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汽车测试报告 2013年第9期 116-122页

作者： sam Philip Tony(译)

脱鞋脱袜用尽手指脚趾四舍五入多除少补，岂不是等于每秒70米？那么一分钟不就可以穿越四十来个足球场吗？随着这对旅行车雷霆不绝划破慕尼黑夜阑人静的无限速公路，我突然思如泉涌，心想自己的破烂心算要是没出错，250km／h可是个挺厉... 详细信息

脱鞋脱袜用尽手指脚趾四舍五入多除少补，岂不是等于每秒70米？那么一分钟不就可以穿越四十来个足球场吗？随着这对旅行车雷霆不绝划破慕尼黑夜阑人静的无限速公路，我突然思如泉涌，心想自己的破烂心算要是没出错，250km／h可是个挺厉害的速度呢!

关键词：行空间四舍五入足球场慕尼黑旅行车公路

Relationship between Cool Coma and heat Coma Temperatures in the Oceanic Sea Skaters halobates Collected near the Sumatra Island in the Indian Ocean

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Natural Science 2017年第5期9卷 145-157页

作者： Takahiro Furuki Noritomo Umamoto Wataru Ohoka Mitsuru Nakajo Chihiro katagiri sam Wouthuyzen Tetsuo harada Laboratory of Environmental Physiology Graduate School of Integrated Arts and Sciences Kochi University Kochi Japan Laboratory of human health Science Graduate School of Medicine Kyoto University Japan Laboratory of Science Education Graduate School of Integrated Arts and Sciences Kochi University Kochi Japan Tokyo Denki University Tokyo Japan Research Center for Oceanography Indonesian Institute of Science LIPI Jakarta Indonesia

In the cruise, MR15-04 by R/V MIRAI, the samplings by the neuston net were performed in 23rd November to 14th December 2016 and three species of halobates (h. germanus, h. micans, h. sp) were used for the temperature tolerance experiments after the collection. The neuston net was towed three times (3 × 15 min) on the starboard side of R/V MIRAI on the water surface with ship speed of 2 knot to water every 3 nights (19:00 - 20:00) at the fixed point in the south-western direction which was located at 50 km from the Sumatra island (4o03'S - 4o05'S, 101o53'E) in the Indonesia. Experiments on cool coma and heat coma were performed on the three species. Seconds for recovery from cool coma and heat coma were also examined on the halobates in this study. Cool coma temperatures, gap temperature needed (temperature from the adapted temperature) for the cool coma and seconds for the recover from cool coma ranged 13.0oC to 25.0oC, 3.1oC to 16.1oC, 1 second to 4370 seconds, respectively. heat coma temperature, gap temperature needed for the heat coma, seconds for the recover from heat coma ranged 29.4oC to 43.1oC, 1.9oC to 15.5oC, 2 seconds to 6420 seconds, respectively. The higher temperature of cool coma temperature during the last five days was shown when Madden-Julian Oscillation has passed over the ship, R/V MIRAI than the previous 10 days in the adults of h. germanus collected at the fixed place neat to Sumatra island (One way ANOVA: F-value = 2.314, df = 7, p = 0.028). Adults of un-described species, h. sp collected near to the Sumatra island, showed lower cool coma temperature [Mean ± SD: 15.51 ± 3.76 (9)] than those of h. germanus collected in the same place [16.96 ± 2.57 (191)]. This lower cool coma temperatures shown by this un-described species might be related to that this species should be a “shore” species inhabiting shore water in which many precipitation could cause the decreased surface temperature from 30oC - 31oC into about 25oC. Most of adults which suffere

关键词： Oceanic Sea Skaters Cool and heat Comas Recovery Seconds from Temperature Comas Madden-Julian Oscillation Precipitation

