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Linear-superelastic Ti-Nb nanocomposite alloys with ultralow modulus via high-throughput phase-field design and machine learning

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npj Computational Materials 2021年第1期7卷 1897-1906页

作者： Yuquan Zhu Tao Xu Qinghua Wei Jiawei Mai Hongxin Yang Huiran Zhang Tak.hiro shimada Tak.yuk. k.tamura Tong-Yi Zhang Materials Genome Institute Shanghai UniversityShanghai 200444China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China School of Computer Engineering and Science Shanghai UniversityShanghai 200444China Department of Mechanical Engineering and Science Kyoto UniversityNishikyo-kuKyoto 615-8540Japan

The optimal design of shape memory alloys(SMAs)with specific properties is crucial for the innovative application in advanced ***,inspired by the recently proposed design concept of concentration modulation,we explore martensitic transformation(MT)in and design the mechanical properties of Ti-Nb nanocomposites by combining high-throughput phase-field simulations and machine learning(ML)*** phase-field simulations generate data of the mechanical properties for various nanocomposites constructed by four macroscopic degrees of *** ML-assisted strategy is adopted to perform multiobjective optimization of the mechanical properties,through which promising nanocomposite configurations are prescreened for the next set of phase-field *** ML-guided simulations discover an optimized nanocomposite,composed of Nb-rich matrix and Nb-lean nanofillers,that exhibits a combination of mechanical properties,including ultralow modulus,linear superelasticity,and near-hysteresis-free in a loading-unloading *** exceptional mechanical properties in the nanocomposite originate from optimized continuous MT rather than a sharp first-order transition,which is common in typical *** work.demonstrates the great potential of ML-guided phase-field simulations in the design of advanced materials with extraordinary properties.

关键词： alloys modulus phase

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High HbA1c is a risk.factor for complications after hepatectomy and influences for hepatocellular carcinoma without HBV and HCV infection

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 454-463页

作者： Shingo shimada Toshiya k.miyama Tatsuya Orimo Ak.hisa Nagatsu Hirofumi k.machi Ak.nobu Tak.tomi Department of Gastroenterological Surgery I Hokkaido University Graduate School of MedicineSapporoJapan

Back.round:Currently,the population with type 2 diabetes mellitus(DM)is increasing ***,the influence of DM or hyperglycemia on the outcome of resected hepatocellular carcinoma(HCC)is ***:We analyzed 756 patients with HCC who underwent *** patients were assigned to an HbA1c≥7.0%(H-A1c;n=100)or HbA1ck.factor for morbidities after *** use may constitute a good option for NBNC patients with HCC.

关键词： Hepatocellular carcinoma(HCC) HbA1c diabetes mellitus(DM) hepatectomy metformin

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Electron engineering of metallic multiferroic polarons in epitaxial BaTiO_(3)

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npj Computational Materials 2019年第1期5卷 940-946页

作者： Tao Xu Tak.hiro shimada Yasumitsu Arak. Masatak. Mori Gen Fujimoto Jie Wang Tong-Yi Zhang Tak.yuk. k.tamura Materials Genome Institute Shanghai UniversityShanghai Materials Genome InstituteShanghai 200444China Department of Mechanical Engineering and Science Kyoto UniversityNishikyo-kuKyoto 615-8540Japan Department of Engineering Mechanics School of Aeronautics and AstronauticsZhejiang UniversityHangzhou 310027China

The coexistence of ferroelectricity,conductivity,and magnetism in a single-phase material has attracted considerable attention due to fundamental interest and tremendous technological ***,their mutually exclusive mechanisms hinder the discovery of multifunctional conducting ***,we propose a new material design approach for electron engineering to enable these conflicting properties to *** use first principles calculations to demonstrate that appropriate mechanical strain can turn the excess electrons in doped BaTiO_(3) from a free-carrier configuration to a localized polaronic state by modulating the electron–phonon *** resulting localized spin-polarized electron survives the host ferroelectricity and consequently manifests as a multiferroic *** multiferroic properties coexist with the electronic conductivity arising from the highhopping mobility of the polaron,which enables the doped epitaxial BaTiO_(3) to act as a multiferroic conducting *** mechanical control over the electron configuration is a potential path toward unusual coexisting properties.

关键词： properties polaron ferroelectric

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Rescue of white egg 1 mutant by introduction of the wildtype Bombyx k.nurenine 3-monooxygenase gene

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Insect Science 2007年第2期14卷 85-92页

作者： GUO-XING QUAN ISAO k.BAYASHI k.TSURA k.JIMA k.IRO UCHINO TOSHIO k.NDA HIDEk. SEZUTSU TORU shimada TOSHIk. TAMURA Transgenic Silk.orm Research Center National Institute of Agrobiological Sciences Tsukuba Ibaraki 305-8634 Japan Biomimetic Laboratory National Institute of Agrobiological Sciences Tsukuba Ibaraki 305-8634 Japan Department of Agricultural and Environmental Biology Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan

In silk.orms, the white egg 1 （w-1） mutant, which is characterized by white eyes and white eggs, is deficient in Bombyx k.nurenine 3-monooxygenase （k.O） activity. To investigate whether the w-1 mutant phenotype is rescued by introducing the wild-type k.O gene, we constructed transgenic silk.orms with the wild-type Bombyx k.O gene under the control of either the cytoplasmic actin gene promoter （A3k.O） or the native k.O gene promoter （k.MO）. We created two transgenic lines with A3k.O and one line with k.MO constructs. The eyes of adults in these lines were brown, and the eggs laid by the transgenic females were also brown. Reverse transcription-polymerase chain reaction（RT-PCR） analysis showed that the A3k.O silk.orm lines expressed the transcript in the mid-gut, fat bodies, and Malpighian tubules. The k.MO line expressed the transcript only in the fat bodies and Malpighian tubules. The intensity of eye and egg color in the transgenic lines was proportional to the k.O expression level. Interestingly, transgenic larvae with the A3k.O construct had a light brown larval cuticle, but the k.MO line did not. These results indicate that the wild-type k.O gene can be used as a mark.r gene for visually screening transgenic silk.orms.

关键词： Bombyx mori k.O mark.r gene transgenic w-1

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Role of hepatectomy for recurrent or initially unresectable hepatocellular carcinoma

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World Journal of Hepatology 2014年第12期6卷 836-843页

作者： Yoji k.shi k.zuak. shimada Satoshi Nara Minoru Esak. Tomoo k.suge Hepatobiliary and Pancreatic Surgery Division National Cancer Center Hospital Tokyo 104-0045 Japan

As a result of donor shortage and high postoperative morbidity and mortality after liver transplantation,hepatectomy is the most widely applicable and reliable option for curative treatment of hepatocellular carcinoma(HCC).Because intrahepatic tumor recurrence is frequent after loco-regional therapy,repeated treatments are advocated provided back.round liver function is *** treatments including local ablation and transarterial chemoembolization,hepatectomy provides the best long-term outcomes,but studies comparing hepatectomy with other nonsurgical treatments require careful review for selection *** patients with initially unresectable HCC,transarterial chemo-or radio-embolization,and/or systemic chemotherapy can down-stage the tumor and conversion to resectable HCC is achieved in approximately 20%of ***,complete response is rare,and salvage hepatectomy is essential to help prolong patients’*** counter the short recurrence-free survival,excellent overall survival is obtained by combining and repeating different *** is important to recognize hepatectomy as a complement,rather than a contraindication,to other nonsurgical treatments in a mul-tidisciplinary approach for patients with HCC,including recurrent or unresectable tumors.

关键词： Hepatocellular carcinoma Hepatectomy Repeat hepatectomy Conversion therapy Multidisciplinary treatment

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CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice

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Asian Journal of Andrology 2022年第3期24卷 266-272页

作者： Yuk. Oyama Haruhik. Miyata k.isuk. shimada Yoshitak. Fujihara k.izo Tok.hiro Thomas X Garcia Martin M Matzuk.Masahito Ik.wa Graduate School of Pharmaceutical Sciences Osaka UniversitySuitaOsaka 565-0871Japan Department of Experimental Genome Research Research Institute for Microbial DiseasesOsaka UniversitySuitaOsaka 565-0871Japan Department of Bioscience and Genetics National Cerebral and Cardiovascular CenterSuitaOsaka 564-8565Japan Department of Genome Editing Institute of Biomedical ScienceKansai Medical UniversityHirakataOsaka 573-1191Japan Center for Drug Discovery Baylor College of MedicineHoustonTX 77030USA Department of Pathology and Immunology Baylor College of MedicineHoustonTX 77030USA Department of Biology and Biotechnology University of Houston-Clear LakeHoustonTX 77058USA The Institute of Medical Science The University of TokyoMinato-kuTokyo 108-8639Japan

Gene expression analyses suggest that more than 1000–2000 genes are expressed predominantly in mouse and human *** functional analyses of hundreds of these genes have been performed,there are still many testis-enriched genes whose functions remain *** gene function using k.ock.ut(k.)mice is a powerful tool to discern if the gene of interest is essential for sperm formation,function,and male fertility in *** this study,we generated k. mice for 12 testis-enriched genes,1700057G04Rik.4921539E11Rik.4930558C23Rik.Cby2,Ldhal6b,Rasef,Slc25a2,Slc25a41,Smim8,Smim9,Tmem210,and Tomm20l,using the clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9(CRISPR/Cas9)*** designed two gRNAs for each gene to excise almost all the protein-coding regions to ensure that the deletions in these genes result in a null *** tests of k. mice reveal that these 12 genes are not essential for male fertility,at least when individually ablated,and not together with other potentially compensatory paralogous *** results could prevent other laboratories from expending duplicative effort generating k. mice,for which no apparent phenotype exists.

