flow rate of 1.0 mL/min. The optimized and applied chromatographic conditions permitted separation of polyhexanide from interacting raatrix with subsequent detection at a wavelength of 235 nm with good sensitivity. The method validation was carried out with regard to the guidelines for analytical procedures demanded by the International Conference on Harmonisation （ICH）. Mean recoveries of 102% and 101% for gel-like as well as liquid preparations were obtained. Suitable repeatability as well as intermediate precision could bc achieved with limits of detection ≤0.004 mg/mL for both formulations, equivalent to ≤0.004% PHMB concerning sample preparation. Determination of PHMB was accomplished without tedious sample preparation. Interacting matrix could be eliminated by the chromatographicprocedure with excellent performance of system suitability. All analytical requirements were fulfilled permitting a reliable and precise determination of PHMB in pharmaceuticals. Further- more, the developed method was applied to stability testing of pharmaceutical preparations containing PHMB.

关键词： Polyhexamethylene biguanide Polyhexanide Pharmaceuticals High performance liquid chromatography

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Machine learning-based decision tool for selecting patients with idiopathic acute pancreatitis for endosonography to exclude a biliary aetiology

引用

世界胃肠病学杂志:英文版 2023年第35期29卷 5138-5153页

作者： Simon Sirtl Michal Żorniak Eric Hohmann Georg beyer Miriam Dibos Annika Wandel Veit Phillip Christoph Ammer-Herrmenau Albrecht Neesse Christian Schulz Jörg Schirra Julia Mayerle Ujjwal Mukund Mahajan Department of Medicine II LMU University HospitalMunich 81377Germany Department of Endoscopy Maria Sklodowska-Curie National Research Institute of OncologyGliwice 44-113Poland Department of Internal Medicine II School of MedicineUniversity Hospital Rechts der IsarTechnical University of MunichMunich 81675Germany Department of Gastroenterology Gastrointestinal Oncology and EndocrinologyUniversity Medical CenterGöttingen 37075Germany

BACkGROUND Biliary microlithiasis/sludge is detected in approximately 30%of patients with idiopathic acute pancreatitis(IAP).As recurrent biliary pancreatitis can be prevented,the underlying aetiology of IAP should be *** To develop a machine learning(ML)based decision tool for the use of endosonography(EUS)in pancreatitis patients to detect sludge and *** We retrospectively used routinely recorded clinical and laboratory parameters of 218 consecutive patients with confirmed AP admitted to our tertiary care hospital between 2015 and *** who did not receive EUS as part of the diagnostic work-up and whose pancreatitis episode could be adequately explained by other causes than biliary sludge and microlithiasis were *** trained supervised ML classifiers using H_(2)*** automatically selecting the best suitable predictor model to predict microlithiasis/*** predictor model was further validated in two independent retrospective cohorts from two tertiary care centers(117 patients).RESULTS Twenty-eight categorized patients’variables recorded at admission were identified to compute the predictor model with an accuracy of 0.84[95%confidence interval(CI):0.791-0.9185],positive predictive value of 0.84,and negative predictive value of 0.80 in the identification cohort(218 patients).In the validation cohort,the robustness of the prediction model was confirmed with an accuracy of 0.76(95%CI:0.673-0.8347),positive predictive value of 0.76,and negative predictive value of 0.78(117 patients).CONCLUSION We present a robust and validated ML-based predictor model consisting of routinely recorded parameters at admission that can predict biliary sludge and microlithiasis as the cause of AP.

关键词： Acute pancreatitis Idiopathic acute pancreatitis Biliary pancreatitis Microlithiasis Sludge Endosonography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

铂纳米离子簇对CH4的催化氧化

铂纳米离子簇对CH4的催化氧化

引用

第十三届全国催化学术会议

作者：孙政 beyer M．k． Bondybey V．E．中国科学院化学研究所慕尼黑工业大学化学系慕尼黑工业大学化学系

＜正＞作为温室气体的两种重要成分,对CH4、N2O之间的化学反应特别是在存在催化剂的条件下的化学反应的研究无疑有着重要的理论和现实意义。由于通常的催化剂结构复杂,所以在研究异相催化反应时,一般很难了解实时的催化进程和反应

关键词：甲烷一氧化二氮氧化还原反应时间分辨动力学催化机理质谱

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

The Middle Eastern Eagle： How the MENA Region Can Rise

引用

International Relations and Diplomacy 2014年第2期2卷 144-149页

作者： Anna Cornelia beyer University of Hull Quebec UK

The Middle Eastern and North African (MENA) region has the potential to rise if it puts the recent changes to good use. Political changes in some countries might have opened the way for liberalization, which in turn again might facilitate democratization. Both will benefit the economic development of the region. So far, economic growth is hindered by excessive and ineffective public sectors, which do not provide sufficient opportunities for the growing young population. Privatization of some services and a general liberalization of the markets might help bring the young workforce into employment and in the long run will fuel an economic upswing.

关键词：国际关系外交外交行政外交政策

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Golden rice on a mission

Golden rice on a mission

引用

第十四届全国植物基因组学大会

作者： Peter beyer Faculty of Biology University of Freiburg

Golden Rice(GR) denotes a genetically modified rice(Oryza sativa) that produces B-carotene(provitamin A) in the grain’s *** ofβ-carotene confers a yellow color to the grain,which becomes visible after *** towards th... 详细信息

关键词： rice provitamin A beta carotene biofortification genetic modification

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Pierre-Auguste Renoir, 1841-1919

Pierre-Auguste Renoir, 1841-1919

引用

作者： Peter H. Feist translation Hugh beyer.

