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Rbfox1 controls alternative splicing of focal adh.sion genes in cardiac muscle cells

Journal of Molecular Cell Biology 2024年第1期16卷 54-65页

作者： Peter Zorn Jaime Calvo Sánch.z Tala Alak.ras Barbara Sch.eier Mich.el Gek.e Stefan h.ttelmaier Marcel k.h. Junior Group‘Non-coding RNAs and RBPs in h.man Diseases’ Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany Julius Bernstein Institute of Ph.siology Medical FacultyUniversity of Halle–Wittenberg06112 Halle(Saale)Germany Institute of Molecular Medicine Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany

Alternative splicing is one of th. major cellular processes th.t determine th. tissue-specific expression of protein ***,it remains ch.llenging to identify ph.siologically relevant and tissue-selective proteins th.t are generated by alternative ***,we investigated th. target spectrum of th. splicing factor Rbfox1 in th. cardiac muscle context in more *** using a combination of in silico target prediction and in-cell validation,we identified several focal adh.sion proteins as alternative splicing targets of *** focused on th. alternative splicing patterns of vinculin(metavinculin isoform)and paxillin(extended paxillin isoform)and identified both.as potential Rbfox1 *** analyses suggested th.t both.isoforms are promoted by Rbfox1 due to binding in th. *** adh.sions play an important role in th. cardiac muscle context,since th.y mainly influence cell sh.pe,cytosk.letal organization,and cell–matrix *** data confirmed th.t depletion of Rbfox1 ch.nged cardiomyoblast morph.logy,cytosk.letal organization,and multinuclearity after differentiation,wh.ch.migh. be due to ch.nges in alternative splicing of focal adh.sion ***,our results indicate th.t Rbfox1 promotes alternative splicing of focal adh.sion genes in cardiac muscle cells,wh.ch.migh. contribute to h.art disease progression,wh.re downregulation of Rbfox1 is frequently observed.

关键词： Rbfox1 alternative splicing focal adh.sion cardiac muscle cells

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Role of marine natural products in th. development of antiviral agents against SARS‑CoV‑2:potential and prospects

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Marine Life Science & Tech.ology 2024年第2期6卷 280-297页

作者： D.P.Nagah.watta N.M.Liyanage Th.lina U.Jayawardena h.h.A.C.k.Jayawardh.na Seong‑h.n Jeong h.ung‑Jun k.on You‑Jin Jeon Department of Marine Life Sciences Jeju National UniversityJeju 690-756Republic of Korea Department of ch.mistry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada Marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Functional Biomaterial Research.Center Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel coronavirus,k.own as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),h.s surfaced and caused global concern owing to its ***-CoV-2 is th. causative agent of coronavirus disease 2019;h.wever,it was only discovered at th. end of th. year and was considered a pandemic by th. World h.alth.***,th. develop-ment of novel potent inh.bitors against SARS-CoV-2 and future outbreak. is urgently *** naturally occurring bioactive substances h.ve been studied in th. clinical setting for diverse *** intricate infection and replication mech.nism of SARS-CoV-2 offers diverse th.rapeutic drug targets for developing antiviral medicines by employing natural products th.t are safer th.n synth.tic *** natural products(MNPs)h.ve received increased attention in th. development of novel drugs owing to th.ir h.gh.diversity and ***,th.s review article investigates th. infection and replication mech.nisms,including th. function of th. SARS-CoV-2 genome and ***,we h.gh.igh.ed anti-SARS-CoV-2 th.rapeutic intervention efforts utilizing MNPs and predicted SARS-CoV-2 inh.bitor design.

关键词： SARS-CoV-2 Marine natural products Drug targets Inh.bitors

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A new tech.ique for fault diagnosis in transformer insulating oil based on infrared spectroscopy measurements

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h.gh.Voltage 2024年第2期9卷 319-335页

作者： Moh.med M.F.Darwish.Moh.med h.A.h.ssan Nagat M.k.Abdel-Gawad Matti Leh.onen Diaa-Eldin A.Mansour Department of Electrical Engineering Faculty of Engineering at ShoubraBenha UniversityCairoEgypt Department of Electrical Engineering and Automation School of Electrical EngineeringAalto UniversityEspooFinland Department of Electrical Power Engineering Egypt-Japan University of Science and Technology(E-JUST)New Borg El-Arab CityEgypt Department of Electrical Power and Mach.nes Engineering Faculty of EngineeringTanta UniversityTantaEgypt

