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Sperm immobilization activity of Allium sativum L. and other plant extracts

Asian Journal of Andrology 2003年第2期5卷 131-135页

作者： kausiki Chakrabarti Sulagna Pal Asok k.bhattacharyya Reproductive Biology Laboratory Department of Biochemistry University of Calcutta Calcutta-700 019 IndiaReproductive Biology Laboratory Department of Biochemistry University of Calcutta Calcutta-700 019 IndiaReproductive Biology Laboratory Department of Biochemistry University of Calcutta Calcutta-700 019 India

Aim: To identify possible spermicidal agents through screening a number of edible medicinal plants with antimicrobial activity. Methods: Initial screening was made on the basis of ram cauda epididymal sperm immobilization immediately after addition of extracts. The most potent extract was selected and was evaluated on both ram and human spermatozoa. To unravel its mode of action several sperm functional tests were carried out, namely viability of cells, hypo-osmotic swelling test for membrane integrity and assays of membrane-bound enzyme 5'-nucleotidase and acrosomal marker enzyme acrosin. Results: The crude aqueous extract of the bulb of Allium sativum L. showed the most promising results by instant immobilization of the ram epididymal sperm at 0.25 g/mL and human ejaculated sperm at 0.5 g/mL. Sperm immobilizing effects were irreversible and the factor of the extract responsible for immobilization was thermostable up to 90 癈. On boiling at 100 癈 for 10 minutes, this activity was markedly reduced. Moreover, this extract was able to cause aggregation of ram sperms into small clusters after 30 minutes of incubation at 37 癈. However this property was not found in human spermatozoa. More than 50 % reduction in sperm viability and hypo-osmotic swelling occurred in treated sperm as compared with the controls, indicating the possibility of plasma membrane disintegration which was further supported by the significant reduction in the activity of membrane bound 5'-nucleotidase and acrosomal acrosin. Conclusion: The crude aqueous extract of A. sativum bulb possesses spermicidal activity in vitro.

关键词： Allium sativum plant extracts sperm immobilization farm animals ram human spermicidal agents thermostability

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Transient flows of Maxwell fluid with slip conditions

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Applied Mathematics and Mechanics(English Edition) 2013年第2期34卷 153-166页

作者： T.HAYAT S.ZAIB S.ASGHAR k.bhattacharyya S.A.SHEHZAD Department of Mathematics Quaid-i-Azam University Department of Mathematics Comsats Institute of Information Technology Department of Mathematics University of Burdwan

Two fundamental flows, namely, the Stokes and Couette flows in a Maxwell fluid are considered. The exact analytic solutions are derived in the presence of the slip condition. The Laplace transform method is employed for the development of such solutions. Limiting cases of no-slip and viscous fluids can be easily recovered from the present analysis. The behaviors of embedded flow parameters are discussed through graphs.

关键词： slip condition exact solution Maxwell fluid residue

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SARS-CoV-2 spike protein-ACE2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPk

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1174-1185页

作者： Sumit bhattacharyya Joanne k.Tobacman Jesse Brown VA Medical Center and University of Illinois at Chicago ChicagoIL 60612USA

Immunostaining in lungs of patients who died with CovID-19 infection showed increased intensity and distribution of chondroitin sulfate and decline in N-acetylgalactostamine-4-sulfatase(Arylsulfatase B;ARSB).To explain these findings,human small airway epithelial cells were exposed to the SARS-CoV-2 spike protein receptor binding domain(SPRBD)and transcriptional mechanisms were ***-p38 MAPk and phospho-SMAD3 increased following exposure to the SPRBD,and their inhibition suppressed the promoter activation of the carbohydrate sulfotransferases CHST15 and CHST11,which contributed to chondroitin sulfate *** in ARSB was mediated by phospho-38 MAPk-induced N-terminal Rb phosphorylation and an associated increase in Rb-E2F1 binding and decline in E2F1 binding to the ARSB *** increases in chondroitin sulfotransferases were inhibited when treated with phospho-p38-MAPk inhibitors,SMAD3(SIS3)inhibitors,as well as antihistamine desloratadine and antibiotic *** the mouse model of carrageenan-induced systemic inflammation,increases in phosphop38 MAPk and expression of CHST15 and CHST11 and declines in DNA-E2F binding and ARSB expression occurred in the lung,similar to theobserved effects in this SPRBD model of COVID-19 *** accumulation of chondroitin sulfates is associated with fibrotic lung conditions and diffuse alveolar damage,increased attention to p38-MAPk inhibition may be beneficial in amelioratingCovid-19infections.

