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Evaluation of a Possible Effect of In-House Cryoprecipitate Transfusion on Outcome of Severe Upper Gastrointestinal Bleeding: A Retrospective Cohort Study

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Open Journal of Blood Diseases 2019年第1期9卷 20-29页

作者： Hiroshi Fujita Shigek. nishimura k.zuhiro Sugiyama Department of Transfusion Medicine Tokyo Metropolitan Bokutoh Hospital Tokyo Japan Tertiary Emergency Medical Center Tokyo Metropolitan Bokutoh Hospital Tokyo Japan

Purposes: Hypofibrinogenemia is usually complicated with severe and massive upper gastrointestinal (GI) bleeding, especially in liver cirrhosis. In Japan, neither fibrinogen concentrate nor cryoprecipitate (CRYO) is available for cases of acquired hypofibrinogenemia to recover the hemostatic level of fibrinogen rapidly. We prepared and produced in-house CRYO from fresh frozen plasma, and compared mortality between pre-implementation and post-implementation of CRYO. Methods: We performed a retrospective cohort study of patients admitted to our single tertiary medical center with upper GI bleeding from January 2011 to December 2016. The observational control period was from January 2011 to February 2013. From March 2013 to December 2016, we implemented the transfusion of CRYO, which was prepared and produced in our hospital. Clinical outcomes were compared between the patients in the two periods. Patients: Eleven patients in the control period and 10 in the intervention period were eligible for analysis. Results: In-hospital mortality (55% vs. 20%, P = 0.238) and mortality within 24 hour after admission (27% vs. 0%, P = 0.246) tended to be lower in the intervention period than in the control period, although the patients had more severe coagulation on admission than those in the control period. The plasma fibrinogen level before the treatment of hemostasis in the intervention period was higher than that in the control period (80 ± 9 mg/dL vs. 127 ± 15 mg/dL, P Conclusion: Implementation of in-house CRYO transfusion may reduce the rate of mortality due to severe upper GI bleeding.

关键词： Esophageal Varix Resuscitation Mortality Hypofibrinogenemia

Sediment Oxygen Demand of a Leachate Pond at an Offshore Municipal Solid Waste Disposal Site 2 Years after the Site Was Closed

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Journal of Geoscience and Environment Protection 2018年第4期6卷 181-193页

作者： Shogo Sak.ta Jun Nishimoto k.zuyuk. nishimura Department of Environmental Sciences Prefectural University of Hiroshima Shobara City Japan

Various water quality parameters of a leachate pond at an offshore municipal solid waste disposal site were monitored. The pH, dissolved oxygen (DO), and water temperature at the bottom of the leachate pond were measured during Sep. (the 1st period) and Nov.-Dec. (the 2nd period) of 2011. The results suggested that the stratification of water temperature in the pond had gradually brok.n down due to convection occurring between the end of the 1st period and the 2nd period. The pH was almost constant at 10 - 11 during the 1st period and was approximately 11.5 during the 2nd period. The DO was almost zero during both periods. An anaerobic batch experiment with sampled sediment was undertak.n to elucidate the mechanism of material leaching from the sediment. DO decreased under all experimental conditions. With respect to oxidation reduction potential (ORP) and total sulfide in addition to DO, the condition most closely mimick.ng that of the site became the most anaerobic. The average sediment oxygen demand, SODave, was calculated using a brief numerical model based on batch experiment data. The SODave was 1114.7 mg/m2/d, indicating that at least 434 g/d of oxygen must be supplied to the leachate pond to maintain the DO.

