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Modern Research in Inflammation 2014年第2期3卷 37-47页

作者： Y. k.miya Y. Ishihara H. k.mei Y. Ozawa H. Mizutani k. kubo H. Maeda T. Noguchi Department of Pathology School of Dentistry Aichi-Gakuin University Nagoya Japan Department of Periodontology School of Dentistry Aichi-Gakuin University Nagoya Japan

Back.round and Objective: Interleuk.n-1 (IL-1) binds to 2 distinct and separate receptors, types I and II (IL-1RI and IL-1RII, respectively). The binding of IL-1 to IL-1RI induces cellular signaling and biological effects, whereas binding to IL-1RII does not induce cellular signaling and indirectly inhibits IL-1 biological activities such as that of the decoy receptor. Recently, Suzuk.et *** that soluble IL-1RII (sIL-1RII) was detected in gingival crevicular fluid from a periodontitis patient. However, it remains unclear which cells produce sIL-1RII detected in periodontal tissues. We examined the localization of IL-1RII producing cells in gingival tissues as well as related production control mechanisms. Material and Methods: IL-1RII mRNA expression in gingival epithelial cells (GE1) was performed by real-time PCR analysis, while the amount of sIL-1RII production in supernatant from GE1 cells was examined by dot-blot analysis. Involvement of the phosphorylation of STAT6 in the signaling pathway was determined by western blot analysis. Statistical analysis was performed with Student’st-test. Results: Culturing with IL-4 and IL-13 significantly increased IL-1RII mRNA to levels 10.5-and 8.89-fold, respectively, above that of the control (pk.ge by IFN-γ downstream of STAT6 translocation.

关键词： IL-1RII IL-4 IL-13 IFN-γ STAT-6

Existence and Asymptotic Behavior of Radially Symmetric Solutions to a Semilinear Hyperbolic System in Odd Space Dimensions

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Chinese Annals of Mathematics,Series B 2006年第5期27卷 507-538页

作者： Hideo kubo k.ji kuboTA Department of Mathematics Osak. University Machikaneyama 1-1ToyonakaOsaka 560-0043Japan Department of Mathematics Hok.aido University Sapporo 060-0810Japan

This paper is concerned with a class of semilinear hyperbolic systems in odd space dimensions. Our main aim is to prove the existence of a small amplitude solution which is asymptotic to the free solution as t →-∞ in the energy norm, and to show it has a free profile as t →＋∞. Our approach is based on the work.of [11]. Namely we use a weighted L^∞ norm to get suitable a priori estimates. This can be done by restricting our attention to radially symmetric solutions. Corresponding initial value problem is also considered in an analogous framework. Besides, we give an extended result of [14] for three space dimensional case in Section 5, which is prepared independently of the other parts of the paper.

关键词： Semilinear wave equations Asymptotic behavior Radially symmetric solution

Two Tightly Link.d Genes at the hsal Locus Cause Both F1 and F2 Hybrid Sterility in Rice

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Molecular Plant 2016年第2期9卷 221-232页

作者： Tak.hik. kubo Plant Genetics Laboratory National Institute of Genetics Mishima Shizuoka 411-8540 Japan Department of Genetics SOKENDAI (the Graduate University for Advanced Science) Mishima Shizuoka 411-8540 Japan STAY GREEN Co. Ltd. Kisarazu Chiba 292-0818 Japan Bioscience and Biotechnology Center Nagoya University Nagoya Aichi 464-8601 Japan Plant Breeding Laboratory Division of Genetics and Plant Breeding Department of Applied Genetics and Pest Management Faculty of Agriculture Kyushu University Fukuoka 812-8581 Japan These authors contributed equally to this article

Molecular mechanisms of hybrid break.own associated with sterility (F2 sterility) are poorly understood as compared with those of F1 hybrid sterility. Previously, we characterized three unlink.d epistatic loci, hybrid sterility-a1 (hsa1), hsa2, and hsa3, responsible for the F2 sterility in a cross between Oryza sativa ssp. indica and japonica. In this study, we identified that the hsa1 locus contains two interacting genes, HSA1a and HSA1b, within a 30-k. region. HSA1a-j (japonica allele) encodes a highly conserved plant-specific domain of unk.own function protein (DUF1618), whereasthe indica allele (HSA1a-is) has two deletion mutations that cause disruption of domain structure. The second gene, HSA1b-is, encodes an uncharacterized proteinwith some similarity to a nucleotide-binding protein. Homozygous introgression of indica HSA1a-is-HSA1b-is alleles into japonica showed female gamete abortion at an early mitotic stage. The fact that the recombinant haplotype HSA1a-j-HSA1b-is caused semi-sterility in the heterozygous state with the HSA1a-is-HSA1b-is haplotype suggests that variation in the hsa1 locus is a possible cause of the wide-spectrum sterility barriers seen in F1 hybrids and successive generations in rice. We propose a simple genetic model to explain how a single causal mechanism can drive both F1 and F2 hybrid sterility.

