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Contributing to a Healthy Older p.p.lation of the Future: Investigating the Daily Walk.ng Step. of Work.ng Adults in Hong k.ng

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Journal of Biosciences and Medicines 2015年第9期3卷 22-31页

作者： Linda Y. k. Lee Simon C. Lam S. L. wong Alisa k. p. wong Cheryl C. Y. Yeung Division of Nursing and Health Studies The Open University of Hong Kong Hong Kong China

Develop.ng a healthy lifestyle during adulthood is one of the essential factors to p.ep.re for healthy aging. This cross-sectional descrip.ive study investigated the daily walk.ng step. of 893 work.ng adults from nine occup.tion categories in Hong k.ng. Their daily walk.ng step. were measured using a p.dometer. Analysis of variance (ANOVA) was used to comp.re the difference in daily walk.ng step. between p.rticip.nts in different occup.tion category. Chi-square test was used to comp.re the difference in p.op.rtion of work.ng adults in each occup.tion category who walk.d and did not walk.10,000 step. p.r day. Results reveal that the p.rticip.nts in average walk.d 8661 step. p.r day. “p.ant and machine op.rators and assemblers” and “clerk.” were the two least active group.. p.rticip.nts from the nine occup.tion categories demonstrated a significant difference in the number of daily walk.ng step.. p.st hoc analysis revealed a significant difference between “p.ant and machine op.rators and assemblers” and “service work.rs and shop.sales work.rs” (p.p.ant and machine op.rators and assemblers” and “craft and related work.rs” (p.p.rticip.nts from the nine occup.tion categories also demonstrated a significant difference in the p.op.rtion of those who walk.d and did not walk.10,000 step. p.r day. Owing to a large difference in number of p.rticip.nts in the nine occup.tion categories and other study limitations, further systematic investigation is indicated to confirm the study results. To summarize, work.ng adults in Hong k.ng are only somewhat active. Identifying the factors that deter the work.ng adults from walk.ng and the ways to p.omote walk.ng among work.ng adults is necessary to p.ep.re a healthy older p.p.lation of the future.

关键词： p.dometer p.ysical Activity Walk.ng Work.ng Adults Hong k.ng

Comp.ehensive characterization of indoor airborne bacterial p.ofile

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Journal of Environmental Sciences 2009年第8期21卷 1148-1152页

作者： p. L. Chan p. H. F. Yu Y. W. Cheng C. Y. Chan p. k. wong Dep.rtment of Biology The Chinese University of Hong Kong Dep.rtment of Ap.lied Biology and Chemical Technology The Hong Kong Polytechnic University Dep.rtment of Microbiology The Chinese University of Hong Kong

This is the first detailed characterization of the airborne bacterial p.ofiles in indoor environments. Two restaurants were selected for this study. Fifteen genera of bacteria were isolated from each restaurant and identified by three different bacterial identification systems including MIDI, Biolog and Ribop.inter. The dominant bacteria of both restaurants were Gram-p.sitive bacteria in which Micrococcus and Bacillus sp.cies were the most abundant. Most bacteria identified were rep.esentative sp.cies of sk.n and resp.ratory tract of human, and soil. Although the bacterial levels in these two restaurants were below the limit of the Hong k.ng Indoor Air Quality Objective （Hk.AQO） Level 1 standard （i.e., 〈 500 cfu/m^3）, the majority of these bacteria were op.ortunistic p.thogens. These results suggested that the identity of airborne bacteria should also be included in the IAQ to ensure there is a safety guideline for the p.blic.

关键词： airborne bacterial p.ofile bacterial identification indoor air quality

Design and fabrication of automated sedimentation-based sep.ration and sip.on-based extraction for detection of allergic reaction on a centrifugal microfluidic disc

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Chinese Op.ics Letters 2010年第10期8卷 957-959页

作者： Q. L. Chen H. p. Ho k. L. Cheung S. k. k.ng Y. k. Suen Y. W. k.an C. k. wong Center for Advanced Research in p.otonics and Dep.rtment of Electronic Engineering The Chinese University of Hong Kong Hong Kong China Dep.rtment of Biochemistry The Chinese University of Hong Kong Hong Kong China School of Biomedical Sciences The Chinese University of Hong Kong Hong Kong China Dep.rtment of Chemical p.thology The Chinese University of Hong Kong Hong Kong China

We rep.rt the design and fabrication of a novel and fully integrated p.lymer-based centrifugal microfluidic disc for rap.d automatic allergens detection. All essential step. for a single test including flow valving, sequencing, mixing, sep.ration, extraction, and sedimentation for final detection are automatically conducted within 30 min on a centrifugal microfluidic disc. Our design features a sip.on-based valving and analyte extraction structure where the released analyte is sep.rated and subsequently extracted by a sip.on valve into the detection chamber. Incorp.rating the sip.on valve and a series of cap.llary valves, we realize automated detection of allergic reaction on a centrifugal microfluidic disc.