关键词： Offshore Disposal Site Leachate Pond Sediment Sediment Oxygen Demand

Phosphorylation Properties of the N-Terminal Region of Twitchin from Molluscan Catch Muscle

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American Journal of Molecular Biology 2019年第3期9卷 110-120页

作者： Daisuk. Funabara Yuuk. nishimura Satoshi k.noh Graduate School of Bioresources Mie University Tsu Japan

Molluscan smooth muscles, such as the bivalve adductor muscles and the mussel anterior byssus retractor muscles (ABRM), exhibit a unique contraction called “catch”. Catch contraction is regulated through twitchin phosphorylation and dephosphorylation. Twitchin from the ABRM of the Mediterranean mussel, Mytilus galloprovincialis, is phosphorylated by cAMP-dependent protein k.nase (Pk.), and Pk. phosphorylation sites are located in both the N- and C-terminal regions of the twitchin molecule. The D2 site, which is adjacently located to the C-terminus, participates in forming a myosin, actin, and twitchin complex that is thought to contribute towards the maintenance of tension in the catch state. In contrast, although it has been reported to interact with thin-filaments, the molecular function of the region including the D1 site has remained largely unstudied. Three additional Pk. consensus sequences were identified near the D1 site;however, it was not k.own if these sites could be directly phosphorylated by Pk.. Here, we performed phosphorylation assays to identify phosphorylation sites near the D1 site using recombinant protein variants (TWD1-SSSS, TWD1-AAAS, TWD1-AASA, TWD1-ASAA, TWD1-SAAA, and TWD1-AAAA). All variants, except TWD1-AAAA (where all phosphorylatable serine residues were replaced by alanines), were phosphorylated by Pk.. The four phosphorylation sites were named D1-1, D1-2, D1-3, and D1-4 (the originally identified D1) in order from the N-terminus. Phosphorylation assays using a 1/12.5 weight ratio of Pk. to each TWD1 variant revealed that D1-4 was the most rapidly phosphorylated, closely followed by D1-1. However, D1-2 and D1-3 were phosphorylated at a lower level under equivalent conditions and were not phosphorylated when Pk. was incubated with each TWD1 variant at a 1/100 weight ratio. Furthermore, we observed that TWD1-SSSS was phosphorylated in a stepwise fashion. These findings contribute towards the elucidation of the function of the twitchin D1

关键词： Catch Contraction Phosphorylation Phos-Tag Gel Electrophoresis Pk. Twitchin

Role of narrow band imaging in endoscopic submucosal dissection

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World Journal of Gastrointestinal Endoscopy 2012年第9期4卷 387-397页

作者： k.uichi Nonak. Mak.to nishimura Hiroto k.ta Department of Gastroenterology Saitama Medical University International Medical CenterSaitama 350-1298Japan

Narrow band imaging(NBI) is a new image enhancement system employing optic digital methods to enhance images of blood vessels on mucosal surfaces,allowing improved visualization of mucosal surface *** have progressed over the last several years,and the clinical usefulness has been *** has become frequently applied for preoperative diagnosis before endoscopic submucosal dissection(ESD) of digestive tract cancers,as well as for assessment of the range of ESD for en-bloc resection of large *** has been reached with regard to the usefulness of NBI for detecting micro-lesions of esophageal squamous cell carcinoma indicated for ESD,for the diagnosis of the range and *** has also been attracting attention for diagnosing gastric cancer based on the observation of micro blood vessels on the mucosal surface and mucosal surface *** usefulness of NBI has been reported in relation to various aspects of colon cancer,including diagnoses of the presence,quality,range,and depth of ***,as NBI has not surpassed diagnostic methods based on magnifying observation combined with the established and widely employed dye method,its role in ESD is limited at *** NBI is very useful for the diagnosis of digestive tract cancers,comprehensive endoscopic diagnosis employing the combination of conventional endoscopy including dye spraying,EUS,and NBI may be important and essential for ESD.

关键词： Endoscopic submucosal dissection Narrow band imaging Digestive tract cancer

Corrosion Performance of Si and Al-bearing Ultrafine Grained Weathering Steel

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Corrosion Performance of Si and Al-bearing Ultrafine Grained...

7β-[1-(2-氨噻唑基-4)-1-环丙甲酰氨]头孢烯衍生物的合成及抗菌活性

第二届先进钢铁结构材料国际会议

作者： T.nishimura Corrosion Resistant Group Steel Research Center National Institute for Material Science （NIMS） Japan

＜正＞The iron rust phase has been analyzed by using EPMA and TEM after simulating marine corrosion tests. The ultrafine grained （UFG） weathering steel containing Si and Al showed higher corrosion resistance than carbon steel in the *** and Si were identified as A13+ and Si2+ in the complex oxide of inner rust by EPMA and TEM. It was demonstrated that that Si and Al tak. part in the conversion of inner rust into fine structure that prevents the penetration of Cl ions.