四环素诱导调控DEC1表达的Vero细胞系的构建及鉴定

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畜牧与兽医 2017年第5期49卷 103-108页

作者：郇文彬明鑫鲍晨沂洪涛 JUNG Yong-sam 钱莺娟南京农业大学动物医学院江苏南京210095

为了构建四环素(tetracycline,Tet)诱导的利用Tet-on诱导表达系统调控的Vero-TR母细胞,建立Tet诱导表达或沉默DEC1的Vero细胞系并加以鉴定。试验将表达Tet阻遏蛋白(Tet repressor protein,TetR)的pc DNA6转染至Vero细胞,通过Blasticidin筛选稳定表达TetR的阳性细胞克隆,即Vero-TetR母细胞系。将克隆有DEC1基因(CDS区的pc DNA4真核表达载体或克隆有特异性靶向DEC1基因的shRNA的p Babe-h1真核表达载体,分别转染至Vero-TR细胞,通过Zeocin或Puromycin筛选诱导表达或沉默DEC1的阳性细胞克隆,命名为Vero-DEC1和VerosiDEC1。利用Western blot检测Vero细胞中Tet诱导表达或沉默DEC1的效果。最后成功构建了Vero-TR、Vero-DEC1和Vero-siDEC1的稳定细胞系,Western blot结果显示DEC1能够在Tet的调控下有效表达或沉默。Vero-TR母细胞系的成功构建为建立其他宿主细胞基因表达或沉默的细胞系提供了重要材料,Vero-DEC1和Vero-siDEC1细胞系的成功构建为研究DEC1在正常或感染等应激情况下的生物学功能奠定了基础。

关键词： Tet诱导调控细胞系 DEC1 基因表达基因沉默

A Combined COX and LOX Inhibitor Regimen Fails to Mimic the Action of Dexamethasone Against Cisplatin-Induced Acute and Delayed Emesis in the Ferret

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A Combined COX and LOX Inhibitor Regimen Fails to Mimic the ...

Immunohistochemical profiles of dural tail in intracranial meningiomas

第十五届国际药理学大会

作者： Rudd John A. sam Tasia S. W. Ngan Man P. Chinese University of hong kong Chinese University of hong kong Chinese University of hong kong

＜正＞ The anti - emetic action of glucocorticoids in the clinic may involve an ability to reduce the synthesis of eicosanoids. In the present studies, therefore, we investigated the potential of the non - selective COX inhibitor, indomethacin,and the LOX inhibitor, Mk-886（3-1-（p- chlorobenzyl） - 5 - （isopropyl） - 3 -tert- butylthioindol -2-yl）-2.2- dimethylpropanoic acid), to reduce cisplatin（5mg/kg,i. p.） - induced acute and delayed emesis in the ferret. Indomethacin （3-30 mg/kg/8 h, i. p.） potentiated significantly cisplatin - induced retching + vomiting （P＜0.05） and was also emetic when used alone. Conversely. Mk-886 （1-10 mg/kg/8 h, i.p.） was inactive to modify cisplatin - induced emesis （P＞0.05）. The combination treatment of indomethacin （10 mg/kg/8 h, i.p.） with Mk - 886 （10 mg/kg/8 h, i. p.） did not affect significantly （P＜0.05） cisplatin induced retching + vomiting,but had a different profile （P＜0.05） from dexamethasone （1 mg/kg/8 h,i.p.）. which produced a trend for *** studies are required to fully elucidate the mechanism of anti - emetic action of glucocorticoids.

关键词： Emesis cyclooxygenase lipoxygenase dexamethasone

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Immunohistochemical profiles of dural tail in intracranial m...

Synthesis, spectral characterization and biological activities of Organotin(IV) complexes with ortho-vanillin-2-hydrazinopyridine (VhP)

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Shin Jung Tae-Young Jung In-Young kim kyung-Sub Moon sam-Suk kang Brain Tumor Research Laboratory Department of NeurosurgeryBrain Tumor ＆ Gamma Knife CenterChonnam National University Hwasun Hospital ＆ Medical School