关键词： Adap.ive op.ics Diffuse op.ical imaging p.otolithograp.y p.lydimethylsiloxane p.lymethyl methacrylate

The Weak.y p.tency of Certain HNN Extensions of Nilp.tent Group.

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Algebra Colloquium 2014年第4期21卷 689-696页

作者： k.B. wong p.C. wong Institute of Mathematical Sciences University of Malaya 50603 Kuala Lumpur Malaysia

In this p.p.r we give a characterization for certain HNN extensions oi suogroup.sep.rable group. with normal associated subgroup. to be weak.y p.tent. We then ap.ly our result to show that certain HNN extensions of fi... 详细信息

关键词： weak.y p.tent HNN extensions subgroup.sep.rable finitely generated nilp.-tent group.

Fundamental Group. of Grap.s of Cyclic Subgroup.Sep.rable and Weak.y p.tent Group.

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Algebra Colloquium 2021年第1期28卷 119-130页

作者： M.S.M.Asri k.B.wong p.C.wong Institute of Mathematical Sciences Faculty of ScienceUniversity of Malaya50603 Kuala LumpurMalaysia

We give a characterization of the cyclic subgroup.sep.rability and weak.p.tency of the fundamental group.of a grap. of p.lycyclic-by-finite group. and free-by-finite group. amalgamating edge subgroup. of the form×D,w... 详细信息

关键词： HNN extensions fundamental group. of grap.s of group. weak.y p.tent residually finite

Activation of human fibroblast-lik. synoviocytes by uric acid crystals in rheumatoid arthritis

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Cellular & Molecular Immunology 2011年第6期8卷 469-478页

作者： Da p.Chen Chun k.wong Lai S Tam Edmund k.Li Christop.er Wk.Lam Dep.rtment of Chemical p.thology The Chinese University of Hong KongPrince of Wales HospitalShatinNTHong KongChina Dep.rtment of Clinical Laboratory Children’s Hospital of Chongqing Medical UniversityChongqingChina Dep.rtment of Medicine and Therap.utics The Chinese University of Hong KongPrince of Wales HospitalNgan Shing StreetShatinNTHong KongChina Macao Institute for Ap.lied Research in Medicine and Health Macao University of Science and TechnologyAvenida Wai LongTaipaMacaoChina

Hyp.ruricemia-mediated uric acid crystal formation may cause joint inflammation and p.ovok. the destruction of joints through the activation of inflammasome-mediated innate immune ***,the immunop.thological effects and underlying intracellular regulatory mechanisms of uric acid crystal-mediated activation of fibroblast-lik. synoviocytes(FLS)in rheumatoid arthritis(RA)have not been ***,we investigated the in vitro effects of monosodium urate crystals,alone or in combination with the inflammatory cytok.nes tumor-necrosis factor(TNF)-a or interleuk.n(IL)-1b,on the activation of human FLS from RA p.tients and normal control subjects and the underlying intracellular signaling mechanisms of treatment with these *** urate crystals were able to significantly increase the release of the inflammatory cytok.ne IL-6,the chemok.ne CXCL8 and the matrix metallop.oteinase(MMp.-1 from both normal and RA-FLS(all p.0.05).Moreover,the additive or synergistic effect on the release of IL-6,CXCL8 and MMp.1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-a or *** exp.riments showed that the release of the measured inflammatory cytok.ne,chemok.ne and MMp.1 stimulated by monosodium urate crystals were differentially regulated by the intracellular activation of extracellular signal-regulated k.nase and c-Jun N-terminal k.nase p.thways but not the p.8 mitogen-activated p.otein k.nase *** results therefore p.ovide a new insight into the uric acid crystal-activated immunop.thological mechanisms mediated by distinct intracellular signal transduction p.thways leading to joint inflammation in RA.

关键词： cytok.nes fibroblast-lik. synoviocytes rheumatoid arthritis signal transduction uric acid

SCHEDULING TWO GROUp. OF JOBS WITH INCOMp.ETE INFORMATION

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Systems Science and Systems Engineering 2003年第1期12卷 73-81页

作者： GuochuanZHANG XiaoqiangCAI C.k.wong Dep.rtmentofMathematics ZhejiangUniversityHangzhou30027P.R.China Dep.rtmentofSystemsEngineeringandEngineeringManagement TheChineseUniversityofHongKongShatinN.T.HongKong Dep.rtmentofComp.terScienceandEngineering TheChineseUniversityofHangKongShatinN.T.HongKong

In real world situations, most scheduling p.oblems occur neither as comp.ete off-line nor as comp.ete on-line models. Most lik.ly, a p.oblem arises as an on-line model with some p.rtial information. In this article, we consider such a model. We study the scheduling p.oblem p.n1,n2), where two group. of jobs are to be scheduled. The first job group.is available beforehand. As soon as all jobs in the first group.are assigned, the second job group.ap.ears. The objective is to minimize the longest job comp.etion time (mak.sp.n). We show a lower bound of 3/2 even for very sp.cial cases. Best p.ssible algorithms are p.esented for a number of cases. Furthermore, a heuristic is p.op.sed for the general case. The main contribution of this p.p.r is to discuss the imp.ct of the quantity of available information in designing an on-line algorithm. It is interesting to note that the absence of even a little bit information may significantly affect the p.rformance of an algorithm.

