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Win. Motion. aroun. the Tropical Cirrus Usin. Simultan.ous Radar an. Lidar Observation. over Gadan.0} (13.45°n. 79.18°E), In.ia

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In.ern.tion.l Journ.l of Geoscien.es 2014年第11期5卷 1241-1253页

作者： C. Dhan.n.aya Rao M. Arun.chalam srinivasan M. k.ishn.iah Y. Bhavan. k.mar S. V. B. Rao Departmen. of Physics Sri Venkateswara University Tirupati India Seshachala In.titute of Techn.logy Puttur India n.tion.l Atmospheric Research Laboratory (n.RL) Gadanki India

The presen. study describes variation.of peak.lin.ar depolarization.ratio (LDR) with win. aroun. the cloud altitude usin. simultan.ous observation.of win.s an. cirrus cloud for the first time usin. In.ian.MST radar an. polarization.lidar co-located over a low latitude station.Gadan.0} (13.7°n.an. 79.2°E). Three differen. cases of passage of the cirrus at differen. altitudes are n.ticed, on. durin. a n.rth-East mon.oon.day an. other two durin. South-West mon.oon.days. The zon.l win. below the cloud height has shown.similar variation.with LDR durin. 02 n.vember 2006 an. the meridion.l win. within.the cloud height durin. 25 July 2007 an. 08 Jun. 2006 has shown.opposite variation.with LDR. Even.though there is a sign.fican. in.rease in.zon.l win. due to the existen.e of tropical easterly jet (TEJ) above cloud height durin. 25 July 2007 an. 08 Jun. 2006, also, the vertical win. is foun. to be con.in.ously varyin. durin. 25 July 2007 an. it is upward domin.n. in.the in.tial stage an. is mostly down.ard in.the later stage of observation.on.08 Jun. 2006, there is a slight descen. in.cloud altitude on.y durin. 25 July 2007. Thus, the win. above the cloud height alon. may n.t affect the ascen./descen. of the cloud top altitude. The poten.ial temperature gradien. is high within.the cloud heights when.the cirrus presen. n.ar the cold poin. tropopause in.icates the maximum air-mass mixin. n.ar the tropopause.

关键词： Cirrus Cloud LDR Win.s TEJ Lidar Radar

蜘蛛丝蛋白n.结构域的p H和盐依赖性寡聚的结构基础

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蜘蛛丝蛋白N端结构域的p H和盐依赖性寡聚的结构基础

硬膜外麻醉下清醒病人的心脏瓣膜替换合并冠状动脉搭桥手术的临床应用

2021第二十一届全国波谱学学术年会

作者： CHAk.ABORTY Rusha 樊劲松 LAI Chon. Cheon. RAGHUVAMSI Palur Ven.0}ta CHEE Pin.Xuan.An.n. Gan.sh srinivasan 杨代文新加坡国立大学生物系

＜正＞蜘蛛丝是由一种或多种类型的丝蛋白（它们的高分子量为300-600k.a的丝蛋白）有序自组装而成。每个丝蛋白由相对保守的n.结构域（n.D）和C端结构域（CTD）以及具有多个重复单位（RP）的非保守结构域组成。蜘蛛丝蛋白以很高的浓度...

＜正＞蜘蛛丝是由一种或多种类型的丝蛋白（它们的高分子量为300-600k.a的丝蛋白）有序自组装而成。每个丝蛋白由相对保守的n.结构域（n.D）和C端结构域（CTD）以及具有多个重复单位（RP）的非保守结构域组成。蜘蛛丝蛋白以很高的浓度（高达50%w/w）存储在蜘蛛丝腺囊区域中。CTD和n.D在防止蜘蛛丝蛋白在成丝前过早聚集方面都起着至关重要的作用。从丝腺囊到喷丝头,蜘蛛丝蛋白经历了几种环境变化,例如p H降低,离子强度下降以及纺丝管直径减小。这些变化改变了蜘蛛丝蛋白的组装模式并触发了纤维的形成。体外研究表明,在高p H和高离子强度下,既在对应丝腺腔内的条件下,所有丝蛋白的n.D均以单体形式存在。从管腔到喷丝头出口,随着p H值和盐浓度的降低,主要和次要ampullate silk.protein.n.D从单体形式转变为反平行二聚体形式[1],但acin.form silk.protein.n.D（AcSpn.组装形成低聚物。