关键词： hybrid sterility epistasis Oryza sativa DUF1618 protein embryo sac abortion

Study of Particle Behavior for Steady-State Operation in JT-60U

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Plasma Science and Technology 2006年第1期8卷 50-54页

作者： H.kubo Japan Atomic Energy Agency Naka-shiIbaraki-ken311-0193JapantheJT-60Team

This paper summarizes recent studies of particle balance in long pulse discharges, long-term erosion/deposition and hydrogen retention for carbon divertor tiles, and particle behavior in SOL and divertor plasmas related to the two foregoing topics in JT-60U. Global saturation of the particle inventory appeared in the later phase of an ELMy H-mode plasma after several long pulse discharges. As for carbon divertor tiles, erosion was dominant in the outer divertor, and deposition was dominant in the inner divertor. Hydrogen isotope concentration （H＋D）/C in the deposition layer was estimated to be -0.032. The SOL plasma flow towards the inner divertor was observed at the low-field-side midplane, and influence of the E, x B drift flow from the outer divertor to the inner divertor via the private region on the divertor particle flux was evaluated to be large in the attached divertor plasmas. The preferential deposition in the inner divertor can be a consequence of these flows. For direct observation of the hydrogen molecular behavior in the divertor plasmas, hydrogen molecular line emission was measured and the fall in the emission intensity with distance from the divertor plates was reproduced by calculation with a neutral transport code and a collisional radiative modeling code.

关键词： tok.mak divertor SOL carbon hydrogen

Optimization of body configuration and joint-driven attitude stabilization for transformable spacecraft under solar radiation pressure

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Astrodynamics 2024年第1期8卷 47-60页

作者： Yuk. kubo Toshihiro Chujo Institute of Space and Astronautical Science Japan Aerospace Exploration AgencyKanagawa252-5210Japan Department of Mechanical Engineering Tokyo Institute of TechnologyTokyo152-8550Japan

The solar sail is one of the most promising space exploration systems due to its theoretically infinite specific impulse achieved through solar radiation pressure(SRP).Recently,researchers have proposed“transformable spacecraft”capable of actively reconfiguring their body configurations using actuatable *** spacecraft,if used similarly to solar sails,are expected to significantly enhance orbit and attitude control capabilities owing to their high redundancy in control degrees of ***,controlling them becomes challenging due to their large number of inputs,leading previous researchers to impose strong constraints to limit their potential control *** study focuses on novel attitude control techniques for transformable spacecraft under *** developed two methods,namely,joint angle optimization to obtain arbitrary SRP force and torque,and momentum damping control driven by joint angle *** proposed methods are formulated in a general manner and can be applied to any transformable spacecraft comprising front faces that can predominantly receive the SRP on each *** validity of our proposed method is confirmed through numerical *** study contributes to mak.ng most of the high control redundancy of transformable spacecraft without the need for expendable propellants,thus significantly enhancing the orbit and attitude control capabilities.

关键词： solar sail transformable spacecraft attitude-joint coupled motion attitudestabilization

The Roles of Nuclear Energy in Hydrogen Production

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Engineering 2022年第9期16卷 16-20页

作者： Shinji kubo Japan Atomic Energy Agency Ibaraki-ken 311-1393Japan

*** energy as primary energy and hydrogen energy as secondary energy Fossil resources are unevenly distributed on the earth and are a finite source of primary energy that is widely used in industry(factories,etc.),transportation(automobiles,etc.),and energy conversion(power generation,etc.).It must be said that the mass consumption of fossil resources is *** energies that can replace fossil-fuel-based energy include renewable energy and nuclear energy,while hydrogen energy has the potential to be a secondary energy source that can be widely used in industry for various purposes,including the use of hydrogen as raw material for chemical products,a reducing agent,and *** example,the International Energy Agency(IEA)has provided a roadmap[1]for achieving net-zero emissions by 2050,stating that about 530 Mt∙a^(-1)of global hydrogen is *** is about six times the hydrogen demand in 2020(about 90 Mt∙a^(-1)).

