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Promoting Sickle Cell Trait Awareness and Education: A Typology of Interventions in the United States to Inform Ongoing Efforts to Patients and Providers

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Health 2024年第4期16卷 280-308页

作者： stacey Cunnington Jacey Greece Department of Community Health Sciences Boston University School of Public Health Boston Massachusetts USA

Research Background: Sickle cell trait has no treatment or cure and predominantly affects people who are Black, but can affect anyone of any race or ethnicity. While commonly incorrectly considered benign by providers and the public, people with a sickle cell trait experience life-threatening outcomes that are exacerbated by extreme conditions. There is a severe lack of awareness and understanding of sickle cell trait and the associated health complications among sickle cell trait carriers and healthcare providers. Purpose/Aim: Interventions that aim to improve awareness of sickle cell trait differ in approaches and are not well documented in the literature. This typology aims to highlight current efforts to inform targeted interventions that raise awareness through consistent messaging, educate people and providers on sickle cell trait and the related health complications, and support the design and implementation of comprehensive sickle cell trait awareness initiatives. Methods: We conducted a scoping review of United States-based sickle cell trait interventions and performed a content analysis to identify the categories and characteristics of these efforts. We then organized the results into a typology according to established protocols. Results: Among 164 interventions, twenty-five (15%) met the typology inclusion criteria described above and were grouped into categories: Seven of twenty-five interventions were Educational Interventions (28%), three of twenty-five interventions (12%) were Combined Screening and Educational-Based Interventions, eight of twenty-five interventions (32%) were Policy and Guideline-Based Intervention, and six of twenty-five interventions (24%) were Sickle Cell Trait Organization-Led Interventions. Conclusions: There is a lack of consistency in messaging across interventions whether delivered by credible healthcare institutions or national organizations, which can result in lack of education and awareness and confusion around sickle ce

关键词： Sickle Cell Trait Awareness Sickle Cell Trait Messaging Sickle Cell Trait Intervention Typology Scoping Review

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盗版泰勒经济

商业周刊（中文版） 2024年第6期 8-10页

作者： Ella Ceron stacey Rene 晴川(译) 不详

泰勒·斯威夫特(Taylor Swift)的歌迷们若想购买T恤、紧身衣、友谊手环或各种其他纪念品来表达他们对这位流行巨星的热爱,他们或许会考虑去官网。但最近试过的人都不太走运。这家店在新专辑《The Tortured Poets Department》发布之前,... 详细信息

泰勒·斯威夫特(Taylor Swift)的歌迷们若想购买T恤、紧身衣、友谊手环或各种其他纪念品来表达他们对这位流行巨星的热爱,他们或许会考虑去官网。但最近试过的人都不太走运。这家店在新专辑《The Tortured Poets Department》发布之前,只提供珍藏版CD、磁带和黑胶唱片的预订。不过,这并没有妨碍“泰勒迷经济”的蓬勃发展,因为在Etsy、亚马逊(***)和Redbubble等按需印制网站上已涌现了无数的零售店铺,提供大量带有泰勒照片或歌词的商品。

关键词：斯威夫特黑胶唱片珍藏版紧身衣泰勒亚马逊

Effectiveness of Wastewater-Based Epidemiology as an Early Warning Tool to Detect SARS-CoV-2 (COVID-19)

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Health 2024年第7期16卷 635-656页

作者： Rakib Ahmed Chowdhury Daniel E. Meeroff Sumaiya Sharmin Alamgir kabir Sara Hollenbeck Valerie Dalencourt Thu Nguyen Zack Farmer Frederick Bloetscher Waseem Asghar stacey Volnick College of Engineering and Computer Science Florida Atlantic University Boca Raton FL USA