关键词： Rust Al Si Wethering Steel Ultrafine Grain

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国外医药（抗生素分册） 1992年第3期13卷 169-171页

作者： nishimura S 严敏

自发现头孢唑肟、头孢甲肟及头孢噻肟具有强的抗菌活性以来,众多研究工作者对合成烷氧亚氨头孢烯衍生物的研究产生了极大兴趣。在头孢烯C-7位上引入烷氧亚氨基能导致抗菌活性增强并扩大抗菌谱。另一方面,新型的头孢烯衍生物,如SG-164(3)... 详细信息

自发现头孢唑肟、头孢甲肟及头孢噻肟具有强的抗菌活性以来,众多研究工作者对合成烷氧亚氨头孢烯衍生物的研究产生了极大兴趣。在头孢烯C-7位上引入烷氧亚氨基能导致抗菌活性增强并扩大抗菌谱。另一方面,新型的头孢烯衍生物,如SG-164(3)与7432-S(4)。

关键词：头孢烯衍生物合成抗菌活性

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肿瘤的细胞免疫治疗

郑州大学学报（医学版） 2011年第2期46卷 165-169页

作者：张毅 Michael nishimura 郑州大学第一附属医院生物细胞治疗中心郑州450052 郑州大学生物工程系郑州450001 美国南卡罗来纳州医科大学外科学查理斯顿29425

近年来,肿瘤的常规治疗方法均取得了很大改进,患者的长期存活率有所提高。手术、放射治疗和化学治疗能治愈部分肿瘤患者,但由于不能杀死全部肿瘤细胞,多数患者仍不能免于复发或转移的发生。作为现代肿瘤治疗的第4种模式,

关键词：肿瘤细胞免疫治疗肿瘤抗原肿瘤浸润性淋巴细胞

Outcomes of endoscopic endonasal dacryocysto-rhinostomy for intractable lacrimal dacryostenosis and associated factors

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1471-1475页

作者： Tohru Tanigawa Hirok.zu Sasak. Hiroshi Nonoyama Yuichiro Horibe k.nihiro nishimura Tetsuro Hoshino Tetsuya Ogawa k.nta Murotani Hiromi Ueda Masahiro k.neda Department of Otolaryngology Aichi Medical University Department of Otolaryngology Tono Kosei Hospital Division of Biostatistics Clinical Research CenterAichi Medical University Department of Ophthalmology Tono Kosei Hospital

AIM：To examine the effects of patient age,canalicular obstruction,mode of anesthesia,and duration of nasolacrimal intubation on the outcomes of endoscopic endonasal dacryocystorhinostomy（DCR）. METHODS： Totally 56 eyes of 46 patients with prolonged epiphora underwent minimally invasive endoscopic endonasal DCR.A successful surgical outcome was defined as a significant improvement in symptoms,adequate water passage from the puncta to the nasal cavity,and patency of the DCR *** outcomes were assessed at least 6mo after ***＇s exact test was used to discuss the factors,and then the logistic regression analysis was made by SAS9.4 ***： The overall success rate was 75.0%,and complete resolution was observed in 27 *** success rate was higher for patients with ≥6mo intubation than for those with 〈6mo ***,there were no significant differences in outcomes between groups stratified by age（〈65 or ≥65y）,presence or absence of canalicular obstruction,mode of anesthesia（local or general）,and use or nonuse of a radiowave *** patient developed subcutaneous emphysema around the eye and nose and one developed subcutaneous hemorrhage after surgery. CONCLUSION： Endoscopic endonasal DCR can be considered safe and minimally invasive with reasonable success rates,particularly when the duration of nasolacrimal intubation is ≥6mo.

关键词： dacryocystorhinostomy endoscopy,, intubation epiphora

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时间轴上的徘徊——北京西城区城市更新探索

世界建筑 2004年第2期 58-64页

作者： Rik. nishimura,Rachel Jaffe MAUD MUP