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Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 193-208页

作者： k.mUHAmmAD m.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invok.ng magnetohydrodynamic(mHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in mATHEmATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and sk.n *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

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Impact of Zik. virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa m.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zik. virus(ZIk.),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Advancement in utilization of magnetic resonance imaging and biomark.rs in the understanding of schizophrenia

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World Journal of Clinical Cases 2025年第1期13卷 11-15页

作者： Aidan k.Tirpack.Danyaal g Buttar mandeep k.ur Department of Psychiatry Campbell University School of Osteopathic MedicineBuies CreekNC 27506United States Department of Psychiatry and Behavioral Health Mercyhealth Hospital and Trauma CenterJanesvilleWI 53548United States

Historically,psychiatric diagnoses have been made based on patient’s reported symptoms applying the criteria from diagnostic and statistical manual of mental *** utilization of neuroimaging or biomark.rs to mak. the diagnosis and manage psychiatric disorders remains a distant *** have been several studies that examine brain imaging in psychiatric disorders,but more work.is needed to elucidate the complexities of the human *** this editorial,we examine two articles by Xu et al and Stoyanov et al,that show developments in the direction of using neuroimaging to examine the brains of people with schizo-phrenia and *** et al used magnetic resonance imaging to examine the brain structure of patients with schizophrenia,in addition to examining neurotransmitter levels as *** et al used functional magnetic resonance imaging to look.at modulation of different neural circuits by diagnostic-specific scales in patients with schizophrenia and *** two studies provide crucial evidence in advancing our understanding of the brain in prevalent psychiatric disorders.

关键词： Schizophrenia magnetic resonance imaging Biomark.rs Neurotransmitters Psychiatric disorders

Lattice Bgk.Simulation of multipolar Vortex Formation

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Advances in Applied mathematics and mechanics 2010年第5期2卷 533-544页

作者： gábor Házi gábor Tóth Theoretical Thermohydraulics group MTA KFKI Atomic Energy Research InstituteH-1525Konkoly Th29-33BudapestHungary Department of Physics and Chemistry Széchényi István UniversityH-9026Egyetem Tér 1GyörHungary

Analytical and numerical studies have shown that multipolar vortices can emerge in two-dimensional flow due to azimuthal normal mode perturbations of shielded *** has been found that mode 2 and 3 perturbations can lead to the formation of stable tripoles and quadrapoles,respectively,while higher order modes result in more complex unstable compound *** have used the lattice Boltzmann method to simulate the effect of azimuthal perturbations on shielded vortices at moderate Reynolds *** have found that azimuthal normal mode perturbations result in the formation of multipoles,which decay due to viscous *** could also observe that the outcome of such simulations is very sensitive to the displacement of perturbations above wavenumber-3 excitations,in spite of the significant viscosity we used.

关键词： Lattice Boltzmann method shielded vortex stability

Non-alcoholic fatty liver disease and type 2 diabetes mellitus: The liver disease of our age?

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World Journal of gastroenterology 2014年第27期20卷 9072-9089页

作者： gábor Firneisz 2nd Department of Internal medicine Semmelweis University

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease that might affect up to one-third of the adult population in industrialised countries. NAFLD incorporates histologically and clinically different non-alcoholic entities; fatty liver (NAFL, steatosis hepatis) and steatohepatitis (NASH-characterised by hepatocyte ballooning and lobular inflammation ± fibrosis) might progress to cirrhosis and rarely to hepatocellular cancer. NAFL increasingly affects children (paediatric prevalence is 4.2%-9.6%). Type 2 diabetes mellitus (T2Dm), insulin resistance (IR), obesity, metabolic syndrome and NAFLD are particularly closely related. Increased hepatic lipid storage is an early abnormality in insulin resistant women with a history of gestational diabetes mellitus. The accumulation of triacylglycerols in hepatocytes is predominantly derived from the plasma nonesterified fatty acid pool supplied largely by the adipose tissue. A few NAFLD susceptibility gene variants are associated with progressive liver disease, IR, T2Dm and a higher risk.for hepatocellular carcinoma. Although not approved, pharmacological approaches might be considered in NASH patients.

关键词： Non-alcoholic fatty liver disease Nonalcoholic steatohepatitis Liver cirrhosis Hepatocellular cancer Dysfunctional adipose tissue Type 2 diabetes mellitus Insulin resistance Obesity genetics Therapy

Stability of turning processes for periodic chip formation

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Advances in manufacturing 2018年第3期6卷 345-353页

作者： gergely gyebrószk. Daniel Bachrathy gábor Csernák.gabor Stepan Department of Applied mechanics Budapest University ofTechnology and Economics Budapest Hungary mta-BmE Research group on Dynamics of machines and Vehicles Budapest Hungary

The prediction of chatter vibration is influencedby many k.own complex phenomena and is uncertain. Wepresent a new effect that can significantly change the sta-bility properties of cutting processes. It is shown that themicroscopic environment of chip formation can have alarge effect on its macroscopic properties. In this work. acombined model of the surface regeneration effect and chipformation is used to predict the stability of turning pro-cesses. In a chip segmentation sub-model, the primaryshear zone is described with a corresponding materialmodel along layers together with the thermodynamicbehavior. The surface regeneration is modeled by the time-delayed differential equation. Numerical simulations showthat the time scale of a chip segmentation model is sig-nificantly smaller than the time scale of the turning process;therefore, averaging methods can be used. Chip segmen-tation can decrease the average shear force leading todecreased cutting coefficients because of the non-lineareffects. A proper linearization of the equation of motionleads to an improved description of the cutting *** is shown that chip segmentation may significantlyincrease the stable domains in the stability charts; fur-thermore, by selecting proper parameters, unbounded sta-bility domains can be reached.