Condition monitoring of th. insulating system with.n power transformers h.s a massive importance according to th. electrical *** gas analysis(DGA)is frequently used for th.s ***,DGA lack. th. necessary level of accuracy to identify all equipment faults,particularly in th.ir initial stages of ***,it does not h.ve th. capability for real-time monitoring and relies on manual sampling and laboratory testing,causing potential delays in fault ***,th. interpretation of DGA data necessitates specialised expertise,wh.ch.may pose difficulties for smaller entities th.t h.ve limited access to ***,th. contribution of th.s research.is to use infrared spectroscopy measurements as a new effective tech.ique substituting th. DGA meth.d for fault diagnosis in insulating *** inception faults th.t were considered in th.s study were th. electrical fault(disch.rges of h.gh.energy)and th. th.rmal fault(300°Ch.t,two test cells were crafted especially for serving th. simulation processes inside th. laboratory for both.types of inception ***,six samples of pure paraffinic mineral oil were tak.n to be degraded in th. *** th.t,all of th.m besides anoth.r sample th.t were not subjected to any k.nd of faults were tak.n to be examined by Fourier transform infrared(FTIR)spectroscopy to obtain an overview of th. oil's beh.viour in each.fault *** th.t,th. FTIR analysis was initially verified utilising th. DGA ***,for furth.r affirmation,th. dielectric dissipation factor(DDF)for all samples was *** th. final analysis,th. verification tests provide experimental evidence about th. outperformance of th.s new optical tech.ique in detecting th. transformer's inception faults in addition to proving its potential for being a superior alternative to th. well-k.own traditional diagnostic tech.iques.

关键词： fault diagnosis spectroscopy

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Th. Early Warning Signs of a Strok.: An Approach.Using Mach.ne Learning Predictions

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Journal of Computer and Communications 2024年第6期12卷 59-71页

作者： Esraa h. Augi Almabruk.Sultan Department of Computer Science University of Benghazi Benghazi Libya

Early strok. prediction is vital to prevent damage. A strok. h.ppens wh.n th. blood flow to th. brain is disrupted by a clot or bleeding, resulting in brain death.or injury. h.wever, early diagnosis and treatment reduce long-term needs and lower h.alth.costs. We aim for th.s research.to be a mach.ne-learning meth.d for forecasting early warning signs of strok.. Th. meth.dology we employed feature selection tech.iques and multiple algorith.s. Utilizing th. XGboost Algorith., th. research.findings indicate th.t th.ir proposed model ach.eved an accuracy rate of 96.45%. Th.s research.sh.ws th.t mach.ne learning can effectively predict early warning signs of strok., wh.ch.can h.lp reduce long-term treatment and reh.bilitation needs and lower h.alth.costs.

关键词： Mach.ne Learning Strok. k.Nearest Neigh.ors Decision Tree Random Forest GXboost

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h.percoagulable state and risk.of venous th.omboembolism in Cush.ng syndrome

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Zh.ng nan da xue xue bao. Yi xue ban = Journal of Central South.University. Medical sciences 2024年第6期49卷 825-831页

作者： Liu Y. Tang Y. Tan h. Li J. Department of Endocrinology and Metabolism Center of Pituitary Adenoma and Related Diseases West China Hospital Sichuan University Chengdu 610041 China

库欣综合征(Cush.ng syndrome，CS)是以高皮质醇血症为特征的内分泌代谢疾病，高皮质醇血症可诱发高凝状态，导致静脉血栓栓塞(venous th.omboembolism，VTE)风险增加。无论是垂体来源的库欣病(Cush.ng disease，CD)，还是肾上腺来源的... 详细信息

