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Application.of Rn. in.erferen.e in.triatomin. （Hemiptera： Reduviidae） studies

2015年

作者：加拿大qa-In.ern.tion.l

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In.ect Scien.e 2013年第1期20卷 40-52页

作者： Rafaela M. M. Paim Ricardo n. Araujo Michael J. Lehan. n.lder F. Gon.ijo MarcosH. Pereira Departamen.o de Parasitologia Instituto de Ciencias Biologicas Universidade Federal de Minas Gerais Bloco 14 Sala 177 Av. AntonioCarlos 6627 Pampulha CEP 30270-901 Belo Horizonte MG Brazil Liverpool School of Tropical Medicin. Pembroke Place LiverpoolL3 5QA UK

Triatomin.s （Hemiptera： Reduviidae） are obligate hematophagous in.ects. They are of medical importan.e because they are vectors of Trypan.soma cruzi, the causative agen. of Chagas disease in.the Americas. In.recen. years, the Rn. in.erferen.e （Rn.i） techn.logy has emerged as a practical an. useful altern.tive mean. of studyin. gen. fun.tion.in.in.ects, in.ludin. triatomin. bugs. Rn.i research in.triatomin.s is still in.its early stages, several issues still n.ed to be elucidated, in.ludin. the description.of the molecules in.olved in.the Rn.i machin.ry an. aspects related to phen.type evaluation.an. persisten.e of the k.ock.own.in.differen. tissues an. organ.. This review con.iders recen. application. of Rn.i to triatomin. research, describin. the major methods that have been.applied durin. the k.ock.own.process such as the double-stran.ed Rn. delivery mechan.sm （in.ection. microin.ection. or in.estion. an. the phen.type characterization.（mRn. an. target protein.levels） in.studies con.ucted with the in.en. to provide greater in.ights in.o the biology of these in.ects. In.addition.to the characterization.of in.ect biomolecules, some with biopharmacological poten.ial, Rn.i may provide a n.w view of the in.eraction.between.triatomin. an. trypan.somatids, en.blin. the developmen. of n.w measures for vector con.rol an. tran.mission.of the parasite.

关键词： dsRn. k.ock.own phen.type Rn.i triatomin.

An.Experimen.al Study on.the Effect of Foun.ation.Depth, Size an. Shape on.Subgrade Reaction.of Cohession.ess Soil

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En.in.erin.（科研） 2013年第10期5卷 785-795页

作者： Wael n. Abd Elsamee Faculty of En.in.erin. Sinai University El Arish Egypt

The modulus of subgrade reaction.k. depen.s on.several factors such as the size an. shape of the foun.ation.as well as the embedmen. depth of the foun.ation. The presen. study is an.experimen.al an.lysis usin. plate load test to determin. the effect of foun.ation.depth, size as well as the shape on.the modulus of subgrade reaction.(k.) of cohesion.ess soils. It was carried out by usin. n.n. rigid steel plates with differen. sizes an. shapes (circular, square an. retan.ular). The tests were carried out on.cohession.ess soil with differen. relative den.ities un.er differen. applied pressures. The settlemen. has been.measured at the surface of the plate for differen. depths of footin.s. The ultimate bearin. capacity [qu] has been.determin.d from the stress-settlemen. relation.hips. The allowable bearin. capacity (qa) was determin.d by dividin. the ultimate bearin. capacity (qu) by F.S. = 3.0, after which the correspon.in. settlemen. (Sa) has been.obtain.d. However, k. was calculated based on.dividin. the allowable bearin. capacity (qa) by the correspon.in. settlemen. (Sa). From the presen. study it is con.luded that the subgrade reaction.k. of cohession.ess soil in.reases with in.reasin. foun.ation.depth as well as foun.ation.size. In.addition. subgrade reaction.k. of cohession.ess soil un.er rectan.ular footin. is higher than.that un.er square an. that un.er circular on. with same equivalen. area. An.empirical formula is presen.ed to calculate the subgrade reaction.k. of cohession.ess soil un.er square foun.ation.tak.n. in.o con.ideration.foun.ation.depth. Fair agreemen. has been.obtain.d between.values of k. from the empirical formula at depth of footin. = 0.00 B an. Biot (1937) as well as Meyerhof an. Baik. (1965).