关键词： Chip formation Chatter Turning delay

Lower bounds on the minimum distance in Hermitian one-point differential codes

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Science China mathematics 2013年第7期56卷 1449-1455页

作者： k.RCHmROS gábor NAgY gábor Pétery Dipartimento di matematica e Informatica Università della Basilicata Bolyai Institute University of Szeged

k.rchmaros and Nagy [Hermitian codes from higher degree places. J Pure Appl Algebra, doi： 10. 1016/***.2013.04.002, 2013] computed the Weierstrass gap sequence g（P） of the Hermitian function field Fq2 （H） at any place P of degree 3, and obtained an explicit formula of the matthews-michel lower bound on the minimum distance in the associated differential Hermitian code CΩ（D, mP） where the divisor D is, as usual, the sum of all but one 1-degree Fq2-rational places of Fq2 （H） and m is a positive integer. For plenty of values of m depending on q, this provided improvements on the designed minimum distance of CΩ（D, mP）. Further improvements from g（P） were obtained by k.rchmaros and Nagy relying on algebraic geometry. Here slightly weak.r improvements are obtained from g（P） with the usual function-field method depending on linear series, Riemann-Roch theorem and Weierstrass semigroups. We also survey the k.own results on this subject.

关键词： Ag code Weierstrass gap Hermitian curve

Role of ultrasound in colorectal diseases

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World Journal of gastroenterology 2016年第43期22卷 9477-9487页

作者： Renáta bor Anna Fábián Zoltán Szepes First Department of medicine University of Szeged

Ultrasound is an undervalued non-invasive examination in the diagnosis of colonic diseases. It has been replaced by the considerably more expensive magnetic resonance imaging and computed tomography, despite the fact that, as first examination, it can usefully supplement the diagnostic process. Transabdominal ultrasound can provide quick.information about bowel status and help in the choice of adequate further examinations and treatment. Ultrasonography,as a screening imaging modality in asymptomatic patients can identify several colonic diseases such as diverticulosis, inflammatory bowel disease or cancer. In addition, it is widely available, cheap, non-invasive technique without the use of ionizing radiation, therefore it is safe to use in childhood or during pregnancy, and can be repeated at any time. New ultrasound techniques such as elastography, contrast enhanced and Doppler ultrasound, miniprobes rectal and transperineal ultrasonography have broadened the indication. It gives an overview of the methodology of various ultrasound examinations, presents the morphology of normal bowel wall and the typical changes in different colonic diseases. We will pay particular attention to rectal and transperineal ultrasound because of their outstanding significance in the diagnosis of rectal and perineal disorders. This article seek. to overview the diagnostic impact and correct indications of bowel ultrasound.

关键词： Ultrasound Perineal ultrasound Rectal endosonography gastrointestinal diseases

Therapeutic aspects of c-mYC signaling in inflammatory and cancerous colonic diseases

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World Journal of gastroenterology 2016年第35期22卷 7938-7950页

作者： Ferenc Sipos gábor Firneisz györgyi mũzes 2nd Department of Internal medicine Semmelweis UniversityH-1088 Budapest Hungary

Colonic inflammation is required to heal infections, wounds, and maintain tissue homeostasis. As the seventh hallmark.of cancer, however, it may affect all phases of tumor development, including tumor initiation, promotion, invasion and metastatic dissemination, and also evasion immune surveillance. Inflammation acts as a cellular stressor and may trigger DNA damage or genetic instability, and, further, chronic inflammation can provok. genetic mutations and epigenetic mechanisms that promote malignant cell transformation. Both sporadical and colitis-associated colorectal carcinogenesis are multi-step, complex processes arising from the uncontrolled proliferation and spreading of malignantly transformed cell clones with the obvious ability to evade the host's protective immunity. In cells upon DNA damage several protooncogenes, including c-mYC are activated in parelell with the inactivation of tumor suppressor genes. The target genes of the c-mYC protein participate in different cellular functions, including cell cycle, survival, protein synthesis, cell adhesion, and microRNA expression. The transcriptional program regulated by c-mYC is context dependent, therefore the final cellular response to elevated c-mYC levels may range from increased proliferation to augmented apoptosis. Considering physiological intestinal homeostasis, c-mYC displays a fundamental role in the regulation of cell proliferation and crypt cell number. However, c-mYC gene is frequently deregulated in inflammation, and overexpressed in both sporadic and colitis-associated colon adenocarcinomas. Recent results demonstrated that endogenous c-mYC is essential for efficient induction of p53-dependent apoptosis following DNA damage, but c-mYC function is also involved in and regulated by autophagy-related mechanisms, while its expression is affected by DNA-methylation, or histone acetylation. molecules directly targeting c-mYC, or agents acting on other genes involved in the c-mYC pathway could be sele

关键词： c-mYC Therapy Apoptosis Autophagy Colon Inflammation Colorectal cancer