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江苏大学学报（医学版） 2006年第3期16卷 229-231页

作者：曹彬 Vivek.Jawali Murali Chak.avarthy srinivasan k.lar Murali Man.har 南京市鼓楼医院心胸外科 Wock.ardt Hospital&Heart in.titute Bangalore Karnataka 560052India

目的:探索硬膜外麻醉下清醒病人的心脏瓣膜替换合并冠状动脉搭桥手术临床应用的可行性。方法:在高位胸段硬膜外麻醉下对4例术前超声心动图显示主动脉瓣或二尖瓣狭窄和(或)关闭不全,冠状动脉造影显示多支病变的患者行心脏瓣膜替换合并冠... 详细信息

目的:探索硬膜外麻醉下清醒病人的心脏瓣膜替换合并冠状动脉搭桥手术临床应用的可行性。方法:在高位胸段硬膜外麻醉下对4例术前超声心动图显示主动脉瓣或二尖瓣狭窄和(或)关闭不全,冠状动脉造影显示多支病变的患者行心脏瓣膜替换合并冠状动脉搭桥手术,均无气管内插管,所有病人在手术前晚行硬膜外置管。结果:行主动脉瓣替换术3例、二尖瓣替换术1例。冠状动脉搭桥9支(2支桥3例,3支桥1例)。无手术死亡或术中转为全身麻醉病例,术后在外科监护室和病房的住院时间分别为(10.6±8.4)h和(3.5±2.3)d。结论:本组的早期经验提示硬膜外麻醉下清醒病人的心脏瓣膜替换合并冠状动脉搭桥手术避免了气管内插管全身麻醉,从而避免了全身麻醉对身体的伤害。

关键词：清醒病人硬膜外麻醉心脏瓣膜替换合并冠状动脉搭桥手术

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3T磁共振波谱成像证明多发性硬化症中谷氨酸升高

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 61-61页

作者： srinivasan R. Sailasuta n. Hurd R. 夏峰 Cen.er for Molecular an. Fun.tion.l Imagin. Department of Radiology University of California-San Francisco 185 Berry Street SanFrancisco CA 94107- 1739 United States

Histopathological reports of multiple sclerosis an. its an.mal models have sh own.eviden.e of a lin.0}between.axon.l in.ury in.active lesion. an. impaired glut amate metabolism. Mature oligoden.rocytes play a role in.glutamate uptak. to mai n.ain.glutamate homeostasis but in.multiple sclerosis white matter the loss of e xpression.of glutamate tran.porters in.the lesion.vicin.ty results in.in.ffectiv e glutamate removal. Usin. a magn.tic reson.n.e spectroscopy techn.que that isol ates the glutamate reson.n.e at 3 T, we compared glutamate levels between.n.rmal subjects an. multiple sclerosis patien.s in.differen. brain.areas. Metabolite c on.en.ration. (glutamate, glutamin., n. acetyl- aspartate, myo- in.sitol, cho lin., creatin.) were derived from LC model an. corrected for T1 relaxation.time. Glutamate con.en.ration. were foun. to be elevated in.acute lesion. (P=0.02) an.d n.rmal- appearin. white matter (P=0.03), with n. sign.fican. elevation.in.chr on.c lesion. (P=0.77). The n. acetyl- aspartate level in.chron.c lesion. was s ign.fican.ly lower (P n.in.acute lesion. an. n.rmal- appearin. whit e matter. The cholin. level in.acute lesion. was sign.fican.ly higher (P n.in.chron.c lesion.. Eviden.e was also foun. for in.reased glial activity in.multiple sclerosis, with sign.fican.ly higher (P n.sitol leve ls in.acute lesion. compared with con.rol white matter. These in.vivo results su pport the hypothesis that altered glutamate metabolism is presen. in.brain. of m ultiple sclerosis patien.s.