Medical diagnostic tests to detect Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) for individuals in the United States were initially limited to people who were traveling or symptomatic to track disease incidence due to the cost of providing testing for all people in a community on a routine basis. As an alternative to randomly sampling large groups of people to track disease incidence at significant cost, wastewater-based epidemiology (WBE) is a well-established and cost-effective technique to passively measure the prevalence of disease in communities without requiring invasive testing. WBE can also be used as a forecasting tool since the virus is shed in individuals prior to developing symptoms that might otherwise prompt testing. This study applied the WBE approach to understand its effectiveness as a possible forecasting tool by monitoring the SARS-CoV-2 levels in raw wastewater sampled from sewer lift stations at a large public university campus setting including dormitories, academic buildings, and athletic facilities. The WBE analysis was conducted by sampling from building-specific lift stations and enumerating target viral copies using RT-qPCR analysis. The WBE results were compared with the 7-day rolling averages of confirmed infected individuals for the following week after the wastewater sample analysis. In most cases, changes in the WBE outcomes were followed by similar trends in the clinical data. The positive predictive value of the applied WBE approach was 86% for the following week of the sample collection. In contrast, positive correlations between the two data with Spearmen correlation (rs) ranged from 0.16 to 0.36. A stronger correlation (rs = 0.18 to 0.51) was observed when WBE results were compared with COVID-19 cases identified on the next day of the sampling events. The P value of 0.007 for Dorm A suggests high significance, while moderate significance was observed for the other dormitories (B, C, and D). The outcomes of this in

关键词： SARS-CoV-2 Wastewater Detection Wastewater-Based Epidemiology (WBE)

Use of perioperative chemotherapy in colorectal cancer metastatic to the liver

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Gastroenterology Report 2019年第5期7卷 301-311,I0001页

作者： Lynn k.Symonds stacey A.Cohen Division of Oncology University of WashingtonSeattleWAUSA Clinical Research Division Fred Hutchinson Cancer Research CenterSeattleWAUSA

A curative-intent approach may improve survival in carefully selected patients with oligometastatic colorectal *** treatments are most frequently administered to patients with isolated liver metastasis,though they may be judiciously considered for other sites of *** be considered for curative intent with surgery,patients must have disease that can be definitively treated while leaving a sufficient functional liver *** chemotherapy may be used for upfront resectable disease as a test of tumor biology and/or for upfront unresectable disease to increase the likelihood of resectability(so-called‘conversion’chemotherapy).While conversion chemotherapy in this setting aims to improve survival,the choice of a regimen remains a complex and highly individualized *** this review,we discuss the role of RAS status,primary site,sidedness,and other clinical features that affect chemotherapy treatment selection as well as key factors of patients that guide individualized patient-treatment recommendations for colorectal-cancer patients being considered for definitive treatment with metastasectomy.

关键词： metastatic colorectal cancer perioperative chemotherapy conversion chemotherapy liver resection kRAS steatohepatitis

Automatic prediction of time to failure of open pit mine slopes based on radar monitoring and inverse velocity method

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International Journal of Mining Science and Technology 2014年第2期24卷 275-280页

作者： Osasan k.S. stacey T.R. School of Mining Engineering Faculty of Engineering and Built EnvironmentUniversity of the Witwatersrand

Radar slope monitoring is now widely used across the world, for example, the slope stability radar(SSR)and the movement and surveying radar(MSR) are currently in use in many mines around the ***, to fully realize the effectiveness of this radar in notifying mine personnel of an impending slope failure, a method that can confidently predict the time of failure is necessary. The model developed in this study is based on the inverse velocity method pioneered by Fukuzono in 1985. The model named the slope failure prediction model(SFPM) was validated with the displacement data from two slope failures monitored with the MSR. The model was found to be very effective in predicting the time to failure while providing adequate evacuation time once the progressive displacement stage is reached.

