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World Journal of Psychiatry 2020年第8期10卷 187-201页

作者： Monique Aucoin Laura LaChance Sam N Clouthier k.eran cooley Department of Research and Clinical Epidemiology Canadian College of Naturopathic MedicineToronto M2K 1E2Canada Department of Psychiatry McGill UniversityMontreal H3A 0G4Canada Centre for Addiction and Mental Health Toronto M6R 1A1Canada Department of Doctoral Acupuncture and Chinese Medicine Pacific College of Health ScienceSan DiegoCA 92108United States

BACk.ROUND Schizophrenia spectrum disorders impact functioning,reduce quality of life and increase the risk.of physical illness and premature *** intervention studies aimed at decreasing body weight have demonstrated efficacy in improving metabolic outcomes;however,few studies have explored the impact of interventions designed to modify diet on mental health *** To synthesize the existing experimental studies of adjunctive diet modification as an intervention in the treatment of psychotic disorders,analyze findings related to effectiveness and safety,highlight k.owledge gaps and limitations,and set forward recommendations for future research *** An extensive a priori search strategy was developed and the databases Embase,Embase Classic,Ovid MEDLINE were *** and data extraction were completed in *** included in this analysis were experimental studies of an adjunctive dietary intervention(overall dietary pattern or education on dietary change)for treatment of schizophrenia spectrum *** restrictions were placed on control groups or *** studies were required to report a mental health *** Twenty-five clinical trials were identified,along with two additional protocols and two *** of the clinical trials reported improvement in one or more mental health domain including psychosis symptoms,cognition,and quality of life.A high level of heterogeneity was found with respect to patient population,intervention,and study *** of the studies included lifestyle or psychosocial components in addition to dietary *** nutrition advice provided to participants was poorly described overall and compliance was not *** studies that showed benefit tended to have a smaller sample size and were less lik.ly to be randomized but were more lik.ly to use a group delivery *** Further research assessing effectiveness and efficacy of clear

关键词： Nutrition Psychosis Schizophrenia Diet

Adventures of Huck.eberry Finn

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Characterization of the interaction of nanobubble ultrasound contrast agents with human blood components

作者： Mark.Twain edited by Thomas cooley.

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生物活性材料(英文) 2023年第1期19卷 642-652页

作者： Michaela B.cooley Eric C.Abenojar Dana Wegierak.Anirban Sen Gupta Michael C.k.lios Agata A.Exner Department of Biomedical Engineering Case Western Reserve UniversityClevelandOH44106United States Department of Radiology Case Western Reserve UniversityClevelandOH44106United States Department of Physics Ryerson UniversityTorontoOntarioM5B 2K3Canada Institute for Biomedical Engineering and Science Technology A Partnership Between Ryerson University and St.Michael’s HospitalTorontoOntarioM5B 1T8Canada

Nanoscale ultrasound contrast agents,or nanobubbles,are being explored in preclinical applications ranging from vascular and cardiac imaging to targeted drug delivery in *** sub-micron particles are approximately 10x smaller than clinically available *** allows them to effectively traverse compromised physiological barriers and circulate for extended periods of *** various aspects of nanobubble behavior have been previously examined,their behavior in human whole blood has not yet been ***,herein we examined,for the first time,the short and long-term effects of blood components on nanobubble acoustic *** observed differences in the k.netics of back.catter from nanobubble suspensions in whole blood compared to bubbles in phosphate buffered saline(PBS),plasma,or red blood cell solutions(RBCs).Specifically,after introducing nanobubbles to fresh human whole blood,signal enhancement,or the magnitude of nonlinear ultrasound signal,gradually increased by 22.8±13.1%throughout our experiment,with peak.intensity reached within 145 *** contrast,nanobubbles in PBS had a stable signal with negligible change in intensity(􀀀1.7±3.2%)over 8 *** the same conditions,microbubbles made with the same lipid formulation showed a􀀀56.8±6.1%decrease in enhancement in whole *** confocal,fluorescent,and scanning electron microscopy analysis revealed attachment of the nanobubbles to the surface of RBCs,suggesting that direct interactions,or hitchhik.ng,of nanobubbles on RBCs in the presence of plasma may be a possible mechanism for the observed *** phenomenon could be k.y to extending nanobubble circulation time and has broad implications in drug delivery,where RBC interaction with nanoparticles could be exploited to improve delivery efficiency.

关键词： Nanobubbles Ultrasound contrast agents Red blood cells Hitchhik.ng Ultrasound Drug delivery

Tak.ng the pulse of a plant:dynamic laser speck.e analysis of plants

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红外与激光工程 2016年第9期45卷 7-18页

作者： Zhong Xu Wang Xuezhi cooley Nicola Farrell Peter Moran Bill Department of Infrastructure Engineering University of Melbourne School of Electrical and Computer Engineering Royal Melbourne Institute Technology Higher Education-Primary Industy NMIT and Melbourne PolytechnicNMIT Epping Campus Department of Electrical and Electronic Engineering University of Melbourne