关键词：多发性硬化症磁共振波谱成像弛豫时间产物浓度慢性损伤磁共振波谱技术少突胶质细胞动物模型神经胶质细胞组织病理学

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Vedolizumab for ulcerative colitis: Real world outcomes from a multicen.er observation.l cohort of Australia an. Oxford

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World Journ.l of Gastroen.erology 2020年第30期26卷 4428-4441页

作者： Samba Siva Reddy Pulusu Ashish srinivasan k.upa k.ishn.prasad Dan.el Chen. Jak.b Begun.Charlottek.un. Dan.el Van.Lan.en.erg Len. Thin.Tamara Mogilevsk. Peter De Cruz Graham Radford-Smith Emma Flan.gan.Sally Bell Soleiman.k.shk.oli Miles Sparrow Simon.Ghaly Peter Bampton.Elise Sawyer Susan.Con.or Quart-ul-ain.Rizvi Jan. M An.rews Gillian.Mahy Paola Chivers Simon.Travis Ian.Craig Lawran.e Cen.re for In.lammatory Bowel Diseases St John of God HospitalSubiaco 6008Western AustraliaAustralia Tran.lation.l Gastroen.erology Un.t NIHR Oxford Biomedical Research CentreOxford University Hospitals NHS Foundation TrustJohn Radcliffe HospitalOxford OX39DUUnited Kingdom In.lammatory Bowel Disease Research Group Queensland institute of Medical ResearchHerston 4006QueenslandAustralia Departmen. of Gastroen.erology Mater HospitalBrisbane 4101QueenslandAustralia Departmen. of Gastroen.erology Mater HospitalSouth Brisbane 4101QueenslandAustralia of Gastroen.erology Eastern HealthBox Hill 3128VictoriaAustralia Departmen. of Gastroen.erology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Departmen. of Gastroen.erology Austin HealthHeidelberg 3084VictoriaAustralia Departmen. of Gastroen.erology St Vincent’s HospitalFitzroy 3065VictoriaAustralia Departmen. of Gastroen.erology Northern HealthEpping 3076VictoriaAustralia Departmen. of Gastroen.erology The Alfred HospitalMelbourne 3004VictoriaAustralia Departmen. of Gastroen.erology St Vincent’s HospitalDarlinghurst 2010New South WalesAustralia Departmen. of Gastroen.erology Flinders Medical CentreBedford Park 5042South AustraliaAustralia Departmen. of Gastroen.erology Liverpool HospitalSydney 2170New South WalesAustralia Departmen. of Gastroen.erology Royal Adelaide Hospital&University of AdelaideAdelaide 5000South AustraliaAustralia Departmen. of Gastroen.erology Townsville HospitalDouglas 4814QueenslandAustralia In.titute for Health Research University of Notre DameFremantle 6160Western AustraliaAustralia School of Medicin. an. Pharmacology University of Western AustraliaCrawley 6009Western AustraliaAustralia

BACk.ROUn. Vedolizumab(VDZ),a human.sed mon.clon.l an.ibody that selectively in.ibits alpha4-beta7 in.egrin. is approved for use in.adult moderate to severe ulcerative colitis(UC)*** To assess the efficacy an. safety of VDZ in.the real-world man.gemen. of UC in.a large multicen.er cohort in.olvin. two coun.ries an. to iden.ify predictors of achievin. *** A retrospective review of Australian.an. Oxford,Un.ted k.n.dom data for UC *** respon.e at 3 mo,en.oscopic remission.at 6 mo an. clin.cal remission.at 3,6 an. 12 mo were *** regression.models an. k.plan.Meier curves were performed to assess the time to remission.time to failure an. the covariates in.luen.in. *** outcomes were *** Three hun.red an. three UC patien.s from 14 cen.res in.Australia an. Un.ted k.n.dom,[60%n.182,an.i-Tn. n.ïve]were *** clin.cal respon.e was 79%at 3 mo with more Australian.patien.s achievin. clin.cal respon.e compared to Oxford(83%vs 70%P=0.01).Clin.cal remission.for all patien.s was 56%,62%an. 60%at 3,6 an. 12 mo ***-Tn. n.ive patien.s were more lik.ly to achieve remission.than.exposed patien.s at all the time poin.s(3 mo 66%vs 40%Pn.patien.s achieved en.oscopic remission.at 6 mo compared to Oxford(69%vs 43%P=0.01).On.multi-variate an.lysis,an.i-Tn. n.ïve patien.s were 1.8(95%CI:1.3-2.3)times more lik.ly to achieve remission.than.an.i-Tn. exposed(Pn.s(11%)had colectomy by 12 *** VDZ was safe an. effective with 60%of UC patien.s achievin. clin.cal remission.at 12 mo an. prior an.i-Tn. exposure in.luen.ed this outcome.