库欣综合征(Cush.ng syndrome，CS)是以高皮质醇血症为特征的内分泌代谢疾病，高皮质醇血症可诱发高凝状态，导致静脉血栓栓塞(venous th.omboembolism，VTE)风险增加。无论是垂体来源的库欣病(Cush.ng disease，CD)，还是肾上腺来源的非促肾上腺皮质激素(adrenocorticotropic h.rmone，ACTh.依赖性CS，手术均是一线治疗选择。在手术和疾病本身的双重影响下，VTE风险进一步增加，甚至导致肺栓塞，严重威胁患者生命安全。此外，高凝状态的CS患者的心血管病和VTE发生率乃至病死率均高于正常人群，未经治疗的活动性CS患者的VTE发生率较普通人群升高了17.8倍。近年来，CS高凝状态与VTE之间的关系引起了越来越多临床医师的重视。进一步了解CS高凝状态的临床流行病学特点、病理生理机制和VTE及肺栓塞的临床防治，可以为CS患者预防性抗凝药物规范化使用提供参考。.; Cush.ng syndrome (CS) is an endocrine-metabolic disorder ch.racterized by h.percortisolism. Elevated cortisol levels can induce a h.percoagulable state, increasing th. risk.of venous th.omboembolism (VTE). Both.pituitary-origin Cush.ng disease (CD) and adrenal-origin non-adrenocorticotropic h.rmone (ACTh.-dependent CS are primarily treated with.surgery. Th. dual impact of surgery and th. underlying disease furth.r elevates th. risk.of VTE, potentially leading to pulmonary embolism, wh.ch.poses a severe th.eat to patient survival. Additionally, CS patients in a h.percoagulable state h.ve a h.gh.r incidence of cardiovascular diseases and VTE, and even mortality compared with.th. general population. Untreated active CS patients h.ve a 17.8-fold increased risk.of VTE compared to th. general population. In recent years, th. relationsh.p between th. h.percoagulable state in CS and VTE h.s garnered increasing attention from clinicians. A better understanding of th. clinical epidemiological ch.racteristics, path.ph.siological mech.nisms, and clinical prevention and treatment of VTE and pulmonary embolism in CS can provide valuable references for th. standardized use of proph.lactic anticoagulant th.rapy in CS patients.

关键词： Cush.ng syndrome h.percoagulable state venous th.omboembolism

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Olefin Polymerization Beh.vior of Titanium(IV) Complexes with.Fluorinated and Non-fluorinated Aliph.tic Ph.noxyimine Ligands

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ch.nese Journal of Polymer Science 2024年第1期42卷 52-62,I0007页

作者： Vladislav A.Tusk.ev k.sim F.Magomedov Svetlana ch.Gagieva Dmitry A.k.rmaev Yulia V.Nelyubina Evgenii k.Golubev Maria D.Evseeva Vik.or G.Vasil'ev Galina G.Nik.forova Mik.ail I.Buzin Vyach.slav S.Bogdanov Boris M.Bulych.v Department of ch.mistry M.V.Lomonosov Moscow State UniversityMoscow 119992Russian Federation A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of SciencesMoscow119991Russian Federation Enik.lopov Institute of Synth.tic Polymer Materials Russian Academy of SciencesMoscow 117393Russian Federation

A series of Ti(Ⅳ) dich.oride and dialk.xide com plexes with.ph.noxyimine ligands containing fluorinated and nonfluorinated aliph.tic imine fragments h.ve been *** molecular structures of complexes 1 and 4 were establish.d by single-crystal X-ray diffraction *** complexes adopt a distorted octah.dral coordination structure around th. titanium atom and two oxygen atoms are situated in trans position wh.le two nitrogen atoms and two outgoing ligands(Cl or iPrO) are situated in cis *** of activators(MMAO-12 and combinations Et_nAICl_(3-n)+Bu_(2)Mg) and outgoing ligand(Cl or iPrO) nature on th. catalytic activity and properties of th. resulting polymers was *** Ti complexes,despite th. nature of th. outgoing ligands(Cl or iPrO) in th. presence of Al/Mg activators,was found to display a h.gh.eth.lene polymerization activity in th. range 1600-3830 k._(polymer)·mol_(Ti)^(-1)·h.(-1)·atm^(-1) with.a viscosity average molecular weigh.(M_v) value in th. range 1.1×10~6-7.1×10~6 Dalton(Da).Th. resulting Uh.WPE can be processed by a solventless meth.d into h.gh.strength.and h.gh.modulus oriented *** rh.ological ch.racteristics of a polymer melt h.ve been *** absence of a cross-over point did not allow to compare th. values of th. molecular weigh. distribution of polymers obtained on fluorinated and non-fluorinated pre-catalysts,h.wever,th. estimation of th. entanglement density is in good agreement with.th. mech.nical ch.racteristics of oriented film *** activation with.meth.lalumoxane,th. activity of th. com plexes decreased very significantly;h.wever,a polymer with.a molecular weigh. of about 12 million Da was *** th. process of eth.lene/octene-1 copolymerization,fluorine-containing precatalysts sh.wed a clear advantage over non-fluorinated analogues both.in activity and in comonomer content.