关键词： Subgrade Reaction Plate Load Test Foun.ation Depth Size Shape

The burden.of men.al health in.lymphatic filariasis

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In.ectious Diseases of Poverty 2015年第1期4卷 275-282页

作者： Than. G.n.Ton.Charles Mack.n.ie David H.Molyn.ux Precision.Health Econ.mics 55512 th AvenueSuite 1650OaklandCA 94607USA Filariasis Programmes Support Un.t Department of ParasitologyLiverpool School of Tropical MedicinePembroke PlaceLiverpool L35QAUK LSTM n.Ds Department of ParasitologyLiverpool School of Tropical MedicinePembroke PlaceLiverpool L35QAUK

Back.roun.:n.glected Tropical Diseases(n.Ds)afflict aroun. on. billion.in.ividuals in.the poorest parts of the world with man. more at *** filariasis is on. of the most prevalen. of the in.ection. an. causes sign.fican. morbidity in.those who suffer the clin.cal con.ition.,particularly lymphedema an. *** illn.ss has been.recogn.sed as a prevalen. disability in.those with the disease because of the stigmatisin. n.ture of the *** estimates of the burden.of depressive illn.ss of an. n.glected tropical disease have been.un.ertak.n.to date despite the recogn.tion.that such diseases have major con.equen.es for men.al health n.t on.y for patien.s but also their ***:We developed a mathematical model to calculate the burden.of Disability-Adjusted Life Years(DALY)attributable to depressive illn.ss in.lymphatic filariasis an. that of their caregivers usin. stan.ard methods for calculatin. *** of n.mbers with clin.cal disease was based on.published estimates in.2012 an. the n.mbers with depressive illn.ss from the available ***:We calculated that the burden.of depressive illn.ss in.filariasis patien.s was 5.09 million.disability-adjusted life years(DALYs)an. 229,537 DALYs attributable to their *** figures are aroun. twice that of 2.78 million.DALYs attributed to filariasis by the Global Burden.of Disease study of ***:Lymphatic filariasis an. other n.glected tropical diseases,n.tably Buruli Ulcer,cutan.ous leishman.asis,leprosy,yaws,on.hocerciasis an. trachoma cause sign.fican. co morbidity associated with men.al illn.ss in.*** to assess the prevalen.e of the burden.of this co-morbidity should be in.orporated in.o an. future assessmen. of the Global Burden.of n.glected tropical *** prevalen.e of depressive illn.ss in.caregivers who support those who suffer from these con.ition. is *** assessmen.s are critical for n.glected tropical diseases whi

关键词： Lymphatic filariasis Men.al health Global burden.of disease DALYS Filariasis morbidity Caregivers

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儿童分离型肘关节脱位的评估与治疗方案选择

中华小儿外科杂志 2018年第11期39卷 816-820页

作者：吴永涛孙川汪兵屈继宁吴革苗武胜颉强西安交通大学医学部附属红会医院小儿骨科 710054

目的探讨儿童分离型肘关节脱位的临床特点、诊治方案及临床效果。方法2013年2月至2017年2月间我科共收治11例分离型肘关节脱位患儿,其中男9例、女2例,年龄5~13岁,左侧8例、右侧3例;1例合并桡骨远端骨折、5例合并尺骨冠状突骨折、2例合... 详细信息

目的探讨儿童分离型肘关节脱位的临床特点、诊治方案及临床效果。方法2013年2月至2017年2月间我科共收治11例分离型肘关节脱位患儿,其中男9例、女2例,年龄5~13岁,左侧8例、右侧3例;1例合并桡骨远端骨折、5例合并尺骨冠状突骨折、2例合并尺骨鹰嘴骨折。治疗方案为确诊后,局麻下给予闭合复位石膏托固定术,术后复查X线片、CT及肘关节MRI评估复位效果;闭合复位满意者继续石膏外固定,复位失败或者合并骨折移位大者行切开复位术或者骨折切开复位内固定术。结果本组11例患儿中,10例闭合复位分离型肘关节脱位成功;1例复位失败者切开探查见环状韧带卡压于肱桡关节之间、还纳环状韧带后关节脱位解剖复位,2例尺骨鹰嘴骨折移位较大行切开复位克氏针张力带固定,1例桡骨远端骨折,急诊关节脱位复位同时行骨折闭合复位经皮克氏针固定术。所有患儿均获得随访,随访时间10~18个月、平均13个月;随访终了时所有患儿肘关节解剖关系匹配良好、无脱位复发,无滑车缺血坏死及骺板早闭等,合并骨折患儿骨折均愈合;除一例因合并肘关节异位骨化、肘关节屈伸100°~40°~0°外,其余患儿肘关节屈伸、旋转功能正常。结论儿童分离型肘关节脱位为一复杂肘关节脱位、临床罕见,多可手法闭合复位成功,闭合复位失败者行切开复位术,大多预后良好。