关键词： ACE2 lung inhibited

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Intrumer:A Multi Module Distributed Explainable IDS/IPS for Securing Cloud Environment

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Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A S.k.B.Sangeetha Department of Computer Science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDS,have been developed to tackle these ***,most conventional Intrusion Detection System(IDS)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDSmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDS datasets CICIDS 2017,Honeypots,and NSL-kDD were conducted to demonstrate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

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FINITE ELEMENT ANALYSIS OF A VERTICAL RECTANGULAR PLATE COUPLED WITH AN UNBOUNDED FLUID DOMAIN ON ONE SIDE USING A TRUNCATED FAR BOUNDARY

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Journal of Hydrodynamics 2009年第2期21卷 190-200页

作者： PANI P. k. bhattacharyya S. k. Civil Engineering Department IGIT Sarang Orissa 759146 India Civil Engineering Department IIT Kharagpur 721302 India

The dynamic pressure distribution on a rectangular plate attached to a rigid wall and supporting an infinitely large extent of fluid subjected to a harmonic ground excitation is evaluated in the time domain. Governing equations for the fluid domain are set considering the compressibility of the fluid with negligibly small change in density and a linearized free surface. A far boundary condition for the three-dimensional fluid domain is developed so that the far boundary is truncated at a closer proximity to the structure. The coupled problem is solved independently for the structure and the fluid domain by transferring the acceleration of the plate to the fluid and pressure of the fluid to the plate in sequence. Helmholtz equation for the three-dimensional fluid domain and Mindlin＇s theory for the two-dimensional plate are used for the solution of the interacting domains. Finite element technique is adopted for the solution of this problem with pressure as nodal variable for the fluid domain and displacement for the plate. The time dependent equations are solved in each of the interacting domain using Newmark-fl method. The effectiveness of the technique is demonstrated and the influences of surface wave, exciting frequency and flexibility of the plate on dynamic pressure are investigated.

关键词： fluid-structure interaction compressible fluid linear surface wave truncation boundary dynamic pressure

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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

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Seismic passive earth resistance using modified pseudo-dynamic method

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Earthquake Engineering and Engineering Vibration 2017年第2期16卷 263-274页

作者： Anindya Pain Deepankar Choudhury S. k. bhattacharyya Academy of Scientific and Innovative Research(AcSIR) New Delhi 110001IndiaCSIR-Central Building Research InstituteRoorkee 247667India Dept.of Civil Engineering lndian Institute of Technology BombayPowaL Mumbai 400076lndiaAcademy of Scientific and Innovative Research(AcSIR)New Delhi 110001India Dept.of Civil Engineering Indian Institute of Technology KharagpurWest Bengal721302IndiaCSIR-Central Building Research InstituteRoorkee 247667India

In earthquake prone areas, understanding of the seismic passive earth resistance is very important for the design of different geotechnical earth retaining structures. In this study, the limit equilibrium method is used for estimation of critical seismic passive earth resistance for an inclined wall supporting horizontal cohesionless backfill. A composite failure surface is considered in the present analysis. Seismic forces are computed assuming the backfill soil as a viscoelastic material overlying a rigid stratum and the rigid stratum is subjected to a harmonic shaking. The present method satisfies the boundary conditions. The amplification of acceleration depends on the properties of the backfill soil and on the characteristics of the input motion. The acceleration distribution along the depth of the backfill is found to be nonlinear in nature. The present study shows that the horizontal and vertical acceleration distribution in the backfill soil is not always in-phase for the critical value of the seismic passive earth pressure coefficient. The effect of different parameters on the seismic passive earth pressure is studied in detail. A comparison of the present method with other theories is also presented, which shows the merits of the present study.

关键词： retaining wall earthquake limit equilibrium method modified pseudo-dynamic method passive earthpressure composite failure mechanism

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Heat transfer in boundary layer stagnation-point flow towards a shrinking sheet with non-uniform heat flux

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Chinese Physics B 2013年第7期22卷 328-333页

作者： krishnendu bhattacharyya Department of Mathematics The University of Burdwan

In this paper, the effect of non-uniform heat flux on heat transfer in boundary layer stagnation-point flow over a shrinking sheet is studied. The variable boundary heat fluxes are considered of two types： direct power-law variation with the distance along the sheet and inverse power-law variation with the distance. The governing partial differential equations （PDEs） are transformed into non linear self-similar ordinary differential equations （ODEs） by similarity transformations, and then those are solved using very efficient shooting method. The direct variation and inverse variation of heat flux along the sheet have completely different effects on the temperature distribution. Moreover, the heat transfer characteristics in the presence of non-uniform heat flux for several values of physical parameters are also found to be interesting.

关键词： non-uniform heat flux heat transfer stagnation-point flow shrinking sheet

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位场资料解释方法 ***论文集 1

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1993年

作者： B.k.bhattacharyya 郝书俭郝书翰编译

收《任意磁化柱体的磁异常》、《重磁解释计算机模型化》、《美国黄石公园地区航磁异常分析》等17篇论文。

ISBN: (纸本)7502809589

收《任意磁化柱体的磁异常》、《重磁解释计算机模型化》、《美国黄石公园地区航磁异常分析》等17篇论文。

关键词：重力勘探地质解释学科:文集磁法勘探

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Boundary Layer Flow and Heat Transfer over an Exponentially Shrinking Sheet

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Chinese Physics Letters 2011年第7期28卷 198-201页

作者： krishnendu bhattacharyya Department of Mathematics the University of BurdwanBurdwan-713104West BengalIndia

An analysis is made to study boundary layer flow and heat transfer over an exponentially shrinking *** similarity transformations in exponential form,the governing boundary layer equations are transformed into self-similar nonlinear ordinary differential equations,which are then solved numerically using a very efficient shooting *** analysis reveals the conditions for the existence of steady boundary layer flow due to exponential shrinking of the sheet and it is found that when the mass suction parameter exceeds a certain critical value,steady flow is *** dual solutions for velocity and temperature distributions are *** increasing values of the mass suction parameter,the skin friction coefficient increases for the first solution and decreases for the second solution.

关键词： solution method exponential

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