关键词： FI catalysts Titanium(IV) (Co)polymerization Al/Mg co-catalyst Ultra-h.gh.molecular weigh. polyeth.lene

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Cost effectiveness of nonph.rmacological prevention programs for diabetes:A systematic review of trial-based studies

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ch.onic Diseases and Translational Medicine 2024年第1期10卷 12-21页

作者： Yongyi Xiong Zh.oh.a h.o Samuel Y.S.Wong Benjamin h.k.Yip Jock.y Club Sch.ol of Public h.alth.and Primary Care Prince of Wales HospitalThe Chinese University of Hong KongShatinHong KongChina

Trial-based economic value of prevention programs for diabetes is *** aimed to review th. cost-effectiveness of nonph.rmacological interventions to prevent type-2 diabetes mellitus(T2DM)for h.gh.risk.*** electronic databases were search.d up to March.*** assessing both.th. cost and h.alth.outcomes of nonph.rmacological interventions for people at h.gh.risk.of T2DM were *** quality of th. study was assessed by th. Consolidated h.alth.Economic Evaluation Reporting Standards 2022 *** primary outcome for synth.sis was incremental cost-effectiveness ratios(ICER)for quality-adjusted life years(QALYs),and costs were standardized in 2022 US *** synth.sis was performed,considering different types and delivery meth.ds of *** studies included five based on th. US diabetes prevention program(DPP),six on non-DPP-based lifestyle interventions,four on h.alth.education,and one on screening plus lifestyle *** with.usual care,lifestyle interventions sh.wed h.gh.r potential of cost-effectiveness th.n educational *** lifestyle interventions,DPP-based programs were less cost-effective(median of ICERs:$27,077/QALY)th.n non-DPP-based programs(median of ICERs:$1395/QALY)from h.alth.are perspectives,but with.larger decreases in diabetes ***,th. cost-effectiveness of interventions was more possibly realized th.ough.th. combination of different delivery *** interventions to prevent T2DM in h.gh.risk.populations are both.cost-effective and feasible in various ***,economic evidence from low-and middle-income countries is still lack.ng,and interventions delivered by trained laypersons and combined with.peer support sessions or mobile tech.ologies could be potentially a cost-effective solution in such.settings with.limited resources.

关键词： economic evaluation nonph.rmacological interventions pre-diabetes prevention

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Treh.lose:A sugar molecule involved in temperature stress management in plants

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Th. Crop Journal 2024年第1期12卷 1-16页

作者： Ali Raza Savita Bh.rdwaj Md Atik.r Rah.an Pedro García-Caparrós Madih. h.bib Faisal Saeed Sidra ch.ragh.ch.istine h.Foyer k.dambot h.M.Siddique Rajeev k.Varsh.ey College of Agriculture Fujian Agriculture and Forestry University(FAFU)Fuzhou 350002FujianChina Department of Botany School of Bioengineering and BiosciencesLovely Professional UniversityPhagwara 144411India Department of Botany MCM DAV CollegeKangraHimachal Pradesh 176001India Grassland and Forage Division National Institute of Animal ScienceRural Development AdministrationCheonan 31000Republic of Korea Agronomy Department of Superior Sch.ol Engineering University of AlmeríaAlmeríaSpain National Institute for Genomics and Advanced Biotech.ology National Agricultural Research CentrePark Rd.Islamabad 45500Pakistan Agriculture Health and Environment DepartmentNatural Resources InstituteFaculty of Engineering&ScienceUniversity of GreenwichKent ME44TBUK State k.y Laboratory of Rice Biology China National Rice Research InstituteChinese Academy of Agricultural SciencesHangzhouZhejiangChina Sch.ol of Biosciences College of Life and Environmental SciencesUniversity of BirminghamEdgbaston B152TTUK Th. UWA Institute of Agriculture The University of Western AustraliaCrawleyPerth 6009Australia WA State Agricultural Biotech.ology Centre Centre for Crop and Food InnovationFood Futures InstituteMurdoch UniversityMurdochWA 6150Australia

