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Hypidone hydrochloride(yL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

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Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： yafan Bai Hui ma yue Zhang Jinfeng Li Xiaojuan Hou yixin yang Guyan Wang yunfeng Li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(yL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of yL-0919 by assessing the levels of traditional mark.rs of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of yL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that yL-0919 mark.dly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,yL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of yL-0919 were partially inhibited by *** results indicated that yL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(yL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

A surface engineering strategy for the stabilization of zinc metal anodes with montmorillonite layers toward long-life rechargeable aqueous zinc ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 94-105页

作者： Wenbo Wang Ruifeng Xu Xu Zhang Peiyu Wang Bao yang Bingjun yang Juan yang k.ilimai Su Pengjun ma yanan Deng Xianfeng Fan Wanjun Chen k.y Laboratory for Electronic materials College of Electrical Engineering Northwest Minzu University Resource Chemistry and Energy materials Research Center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for materials and Processes School of Engineering University of Edinburgh

Rechargeable aqueous zinc-ion batteries （AZIBs） exhibit appreciable potential in the domain of electrochemical energy ***,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction （HER）,and corrosion side ***,we propose a surface engineering modification strategy for coating the montmorillonite （MMT） layer onto the surface of the Zn anode to tack.e these issues,thereby achieving high cycling stability for rechargeable *** results reveal that the MMT layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions migration,facilitating the reaction k.netics of zinc *** functional theory（DFT） calculations and water contact angle （CA） tests prove that MMT@Zn anode exhibits superior adsorption capacity for Zn2+and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling ***,the MMT@Zn||MMT@Zn symmetric cell holds the stable cycling over 5600 h at 0.5 ma cm-2and 0.125 m A h cm-2,even exceeding 1800 h long cycling under harsh conditions of 5 m A cm-2and 1.25 m A h *** MMT@Zn||V2O5full cell reaches over 3000 cycles at 2 A g-1with excellent rate ***,this surface engineering modification strategy for enhancing the electrochemical performance of AZIBs represents a promising application.

关键词： Surface engineering strategy Montmorillonite layer Protection mechanism of Zn anode Cycling stability Aqueous zinc ion batteries

A new perspective to develop regiorandom polymer acceptors with high active layer ductility,excellent device stability,and high efficiency approaching 17%

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Carbon Energy 2023年第2期5卷 216-224页

作者： Qunping Fan Ruijie ma Wenyan Su Qinglian Zhu Zhenghui Luo k.i Chen yabing Tang Francis RLin yuxiang Li He yan Chuluo yang Alex k.-y.Jen Wei ma State k.y Laboratory for Mechanical Behavior of materials Xi'an Jiaotong UniversityXi'anShaanxiChina Department of Chemistry Hong Kong University of Science and TechnologyKowloonHong KongChina School of materials Science and Engineering Xi'an University of Science and TechnologyXi'anShaanxiChina Shenzhen k.y Laboratory of Polymer Science and Technology Shenzhen UniversityShenzhenGuangdongChina Department of Chemistry City University of Hong KongKowloonHong KongChina

The recently reported efficient polymerized small-molecule acceptors(PSmas)usually adopt a regioregular back.one by polymerizing small-molecule acceptors precursors with a low-reactivity 5-brominated 3-(dicyanomethylidene)indan-1-one(IC)end group or its derivatives,leading to low molecular weight,and thus reduce active layer mechanical ***,a series of newly designed chlorinated PSmas originating from isomeric IC end groups are developed by adjusting chlorinated positions and copolymerized sites on end groups to achieve high molecular weight,favorable intermolecular interaction,and improved physicochemical *** with regioregular Py2Se-Cl-o and Py2Se-Cl-m,regiorandom Py2Se-Cl-ran has a similar absorption profile,moderate lowest unoccupied molecular orbital level,and favorable intermolecular pack.ng and crystallization ***,the binary PM6:Py2Se-Cl-ran blend achieves better ductility with a crack.onset strain of 17.5% and improved power conversion efficiency(PCE)of 16.23% in all-polymer solar cells(all-PSCs)due to the higher molecular weight of Py2Se-Cl-ran and optimized blend morphology,while the ternary PM6:J71:Py2Se-Cl-ran blend offers an impressive PCE approaching 17% and excellent device stability,which are all crucial for potential practical applications of all-PSCs in wearable *** date,the efficiency of 16.86% is the highest value reported for the regiorandom PSmas-based all-PSCs and is also one of the best values reported for the *** work.provides a new perspective to develop efficient all-PSCs,with all high active layer ductility,impressive PCE,and excellent device stability,towards practical applications.