关键词： replace industry automobile

Review of Divertor Studies in LHD

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Plasma Science and Technology 2006年第1期8卷 14-18页

作者： T. MORISAk. S. MASUZAk. A. k.MORI N. OHYABU M. k.BAYASHI J. MIYAZAWA M. SHOJI 高翔 k. IDA k. Ik.DA O. k.NEk. k. k.WAHATA S. kubo S. MORITA k. NAGAOk. H. NAk.NISHI k. NARIHARA Y. Ok. M. OSAk.BE B. J. PETERSON S. SAk.k.BARA R. SAk.MOTO T. SHIMOZUMA Y. TAk.IRI k. TANAk. k. TOI, k. TSUMORI k. Y. WATABABE T. WATARI H. YAMADA I. YAMADA 严龙文杨青巍杨愚 Y.YOSHIMURA M. YOSHINUMA O. MOTOJIMA National Institute for Fusion Science Toki Gifu 509-5292 Japan Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China Southwesteru Institute of Physics Chengdu 610041 China

In the Large Helical Device （LHD）, two different divertor configurations, i.e. helical divertor （HD） and local island divertor （LID）, are utilized to control the edge plasma. The HD with two X-points is an intrinsic divertor for heliotron devices, accompanied with a relatively thick.ergodic layer outside the confinement region. Edge and divertor plasma behavior from low density to high density regimes is presented, referring to the divertor detachment. The effect of the ergodic layer on the edge transport is also discussed. On the other hand, the LID is an advanced divertor concept which realizes a high pumping efficiency by the combination of an externally induced magnetic island and a closed pumping system. Experimental results to confirm the fundamental divertor performance of the LID are presented.

关键词： LHD divertor ergodic layer magnetic island edge plasma

Study of Chok.d Flows through a Convergent Nozzle

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Journal of Thermal Science 2010年第3期19卷 193-197页

作者： k.zunori kubo Yoshiak. MIYAZATO k.zuyasu MATSUO Department of Mechanical Systems Engineering Faculty of Environmental EngineeringThe University of Kitakyushu1-1 HibikinoWakamatsu-kuKitakyushu City808-0135Japan

When sonic nozzles of significantly smaller diameter are used as standard flow meters,the critical back.pressure ratio is affected by the boundary layer at the nozzle ***,the effect of the boundary layer on chok.ng criteria is still ***,the chok.ng phenomenon of a convergent nozzle flow has been experimentally investigated using four convergent nozzles with the same diameter followed by a straight pipe of a variable *** a result,it is shown that the critical back.pressure ratio is smaller than that for the steady one-dimensional is-entropic flow and decreases as the boundary layer thick.ess ***,the main flow Mach number at the nozzle exit is supersonic when the back.pressure ratio is equivalent to the chok.ng condition,and the Mach number increases as the boundary layer thick.ess increases.

关键词： Boundary Layer Convergent Nozzle Chok.d Flow Chok.ng Pressure Ratio

Observation of MHD Instabilities Driven by Energetic Electrons in the Large Helical Device

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Plasma Science and Technology 2015年第4期17卷 276-279页

作者： Mitsutak. ISOBE k.nihiro OGAWA Ak.hiro SHIMIZU Masak. OSAk.BE Shin kubo k.TOI the LHD Experiment Group National Institute for Fusion Science Toki 509-5292Japan Department of Fusion Science The Graduate University for Advanced Studies(SOKENDAI)Toki 509-5292Japan Department of Energy Engineering and Science Nagoya UniversityNagoya 464-8463Japan

Coherent magnetic fluctuations in an acoustic range of frequency have been regularly observed in low-density（n_e〈0.2×10^（19）m^（-3））plasmas with strong second harmonic electron cyclotron resonance heating（ECRH）on the Large Helical *** X-ray measurements indicated that energetic electrons are generated in these ECRH *** magnetic fluctuations are suppressed in higher density discharges where energetic electrons are not *** ECRH power modulation experiment indicated that the observed magnetohydrodynamic（MHD）mode has an acoustic nature rather than an Alfvenic nature.

关键词： LHD ECRH energetic electron MHD instability

Acoustic Noise from Tandem Wind Rotors of Intelligent Wind Power Unit

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Journal of Thermal Science 2010年第2期19卷 120-125页

作者： k.ichi kubo Nobuhik. Mihara Ak.ra Enishi Toshiak. k.nemoto k.ushu Institute of Technology:Sensui 1-1

The authors had invented the unique wind power unit composed of the large-sized front wind rotor,the small-sized rear wind rotor and the peculiar generator with the inner and the outer rotational armatures without the conventional *** unit is called "Intelligent Wind Power Unit" by the *** front and the rear wind rotors drive the inner and the outer armatures,respectively,while the rotational torque is counter-balanced between both armatures/wind *** paper discusses experimentally the acoustic noise from the front and the rear wind *** acoustic noise,in the counter-rotating operation,is induced mainly from the flow interaction between both rotors,and has the dominant power spectrum density at the frequency of the blade passing *** noise is caused mainly from the turbulent fluctuation due to the flow separation on the blade,when the rear wind rotor stops or rotates in the same direction as the front wind rotor.

关键词： Acoustic noise Wind turbine Tandem wind rotors Counter-rotation