Treh.lose(Tre)is a non-reducing disacch.ride found in many species,including bacteria,fungi,invertebrates,yeast,and even plants,wh.re it acts as an osmoprotectant,energy source,or protein/membrane *** relatively small amounts in plants,Tre concentrations increase following exposure to abiotic ***-6-ph.sph.te,a precursor of Tre,h.s regulatory functions in sugar metabolism,crop production,and stress *** th. various abiotic stresses,temperature extremes(h.at or cold stress)are anticipated to impact crop production worldwide due to ongoing climate *** small amounts of Tre can mitigate negative ph.siological,metabolic,and molecular responses triggered by temperature *** also interacts with.oth.r sugars,osmoprotectants,amino acids,and ph.toh.rmones to regulate metabolic reprogramming th.t underpins temperature stress *** plants expressing Tre-synth.sis genes accumulate Tre and sh.w improved stress ***-wide studies of Tre-encoding genes suggest roles in plant growth.development,and stress *** review discusses th. functions of Tre in mitigating temperature stress—h.gh.igh.ing genetic engineering approach.s to modify Tre metabolism,crosstalk.and interactions with.oth.r molecules—and in-silico approach.s for identifying novel Tre-encoding genes in diverse plant *** consider h.w th.s k.owledge can be used to develop temperature-resilient crops essential for sustainable agriculture.

关键词： Abiotic stress Gene expression Genetic engineering Osmolyte Treh.lose-6-ph.sph.te

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Minimal Invasive Surgery for Esoph.geal Cancer

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Th. ch.nese-German Journal of Clinical Oncology 2004年第4期3卷 233-235页

作者： A. h. h.lsch.r ch. Gutsch.w Department of Visceral- and Vascular Surgery University of CologneDepartment of Visceral- and Vascular Surgery University of Cologne Cologne GermanyCologne Germany

Th.racoscopic esoph.gectomy is only establish.d in some centers and a?ords a cervical anasto- mosis because intrath.racic anastomosis as a routine is tech.ically too di?cult. Laparoscopic mobilisation of th. stomach.(gastrolysis) is an important contribution for minimal invasive surgery of esoph.geal cancer. Th.s procedure reduces th. stress of th. two cavity operation for th. patient and allows th. construction of a comparable gastric conduit lik. by open surgery. Th. tech.ique of laparoscopic gastrolysis as prepa- ration for transth.racic en bloc esoph.gectomy is described in detail and preliminary results are brie?y mentioned.

关键词： esoph.geal cancer minimal invasive surgery laparoscopy

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Natural medicine can substitute antibiotics in animal h.sbandry: protective effects and mech.nisms of rosewood essential oil against Salmonella infection

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ch.nese Journal of Natural Medicines 2024年第9期22卷 785-796页

作者： WANG L. FANG J. WANG h. Zh.NG B. WANG N. YAO X. LI h. QIU J. DENG X. LENG B. WANG J. TAN W. Zh.NG Q. State k.y Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of Education Institute of Zoonosis College of Veterinary Medicine Jilin University Changchun 130062 China Sh.nzh.n Beich.n Biotech.Co. Ltd. Shenzhen 518057 China Department of Obstetrics and Gynecology The Second Hospital of Jilin University Changchun 130041 China

Aniba rosaeodora essential oil (RO) h.s been traditionally used in natural medicine as a substitute for antibiotics due to its notable antidepressant and antibacterial properties. Salmonella, a prevalent path.gen in foodborne illnesses, presents a major ch.llenge to current antibiotic treatments. h.wever, th. antibacterial efficacy and mech.nisms of action of RO against Salmonella spp. remain underexplored. Th.s study aims to elucidate th. ch.mical composition of RO, evaluate its antibacterial activity and mech.nisms against Salmonella in vitro, and furth.r delineate its anti-inflammatory mech.nisms in vivo during Salmonella infection. Gas ch.omatograph.-mass spectrometry (GC-MS) was utilized to ch.racterize th. ch.mical constituents of RO. Th. antibacterial activity of RO was assessed using minimal inh.bitory concentration (MIC) and time-k.ll assays. Various bioch.mical assays were employed to uncover th. potential bactericidal mech.nisms. Additionally, mouse and ch.ck.models of Salmonella infection were establish.d to investigate th. proph.lactic effects of RO treatment. RO exh.bited significant antibacterial activity against both.Gram-positive and Gram-negative bacteria, with.an MIC of 4 mg·mL−1 for Salmonella spp. RO treatment resulted in bacterial damage th.ough.th. disruption of lipid and purine metabolism. Moreover, RO reduced injury and microbial colonization in infected mice and ch.ck.. RO treatment also modulated th. h.st inflammatory response by inh.biting proinflammatory path.ays. In conclusion, our findings demonstrate th.t RO is effective against Salmonella infection, h.gh.igh.ing its potential as an alternative to antibiotics for antibacterial th.rapy. © 2024 ch.na Ph.rmaceutical University

关键词： Aniba rosaeodora Anti-infection Anti-inflammation Antibacterial effect Rosewood essential oil Salmonella

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