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可解释性矿产预测人工智能模型

中国科学:地球科学 2024年第9期54卷 2917-2928页

作者：左仁广成秋明许莹杨帆帆熊义辉王子烨 Oliver P.kreuzer 中国地质大学(武汉)地质过程与矿产资源国家重点实验室中山大学地球科学与工程学院 Corporate Geoscience Group (CGSG) Economic Geology Research Centre (EGRU) College of Science and EngineeringJames Cook University

矿产资源潜力评价主要目的之一是通过整合和分析地质找矿大数据以缩小找矿区域.地质找矿大数据具有数据量大、结构复杂等特征,常常无法对其进行有效地处理和解释.人工智能算法是挖掘地质找矿大数据中潜在非线性矿化模式的有效工具,已经... 详细信息

矿产资源潜力评价主要目的之一是通过整合和分析地质找矿大数据以缩小找矿区域.地质找矿大数据具有数据量大、结构复杂等特征,常常无法对其进行有效地处理和解释.人工智能算法是挖掘地质找矿大数据中潜在非线性矿化模式的有效工具,已经在矿产预测领域表现出优越性能.然而,人工智能驱动的矿产预测目前面临一些挑战,如可解释性差、泛化能力弱、预测结果与物理规律不一致等.本文在前人研究的基础上,将领域知识嵌入人工智能驱动的矿产预测全过程,建立了更加透明和可解释的矿产预测人工智能模型.该模型提供了强大的成矿知识和专家经验指导矿产预测人工智能模型训练的全过程,包括数据输入、模型设计及模型输出等环节,从而提高矿产预测人工智能模型的可解释性和预测性能.总体而言,可解释性矿产预测人工智能模型实现了整个建模过程中先验知识和专家经验的嵌入,为未来矿产预测研究提供了一个有价值和前景的方向.

关键词：人工智能矿产预测地质找矿大数据领域知识可解释性

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Evaluation of ruminal methane and ammonia formation and microbiota composition as affected by supplements based on mixtures of tannins and essential oils using Rusitec

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1607-1622页

作者： Giulia Foggi Melissa Terranova Matteo Daghio Sergej L.Amelchank. Giuseppe Conte Simon Ineichen Monica Agnolucci Carlo Viti Alberto Mantino Arianna Buccioni Michael kreuzer Marcello Mele Department of Agriculture Food and Environment(DAFE)University of Pisa56124 PisaItaly AgroVet‑Strick.of ETH ZurichLindauSwitzerland Department of Agriculture FoodEnvironment and ForestryUniversity of FlorenceFlorence 50144Italy Centro Di Ricerche Agro‑Ambientali“E.Avanzi” University of PisaPisa 56122Italy School of Agricultural Forest and Food Sciences HAFLBern University of Applied SciencesZollikofenSwitzerland Institute of Agricultural Sciences ETH ZurichLindauSwitzerland

Back.round Dietary supplements based on tannin extracts or essential oil compounds(EOC)have been repeatedly reported as a promising feeding strategy to reduce the environmental impact of ruminant husbandry.A previous batch culture screening of various supplements identified selected mixtures with an enhanced potential to mitigate ruminal methane and ammonia *** these,Q-2(named after quebracho extract and EOC blend 2,composed of carvacrol,thymol,and eugenol)and C-10(chestnut extract and EOC blend 10,consisting of oregano and thyme essential oils and limonene)have been investigated in detail in the present study with the semi-continuous rumen simulation technique(Rusitec)in three independent *** this purpose,Q-2 and C-10,dosed according to the previous study,were compared with a non-supplemented diet(negative control,NC)and with one supplemented with the commercial EOC-based Agolin^(R) Ruminant(positive control,PC).Results From d 5 to 10 of fermentation incubation liquid was collected and analysed for pH,ammonia,protozoa count,and gas *** residues were collected for the determination of ruminal *** d 10,samples of incubation liquid were also characterised for bacterial,archaeal and fungal communities by high-throughput sequencing of 16S rRNA and 26S ribosomal large subunit gene *** of the duration of the fermentation period,Q-2 and C-10 were similarly efficient as PC in mitigating either ammonia(-37%by Q-2,-34%by PC)or methane formation(-12%by C-10,-12%by PC).The PC was also responsible for lower feed degradability and bacterial and fungal richness,whereas Q-2 and C-10 effects,particularly on microbiome diversities,were limited compared to *** All additives showed the potential to mitigate methane or ammonia formation,or both,in vitro over a period of 10 ***,several differences occurred between PC and Q-2/C-10,indicating different mechanisms of *** pronounced defaunation caused by PC a

关键词： Additive Bacteria Continuous culture Degradability Fermentation Fungi Greenhouse gas In vitro Microbiome Rumen

