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Paradigm shift in transfusion practices during early COVID-19 pandemic:A single center retrospective study

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World Journal of Virology 2024年第2期13卷 78-86页

作者： Sumukh arun kumar Sushmita Prabhu Ankushi Sanghvi Maya Gogtay Mithil Gowda Suresh Harshit khosla Yuvaraj Singh Ajay kumar Mishra Susan George Department of Internal Medicine Saint Vincent HospitalWorcesterMA 01608United States Department of Hematology and Oncology University of Nebraska Medical CenterOmahaNE 68198United States Hospice and Palliative Care UTHSC and McGovern School of MedicineTexasTX 77030United States Department of Gastroenterology and Hepatology UMass Chan Medical SchoolWorcesterMA 01655United States Division of Cardiology Saint Vincent HospitalWorcesterMA 01608United States

BACkGROUND The advent of coronavirus disease 2019(COVID-19)unveiled the worst national blood crisis that the United States had witnessed in over a *** the pandemic influencing the different stages of the acquisition of blood products outside the hospital setting,we aimed to explore the possible barriers contributing to the shortage of blood products within the medical *** COVID era and pre-COVID *** We conducted a retrospective cross-sectional study on hospitalized patients distinguishing the pattern of blood transfusion during the COVID and pre-COVID era in a community *** was tabulated to include the number of red blood cell(RBC)transfusions and if transfusions met restrictive blood transfusion criteria as per institutional ***-square was applied to test the statistical association between qualitative *** t test and Mann Whitney U test were applied respectively to test the mean difference of quantitative *** A total of 208 patients were included in the study,of which 108 were during COVID era and 100 were during pre-COVID *** leading reason for admission in both the COVID era and pre-COVID era transfused patients was shortness of breath(53.7%and 36%P=0.001),followed by gastrointestinal bleeding(25.9%and 21%P=0.001).There was a higher percentage of RBC transfusions in the intensive care unit in the COVID-era group than in the pre-COVID era group(38.9%vs 22%,P=0.008).The restrictive transfusion criteria were met in 62%vs 79%in the COVID and pre-COVID eras,respectively(P=0.008).CONCLUSION The COVID-era group received RBC transfusions with less stringent adherence to restrictive blood transfusion practices in comparison to pre-COVID era group.

关键词： Blood transfusion Restrictive transfusion COVID-19 Pre-COVID-19 Blood shortage Pandemic

Identification of strategy parameters for particle swarm optimizer through Taguchi method

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第12期7卷 1989-1994页

作者： kHOSLA arun kUMAR Shakti AGGARWAL k.k. Department of Electronics and Communication Engineering National Institute of Technology Jalandhar 144011 India Centre for Advanced Technology Haryana Engineering College Jagadhari 135003 India Vice Chancellor GGS Indraprastha University Delhi 110006 India

Particle swarm optimization （PSO）, like other evolutionary algorithms is a population-based stochastic algorithm inspired from the metaphor of social interaction in birds, insects, wasps, etc. It has been used for finding promising solutions in complex search space through the interaction of particles in a swarm. It is a well recognized fact that the performance of evolutionary algorithms to a great extent depends on the choice of appropriate strategy/operating parameters like population size, crossover rate, mutation rate, crossover operator, etc. Generally, these parameters are selected through hit and trial process, which is very unsystematic and requires rigorous experimentation. This paper proposes a systematic based on Taguchi method reasoning scheme for rapidly identifying the strategy parameters for the PSO algorithm. The Taguchi method is a robust design approach using fractional factorial design to study a large number of parameters with small number of experiments. Computer simulations have been performed on two benchmark functionsiRosenbrock function and Griewank functionito validate the approach.

关键词： Strategy parameters Particle swarm optimization (PSO) Taguchi method ANOVA

Pre-treatment of rocks prior to comminution--A critical review of present practices

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International Journal of Mining Science and Technology 2017年第2期27卷 339-348页

作者： Somani Aditya Nandi Tapas k. Pal Samir k. Majumder arun k. Department of Mining Engineering Indian Institute of TechnologyKharagpur 721302India Cryogenic Engineering Centre Indian Institute of TechnologyKharagpur 721302India

It has been an established fact that comminution processes, crushing and grinding, are most energy intensive processes which account for more than half of the total energy consumed in mineral *** alternative pre-treatment methods have been tried by experts around the globe. Although these methods yielded positive results in terms of reduction in energy consumption in crushing and particularly, in grinding operations at laboratory scale, their industrial application still remains an unresolved issue and challenge. Present review paper describes each one of these methods along with outcome of earlier studies and issues that need to be addressed through further rigorous experimental *** also suggests the direction in which future studies can be carried out to meet the primary objective of making comminution processes more energy efficient than today they are.

