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旅游世界 2013年第8期 116-121页

作者：马赛 Suk wan stacey

提起五渔村,首先映入脑海的,是如同上帝打翻了调色盘的海边小镇,以及那个将爱情紧紧锁住的的爱情小路。

关键词：渔村纯净爱情

Decoding cancer's camouflage: epithelial-mesenchymal plasticity in resistance to immune checkpoint blockade

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Cancer Drug Resistance 2020年第4期3卷 832-853页

作者： Maria L.Lotsberg Austin Rayford Jean Paul Thiery Giuliana Belleggia stacey D’Mello Peters James B.Lorens Salem Chouaib Stephane Terry Agnete S.T.Engelsen Centre for Cancer Biomarkers and Department of Biomedicine University of BergenBergen 5009Norway BerGenBio ASA Jonas Lies vei 91Bergen 5009Norway INSERM UMR 1186 Integrative Tumour Immunology and ImmunotherapyGustave RoussyFac.de Médecine-Univ.Paris-SudUniversitéParis-SaclayVillejuif 94805France Cancer Science Institute of Singapore National University of SingaporeSingaporeSingapore 117599Singapore Department of Biochemistry Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore 119228Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnology and ResearchA-STARSingaporeSingapore 138673Singapore Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510005China School of Medicine Clinical Skills Assessment ProgramUniversity of ConnecticutFarmingtonCT 06030USA Thumbay Research Institute of Precision Medicine Gulf Medical UniversityAjman 4184United Arab Emirates UniversitéParis-Saclay INRAEAgroParisTechGABIJouy-en-Josas 78350France

Epithelial-mesenchymal plasticity(EMP)of cancer cells contributes to cancer cell heterogeneity,and it is well established that EMP is a critical determinant of acquired resistance to cancer treatment modalities including radiation therapy,chemotherapy,and targeted ***,we aimed to explore how EMP contributes to cancer cell camouflage,allowing an ever-changing population of cancer cells to pass under the radar of our immune system and consequently compromise the effect of immune checkpoint blockade *** ultimate clinical benefit of any combination regimen is evidenced by the sum of the drug-induced alterations observed in the variety of cellular populations composing the tumor immune *** finely-tuned molecular crosstalk between cancer and immune cells remains to be fully elucidated,particularly for the spectrum of malignant cells along the epithelial to mesenchymal ***-dimensional single cell analyses of specimens collected in ongoing clinical studies is becoming a key contributor to our understanding of these *** review will explore to what extent targeting EMP in combination with immune checkpoint inhibition represents a promising therapeutic avenue within the overarching strategy to reactivate a halting cancer-immunity cycle and establish a robust host immune response against cancer *** strategies currently in clinical development will be discussed.

关键词： Epithelial-to-mesenchymal transition epithelial-mesenchymal plasticity immune evasion tumor immune microenvironment intrinsic and extrinsic mechanisms of resistance to immune checkpoint blockade therapeutic opportunity

地震预报研究——对此问题及将来工作方向的个人见解

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地震学报 1984年第1期10卷 1-7页

作者： F.D.stacey 澳大利亚昆士兰大学物理系

本文是作者于1983年访华期间接受中国学术刊物的请求而撰写的。文中指出,地震应力在数量上相当小,因此它的效应一定很微妙,需要有灵敏的仪器去觉察它们。文中对压磁效应、波速比、应变、地倾斜、大地测量、电阻率、水氡和前震等各国常... 详细信息

本文是作者于1983年访华期间接受中国学术刊物的请求而撰写的。文中指出,地震应力在数量上相当小,因此它的效应一定很微妙,需要有灵敏的仪器去觉察它们。文中对压磁效应、波速比、应变、地倾斜、大地测量、电阻率、水氡和前震等各国常用的地震预报手段进行了评价,提出了建议。结论为,虽然注意到了 Brune(1979)关于“在原理上地震可能是不可预报的”强有力的论证,但作者并不那样悲观。认为地壳可能十分不均匀,它的状态可能是多变的,这就要求我们拥有大量数据。所以必须同时使用几种方法和大量的仪器进行观测。更多的注意力应放在:(1)地震波传播的各向异性和衰减,(2)多色激光测距,(3)改善构造磁学中的信噪比,(4)在电导率测量中使用可交替极性的供电极和较大面积的测量极网和(5)对前震和余震序列的统计学分析进行重新仔细检验。

关键词：地震预报磁学信噪比电磁学信号噪声比震磁效应震源体积地震序列余震序列个人见解

Challenges in Cardiovascular Risk Prediction and Stratifi cation in Women

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Cardiovascular Innovations and Applications 2019年第B2期3卷 329-348页

作者： Sonia Henry,MD Rachel Bond,MD stacey Rosen,MD Cindy Grines,MD Jennifer Mieres,MD Northwell Health Department of CardiologyNorthshore University HospitalHofstra School of Medicine300 Community DriveManhassetNY 11030USA Northwell Health Department of CardiologyHofstra North Shore-LIJ School of MedicineLenox Hill Hospital110 E.59th StreetSuite 8ANew YorkNY 10022USA Northwell Health Department of CardiologyHofstra School of MedicineThe Katz Institute for Women’s Health1981 Marcus AvenueSuite E110Lake SuccessNY 11042USA Hofstra School of Medicine Northwell Health1979 Marcus Avenue Suite 236Lake SuccessNY 11042USA

There has been an appropriate focus,since the turn of the 21 st century,on sex-and gender-specifi c cardiovascular disease(CVD)as increasing evidence suggests that there are substantial differences in the risk factor profi le,social and environmental factors,clinical presentation,diagnosis,and treatment of ischemic heart disease in women compared with *** a result of increased awareness,detection,and treatment of ischemic heart disease in women,there has been signifi cant reduction(greater than 30%)in cardiovascular mortality,and in 2013,more US men than US women died of ***,continued efforts are required as CVD remains the leading cause of cardiovascular morbidity and death of women in the Western world,and in women younger than 55 years there has been a rise in cardiovascular *** this article,we review several of the contributing factors that continue to cause challenges in accurate risk prediction and risk stratifi cation in women.