艾滋病的肝脏病变——227例HIV阳性患者尸检的回顾性分析

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德国医学 1998年第3期15卷 193-197页

作者： A.Trojan k.-a.kreuzer R.Flury M.Schmid J.Schneider S.Schr der 武忠弼 k.ntonsspital Winterthur Institut für PathologieBrauerstr.15CH-8401 Winterthur 同济医科大学

艾滋病的特征是机会性感染和经常出现恶性肿瘤,而肝脏则很少成为主要的或仅有的受累脏器。HIV感染的经过和结局更多地决定于许多继发性感染性和肿瘤并发症,只有在例如病毒性肝炎等例外情况下,肝脏病损本身可导致患者死亡。然而,肝脏在HI... 详细信息

艾滋病的特征是机会性感染和经常出现恶性肿瘤,而肝脏则很少成为主要的或仅有的受累脏器。HIV感染的经过和结局更多地决定于许多继发性感染性和肿瘤并发症,只有在例如病毒性肝炎等例外情况下,肝脏病损本身可导致患者死亡。然而,肝脏在HIV感染及其后续疾病中却具有重要地位。有根据认为,肝脏网状内皮系统的细胞载有CD_4抗原,

关键词：艾滋病 HIV 临床表现肝脏病变

利用实时反向转录PCR的分子定量监测TEL-AML1^+儿童急性淋巴细胞性白血病的治疗反应和缓解状况

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德国医学 2001年第6期18卷 338-340页

作者： k.Seeger k.-a.kreuzer U.Lass T.Taube D.Buchwald C.Eck.rt G.k.?)rner Ch.-A.Schmidt G.Henze 吴秀丽 Department of Pediatric Oncology/Hematology Otto-Heubner-CentrumCharite Medical CenterCampus VirchowHumboldt-University at Berlin 暨南大学医学院血液病研究所

运用分子生物学技术及流式细胞术,对治疗反应和微小残留白血病病灶(MRD)进行灵敏的定量分析,可以更加可靠地预测儿童急性淋巴细胞性白血病(ALL)患者的预后及复发风险 .分子水平的研究大多数利用T细胞受体(TCR)和免疫球蛋白基因重排作为... 详细信息

运用分子生物学技术及流式细胞术,对治疗反应和微小残留白血病病灶(MRD)进行灵敏的定量分析,可以更加可靠地预测儿童急性淋巴细胞性白血病(ALL)患者的预后及复发风险 .分子水平的研究大多数利用T细胞受体(TCR)和免疫球蛋白基因重排作为唯一克隆特异性标志来监测MRD,但这种DNA水平上的研究方法时间长、费用高而且工作量大.在儿童ALL 中,有35%～45%出现染色体易位,形成融合基因,出现嵌合体转录本以及表达相应的蛋白质 .儿童初发前B细胞-急性淋巴细胞性白血病(BCP-ALL)最常见的基因重排是隐性易位t(1 2;21)(p13;q22),可导致21号染色体上的AML1序列与12号染色体的TEL基因融合.TEL和AM L1这两种转录因子均为正常造血所必需,而且它们的基因部位分别与急性或慢性白血病及骨髓增生异常综合征相关的染色体易位有关.

关键词：儿童急性淋巴细胞性白血病实时反向转录PCR 治疗

Discrete time transfer matrix method for dynamics of multibody system with flexible beams moving in space

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Acta Mechanica Sinica 2012年第2期28卷 490-504页

作者： Xiao-Ting Rui Edwin kreuzer Bao Rong Bin He Institute of Launch Dynamics Nanjing University of Science&Technology210094 NanjingChina Mechanics and Ocean Enginnering of Hamburg University of Technology HamburgGermany

In this paper, by defining new state vectors and developing new transfer matrices of various elements mov- ing in space, the discrete time transfer matrix method of multi-rigid-flexible-body system is expanded to study the dynamics of multibody system with flexible beams moving in space. Formulations and numerical example of a rigid- flexible-body three pendulums system moving in space are given to validate the method. Using the new method to study the dynamics of multi-rigid-flexible-body system mov- ing in space, the global dynamics equations of system are not needed, the orders of involved matrices of the system are very low and the computational speed is high, irrespec- tive of the size of the system. The new method is simple, straightforward, practical, and provides a powerful tool for multi-rigid-flexible-body system dynamics.