关键词： Vedolizumab Ulcerative colitis Outcomes

Sedimen. Characteristics of Tidal Deposits at Man.vi, Gulf of k.chchh, Gujarat, In.ia: Geophysical, Textural an. Min.ralogical Attributes

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In.ern.tion.l Journ.l of Geoscien.es 2012年第3期3卷 515-524页

作者： Deshraj Trivedi Man. Christy Raicy k.ravan.att Devi Deven.er k.mar Ilya Buyn.vich P. srinivasan n.gesh R. Iyer R. Guin.D. Sen.upta Rajesh R. n.ir Departmen. of Earth an. En.iron.en.al Scien.e Temple University 1901 N. 13th Street Philadelphia PA 19122 USA Departmen. of Geology an. Geophysics Indian Institute of Technology Kharagpur-721302 Departmen. of Ocean.En.in.erin. Indian Institute of Technology Madras-600036 n.tion.l Geophysical Research In.titute Hyderabad 500606 India Structural En.in.erin. Research Cen.re Chennai-600113 Variable En.rgy Cyclotron.Cen.re Kolkatta 700064

The textural an. min.ralogical characteristics of subsurface sedimen.s alon. with Groun. Pen.tratin. Radar (GPR) data collected alon. the Western.margin.of In.ia were used to un.erstan. the deposition.l en.iron.en.s an. the proven.n.e of sedimen.s. Textural attributes such as mean. stan.ard deviation. sk.wn.ss an. k.rtosis show fluctuation. due to fluvio-marin. in.eraction.an. it is well un.erstood that the bottom sedimen.s are en.iched with muddy san., which may be deposited by mean.of tidal in.asion. The abun.an.e of very coarse silt to very fin. san. in.icates the prevalen.e of low en.rgy en.iron.en.. The Lin.ar Discrimin.te Fun.tion.an.lysis in.icates the fluvio marin. deposition.of sedimen.s un.er low en.rgy con.ition. GPR data upto a depth of 5 m shows the stratigraphic sequen.es of very fin. san.s an. coarse silt. Optically Stimulated Lumin.scen.e (OSL) datin. of sedimen.s implies that the tidal sedimen.s had deposited between.~30 ± 1 an. ~90 ± 4 years before Presen.. XRD studies results the domin.n.e of k.feldspar an. deficien.y of clay min.rals, in.icatin. that most of the sedimen.s are derived from hin.erlan.. Studies in.icate that the Proven.n.e of sedimen.s in.the Man.vi area is n.t related to In.us delta even.though a con.iderable part of Gulf sedimen.s are deposited by the In.us River.

关键词： Tidal Curren.s Man.vi Grain Size An.lysis XRD GPR Data OSL Ages

Developin. a don.tion.after cardiac death risk.in.ex for adult an. pediatric liver tran.plan.ation

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World Journ.l of Tran.plan.ation 2017年第3期7卷 203-212页

作者： Shirin.Elizabeth k.orsan.i Emman.uil Giorgak.s Hector Vilca-Melen.ez John.O'Grady Michael Hen.ghan.Varun. Aluvihare Abid Suddle k.sh Agarwal k.ishn. Men.n.An.reas Prachalias Parthi srinivasan Mohamed Rela Wayel Jassem n.gel Heaton In.titute of Liver Studies King’s College Hospital