关键词： sex and gender disparity risk prediction risk stratifi cation ischemic heart disease

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酸奶可治疗传染病?(英文)

大学英语 2014年第7期 33-34,43页

作者： stacey Burling 木子

In a medical system rife with1complex equipment and outrageously expensive2drugs,a Pennsylvania hospital has turned to a cheap,low-tech solution for one of modern medicine’s most challenging *** Redeemer in Montgomery County,Pa.,is using yogurt—the kind you could buy at the grocery store—to fight ***3,a hospital-acquired infection that has been growing throughout the *** dietitians4began encouraging patients taking antibiotics5to eat yogurt,the infection rate fell by *** Redeemer has now expanded the program to its nursing-home residents.

关键词：传染病治疗酸奶英文 the could has most

Gestational carriers: A viable alternative for women with medical contraindications to pregnancy

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Open Journal of Obstetrics and Gynecology 2013年第5期3卷 24-31页

作者： Raymond M. Anchan stacey A. Missmer katharine F. Correia Elizabeth S. Ginsburg Department of Obstetrics Gynecology and Reproductive Biology Brigham & Women’s Hospital and Harvard Medical School Boston USA

Objective: Compare the efficacy of surrogate or gestational carrier (GC) cycles to that of autologous in vitro fertilization (IVF)/intracytoplasmic sperm injections (ICSI) in patients with gynecologic or medical co-morbidities contraindicative to pregnancy. Design: Retrospective cohort study. Setting: Infertility patients from a single university hospital-based program from 1998-2009. Intervention(s): 128 GC cycles from 80 intended parents were identified and compared with 15,311 IVF or ICSI cycles. Main Outcome Measure(s): The peak estradiol (E2), number of oocytes retrieved, cycle cancellation, ongoing pregnancy, and live-birth were compared between GCs and autologous IVF carriers. Indications for GC use were also identified. Multiple cycles contributed by the same patient were accounted for using multivariable generalized estimating equations and two-sided Wald p-values. Results: Uterine factors (67%) was the most common indication for using a GC, followed by non-gynecologic medical conditions including coagulopathies (13%), end stage renal disease (10%), cardiovascular disease (5%) and cancer (5%). Adjusting for age, ovulation induction in GC cycles had similar peak E2 levels and number of oocytes retrieved relative to IVF cycles (p = 0.23 and 0.43, respectively). Clinical pregnancy (49% vs. 42%, p = 0.28) and live-birth rates (31% vs. 32%, p = 0.74) were also comparable. A sub-analysis of GC cycles in those women with uterine factor indications, demonstrated significantly higher clinical pregnancy rates (OR = 2.0;CI = 1.2 - 3.5) with 60% greater odds of live-birth relative to IVF/ICSI cycles, however this odds was not statistically significant for differences in live-birth (CI = 0.9 - 2.9). Conclusions: GCs are a viable alternative to start families for patients with medical co-morbidities precluding pregnancy.

关键词： IVF Donor Egg Gestational Carriers Gestational Surrogacy Infertility Medical Comorbidities

Differential truncation and uridyiation patterns of microRNAs in plant hen1 mutants reveal distinct routes of microRNA turnover

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Differential truncation and uridyiation patterns of microRNA...

Electrical control of quantum emitters in a Van der Waals heterostructure

第十三届全国植物基因组学大会

作者： Blake C.Meyers stacey A.Simon katherine Petsch Marja Timmermans University of Delaware Dept.of Plant & Soil SciencesNewarkDE19711USA Cold Spring Harbor Laboratory Cold Spring HarborNY 11724USA

miRNA levels depend on both biogenesis and *** methyltransferase HEN1 stabilizes plant miRNAs,animal piRNAs,and siRNAs in both kingdoms via 3’ terminal *** of HEN1 in plants results in non-templated oligouridylation and accelerated degradation of *** hen1 mutants from Arabidopsis,rice and maize,we found that the patterns of miRNA truncation and

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Light(Science & Applications) 2022年第8期11卷 1790-1798页

作者： Simon J.U.White Tieshan Yang Nikolai Dontschuk Chi Li Zai-Quan Xu Mehran kianinia Alastair stacey Milos Toth Igor Aharonovich School of Mathematical and Physical Sciences University of Technology SydneyUltimoNSW2007Australia ARC Centre of Excellence for Transformative Meta-Optical Systems University of Technology SydneyUltimoNSW2007Australia School of Physics University of MelbourneParkvilleVIC3010Australia School of Science RMIT UniversityMelbourneVIC3001Australia

Controlling and manipulating individual quantum systems in solids underpins the growing interest in the development of scalable quantum ***,hexagonal boron nitride(hBN)has garnered significant attention in quantum photonic applications due to its ability to host optically stable quantum ***,the large bandgap of hBN and the lack of efficient doping inhibits electrical triggering and limits opportunities to study the electrical control of ***,we show an approach to electrically modulate quantum emitters in an hBN-graphene van der Waals *** show that quantum emitters in hBN can be reversibly activated and modulated by applying a bias across the ***,a significant number of quantum emitters are intrinsically dark and become optically active at non-zero *** explain the results,we provide a heuristic electrostatic model of this unique ***,employing these devices we demonstrate a nearly-coherent source with linewidths of~160 *** results enhance the potential of hBN for tunable solid-state quantum emitters for the growing field of quantum information science.

关键词： quantum hexagonal boron