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Measurement and analysis technologies for magnetic pulse welding： established methods and new strategies

引用

Advances in Manufacturing 2016年第4期4卷 322-339页

作者： J. Bellmann J. Lueg-Althoff S. Schulze S. Gies E. beyer A. E. Tekkaya Institute of Manufacturing Science and Engineering TUDresden 01062 Dresden Germany Fraunhofer Institute for Material and Beam Technology Winterbergstrasse 28 01277 Dresden Germany Institute of Forming Technology and LightweightConstruction TU Dortmund Baroper Strasse 30344227 Dortmund Germany

Magnetic pulse welding （MPW） is a fast and clean joining technique that offers the possibility to weld dissimilar metals, e.g., aluminum and steel. The high-speed collision of the joining partners is used to generate strong atomic bonded areas. Critical brittle intermetallic phases can be avoided due to the absence of external heat. These features attract the notice of industries performing large scale productions of dissimilar metal joints, like automo- tive and plant engineering. The most important issue is to guarantee a proper weld quality. Numerical simulations are often used to predict the welding result a priori. Nevertheless, experiments and the measurement of process parameters are needed for the validation of these data. Sensors nearby the joining zone are exposed to high pressures and intense magnetic fields which hinder the evaluation of the electrical output signals. In this paper, existing analysis tools for process development and quality assurance in MPW are reviewed. New methods for the process monitoring and weld characterization during and after MPW are introduced, which help to overcome the mentioned drawbacks of established technologies. These methods are based on optical and mechanical measuring technologies taking advantage of the hypervelocity impact flash, the impact pressure and the deformation necessary for the weld formation.

关键词： Magnetic pulse welding (MPW) Processmonitoring Collision conditions Dissimilar metaljoining Materials testing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

X线造影剂的副反应和合并症——危险性的减少和预防

引用

放射学实践 1989年第1期4卷 16-19页

作者： Von H.k.beyer 陈绍红 klinik für Radiologie des katholischen Marienhospitals Herne Ruhr-Universitt Bochum 同济医科大学附属同济医院

数十年来,自脉管内注入高密度造影剂以显示器官和大血管早已成为常规方法。现在,它已大量用于肾盂、尿路、胆囊、动脉造影以及CT 诊断。目前在德国每年大约进行200万次X 线造影检查。然而其缺点也是明显的。

关键词： X线造影剂副作用合并症预防

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

铂纳米离子簇对CH4的催化氧化的时间分辨动力学研究

铂纳米离子簇对CH4的催化氧化的时间分辨动力学研究

引用

第四届全国环境催化与环境材料学术会议

作者：孙政葛茂发王殿勋 beyer M．k． Bondybey V．E．中国科学院化学研究所中国科学院化学研究所中国科学院化学研究所慕尼黑工业大学化学系慕尼黑工业大学化学系

作为温室气体的两种重要成分,对CH4、N2O之间的化学反应特别是在存在催化剂的条件下的化学反应的研究无疑有着重要的理论和现实意义。本工作采用傅立叶变换离子回旋共振质谱仪（FT-ICR-MS）开展了在铂纳米阳离子簇Ptn+（n=4．6）催化条... 详细信息

作为温室气体的两种重要成分,对CH4、N2O之间的化学反应特别是在存在催化剂的条件下的化学反应的研究无疑有着重要的理论和现实意义。本工作采用傅立叶变换离子回旋共振质谱仪（FT-ICR-MS）开展了在铂纳米阳离子簇Ptn+（n=4．6）催化条件下的CH4、N2O间的氧化还原化学反应,并开展了该反应的时间分辨动力学研究。实验结果表明,铂纳米阳离子簇对该氧化还原反应有着明显的尺寸效应:对CH4／N2O氧化还原体系,Pt5+与Pt6+有着明显的活化作用,从而加速该氧化还原反应的进行:而Pt4+对该反应则没有明显的活化作用。

关键词：甲烷一氧化二氮氧化还原反应时间分辨动力学催化机理质谱

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

傅立叶变换离子回旋共振质谱技术在化学反应动力学中的应用

傅立叶变换离子回旋共振质谱技术在化学反应动力学中的应用

引用

第九届全国化学动力学会议

作者：孙政葛茂发王殿勋 M．k.beyer V．E．Bondybey 中国科学院化学研究所中国科学院化学研究所中国科学院化学研究所 PCII Department of Chemistry Technical Univeristy of Munich PCII Department of Chemistry Technical Univeristy of Munich

＜正＞分子反应动力学在最近几十年来的发展已经为物质科学研究的提供了原位、实时研究的基础理论和实验方法与技术;从另一个方面讲,原子、分子团簇以及分子聚集体的研究不仅能提供从气相到凝聚相过渡的指示,而且还能为产生新材料、新...

＜正＞分子反应动力学在最近几十年来的发展已经为物质科学研究的提供了原位、实时研究的基础理论和实验方法与技术;从另一个方面讲,原子、分子团簇以及分子聚集体的研究不仅能提供从气相到凝聚相过渡的指示,而且还能为产生新材料、新催化剂和新技术提供前提。傅立叶变换离子回旋共振质谱仪（FT-ICR-MS）由于其特有的

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：