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子宫的磁共振检查——检查技术、正常和病理解剖

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放射学实践 1991年第3期6卷 125-131页

作者： T.Nauert B.Hamm k.-j.wolf 胡国栋 k.inik.fur Radiologie Abt. Rontgendiagnostik Klinikum Steglitz Freie Universitat Berlin 同济医科大学附属同济医院

子宫的磁共振检查使非损伤性诊断技术得到改善,它涉及子宫肿瘤的诊断以及宫颈癌和子宫内膜癌的分期。

关键词：子宫 NMR 病理解剖

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前列腺癌的影象诊断

放射学实践 1987年第3期 81-86页

作者： Von B.Hamm k.-j.wolf 同济医科大学附属同济医院

前列腺癌在男性是继肺癌和结肠直肠癌的第三种最常见的恶性肿瘤.年龄在五十岁前仅有个别前列腺癌病例,此后发病率和死亡率陡增.前列腺癌尚不能进行通用的分期,而是将临床肿瘤分期和组织学的肿瘤分化相结合进行各种分级. T0不能触及肿瘤... 详细信息

前列腺癌在男性是继肺癌和结肠直肠癌的第三种最常见的恶性肿瘤.年龄在五十岁前仅有个别前列腺癌病例,此后发病率和死亡率陡增.前列腺癌尚不能进行通用的分期,而是将临床肿瘤分期和组织学的肿瘤分化相结合进行各种分级. T0不能触及肿瘤.癌肿在手术标本或活检时意外地发现. Tis未浸润的癌肿（原位癌）. T1囊内肿瘤,包绕正常腺体. T2肿瘤局限于腺体,形成柔软的小结节

关键词：前列腺癌超声显象经直肠淋巴造影超声成象淋巴组织淋巴结肿瘤分期

采用Meglumin Diatrizoat进行肝CT延迟4小时扫描的价值

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放射学实践 1987年第4期 161-164页

作者： von T.Rmer B.Hamm Ch.Nauert D.Felsenberg k.-j.wolf 刘经国上海纺建二院

静脉注入团剂造影剂后进行延迟肝CT扫描,可能使健康的和病变的组织之间有较好的鉴别作用。同样,在注入高浓度碘剂4小时后,在健康组织内也只有少量贮积,与病变组织比较,证明延迟CT扫描并没有取得所希望的效果,因而似乎无使用指征。

关键词：造影剂静脉密度 X光乳剂 Meglumin Diatrizoat 肝脏病灶肝实质 CT

NECAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael k.E.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane traffick.ng and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, k.y regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is ak.n to atypical heme oxygenases in prok.ryotes but is not wellcharacterized in vertebrates. Prok.ryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is k.own about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

Association between donor corneal endothelial cell counts and infectious agent reactivity:an eye bank.database analysis

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Annals of Eye Science 2019年第1期4卷 19-22页

作者： Bella j.wolf ji Won k.on Gabriel M.Rand jimmy k.Lee Patrick.k.Gore Moonseong Heo Roy S.Chuck Department of Ophthalmology and Visual ciences Montefiore Medical CenterAlbert Einstein College of MedicineNew YorkNYUSA Department of Ophthalmology Myongji HospitalSeonam University College of MedicineGoyangKorea Lions Eye Institute for Transplant&Research TampaFloridaUSA Saving Sight Eye Bank Kansas CityMissouriUSA Department of Epidemiology and Population Health at Einstein Montefiore Medical CenterAlbert Einstein College of MedicineBronxNew YorkUSA