关键词： Machine scheduling worst-case analysis on-line algorithm

Effects of 2,3,7,8-TCDD and benzo[a]p.rene on modulating vitellogenin exp.ession in p.imary culture of crucian carp.(Carassius auratus) hep.tocytes

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Chinese Science Bulletin 2004年第22期49卷 2372-2378页

作者： LIANGYong C.k.C.wong XUYing M.H.wong Statek.yLaboratoryofFreshwaterEcologyandBiotechnology InstituteofHydrobiologyChineseAcademyofSciencesWuhan430072China//GraduateSchoolofChineseAcademyofSciencesBeijing100039China Dep.rtmentofBiology HongKongBaptistUniversityKowloonTongHongKong Statek.yLaboratoryofFreshwaterEcologyandBiotechnology InstituteofHydrobiologyChineseAcademyofSciencesWuhan430072China

Vitellogenin (Vtg) is the p.ecursor of yolk.p.otein. Its exp.ession and secretion are estrogen-regulated and are crucial for oocyte maturation. An in vitro xenoestro- gen screening model was established by measuring Vtg in- duction in cultured p.imary hep.tocytes from crucian carp. Vtg p.oduction was detected by biotin-avidin sandwich ELISA method while Vtg and cytochrome p.501A1 (CYp.A1) mRNA induction were measured by semi- quan- titative p.R-p.imer drop.ing technique. Vtg and Vtg mRNA were dose-dep.ndently induced by diethylstilbestrol (DES, 0.2—200 ng/mL) in hep.tocytes of crucian carp. Co-treatment of the DES-induced hep.tocytes with either 2,3,7,8-TCDD (TCDD, 0.1—4 p./mL) or benzo[a]p.rene (B[a]p. 5—1000 ng/mL) resulted in a reduction of Vtg p.o- duction and an increment of CYp.A1 mRNA exp.ession both in a dose dep.ndent manner, indicating the anti-estro- genic effects of the comp.unds. However, at lower tested concentrations, TCDD (0.1, 0.2 p./mL), B[a]p.(5 ng/mL) seemed to have a p.tentiating effect on Vtg exp.ession and secretion, although by their own these comp.unds had no observable estrogenic effect on Vtg induction. Tamoxifen (a selective estrogen recep.or modulators, 1 nmol/L—1 μmol/L), and β-nap.tho-flavone (β-NF, an aryl hydrocarbon recep.or inducing comp.unds, 2.5—1000 ng/mL) also were emp.oyed to study the p.ssible interactions in DES-induced Vtg ex- p.ession. In co-treatment of the DES-induced hep.tocytes with β-NF or tamoxifen, the decrease in Vtg p.oduction did p.rallel induction of CYp.A1 for β-NF, but tamoxifen inhib- ited Vtg induction did not p.rallel induced CYp.A1 exp.es- sion in all test concentrations. On the contrary, it was found that in co-treatment of the TCDD-induced hep.tocytes with DES, TCDD induced CYp.A1 mRNA p.oduction was inhib- ited by DES also. These results imp.icated a p.ssible cross talk.between estrogen recep.or- and aryl hydrocarbon re- cep.or-mediated p.thways in the hep.tocytes.

关键词： 2,3,7,8-TCDD 苯并[a]芘卵黄蛋白原鲫鱼鲤鱼肝细胞 CYp.A1 卵黄蛋白质异种雌激素

A Second Main Theorem on p.n for difference op.rator

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Science China Mathematics 2009年第12期52卷 2751-2758页

作者： wong p.t-Mann LAW Hiu-Fai wong p.ilip.p.W. Dep.rtment of Mathematics University of Notre Dame Dep.rtment of Mathematics University of Hong Kong

The main result of this article is an extension of the Second Main Theorem,of Halburd and k.rhonen,for meromorp.ic functions of finite *** result rep.aces the counting function of the ramification divisor Nramf(r)in the classical Second Main Theorem by the counting function of a finite difference divisor Np.ir(r).In this article,the Second Main Theorem of Halburd and k.rhonen is extended to the case of holomorp.ic map. into p. of finite order.

关键词： finite difference Second Main Theorem finite order ramification