关键词： Comminution Rock breakage Microwave Thermal shock

Emerging therapies in gastrointestinal cancers

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World Journal of Gastroenterology 2006年第46期12卷 7440-7450页

作者： Jyoti Nautiyal arun k Rishi Adhip PN Majumdar karmanos Cancer Institute Detroit MI 48201United States karmanos Cancer Institute Veterans Affairs Medical Center Departments of Internal Medicineand Wayne State University Detroit MI 48201 United States

Members of the receptor tyrosine kinase family, that include EGFR, ErbB-2/HER-2, ErbB-3/HER-3 and ErbB-4/ HER-4, are frequently implicated in experimental models of epithelial cell neoplasia as well as in human cancers. Therefore, interference with the activation of these growth factor receptors represents a promising strategy for de- velopment of novel and selective anticancer therapies. Indeed, a number of inhibitors that target either EGFR or HER-2, with the exception of a few that target both; have been developed for treatment of epithelial cancers. Since most solid tumors express different ErbB receptors and/or their ligands, identification of inhibitor(s), targeting multiple EGFR family members may provide a therapeutic benefit to a broader patient population. Here we describe the significance of an ErbB family of receptors in epithelial cancers, and summarize different available therapeutics targeting these receptors. It also emphasizes the need to develop pan-ErbB inhibitors and discusses EGF-Receptor Related Protein, a recently isolated negative regulator of EGFR as a potential pan-ErbB therapeutic for a wide vari- ety of epithelial cancers.

关键词： Gastrointestinal cancers Carcinogenesis Targeted therapies Pan-ErbB family EGF-Receptor Related Protein

Mechanical and Physical Properties of Pineapple Leaf and Sun Hemp Fibre Reinforced Hybrid Natural Composite Fabricated by Compression Moulding Method

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Journal of Bionic Engineering 2022年第1期19卷 257-267页

作者： A.arun Premnath Centre for Composite Science and Tribology Sri Chandrasekharendra Saraswathi Viswa MahavidyalayaKanchipuramTamilnadu631561India

The implementation of natural fibres in polymer composites will result in biodegradable,low cost,recyclable materials for automobile and structural *** the process of making natural fibre composites viable in the global market,it is essential to understand its mechanical and physical *** the present investigation,mechanical and physical properties of pineapple Leaf(PALF)and Sun Hemp(SH)Fibre reinforced with epoxy matrix was studied in terms of weight(wt)%of fibre loading and chemical *** composites were fabricated by compression moulding technique with PALF fibre content varying from 10,15 and 20%of weight *** PALF and SHF were treated with NaOH solution for 1 h at room *** various mechanical properties such as tensile,compression,flexural and impact strength were measured as per ASTM *** density and water absorption were also measured to study the physical properties of the fabricated *** treated composites exhibit a rough surface because of the removal of the cellulose layer which results in better adhesion between the matrix/fibre interface than untreated *** NaOH treated fibres composites outperformed untreated fibre composites in terms of mechanical and physical properties except for impact *** morphological studies of the worn surfaces are examined using Scanning Electron Microscope(SEM).

关键词： Pineapple leaf fibre Compression moulding Mechanical properties Physical properties Morphological studies

Extreme ultraviolet and x-ray transition wavelengths in Rb XXIV

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Chinese Physics B 2015年第10期24卷 115-126页

作者： Indu khatri arun Goyal Sunny Aggarwal A.k.Singh Man Mohan Department of Physics and Astrophysics University of Delhi Department of Physics Shyamlal CollegeUniversity of Delhi Department of Physics D.D.U.CollegeUniversity of Delhi

Energy levels, radiative rates, oscillator strengths and line strengths are reported for transitions among the lowest 97 levels of the（1s22s22p6） 3s23p2, 3s23p3 d, 3s3p3, 3p4, 3s3p23 d, and 3s23d2 configurations of Rb XXIV. A multiconfiguration Dirac-Fock（MCDF） method is adopted for the calculations. Radiative rates, oscillator strengths, and line strengths are provided for all electric dipole（E1）, magnetic dipole（M1）, electric quadrupole（E2）, and magnetic quadrupole（M2）transitions from the ground level to all 97 levels, although calculations are performed for a much larger number of *** achieve the accuracy of the data, comparisons are provided with similar data obtained from the Flexible Atomic Code（FAC） and also with the available theoretical and experimental results. Our energy levels are found to be accurate to better than 1.2%. Wavelengths calculated are found to lie in EUV（extreme ultraviolet） and x-ray regions. Additionally, lifetimes for all 97 levels are obtained for the first time.