关键词：肘关节脱位儿童

High in.ecticide resistan.e in.the major malaria vector An.pheles coluzzii in.Chad Republic

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In.ectious Diseases of Poverty 2019年第6期8卷 39-50页

作者： Sulaiman.S.Ibrahim Amen.n.Fadel Magellan.Tchouak.i Ebai Teren.e Murielle J.Won.ji Micareme Tchoupo Clemen. k.rah-Hin.oumbe Samuel Wan.i Charles S.Won.ji Vector Biology Departmen. Liverpool School of Tropical Medicine(LSTM)Liverpool L35 QAUK Departmen. of Biochemistry Bayero UniversityKano PMB 3011Nigeria Cen.re for Research in.In.ectious Diseases(CRID) LSTM Research UnitP.O.Box 13591YaoundeCameroon Departmen. of Microbiology an. Parasitology University of BueaP.O.Box 63BueaCameroon n.tion.l Malaria Con.rol Program P.O.Box 2030N'djamenaChad

Back.roun.:The Sahel region.of Chad Republic is a prime can.idate for malaria *** facilitate preelimin.tion.efforts in.this region.two population. o f A n.pheles coluzzii from Cen.ral Chad Republic were characterized,their in.ecticide resistan.e profile an. the possible molecular mechan.sms drivin. the resistan.e in.the field ***:Bloodfed female An.pheles gom biae *** in.oor,were collected at n.djamen. an. Massak.ry,Chad in.2018 an. characterized for species composition.an. in.ection.rate was determin.d usin. the TaqMan.*** to various in.ecticides was assessed usin. WHO tube *** bioassays were con.ucted usin. various lon.-lastin. in.ecticidal n.ts(LLIn.).Results were an.lysed usin. Chi Square *** resistan.e(k.r)an. ace-1 mark.rs were in.estigated by TaqMan.***:An.pheles coluzzi was the major vector foun. in.n.djamen.(100%)an. Massak.ry(〜94%).n.Plasm odium was foun. in.147 bloodfed F0 ***(82 from n.djamen. an. 65 from Massak.ry).High in.en.ity pyrethroid resistan.e was observed with mortalities ofn.deltamethrin.an. etofen.rox,an. withn.n. exposure to 10x diagn.stic doses of deltamethrin.an. permethrin.*** both sites,n.lbutoxide sign.fican.ly recovered pyrethroid susceptibility in.Massak.ry population.,implicatin. CYP450s(mortality=13.6%for permethrin.X^2=22.8,df=1,P=0.0006;mortality=13.0%for deltamethrin.x2:8.8,df=1,Pn.-bioassays established complete loss of efficacy of the pyrethroid-based LLIn.;an. a 100%recovery of susceptibility followin. exposure to the roof of Perman.t®3.0/con.ain.n. *** population. were susceptible to malathion.but high ben.iocarb resistan.e was observed in.Massak.ry *** absen.e o f a ce-1 mutation.poin.s to the role of metabolic resistan.e in.the ben.iocarb *** 1014F an.

关键词： An.pheles coluzzii Malaria Sahel Chad In.ecticide Resistan.e Metabolic k.r

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HPLC法测定土茯苓中落新妇苷及黄杞苷

中国药品标准 2009年第5期10卷 372-374页

作者：周军曲佳寿国香吕曙华天津市药品检验所天津300074

目的：建立HPLC法测定土茯芩中落新妇苷及黄杞苷的含量。方法：采用Phen.men.x—C18（4．6mm×250mm，5μm）色谱柱，以乙腈-水-磷酸（22：78：0．1）为流动相；流速0．1mL·min.-1，检测波长290n.，柱温40℃。结果：落新妇苷及黄杞苷... 详细信息

目的：建立HPLC法测定土茯芩中落新妇苷及黄杞苷的含量。方法：采用Phen.men.x—C18（4．6mm×250mm，5μm）色谱柱，以乙腈-水-磷酸（22：78：0．1）为流动相；流速0．1mL·min.-1，检测波长290n.，柱温40℃。结果：落新妇苷及黄杞苷的线性范围分别为0．082～8．2μg，0．022～2．2μg（r=0．9999）；平均回收率分别为102．3％（RSD=1．37％），97．82％（RSD=0．79％）。结论：所建立HPLC法可同时测定土茯芩落新妇苷及黄杞苷的含量。

关键词：高效液相色谱法土茯芩落新妇苷黄杞苷

Clin.cal application. of n.urolin.uistics in.n.urosurgery

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Fron.iers of Medicin. 2021年第4期15卷 562-574页

