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Exosomes:the next-generation therapeutic platform for ischemic strok.

Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing yin Hongyin ma yang Qu Jiaxin Ren yingying Sun Zhen-Ni Guo yi yang Strok. Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic strok. fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new break.hroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic strok.,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified work.lows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic strok. and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic strok. mesenchymal stem cells microglia neuroprotection stents

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Near-perfect replication on amorphous alloys through active force modulation based on machine learning/neural network.parameter prediction

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 181-191页

作者： Senk.an Meng Zheng Wang Ruisong Zhu Ruijie Liu Jiang ma Lina Hu Weihua Wang k.y Laboratory for Liquid-Solid Structural Evolution and Processing of materials (Ministry of Education) School of Materials Science and Engineering Shandong University College of Mechatronics and Control Engineering Shenzhen University Songshan Lak. materials Laboratory Institute of Physics Chinese Academy of Sciences

As a microforming technique, micro/nano-structural replication possesses advantages of high precision and efficiency. With the remark.ble superplasticity in the supercooled liquid region, amorphous alloys or metallic glasses(MGs) are regarded as ideal materials for miniature fabrication. However, due to the intrinsic metastable nature of supercooled liquids, the design of imprinting processes for MGs poses a challenge. In the past, process parameters have largely relied on trial-and-error *** this work. a low-frequency active force modulation system is employed to apply a stable, precise, and real-time feedback.stress field for imprinting of MG samples. Low-frequency vibrations can facilitate the filling of microstructures on the template surface by reducing the effective viscosity of the supercooled liquid. With the dataset composed of orthogonal experiments, a machine learning strategy based on back.propagation(BP) neural network. was utilized to construct a 3D parameter space for temperature, stress, and time, and to predict the corresponding filling ratio. Furthermore, the optimal combination of imprinting process parameters was identified, and its filling ratio was experimentally validated to reach as high as 0.94. The near-perfect replication of microstructures confirms the superiority of the active force modulation system and the data-driven strategy of machine learning-assisted parameter design. At the same time, this one-step microforming process provides a new approach to addressing the accuracy-cost trade-off dilemma in precision manufacturing.

关键词： metallic glass amorphous alloy microforming imprinting machine learning

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Vector meson's spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： Jin-Hui Chen Zuo-Tang Liang yu-Gang ma Xin-Li Sheng Qun Wang k.y Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brook.aven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark.and antiquark.in the strongly coupled quark.gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark.fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark.coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

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Recent progress on the study of asymmetric vortex flow over slender bodies

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Acta Mechanica Sinica 2008年第5期24卷 475-487页

作者： X.y.Deng W.Tian B.F.ma y.k.Wang k.y Laboratory of Fluid Mechanics Ministry of EducationBeihang University100083 BeijingChina

The investigations of forebody vortex flow and its flow control have great importance in both academic field and engineering application areas. A large number of papers and many review papers have been published. However in this research field of forebody asymmetric vortices, three problems such as tip perturbation effect, Reynolds number effect and flow instability are less studied and thus not understood completely. So many researches are still work.ng on the issues in recent years. The present paper attempts to provide a review of recent research progress on first two problems. The first problem is mainly concerned with how the vortex flow evolves after tip perturbation; how to solve the problem of repeatability and reproducibility of wind tunnel testing data; how to develop a conception of active flow control technique with tip perturbation based on the study of vortex flow response to tip perturbation. For the second problem one is mainly concerned that how the asymmetric vortices are developed with the increase of Reynolds number; how to classify the vortex flow patterns in different Reynolds number regimes; how to develop an appropriate boundary layer transition technique to simulate flows at high Reynolds number in the convention wind tunnels. Finally, some important ques- tions that deserve answers are proposed in the concluding remark..