关键词： atomic data energy levels transition probability

Natural compounds in the regulation of proteostatic pathways: An invincible artillery against stress, ageing, and diseases

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Acta Pharmaceutica Sinica B 2021年第10期11卷 2995-3014页

作者： arun Upadhyay Department of Biochemistry Central University of Rajasthan 305817India

Cells have different sets of molecules for performing an array of physiological *** acids have stored and carried the information throughout evolution,whereas proteins have been attributed to performing most of the cellular *** perform these functions,proteins need to have a unique conformation and a definite *** attributes are achieved by a highly coordinated protein quality control(PQC)system comprising chaperones to fold the proteins in a proper threedimensional structure,ubiquitin-proteasome system for selective degradation of proteins,and autophagy for bulk clearance of cell *** kinds of stresses and perturbations may lead to the weakening of these protective cellular machinery,leading to the unfolding and aggregation of cellular proteins and the occurrence of numerous pathological ***,modulating the expression and functional efficiency of molecular chaperones,E3 ubiquitin ligases,and autophagic proteins may diminish cellular proteotoxic load and mitigate various pathological *** medicine and small molecule-based therapies have been well-documented for their effectiveness in modulating these pathways and reestablishing the lost proteostasis inside the cells to combat disease *** present article summarizes various similar reports and highlights the importance of the molecules obtained from natural sources in disease therapeutics.

关键词： Proteostasis Proteinopathies Chaperones Ubiquitin proteasome system Autophagy Cancer Neurodegeneration Ageing Natural molecules Drug discovery

Fuzzy AHP approach for legal judgement summarization

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Journal of Management Analytics 2019年第3期6卷 323-340页

作者： Neha Bansal arun Sharma R.k.Singh Department of Information Technology Indira Gandhi Delhi Technical University for WomenDelhiIndia

Legal documents are generally big and complex documents because of specific vocabulary,semantics and *** of the major challenges in legal processing systems is to generate summary of legal *** date,in most of the legal systems,the summary of judgements is produced manually by legal experts which are then used by Lawyers,Judges and other legal *** manual process of summarization is very inefficient and *** text summarization(ATS)is the process of reducing the content of a textual document,while retaining the core description of text through the use of appropriate *** present work proposes a novel Fuzzy Analytical Hierarchical process(FAHP)based feature weighting scheme which helps in producing an efficient and effective summary of legal *** is applied on a number of legal judgements taken from Indian IT *** of the model is done using ROUGE(Recall-Oriented Understudy for Gisting Evaluation)tool with recall,precision,and f-measure as performance *** generated summaries are further assessed by legal experts and are found to be more promising than the summaries generated by traditional approaches.

关键词： summarization fuzzy AHP feature extraction feature weighting legal information system legal knowledge management social science

Fertilization and Soil Ploughing Practices under Changing Physical Environment Lead to Soil Organic Carbon Dynamics under Conservation Agriculture in Rice-Wheat Cropping System: A Scoping Review

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Agricultural Sciences 2024年第1期15卷 82-113页

作者： Salwinder Singh Dhaliwal Arvind kumar Shukla Sanjib kumar Behera Sarwan kumar Dubey Agniva Mandal Mehakpreet kaur Randhawa Sharanjit kaur Brar Gagandeep kaur Amardeep Singh Toor Sohan Singh Walia Priyadarshani arun khambalkar Department of Soil Science Punjab Agricultural University Ludhiana India Rajmata Vijayaraje Scindia krishi Vishwa Vidyalaya Gwalior India Indian Institute of Soil Science (ISSS) Bhopal India Indian Council of Agricultural Research—Central Soil Salinity Research Institute (ICAR-CSSRI) Karnal India Department of Agricultural Chemistry and Soil Science Bidhan Chandra Krishi Viswavidyalaya Mohanpur India Department of Crop and Soil Sciences Washington State University Pullman USA School of Organic Farming Punjab Agricultural University Ludhiana India Department of Soil Science Rajmata Vijayaraje Sciendia Krishi Viswa Vidalaya Gwalior India

Ploughing and fertilization practices in rice-wheat system have deteriorated the soil carbon (C) pools. Conservation agriculture (CA) based management approaches have proven to enhance C sequestration and reverse the loss of soil-organic-carbon (SOC), which further enhances soil fertility. Different fractions of SOC pools react to the alterations in management practices and indicate changes in SOC dynamics as compared to total C in the soil. Higher SOC levels in soil have been observed in case of reduced/no-till (NT) practices than conventional tillage (CT). However, between CT and zero tillage/NT, total SOC stocks diminished with an increase in soil depth, which demonstrated that the benefits of SOC are more pronounced in the topsoil under NT. Soil aggregation provides physical protection to C associated with different-sized particles, thus, the improvement in soil aggregation through CA is an effective way to mitigate soil C loss. Along with less soil disturbance, residual management, suitable crop rotation, rational application of manures and fertilizers, and integrated nutrient management have been found to be effective in not only improving soil C stock but also enhancing the soil health and productivity. Thus, CA can be considered as a potential method in the build-up of SOC of soil in rice-wheat system.

关键词： Tillage Conservation Agriculture Soil Organic Carbon Carbon Fractions Rice-Wheat System Organic Amendments