关键词： Slope monitoring radar Displacement Rate of displacement Slope failure Slope monitoring Time to failure

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Male mate choice as differential investment in contest competition is affected by female ornament expression

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Current Zoology 2018年第3期64卷 335-344页

作者： stacey L. WEISS Matthew DUBIN Department of Biology University of Puget Sound 1500 N. Warner Street No. 1088 Tacoma WA 98418-1088 USA

High male mating effort and high variation in female quality select for male mate choice, which may be expressed as differential investment of reproductive effort based on female value. Male reproductive effort includes investment in direct contest competition with rival males for access to females, yet variation in male-male contest behavior is rarely examined in the context of male mate choice. We examine such male response to variation in female body size, reproductive state, and female-specific ornamentation in the striped plateau lizard, Sceloporus virgatus. We housed lizards in trios of 2 size-matched males and one female for 5 days, such that all 3 lizards were physi- cally isolated and the males could see the female but not each other. We then placed males simultaneously into the female＇s cage and scored the interaction. Male-male aggression was not significantly affected by female body size, reproductive state, nor ornament color, but was influenced by ornament size which reliably signals the phenotypic quality of the female and her off- spring. In the presence of larger-ornamented females, males engaged in more male-male aggressive display behavior more quickly, and performed fewer high-intensity contact behaviors but were equally likely to escalate to this riskier level of fighting. Our data suggest that males adjust their energetic investment during intrasexual competitive interactions in response to variation in the contested female which, assuming males gain direct or indirect benefits from their strategic allocation of reproductive effort, fits the modern understanding of male mate choice.

关键词： aggression female-specific ornaments intrasexual competition lizards resource quality sexual selection

Hemodynamic improvement using methylene blue after calcium channel blocker overdose

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World Journal of Emergency Medicine 2019年第1期10卷 55-58页

作者： Sophia Ahmed stacey Barnes St.Joseph's Regional Medical Center

Dear editor,Calcium channel blocker overdoses are often fatal despite standard treatment. Methylene blue is a novel adjunct that should be considered in refractory *** accepted therapeutic modalities include intraveno... 详细信息

关键词：小学英语课外阅读阅读材料

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Optimized Hot Spot and Directional Distribution Analyses Characterize the Spatiotemporal Variation of Large Wildfires in Washington,USA,1970-2020

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International Journal of Disaster Risk Science 2022年第1期13卷 139-150页

作者： kevin Zerbe Chris Polit stacey McClain Tim Cook Washington Emergency Management Division Camp MurrayTacomaWA 98430USA

Spatiotemporal analysis of fire activity is vital for determining why wildfires occur where they do,assessing wildfire risks,and developing locally relevant wildfire risk reduction *** various spatial statistical methods,we determined hot spots of large wildfires(>100 acres)in Washington,the United States,and mapped spatiotemporal variations in large wildfire activity from 1970 to *** results found that all hot spots are located east of the crest of the Cascade *** spatiotemporal analysis found that the geographic area wherein most of the state’s acres burned has shrunk considerably since 1970 and has become concentrated over the north-central portion of the state over *** concentration of large wildfire activity in north-central Washington was previously unquantified and may provide important information for hazard mitigation efforts in that *** results highlight the advantages of using spatial statistical methods that could aid the development of natural hazard mitigation plans and risk reduction strategies by characterizing previous hazard occurrences spatially and spatiotemporally.

关键词： Hazard mitigation Natural hazards Spatial statistics Washington state Wildfire

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CHINA＇S PENSION CRISIS： SYSTEM REFORMS START WITH RELAXATION OF ONE-CHILD POLICY

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Frontiers of Law in China-Selected Publications from Chinese Universities 2013年第2期8卷 233-265页

作者： stacey Lee Mitchell Beasley School of Law Temple University Philadelphia USA

China＇s one-child poliey （＂OCP＂） exacerbates the existing weaknesses within the country＇s pension system.I This strict family planning measure is the root cause of sub-replacement fertility and rising dependency ratios within the country. Consequently, the one-child policy shouM not coexist with the nation＇s currently under-funded retirement security program. In order to avert an impending financial and social crisis, the Chinese government shouM immediately confront the issue of pension reform. However, designs to improve the retirement security framework cannot be successfully instituted unless, as an initial step, the one-child policy is relaxed. The focal point of this paper delves into the impracticality of the one-child policy in relation to China ＇ s pension reform efforts.

关键词： SEX-RATIOS SURPLUS BIRTHS MEN