关键词： Multi-rigid-flexible-body system Spatial mo- tion Dynamics Discrete time transfer matrix method

Impact of dietary L-arginine supply during early gestation on myofiber development in newborn pigs exposed to intra-uterine crowding

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Journal of Animal Science and Biotechnology 2017年第4期8卷 945-956页

作者： Johannes Gulmann Madsen Camilo Pardo Michael kreuzer Giuseppe Bee Agroscope Posieux la tioleyre 4 1725 Posieux Switzerland ETH Zurich Institute of Agricultural Sciences Universitsstrasse 2 8092 ZurichSwitzerland

Back.round: Intra-uterine crowding(IUC) observed in hyperprolific sows impairs myofiber hyperplasia and overall fetal growth. Arginine supplementation(ARG) in gestation diets has been shown to positively affect litter and muscle development. The study objective was to assess whether the effect of ARG on offspring characteristics, with special emphasis on myofiber hyperplasia, differs under IUC conditions from these responses,because in that situation growth retardation is particularly prevalent due to reduced fetal nutrient *** oviduct ligation(OL) was used as a model for an uncrowded and hyperprolificacy(IN) as a model for a crowded intra-uterine ***: Five OL and five IN sows were fed a diet supplemented daily with either 43 g L-alanine(Ctrl) or 25 g L-arginine from d 14 to 28 of gestation in a cross-over design(two periods: 5^( th) and 6^( th) parity). At farrowing, two male and two female offspring, respectively, with a low and intermediate birth weight(BtW) were selected. After euthanization, the Semitendinosus muscle(STM) was removed and weighed, and the light and dark.portions(STM_d and STM_l) were prepared for myofiber histochemistry using ATPase staining and the entire STM for gene expression analysis of myogenesis-related genes using RT-qPCR. In addition, various organs were removed and weighed. Data were analyzed using the MIXED model in ***: No effect of either IUC or dietary treatment was found in litter characteristics. Offspring of ARG sows displayed a greater muscle area in STM(P k.dney(P < 0.05), but when expressed relative to birth weight, these differences were absent. In addition, IUC had an effect(P < 0.05) on the expression of one of the myogenesis-related

关键词： Dietary supplement Early gestation Intra-uterine growth restriction Myofiber hyperplasia Neonate Sow prolificacy

Efficient offline production of freestanding thin plastic foils for laser-driven ion sources

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High Power Laser Science and Engineering 2017年第2期5卷 8-12页

作者： Sebastian Seuferling Matthias Alexander Otto Haug Peter Hilz Daniel Haffa Christian kreuzer Jorg Schreiber Fak.ltat fur Physik Ludwig-Maximilians-Universitat Munchen D-85748 Garching Germany

Modern chirped pulse amplification laser systems with continuously improving controllability and increasing power are about to reach intensities of up to 10^(22) W cm^(-2) and have proven their potential to accelerate ions out of plasma to several tens percent of the speed of light. For enabling application, one important step is to increase the repetition rate at which ion bunches are at the disposal. In particular, techniques used so far for thin foil target production can require several days of preparing reasonable amounts for a single campaign. In this paper we describe the reasonably droplet method which we have tested and improved so that the emerging foils with thick.esses of a few nanometres up to micrometre can be used as targets for laser ion acceleration. Their quality and performance can compete with so far employed techniques thereby enabling the production of hundreds of targets per day.

关键词：目标设计和制造和物质的超短波的脉搏激光相互作用

Impact of small molecule-mediated inhibition of ammonia detoxification on lung malignancies and liver metabolism

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Cancer Communications 2023年第4期43卷 508-512页

作者： Georgios Mak.is Semih k.yhan Marvin kreuzer Véronique Rüfenacht Erica Faccin Jarl Underhaug Carmen Diez-Fernandez Philip A.k.obel Martin Poms Nadine Gougeard Vicente Rubio Aurora Martinez Martin Pruschy Johannes Häberle Division of Metabolism and Children’s Research Center University Children’s Hospital ZurichUniversity of ZurichZurichSwitzerland Center for Integrative Human Physiology University of ZurichZurichSwitzerland Department of Radiation Oncology Laboratory for Applied RadiobiologyUniversity Hospital ZurichUniversity of ZurichZurichSwitzerland Department of Biomedicine University of BergenBergenNorway Department of Chemistry University of BergenBergenNorway NUVISAN GmbH Neu-UlmBavariaGermany CDR Life Inc. SchlierenZurichSwitzerland Division of Clinical Chemistry and Biochemistry University Children’s Hospital ZurichUniversity of ZurichZurichSwitzerland Instituto de Biomedicina de Valencia(IBV-CSIC) CIBER de Enfermedades Raras(CIBERER-ISCIII)ValenciaSpain

Dear Editor,Metabolically induced cancer heterogeneity creates a large source of novel potential targets towards an enhanced therapeutic window alone and in combination with classic chemo-and radiotherapy[1,2].This is of particular interest for non-small cell lung cancer(NSCLC),which accounts for more than 80%of all lung tumor types characterized by limited responses to current treatment options[3–5].

关键词： metabolism lung cancer

Molecular biology and biotechnology 3rd ed.

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