Alveolar macrophages (AM) are known to play an essential role in lung defense through their ability to remove the foreign matters reaching the lung alveoli. Cigarette smoke (CS) is a critical risk factor for many lung...
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Alveolar macrophages (AM) are known to play an essential role in lung defense through their ability to remove the foreign matters reaching the lung alveoli. Cigarette smoke (CS) is a critical risk factor for many lung diseases. CS is inhaled into the lung by respiretion and affects AM. It has been previously reported that CS induces inhibition of cytokine production, cell surface receptor expression and antigen presentation in AM. However, the relationship of immune suppression and DNA damage caused by CS in AM is still unclear. Therefore, in this study, we investigated AM immune function and DNA damage in CS-exposed mice. Mice were exposed to CS of 20 cigarettes/day during 10 days using a HambrugⅡsmoking machine. After exposure, AM were obtained by bronchoalveolar lavage. The number of AM was significantly increased in CS-exposed mice compared with non-CS-exposed mice. Phagocytic activity of AM was significantly inhibited by CS exposure. Percentage of CD11b-, CD14-, Toll-like receptor (TLR)2- or TLR4-positive cells was significantly decreased in CS-exposed mice compared with non-CS-exposed mice. Interleukin-1β mRNA expression in lipopolysaccharide-stimulated AM was significantly inhibited by CS exposure. Intracellular reactive oxygen species (ROS) (, H2O2) production of AM was significantly increased, and DNA damage was induced by CS exposure. These results suggest that impaired immune functions by CS exposure may be related to DNA damage via excessive ROS induced by CS. These alterations of AM caused by CS could be associated with infection and development of pulmonary diseases.
Recently theoretical development of optical potential suggests a method to study the repulsive nature due to the *** it is important to explore the repulsive nature of nucleus-nucleus interaction *** repulsive nature ...
Recently theoretical development of optical potential suggests a method to study the repulsive nature due to the *** it is important to explore the repulsive nature of nucleus-nucleus interaction *** repulsive nature of the interaction can be observed as a change of diffraction pattern of the elastic scattering[1].We have finished the experiment of 100Me V/u 12C+12C to measure the angular distributions of elastic and inelastic scattering by using the magnetic spectrometer"Grand Raiden"at RCNP,Osaka *** observed the angular distributions of ground states and three excited *** comparing the theoretical results,we found the obvious three-body-force effect[1].It’s also research the channel coupling effect of the cross section[2].
张量力在介子的交换作用中发挥了重要作用,在核力中提供了最重要的吸引作用,其重要性已经在对氘核及α粒子结合能的解释中得到了验证[1]。为了研究原子核内高动量成分中可能的张量相互作用的效应,基于大阪大学RCNP的"大雷电(Grand Raiden)"高分辨率磁谱仪,我们在已完成的能量为198 Me V,295 Me V和392 Me V的质子束流实验[2]基础上,进行零度角及小角度的高动量
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