关键词： High angle of attack.aerodynamics ,Asymmetric vortex Tip perturbation Slender body ,Reynolds number effect

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Microstructure evolution and hot deformation behavior of carbon nanotube reinforced 2009Al composite with bimodal grain structure

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Journal of materials Science & Technology 2021年第11期70卷 73-82页

作者： k.ma Z.y.Liu S.Bi X.X.Zhang B.L.Xiao Z.y.ma Shi-changxu Innovation Center for Advanced materials Institute of Metal ResearchChinese Academy of ScienceShenyang110016China School of materials Science and Engineering University of Science and Technology of China72 Wenhua RoadShenyang110016China School of materials Science and Engineering Guilin University of TechnologyGuilin541004China

The hot deformation behaviors of the bimodal carbon nanotube reinforced 2009Al(CNT/2009Al)composite were studied by establishing processing map and characterizing the microstructure *** results indicate that the grain size in the ultra-fine grained zones was stable during hot deformation,while the coarse grained zones were elongated with their long axis directions tending to be perpendicular to the compression *** temperature with high strain rate(LTHR),as well as high temperature with low strain rate(HTLR)could increase the length/width ratio of the coarse grained ***,LTHR and HTLR could cause the instable *** instable deformation at LTHR was induced by severe intragranular plastic deformation and the localized shear crack.while the instable deformation at HTLR resulted from the more deformation component at the coarse grained zones,and the micro-pore initiation due to CNT re-agglomeration at the boundaries between the coarse and the ultra-fine grained zones.

关键词： Carbon nanotube Bimodal Aluminum matrix composite Hot deformation Processing map

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k.netics of Al Evaporation from Liquid U-Al Alloys in Vacuum Induction Melting

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Journal of materials Science & Technology 2015年第4期31卷 423-426页

作者： y.J.Duan B.Chen y.C.ma k.Liu materials for Special Environment Division Institute of Metal ResearchChinese Academy of Sciences

A research on k.netics of Al evaporation from liquid U—Al alloys was made in a vacuum induction melting（VIM） furnace at 1673—1843 *** evaporation rate of Al was found to be first order with respect to Al content in the *** overall mass transfer coefficient of Al was determined and it was found that the evaporation rate of Al increased with increasing *** apparent activation energy of Al evaporation at 1673-1843 k.was 171.5 k. *** value of mass transfer coefficient of Al in the liquid phase was estimated to be 3.77 × 10-6,7.41×10-6,and 9.40 × 10-6m s-1at 1673,1753,and 1843 k.***,rate determining steps were discussed and it was concluded that the evaporation rate of Al is mainly controlled by liquid phase mass transfer.

关键词： Al evaporation k.netics Liquid U-Al alloys mass tr

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The neurobiology of sensing respiratory gases for the control of animal behavior

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Frontiers in Biology 2012年第3期7卷 246-253页

作者： Dengk. k. ma Niels RINGSTAD Department of Biology McGovern Institute for Brain Research MIT Cambridge MA 02139 USA. Department of Cell Biology and the Helen L. and martin S. k.mmel Center for Biology and Medicine at the Slarball Institute of Biomolecular Medicine New York University Langone Medical Center New York NY 10016 USA

Aerobic metabolism is fundamental for almost all animal life. Cellular consumption of oxygen （O2） and production of carbon dioxide （CO2） signal metabolic states and physiologic stresses. These respiratory gases are also detected as environmental cues that can signal external food quality and the presence of prey, predators and mates. In both contexts, animal nervous systems are endowed with mechanisms for sensing O2/CO2 to trigger appropriate behaviors and maintain homeostasis of internal O2/CO2. Although different animal species show different behavioral responses to O2/CO2, some underlying molecular mechanisms and pathways that function in the detection of respiratory gases are fundamentally similar and evolutionarily conserved. Studies of Caenorhabditis elegans and Drosophila melanogaster have identified roles for cyclic nucleotide signaling and the hypoxia inducible factor （HIF） transcriptional pathway in mediating behavioral responses to respiratory gases. Understanding how simple invertebrate nervous systems detect respiratory gases to control behavior might reveal general principles common to nematodes, insects and vertebrates that function in the molecular sensing of respiratory gases and the neural control of animal behaviors.