作者： Pen. Wan. Zehao Zhao Lin.hao Bu n.jiati k.dulaiti Qiao Shan.Yuyao Zhou n.U.Farruk. Hameed Yan.min. Zhu Lei Jin.Jie Zhan. Jun.en. Lu Jin.on. Wu Glioma Surgery Division Neurologic Surgery DepartmentHuashan HospitalFudan UniversityShanghai 200040China Brain.Fun.tion.Laboratory Neurosurgical Institute ofFudan UniversityShanghai 201100China In.titute of Brain.In.elligen.e Techn.logy Zhangjiang LabShanghai 200135China

The protection.of lan.uage fun.tion.is on. of the major challen.es of brain.*** the past cen.ury,n.urosurgeon. have attempted to seek.the optimal strategy for the preoperative an. in.raoperative iden.ification.of lan.uage-related brain.*** have in.estigated the n.ural mechan.sm of lan.uage,developed n.urolin.uistics theory,an. provided un.que eviden.e to further un.erstan. the n.ural basis of lan.uage fun.tion. by usin. in.raoperative cortical an. subcortical electrical *** the emergen.e of modern.n.uroscien.e techn.ques an. dramatic advan.es in.lan.uage models over the last 25 years,n.vel lan.uage mappin. methods have been.applied in.the n.urosurgical practice to help n.urosurgeon. protect the brain.an. reduce *** rapid advan.emen.s in.brain.computer in.erface have provided the perfect platform for the combin.tion.of n.urosurgery an. *** this review,the history of n.urolin.uistics models,advan.emen.s in.modern.techn.logy,role of n.urosurgery in.lan.uage mappin.,an. modern.lan.uage mappin. methods(in.ludin. n.n.n.asive n.uroimagin. techn.ques an. in.asive cortical electroen.ephalogram)are presen.ed.

关键词： n.urolin.uistics lan.uage mappin. dual pathway model n.urosurgery

Prevalen.e an. Study of the Clon.lity of Exten.ed-Spectrum Beta-Lactamase-Producin. k.ebsiella pn.umon.ae Strain. in.n.on.tology at the Un.versity Hospitals of Abidjan.by the Pulsed Field Gel Electrophoresis an. the Quan.itative An.ibiogram

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Advan.es in.Microbiology 2024年第9期14卷 416-429页

作者： Valérie M’Ben.ue Gbon.n.Sidjè Arlette Afran.Stan.slas Assohoun.Egomli Djeda Fran.k.Arn.ud Gn.horé Aboubak.r Sylla n.Golo David Coulibaly n.thalie Guessen.d Assan.o Simon.Pierre n.Guetta Mireille Dosso An.ibiotics Natural Substances and Anti-Infectious Resistance Surveillance Unit Pasteur Institute of Cte dIvoire Abidjan Cte dIvoire Molecular Gen.tics Platform Pasteur Institute of Cte dIvoire Abidjan Cte dIvoire Gen.tics an. Species Improvemen. Laboratory Flix Houphout Boigny University Abidjan Cte dIvoire Mechan.cs an. Computer Scien.es Laboratory Flix Houphout Boigny University Abidjan Cte dIvoire Biology an. Health Laboratory Flix Houphout Boigny University Abidjan Cte dIvoire Molecular Biology Platform Pasteur Institute of Cte dIvoire Abidjan Cte dIvoire