OBJECT:The dural tail was first described as a thin,tapering rim of dural enhancement,in continuity with meningiomas on enhanced T1-weighted magnetic resonance（MR） *** the exact nature of the tail pathology is still *** we would like to investigate the immunohistochemical characteristics of dural tail in intracranial *** and METhODS:Twenty-two patients with meningioma undergoing MRI imaging showed dural *** immunohistochemical（IhC） staining,expression of EMA,Vimentin,ki-67,CD34 and vascular endothelial growth factor（VEGF） were evaluated between tumor mass and dural tail of meningioma.h＆E and Masson’s Trichrome staining were also ***:Sixteen of 22 cases（72.7%） show dural tail involved by tumor *** staining showed Vimentin and EMA intensively expressed in tumour mass,ki-67 expression nearly negative in both tumour mass and dural tail,CD34 overexpressed in duarl tail,VEGF overexpressed in tumour cells which invade to dural ***’s Trichrome staining clearly showed components of tumor,tail and dural ***:Our study showed most of dural tail involved by tumor cells（72.7%）,different immunohistochemical staining of CD34,and VEGF profiles obtained between tumour mass and dural tail.

关键词： Dural tail sign Meningioma Immunohistochemisty(IhC) CD34 Vascular endothelial growth factor(VEGF) ki-67 EMA Vimentin

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Open Journal of Inorganic Chemistry 2012年第2期2卷 22-27页

作者： Norrihan sam Md Abu Affan Md Abdus Salam Fasihuddin B. Ahmad Mohd Razip Asaruddin Department of Chemistry Faculty of Resource Science and Technology Universiti Malaysia Sarawak Kota Samarahan Malaysia

Five new organotin(IV) complexes of ortho-vanillin-2-hydrazinopyridine hydrazone with formula [RnSnCl4–n(VhP)] [R = Me2, n = 2 (2);R = Ph2, n = 2 (3);R= nBu2, n = 2 (4);R = nBu, n = 2 (5) and R = 1, n = 0 (6)] have been synthesized by direct reaction of ortho-vanillin-2-hydrazinopyridine hydrazone [(VhP), (1)], base and organotin(IV) chloride(s) in absolute methanol. The hydrazone ligand [(VhP), (1)] and its organotin(IV) complexes (2-6) have been characterized by UV-Visible, FT-IR and 1h NMR spectral studies. Spectroscopic data suggested that in the complexes (2-4), the ligand (1) acted as a neutral bidentate ligand and is coordinated to the tin(IV) atom via the azomethine nitrogen and pyridyl nitrogen atoms, whereas the ligand (1) acted as a uninegative tridentate ligand and coordinated to the tin(IV) atom through phenolic-O, azomethine-N and pyridyl-N atoms in complexes (5-6). The toxicity of the ligand (1) and its organotin (IV) complexes (2-6) were determined against Artemia salina. Organotin(IV) complexes showed moderate activity against Artemia salina. The ligand (1) and its organotin(IV) complexes (2-6) were also tested against four types of bacteria namely Bacillus cereus, Staphylococcus aureus, Escherichia coli and Enterobacter aerogenes. All organotin(IV) complexes and the free ligand (1) showed better antibacterial activities against bacteria. Among the organotin(IV) complexes (2-6), diphenyltin(IV) complex (3) showed higher activity against the four types of bacteria.

关键词： hydrazone Organotin(IV) Complexes Spectral Analyses Toxicity Antibacterial Activity

In-Field Management Practices for Mitigating Soil CO2and Ch4Fluxes under Corn (Zea mays) Production System in Middle Tennessee

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American Journal of Climate Change 2015年第4期4卷 367-378页

作者： sam Dennis Qi Deng Dafeng hui Junming Wang Stephen Iwuozo Chih-Li Yu Chandra Reddy College of Agriculture Human and Natural Sciences Tennessee State University Nashville TN USA Climate and Atmospheric Science Section Illinois State Water Survey Prairie Research Institute University of Illinois at Urbana-Champaign Champaign IL USA