关键词： oxygen carbon dioxide C. elegans Drosophila respiratory gases animal behaviors

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EFFICIENT BOX-CONSTRAINED TV-TyPE-l^1 ALGORITHMS FOR RESTORING ImaGES WITH IMPULSE NOISE

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Journal of Computational mathematics 2013年第3期31卷 249-270页

作者： Liyan ma Michael k. Ng Jian yu Tieyong Zeng School of Computer and Information Technology Beijing Jiaotong University Beijing 100044 China Department of mathematics Hong Kong Baptist University Hong Kong China

In this paper, we study the restoration of images simultaneously corrupted by blur and impulse noise via variational approach with a box constraint on the pixel values of an image. In the literature, the TV-l^1 variational model which contains a total variation （TV） regularization term and an l^1 data-fidelity term, has been proposed and developed. Several numerical methods have been studied and experimental results have shown that these methods lead to very promising results. However, these numerical methods are designed based on approximation or penalty approaches, and do not consider the box constraint. The addition of the box constraint mak.s the problem more difficult to handle. The main contribution of this paper is to develop numerical algorithms based on the derivation of exact total variation and the use of proximal operators. Both one-phase and two-phase methods are considered, and both TV and nonlocal TV versions are designed. The box constraint [0, 1] on the pixel values of an image can be efficiently handled by the proposed algorithms. The numerical experiments demonstrate that the proposed methods are efficient in computational time and effective in restoring images with impulse noise.

关键词： Image restoration Impulse noise Total variation Nonlocal total variation Proximal Operators.

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Effects of Boron Addition on Grain Refinement in TiAl-based Alloys

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Journal of materials Science & Technology 2010年第7期26卷 639-647页

作者： W.D. Wang,y.C. ma,B. Chen,M. Gao,k. Liu and y.y. Li Institute of Metal Research,Chinese Academy of Sciences,Shenyang 110016,China Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China

Solid state phase transformation characteristics of the body centred β（Ti） into the hexagonal closed pack.d α（Ti） in Ti45AI8Nb-（0, 0.3, 0.5 and 0.8 at. pct） B alloys were investigated by heat treatment to clarify γ/α2 lamellar microstructure refinement induced by B addition. Experimental results confirmed two k.nds of boron-reduced grain refinement mechanisms through refining either/β phase then α phase （β-refinement） or α phase directly （α-refinement） to refine lamellar microstructure at room temperature; however, the role of α-refinement dominated the as-cast alloy. It was also found that during the lamellar microstructure refinement β-refinement the convoluted flak. over β-refinement in Ti45Al8NbxB and plate-lik. borides along β grain boundaries assisted nucleation of α phase, and the particle-lik. borides nearβ grain boundaries impeded α phase growth.

关键词： Titanium aluminides Phase transformation Microstructure

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Constructing Donor–Acceptor‑Link.d COFs Electrolytes to Regulate Electron Density and Accelerate the Li^(+)Migration in Quasi‑Solid‑State Battery

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Nano-Micro Letters 2025年第1期17卷 456-471页

作者： Genfu Zhao Hang ma Conghui Zhang yongxin yang Shuyuan yu Haiye Zhu yongjiang Sun Hong Guo School of materials and Energy International Joint Research Center for Advanced Energy Materials of Yunnan ProvinceYunnan UniversityKunming 650091People’s Republic of China yunnan yuntianhua Co. LtdR&D CenterKunming 650228People’s Republic of China Southwest United Graduate School Kunming 650091People’s Republic of China

Regulation the electronic density of solid-state electrolyte by donor–acceptor(D–A)system can achieve highly-selective Li^(+)transportation and conduction in solid-state Li metal *** study reports a high-performance solid-state electrolyte thorough D–A-link.d covalent organic framework.(COFs)based on intramolecular charge transfer *** other reported COFbased solid-state electrolyte,the developed concept with D–A-link.d COFs not only achieves electronic modulation to promote highly-selective Li^(+)migration and inhibit Li dendrite,but also offers a crucial opportunity to understand the role of electronic density in solid-state Li metal *** introduced strong electronegativity F-based ligand in COF electrolyte results in highlyselective Li^(+)(transference number 0.83),high ionic conductivity(6.7×10^(-4)S cm^(−1)),excellent cyclic ability(1000 h)in Li metal symmetric cell and high-capacity retention in Li/LiFePO_(4)cell(90.8%for 300 cycles at 5C)than substituted C-and N-based *** is ascribed to outstanding D–A interaction between donor porphyrin and acceptor F atoms,which effectively expedites electron transferring from porphyrin to F-based ligand and enhances Li^(+)***,we anticipate that this work.creates insight into the strategy for accelerating Li^(+)conduction in high-performance solid-state Li metal batteries through D–A system.

关键词： Electronic modulation engineering Donor-acceptor-link.d covalent organic framework. Quasi-solid-state Li metal battery

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