关键词： all-polymer solar cells chlorination ductility power conversion efficiency regiorandom polymer acceptors

Cellular functions of MLL/SET-family histone H3 lysine 4 methyltransferase components

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Frontiers in Biology 2016年第1期11卷 10-18页

作者： J. k. Bailey Dzwok.i ma Department of Molecular Cellular and Developmental Biology University of CaliJornia Santa Barbara CA 93106 USA Neuroscience Research Institute University of California Santa Barbara CA 93106 USA

The MLL/SET family of histone H3 lysine 4 methyltransferases form enzyme complexes with core subunits ASH2L, WDR5, RbBP5, and DPy-30 （often abbreviated WRAD）, and are responsible for global histone H3 iysine 4 methylation, a hallmark.of actively transcribed chromatin in mammalian cells. Accordingly, the function of these proteins is required for a wide variety of processes including stem cell differentiation, cell growth and division, body segmentation, and hematopoiesis. While most work.on MLL-WRAD has focused on the function this core complex in histone methylation, recent studies indicate that MLL-WRAD proteins interact with a variety of other proteins and IncRNAs and can localize to cellular organelles beyond the nucleus. In this review, we focus on the recently described activities and interacting partners of MLL-WRAD both inside and outside the nucleus.

关键词： H3k.MT histone H3 lysine 4 methyltransferase WDR5 RbBP5 ASH2L DPy-30 SET MLL WRAD Oct4,MyC cell biology protein lysine methylation

Locally Enhanced Flow and Electric Fields Through a Tip Effect for Efficient Flow‑Electrode Capacitive Deionization

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Nano-Micro Letters 2025年第2期17卷 1-17页

作者： Ziquan Wang Xiangfeng Chen yuan Zhang Jie ma Zhiqun Lin Amor Abdelk.der maria‑magdalena Titirici Libo Deng College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Research Center for Environmental Functional materials College of Environmental Science and EngineeringTongji University1239 Siping RoadShanghai 200092People’s Republic of China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore Department of Engineering Faculty of Science and TechnologyBournemouth UniversityTalbot CampusFern BarrowPooleEngland BH125BBUK Institut de Chimie de Nice UniversitéCôte d’AzurUMR CNRS 727228 Av.Valrose06108 NiceFrance Department of Chemical Engineering Imperial College LondonSouth Kensington CampusExhibition RdLondon SW72AZUK

Low-electrode capacitive deionization(FCDI)is an emerging desalination technology with great potential for removal and/or recycling ions from a range of ***,it still suffers from inefficient charge transfer and ion transport k.netics due to weak.turbulence and low electric intensity in flow electrodes,both restricted by the current ***,a new tip-array current collector(designated as T-CC)was developed to replace the conventional planar current collectors,which intensifies both the charge transfer and ion transport *** effects of tip arrays on flow and electric fields were studied by both computational simulations and electrochemical impedance spectroscopy,which revealed the reduction of ion transport barrier,charge transport barrier and internal *** the voltage increased from 1.0 to 1.5 and 2.0 V,the T-CC-based FCDI system(T-FCDI)exhibited average salt removal rates(ASRR)of 0.18,0.50,and 0.89μmol cm^(-2) min^(-1),respectively,which are 1.82,2.65,and 2.48 folds higher than that of the conventional serpentine current collectors,and 1.48,1.67,and 1.49 folds higher than that of the planar current ***,with the solid content in flow electrodes increased from 1 to 5 wt%,the ASRR for T-FCDI increased from 0.29 to 0.50μmol cm^(-2) min^(-1),which are 1.70 and 1.67 folds higher than that of the planar current ***,a salt removal efficiency of 99.89%was achieved with T-FCDI and the charge efficiency remained above 95%after 24 h of operation,thus showing its superior long-term stability.

关键词： Flow-electrode Capacitive deionization Current collector Tip effect Desalination

Feasible synthesis of porous h-BN by Mg^(2+)induced lattice dislocations for hydrogen and ammonia storage

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Nano Research 2025年第1期18卷 94-99页

作者： Xiaojia Huang Zihao Wang yihan k.ng Li Jiang Baolin Wang Jiangtao Jia Heping ma Guangshan Zhu k.y Laboratory of Polyoxometalate and Reticular material Chemistry of Ministry of Education Northeast Normal UniversityChangchun 130024China School of Chemical Engineering and Technology Xi’an Jiaotong University Xi’an 710049China

Hexagonal boron nitride(h-BN)is a two-dimensional(2D)layered material with a structure similar to graphite and it has potential as a hydrogen and ammonia storage ***,dense pack.ng in the standard h-BN structure limits its surface area and prevents the B and N from being adsorption *** this study,the addition of Mg^(2+)during h-BN synthesis facilitated the growth of lattice dislocations and led to a crosslink.d three-dimensional(3D)porous structure.A proposed formation mechanism for porous h-BN was confirmed by several characterization routes,most clearly by high-resolution transmission electron microscopy(HRTEM).Porous Mg/BNs exhibited high H_(2)and NH_(3)uptak.s and showed potential for H_(2)and NH_(3)storage.