Back.round:To evaluate the association between corneal central endothelial cell count(CECC)with reactivity for hepatitis B virus(HBV),hepatitis C virus(HCV),human immunodeficiency virus(HIV),human T-lymphotropic virus-1(HTLV1),and syphilis from an eye bank.***:Eye bank.data included 19,159 donors and 38,318 corneas screened for HBV,HCV,HIV,HTLV1,and syphilis from july 2007-May *** and binary mixed effects models were used to determine the adjusted marginal effect a positive viral screening test had on CECC and morphology,*** models were adjusted for age,race,gender,lens status,and death to *** with missing data were excluded from the *** significance was defined as P values<***:A total of 18,097 donors and 35,136 corneas were included in the final *** CECC for eyes with negative viral screening was 2,597±436 while the average CECC for eyes screening positive for syphilis,HBV,HCV,HIV,and HTLV1 were 2,638±392(P=0.073),2,569±419(P=0.815),2,603±363(P=0.207),2,615±360(P=0.733),and 2,625±436(P=0.362)***:The presence of HBV,HCV,HIV,HTLV1,and syphilis display no association with a statistically significant difference in CECC when compared to normal non-diseased donors.

关键词： Eye bank endothelial cell count infectious reactivity hepatitis B virus(HBV) syphilis

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Wink.e College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Inflammasome link. traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari jennifer C.Munoz Pareja Andrew Reisner Laura Black.ell Yehia Mechref k.vin k.Wang j.Adrian Tyndall Binu Tharak.n Firas k.beissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytosk.letons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleuk.n-1β cytok.ne. One specific inflammasome, the NOD-lik. receptor protein 3, has been proposed to be a k.y regulator of tau phosphorylation where it has been shown that prolonged NOD-lik. receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-lik. receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework.link.ng traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Regulation of Power Conversion in Fuel Cells

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Chemical Research in Chinese Universities 2004年第4期20卷 466-469页

作者： ZHANG j. k. Scott School of Chemical Engineering & Advanced Materials University of Newcastle upon Tyne Newcastle upon TyneSchool of Chemical Engineering & Advanced Materials University of Newcastle upon Tyne Newcastle upon Tyne NE1 7RU UK NE1 7RU UK

Here we report a regulation about power conversion in fuel cells. This regulation is expressed as that total power produced by fuel cells is always proportional to the square of the potential difference between the \{equilibrium\} potential and work.potential. With this regulation we deduced fuel cell performance equation which can describe the potential *** current performance curves, namely, polarization curves of fuel cells with three power source parameters: equilibrium potential E_0; internal resistance R; and power conversion coefficient k. The concept of the power conversion coefficient is a new criterion to evaluate and compare the characteristics and capacity of different fuel cells. The calculated values obtained with this equation agree with practical performance of different types of fuel cells.

关键词： Fuel cell Power conversion coefficient Internal resistance Performance Potential

A multi-attribute decision mak.ng approach of mix design based on experimental soil characterization

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Frontiers of Structural and Civil Engineering 2018年第3期12卷 361-371页

作者： Amit k. BERA Tanmoy MUk.OPADHYAY Ponnada j.MOHAN Tushar k. DEY Faculty of Science & Technology The ICFAI University Dehradun India College of Engineering Swansea University Swansea UK Department of Civil Engineering National Institute of Technical Teachers' Training and Research (NIT'ITR) Kolkata India

The clay mineral composition is one of the major factors that governs the physical properties of silty sand subgrade. Therefore, a thorough k.owledge of mineral composition is essential to predict the optimum engineering properties of the soil, which is generally characterized by different indices lik. maximum dry density （MDD）, California bearing ratio （CBR）, unconfined compressive strength （UCS） and free swelling index （FSI）. In this article, a novel multi- attribute decision mak.ng （MADM） based approach of mix design has been proposed for silty sand- artificial clay mix to improve the characteristic strength of a soil subgrade. Experimental investigation has been carried out in this study to illustrate the proposed approach of selecting appropriate proportion for the soil mix to optimize all the above mentioned engineering properties simultaneously. The results show that a mix proportion containing approximately 90% silty sand plus 10% bentonite soil is the optimal combination in context to the present study. The proposed methodology for optimal decision mak.ng to choose appropriate combination of bentonite and silty sand is general in nature and therefore, it can be extended to other problems of selecting mineral compositions.

关键词： silty sand bentonite soil soil mix design multi-attribute decision mak.ng