The United States continues to be the largest corn producer in the world. how to maximize corn yield and at the same time reduce greenhouse gas emissions, is becoming a challenging effort for growers and researchers. As a result, our understanding of the responses of soil CO2 and Ch4 fluxes to agricultural practices in cornfields is still limited. We conducted a 3-yr cornfield experiment to study the responses of soil CO2 and Ch4 fluxes to various agricultural practices in middle Tennessee. The agricultural practices included no-tillage + regular applications of urea ammonium nitrate (NT-URAN);no-tillage + regular applications of URAN + denitrification inhibitor (NT-inhi- bitor);no-tillage + regular applications of URAN + biochar (NT-biochar);no-tillage + 20% applications of URAN + chicken litter (NT-litter);no-tillage + split applications of URAN (NT-split);and conventional tillage + regular applications of URAN as a control (CT-URAN). A randomized complete block design was used with six replications. The same amount of fertilizer equivalent to 217 kg·N·ha-1 was applied to all of the experimental plots. The results showed that improved fertilizer and soil management, except the NT-biochar treatment significantly increased soil CO2 flux as compared to the conventional tillage (CT-URAN, 487.05 mg CO2 m-2·h-1). Soil CO2 flux increased exponentially with soil temperature (T 2 flux tended to be positively related to corn yield and/or soil moisture. Soil Ch4 flux increased linearly with soil moisture in all treatments. Improved fertilizer and soil management did not alter soil Ch4 flux, but significantly affected its moisture sensitivity. Our results indicated that agricultural practices enhancing corn yield may also result in a net increase in carbon emissions from soil, hence reducing the potential of carbon sequestration in croplands.

关键词： Tillage Fertilizer Management Soil CO2 Flux Soil Ch4 Flux Greenhouse Gases

LDhA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer

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Genomics, Proteomics & Bioinformatics 2023年第1期21卷 177-189页

作者： Oh kwang kwon In hyuk Bang So Young Choi Ju Mi Jeon Ann-Yae Na Yan Gao sam Seok Cho Sung hwan ki Youngshik Choe Jun Nyung Lee Yun-Sok ha Eun Ju Bae Tae Gyun kwon Byung-hyun Park Sangkyu Lee Bk21 Plus kNU Multi-Omics Based Creative Drug Research Team College of PharmacyResearch Institute of Pharmaceutical SciencesKyungpook National UniversityDaegu 41566Republic of Korea Department of Biochemistry and Molecular Biology Chonbuk National University Medical SchoolJeonjuJeonbuk 54896Republic of Korea College of Pharmacy Chosun UniversityGwangju 61452Republic of Korea korea Brain Research Institute Daegu 41068Republic of Korea Department of Urology School of MedicineKyungpook National UniversityDaegu 41566Republic of Korea Department of Urology Kyungpook National University HospitalDaegu 41566Republic of Korea College of Pharmacy Chonbuk UniversityJeonjuJeonbuk 54896Republic of Korea School of Pharmacy Sungkyunkwan UniversitySuwon 16419Republic of Korea

Prostate cancer(PCa)is the most commonly diagnosed genital cancer in men *** 80%of the patients who developed advanced PCa suffered from bone metastasis,with a sharp drop in the survival *** great efforts,the detailed mechanisms underlying castration-resistant PCa(CRPC)remain *** 5(SIRT5),an NAD+-dependent desuccinylase,is hypothesized to be a key regulator of various ***,compared to other SIRTs,the role of SIRT5 in cancer has not been extensively ***,we revealed significantly decreased SIRT5 levels in aggressive PCa cells relative to the PCa *** correlation between the decrease in the SIRT5 level and the patient’s reduced survival rate was also *** quantitative global succinylome analysis,we characterized a significant increase in the succinylation at lysine 118(k118su)of lactate dehydrogenase A(LDhA),which plays a role in increasing LDh *** a substrate of SIRT5,LDhA-k118su significantly increased the migration and invasion of PCa cells and LDh activity in PCa *** study reveals the reduction of SIRT5 protein expression and LDhA-k118su as a novel mechanism involved in PCa progression,which could serve as a new target to prevent CPRC progression for PCa treatment.

关键词： Sirtuin 5 Lactate dehydrogenase A Lysine succinylation PCa progression

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恨天低

汽车测试报告 2012年第5期 138-145页

作者： sam PhILIP 尚红昕（译）

嘭。我翻遍了字典也没找到一个合适的字来表示一块小石头撞上正以近100km／h行进的人的眉骨的声音，所以只好用了这个“嘭”：一种枯燥的、触及骨肉的声音，伴随着视觉的恍惚，接着，几秒钟之后，一阵剧烈的疼痛猛然蹿到脸上。

关键词：轿车车型品牌安全性能