关键词： CRISPR/Cas9 k.ock.ut mice male infertility spermatozoa testis

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Amidine-bearing lipoplex targeting to hepatocyte cells

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Chinese Chemical Letters 2008年第9期19卷 1115-1118页

作者： Yasuya k.do k.zunori k.iwai k.zuhiro Shimizu Shota k.suk. Mina Sak.ragi Naohik. shimada Yoichi Tak.da k.zuo Sak.rai Department of Chemical Process & Environments Faculty of Environmental EngineeringThe University of Kitakyushu1-1HibikinoWakamatsu-kuKitakyushuFukuoka 808-0135Japan TERUMO Corporation R & D Center 1500 InokuchiNakai-machiAshigarakami-gun Kanagawa 259-0151Japan

A lipoplex （i.e., pDNA#1/lipid complex and transfection reagent for pDNA delivery） containing galactosylceramide （GalCer） and an amidine-bearing lipid （TRX） was examined whether the bound pDNA was specifically ingested by hepatocyte via asialoglycoprotein receptor （ASGPR） and then expressed protein. Gel electrophoresis and small-angle X-ray scattering （SAXS） confirmed that the TRX-GalCer liposome#2 complexed with pDNA and the resultant lipoplex took.a hexagonally pack.d inverted cylinder structure when the GalCer composition was less than 20 wt.% of the total lipid. When the lipoplex carrying pGL3 （luciferase-cording pDNA） was administrated to HepG2, the luciferase activity was increased with increasing the GalCer composition until it reached 3 wt.% and then decreased upon further addition of GalCer. When we added galactose itself as a competitor, the luciferase activity was decreased, while glucose did not show such decrease, suggesting that HepG2 ingested the lipoplex via ASGPR-mediated endocytosis. This paper indicated that the hexagonally pack.d inverted cylinder structures of lipoplex may not always provide excellent transfection and presented a possibility that the TRX lipoplex#3 can obtain a cellulartargeting ability through the receptors for oligosaccharide.

关键词： Gene theraphy Amidine Galactosylceramide Targeting

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Beam break.p simulation study for a high energy ERL

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Chinese Physics C 2015年第1期39卷 98-102页

作者：陈思 M.shimada N.Nak.mura 黄森林刘克新陈佳洱 School of Physics University of Chinese Academy of Sciences State k.y Laboratory of Nuclear Physics and Technology Institute of Heavy Ion PhysicsPeking University k.k Oho 1-1 TsukubaIbaraki 305-0801Japan

The maximum beam current that can be accelerated in an energy recovery linac （ERL） can be severely limited by the transverse multi-pass beam break.p instability （BBU）, especially in future ERL light sources with multi-GeV high energy beam energy and more than 100 mA average current. In this paper, the multi-pass BBU of such a high energy ERL is studied based on the simulation of a 3-GeV ERL light source that is proposed by k.k. This work.is expected to provide a reference for future high energy ERL projects.

关键词： energy recovery linac beam break.p higher order mode

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Differentiation of premacular hemorrhages with niveau formation

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International Journal of Ophthalmology(English edition) 2022年第12期15卷 2037-2040页

作者： Yorihisa k.tagawa Hiroyuk. shimada Ak.yuk. k.wamura Hiroyuk. k.nek. k.ji Tanak. Hiroyuk. Nak.shizuk. Department of Ophthalmology School of MedicineNihon UniversityChiyodakuTokyo 101-8309Japan

Dear Editor,W e present three anatomical forms of premacular hemorrhage with niveau formation:hemorrhage in posterior precortical vitreous pock.t(intrapock.t hemorrhage),sub-internal limiting membrane(ILM)hemorrhage,and premacular retrocortical *** formation is the formation of a horizonal boundary between fluid and blood cells when they accumulate in a closed space,because blood cells with higher specific gravity settle in a standing position.

关键词： hemorrhage macular limiting

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Study on control of rock.fragmentation at limestone quarry

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Journal of Coal Science & Engineering(China) 2008年第3期14卷 365-368页

作者： SASAOk. Tak.shi shimada Hidek. SASAk. Tak.yuk. ICHINOSE Masatomo MATSUI k.k.o Department of Earth Resources Engineering Faculty of EngineeringKyushu UniversityFukuoka 819-0395Japan

The size distribution of a muck.pile depends not on only the blasting standard but also on the mechanical properties,joint system,and crack.density of the rock.mass. As,the crack. in the rock.masses are especially heavily developed at the limestone quar- ries in Japan,they,along with the joints,have a large impact on the effects of blasting, such as the size of the muck.***,if the joint system and/or crack.density in a rock.mass can be determined and quantitatively evaluated,the blasting operation can be conducted more effectively,efficiently and ***,guidelines for designing ap- propriate blasting standards based on the rock.mass conditions have not yet been scien- tifically ***,blasting tests were conducted on different mines and faces, under different geological conditions and blasting standards,in order to determine the im- pacts of each factor on the effects of *** the results of a series of blast- ing tests and described the impacts of geological conditions on the size of the muck.pile produced by blast.

关键词： fragmentation blasting standard blasting borehole scoping

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