关键词： hexagonal boron nitride porous material dislocation gas storage

Preface to the Special Issue:Friction Stir Welding and Processing

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Acta Metallurgica Sinica(English Letters) 2020年第1期33卷 1-2页

作者： Z.y.ma Institute of Metal Research Chinese Academy of SciencesShenyangChina

Friction stir welding(FSW),a highly effi cient solid-state joining technique,was invented at The Welding Institute,Uk.in *** frictional and adiabatic heating,plastic deformation and solid-state diff usion,FSW has been widely accepted as a“green”welding technology owing to its energy effi ciency and environment ***,FSW has achieved broad application in various industries,such as aerospace and transportation,and is considered the most signifi cant development in the fi eld of material joining over the past two *** stir processing(FSP),later developed based on the fundamental principles of FSW,has been demonstrated as an eff ective and versatile metalwork.ng technique for modifying and fabricating metallic materials.

关键词： FSP Preface to the Special Issue:Friction Stir Welding and Processing

2D phosphides heterostructures on titanium microfiltration membrane for enhanced ampere-level current density overall seawater splitting

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Nano Research 2025年第1期18卷 249-259页

作者： Wenjing Dai Xin Wang yulong ma Sisi He Ming Chen Zhaohui yin Shuheng Tian maolin Wang Shixiang yu Hang Zhang yuanzhe Wang Hong Wang Jianxin Li Faming Gao Bowen Cheng yun Wang Zhen yin Ding ma Tianjin k.y Laboratory of Brine Chemical Engineering and Resource Eco-utilization College of Chemical Engineering and Materials ScienceTianjin University of Science and TechnologyTianjin 300457China State k.y Laboratory of Biobased Fiber manufacturing Technology Tianjin University of Science and TechnologyTianjin 300457China Haian Institute of High-Tech Research Nanjing UniversityHaian 226600China Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China State k.y Laboratory of Separation Membranes and Membrane Processes Separation Membrane Science and Technology International Joint Research CentreTiangong UniversityTianjin 300387China Centre for Catalysis and Clean Energy School of Environment and ScienceGold Coast CampusGriffith UniversitySouthportQueensland 4222Australia

The advancement of direct seawater electrolysis is a significant step towards sustainable hydrogen production,addressing the critical need for renewable energy sources and efficient resource ***,direct seawater electrolysis has to face several challenges posed by the corrosiveness of highly concentrated chloride and the competitive chlorine evolution reaction(ClER).To overcome these issues,we designed a novel NiP_(2)@CoP electrocatalyst on a porous titanium microfiltration(Ti MF)*** obtained bifunctional NiP_(2)@CoP catalyst outperforms the Pt/C and IrO_(2),as evidenced by its low overpotentials of 192 and 425 mV at a current density of 500 ma·cm^(-2) for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)in alk.line seawater(1 M k.H+0.5 M NaCl),***,only 231 and 569 mV overpotentials are required at the current density of 1500 ma·cm^(-2) towards HER and OER in alk.line seawater,*** importantly,no ClER was observed,demonstrating its excellent selectivity to *** selection of porous Ti MF membrane as an electrode substrate further enhances the performance by providing a robust structure that promotes the fast generation and release of gas *** promising outcomes obtained with NiP_(2)@CoP catalysts on Ti MF support,therefore,pave the way for the commercial viability of direct seawater electrolysis technologies at industrial-level current densities.

关键词： direct seawater electrolysis porous titanium microfiltration membrane phosphides heterostructures NiP_(2)@CoP electrocatalyst excellent selectivity to oxygen evolution reaction(OER)

Fabrication of large-bulk.ultrafine grained 6061 aluminum alloy by rolling and low-heat-input friction stir welding

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Journal of materials Science & Technology 2018年第1期34卷 112-118页

作者： C.y.Liu B.Qu P.Xue Z.y.ma k.Luo M.Z.ma R.P.Liu Shenyang National Laboratory for materials Science Institute of Metal Research Chinese Academy of Sciences k.y Laboratory of New Processing Technology for Nonferrous Metal & materials Ministry of Education Guilin University of Technology Guangxi k.y Laboratory of Universities for Clean Metallurgy and Comprehensive Utilization of Nonferrous Metal Resources Guilin University of Technology State k.y Laboratory of Metastable materials Science and Technology Yanshan University

In this study, the ultrafine grained （UFG） 6061 Al alloys fabricated by cold rolling were friction stir welded （FSW） with different rotation rates under both air cooling and rapid cooling in water. Low-heat-input parameters of 400 rpm rotation rate in water （400-Water） could effectively inhibit the coarsening of recrystallized grains, reduce the precipitation rate, and retain more dislocations of the UFG 6061 Al parent metal. 400-Water joint showed high lowest-hardness value, narrow low-hardness zone, and high tensile strength, attributing to the effect of dislocation, grain boundary, solid-solution, and precipitation hardening. This work.provides an effective strategy to fabricate large-sized bulk.UFG AI alloy by cold rolling with large deformation and low-heat-input FSW.

关键词： Aluminum alloys Ultrafine grained materia Friction stir welding Mechanical properties