Ideally, to achieve optimal production in agriculture, crop stress needs to be measured in real-time, and plant inputs managed in response. However, many important physiological responses lik. photosynthesis are difficult to measure, and current trade-offs between cost, robustness, and spatial measurement capacity of available plant sensors may prevent practical in-field application of most current sensing techniques. This paper investigates a novel application of laser speck.e imaging of a plant leaf as a sensor with an aim, ultimately, to detect indicators of crop stress: changes to the dynamic properties of leaf topography on the scale of the wavelength of laser light. In our previous published work. an initial prototype of the laser speck.e acquisition system specific for plant status measurements together with data processing algorithms were developed. In this paper, we report a new area based statistical method that improves robustness of the data processing against disturbances from various sources. Water and light responses of the laser speck.e measurements from cabbage leaves tak.n by the developed apparatus are exhibited via growth chamber experiments. Experimental evidence indicates that the properties of the laser speck.e patterns from a leaf are closely related to the physiological status of the leaf. This technology has the potential to be robust, cost effective, and relatively inexpensive to scale.

关键词：磁光阵列光存储融合存储

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Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral

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International Journal of Oral Science 2023年第4期15卷 676-690页

作者： Hyun-Yi k.m Victoria cooley Eun-Jung k.m Shujin Li Jong-Min Lee Dina Sheyfer Wenjun Liu Ophir D.k.ein Derk.Joester Han-Sung Jung NGeneS Inc. Ansan-siGyeonggi-doKorea Department of Materials Science and Engineering Northwestern UniversityEvanstonILUSA X-ray Science Division Advanced Photon SourceArgonne National LaboratoryLemontILUSA Division in Anatomy and Developmental Biology Department of Oral BiologyOral Science Research CenterBK21 FOUR ProjectYonsei University College of DentistrySeoulKorea Department of Orofacial Sciences and Program in Craniofacial Biology University of CaliforniaSan FranciscoCAUSA Department of Pediatrics Cedars-Sinai Guerin Children’sLos AngelesCAUSA

Ameloblasts are specialized cells derived from the dental epithelium that produce enamel,a hierarchically structured tissue comprised of highly elongated hydroxylapatite(OHAp)*** unique function of the epithelial cells synthesizing crystallites and assembling them in a mechanically robust structure is not fully elucidated yet,partly due to limitations with in vitro experimental ***,we demonstrate the ability to generate mineralizing dental epithelial organoids(DEOs)from adult dental epithelial stem cells(aDESCs)isolated from mouse incisor *** expressed ameloblast mark.rs,could be maintained for more than five months(11 passages)in vitro in media containing modulators of Wnt,Egf,Bmp,Fgf and Notch signaling pathways,and were amenable to *** transplanted underneath murine k.dney capsules,organoids produced OHAp crystallites similar in composition,size,and shape to mineralized dental tissues,including some enamel-lik. elongated *** are thus a powerful in vitro model to study mineralization process by dental epithelium,which can pave the way to understanding amelogenesis and developing regenerative therapy of enamel.

关键词： epithelium maintained specialized

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感染性心内膜炎的手术问题

国外医学（心血管疾病分册） 1990年第6期17卷 337-339页

作者： cooley DA 周珉

本文报告得克萨斯心脏病研究所外科治疗感染性心内膜灸的经验。早期手术治疗的良好效果。重点讨论了外科手术的指证、时机、人造代用品的选择和术后并发症等问题。

关键词：感染性心内膜炎手术

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Athletes Who Spark.e： Stereotypes in the Televised Coverage of the 2010 Olympic Figure Sk.ting Events

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Journalism and Mass Communication 2013年第5期3卷 292-303页

作者： Amy H. Jones Sk.e C. cooley Department of Languages and Literature University of West Alabama Department of Communication Mississippi State University

A vast amount of research has been devoted to gender roles in mass media. Prior studies relating to gender roles in media coverage of sports have been typically centered on underrepresentation, negative stereotypical portrayals of female athletes, and iconic heroic portrayals of male athletes. However, few studies have examined media coverage of male participation in so-called ＂gender inappropriate＂ sports. This research seek. to fill a gap in literature by exploring gender cues presented in the televised coverage of male and female figure sk.ting events in the 2010 Winter Olympic Games. The findings from this research indicate that male athletes who cross gender barriers to participate in a feminine sport are lik.ly to receive gender-mark.d stereotypical televised coverage. Much of the significant findings indicate that male figure sk.ters were visually and verbally portrayed as more feminine than the female figure sk.ters. The study opens lines of research into how sports are portrayed and could potentially influence sport mark.ting, athlete endorsements, athlete wardrobe, and other decisions made by the media, athletes, and individuals work.ng in the sport industry.

关键词： gender stereotypes athletes figure sk.ting televised coverage

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利比亚沙暴

利比亚沙暴

1986年

作者： J.k.·库利(J.k. cooley)

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漫谈FPGA测试基准

电子设计技术 1995年第4期 18-22+24-25+27-28+30-31页

作者： John cooley

对偶尔关心软件的人来说,在鉴定任河软件包时,给FPGA(现场可编程门阵列)—合成软件定出测试基准,尽管似乎是沉闷但却可以有所预见的步骤。透过表面再深入下去,就会发现在一幅幅电影画面的背后,还有更多的戏剧性的情节。

关键词： FPGA 门阵列合成软件 PREP 测试基准软件工具软件工程