AIM To iden.ify objective predictive factors for don.r after cardiac death(DCD) graft loss an. usin. those factors, develop a don.r recipien. stratification.risk.predictive model that could be used to calculate a DCD risk.in.ex(DCD-RI) to help in.prospective decision.mak.n. on.organ.*** The model in.luded objective data from a sin.le in.titute DCD database(2005-2013, n.= 261). Un.variate survival an.lysis was followed by adjusted Cox-regression.l hazard model. Covariates selected via un.variate regression.were added to the model via forward selection. sign.fican.e level P = 0.3. The warm ischemic threshold was clin.cally set at 30 min. Poin.s were given.to each predictor in.proportion.to their hazard ratio. Usin. this model, the DCD-RI was calculated. The cohort was stratified to predict graft loss risk.an. respective graft survival *** DCD graft survival predictors were primary in.ication.for tran.plan.(P = 0.066), retran.plan.ation.P = 0.176), MELD > 25(P = 0.05), cold ischemia > 10 h(P = 0.292) an. don.r hepatectomy time > 60 min.P = 0.028).Accordin. to the calculated DCD-RI score three risk.classes could be defin.d of low(DCD-RI n.ard(DCD-RI 2-4) an. high risk.DCD-RI > 5) with a 5 years graft survival of 86%, 78% an. 34%, *** The DCD-RI score in.epen.en.ly predicted graft loss(P n. the DCD-RI class predicted graft survival(P < 0.001).

关键词： Liver tran.plan. Don.r after cardiac death Pediatric Adult Survival

血浆胰岛素和血糖对1型糖尿病患者心肌血流的影响

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世界核心医学期刊文摘（心脏病学分册） 2005年第11期1卷 48-49页

作者： srinivasan M. Herrero P. McGill J. B. R. J. Gropler 张平 Cardiovascular Imagin. Laboratory Mallinckrodt Institute of Radiology 510 South Kingshighway Boulevard St. LouisMO63110United States Dr.

OBJECTIVES: The objective of this study was to determin. the impact of in.ulin.an. glucose on.myocardial vasodilator fun.tion.in.patien.s with type 1 diabetes mellitus(T1DM). BACk.ROUn.: The relative importan.e of plasma in.ulin.an. glucose levels on.the abn.rmal vasodilator fun.tion.observed in.T1DM is un.0}own. METHODS: Twen.y T1DM patien.s un.erwen. positron.emission.tomography studies to measure myocardial blood flow(MBF)(in.ml/g/min. at rest(MBFr) an. durin. aden.sin.(MBFa), both un.er baselin. metabolic con.ition. an. then.durin. either hyperin.ulin.-miceuglycemic clamp(HE)(n.10; 40±9 years, 8 female subjects, hemoglobin.A1c HbA1c 7.8±1.1%) or hyperin.ulin.mic-hyperglycemic clamp(HH)(n.10; 44±12 years, 8 female subjects, hemoglobin.A1c 7.7±0.6%). RESULTS: Both groups showed similar MBFr an. MBFa un.er baselin. metabolic con.ition.(p=n.). Compared with baselin. con.ition., MBFr in.reased in.the HH group(pn.t chan.e in.the HE group. Compared with baselin. con.ition., MBFa decreased in.the HH group(pn.t chan.e in.the HE group. Myocardial perfusion.reserve(MPR)(MBFa /MBFr) was similar between.the HE an. HH groups at baselin.(p=n.). Durin. clamp, MPR ten.ed to decrease in.the HH group(pn.t chan.e in.the HE group(p=n.) when.compared with baselin. con.ition.. However, durin. the clamp MPR was sign.fican.ly lower in.the HH group when.compared with the HE group(pn.LUSIOn.: In.the short term, hyperglycemia has a deleterious effect on.myocardial vasodilator fun.tion. which outweighs the ben.ficial effect of hyperin.ulin.mia.

关键词：心肌血流血浆胰岛素血管舒张功能高胰岛素血症

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蜘蛛丝蛋白n.结构域的p H和盐依赖性寡聚的结构基础

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蜘蛛丝蛋白N端结构域的p H和盐依赖性寡聚的结构基础