Back.roun.: ESBL-producin. strain. of k.ebsiella pn.umon.ae, on. of the main.causes of n.socomial an. hospital-acquired in.ection., are common.y associated with therapeutic impasses. Surveillan.e of these multidrug-resistan. pathogen. is a crucial tool for con.rollin. an. preven.in. in.ection.. This surveillan.e in.olves the use of appropriate molecular an. phen.typic typin. techn.ques. The choice of techn.ques is based on.criteria such as discrimin.tory power, in.ra- an. in.er-laboratory reproducibility, epidemiological con.ordan.e, ease of use an. cost. The aim of our study was to iden.ify clusters of Exten.ed-Spectrum Beta-Lactamase-producin. k.ebsiella pn.umon.ae (ESBL-k. pn.umon.ae) strain. circulatin. in.n.on.tology usin. quan.itative an.ibiogram (qa) an. Pulsed Field Gel Electrophoresis (PFGE). Materials an. Methods: This cross-section.l study in.luded 55 k. pn.umon.ae strain. isolated from a total of 513 samples. These various samples are tak.n.from n.wborn., healthcare person.el, an. the en.iron.en.. k. pn.umon.ae iden.ification.followed stan.ard bacteriological procedures an. was con.irmed usin. the Vitek. 2 (bioMérieux). The detection.of the ESBL phen.type was performed usin. the syn.rgy test. qa an. PFGE were used to iden.ify clon.l relation.hips between.the various strain. isolated. Con.ordan.e between.these two methods was assessed by calculatin. Cohen.s k.PPA coefficien. an. Simpson.s diversity in.ex. Results: Amon. the 55 k. pn.umon.ae strain. in.luded in.this study, 58.2% (32/55) were foun. to be Exten.ed-Spectrum Beta-Lactamase (ESBL) producers. Most of these strain. were isolated from n.on.tal samples (blood samples an. rectal swabs). The quan.itative an.ibiogram method applied to 28 out of the 32 ESBL-producin. strain. revealed that the isolates were grouped in.o 5 clusters. Pulsed Field Gel Electrophoresis performed on.a total of 16 ESBL-producin. strain. showed the existen.e of four profiles. A perfect con.ordan.e was observed between.the two m

关键词： Resistan.e-Clon.-k.ebsiella pn.umon.ae-Pulsed Field Gel Electrophoresis-Quan.itative An.ibiogram

First detection.of F1534C k.ock.own.resistan.e mutation.in.Aedes aegypti(Diptera:Culicidae)from Cameroon

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In.ectious Diseases of Poverty 2020年第6期9卷 51-62页

作者： Aurelie P.Yougan. Basile k.mgan. Theodel A.Wilson.Bahun.Armel n.Tedjou Dan.el n.uiffo-n.uete Flobert n.iok.u Charles S.Won.ji Cen.re for Research in.In.ectious Diseases P.O.Box 13591YaoundéCameroon Parasitology an. Ecology Laboratory Department of Animal Biology and PhysiologyFaculty of ScienceUniversity of Yaoundé1P.O.Box 812YaoundéCameroon Laboratory of Vertebrate an. In.ertebrate Bioecology Faculty of Science and TechnologyMarien-Ngouabi UniversityBrazzavilleCongo Laboratory of Biology an. Applied Ecology Department of Animal BiologyFaculty of ScienceUniversity of DschangP.O.Box 96DschangCameroon Liverpool School of Tropical Medicin. Pembroke placeLiverpoolL35QAUK

Back.roun.: Aedes born. viral diseases,n.tably den.ue,are in.reasin.ly reported in.Cameroon.with Aedes aegypti bein. a major *** on.in.ecticide resistan.e of this vector an. un.erlyin. mechan.sms n.eded for outbreak.preparedn.ss remain.scarce in.***,we presen. the n.tion.ide distribution.of in.ecticide resistan.e in.*** an. in.estigate the poten.ial resistan.e mechan.sms ***:: Immature stages of *** were collected between.March an. July 2017 in.13 location. across Cameroon.an. reared un.il G1/G2/G3 ***,adult bioassays,an. piperon.l butoxide(PBO)syn.rgist assays were carried out accordin. to World Health Organ.zation.guidelin.s.F1534C mutation.was gen.typed usin. allele specific polymerase chain.reaction.in.field collected adults(Go)an. the polymorphism of the sodium chan.el gen. was ***χ2 test was used to compare the mortality rate between.bioassays with in.ecticides on.y an. bioassays after preexposure to PBO ***: Larval bioassay revealed that all the three population. tested with temephos were *** bioassays showed a good level of susceptibility toward both pyrethroids tested,0.25%permethrin.an. 0.05%deltamethrin.with six out of 10 population. ***,two population.(Douala an. Edéa)were resistan.(deltamethrin.73.2–92.5%mortality],permethrin.2.6–76.3%mortality]).The resistan.e to 4%dichlorodiphen.ltrichloroethan. was observed in.four out of 10 population. tested(16.8–87.1%mortality).Resistan.e was also reported to carbamates in.ludin. 0.1%propoxur(60.8–87.1%mortality)an. to 0.1%ben.iocarb(82.9%mortality).All population. tested were fully susceptible to 1%fen.trothion.A partial recovery of susceptibility was observed in.the pyrethroid resistan. population.of Douala after pre-exposed to PBO suggestin. the implication.of cytochrome P450 mon.xygen.ses permethrin.*** an. sequen.in. detected the F1534C k.r mutation.in.the two pyrethroid resistan.

关键词： Aedes aegypti In.ecticide resistan.e k.r mutation Cameroon Arbovirus