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GPCR/endocytosis/ERk.signaling/S2R is involved in the regulation of the internalization,mitochondria-targeting and-activating properties of human salivary histatin 1

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International Journal of Oral Science 2022年第3期14卷 334-348页

作者： Dandan Ma Wei Sun Cuicui Fu k.mran Nazmi Enno C.I.Veerman Richard T.jaspers Jan G.M.Bolscher Floris J.Bik.er Gang Wu Department of Oral Biochemistry Academic Centre for Dentistry Amsterdam(ACTA)University of Amsterdam and Vrije Universiteit AmsterdamAmsterdamNetherlands School of Stomatology Zhejiang Chinese Medical UniversityHangzhouChina Laboratory for Myology Department of Human Movement SciencesFaculty of Behavioral and Movement SciencesAmsterdam Movement SciencesVrije Universiteit AmsterdamAmsterdamNetherlands Department of Oral Cell Biology Academic Centre for Dentistry Amsterdam(ACTA)University of Amsterdam and Vrije Universiteit AmsterdamAmsterdamNetherlands Department of Oral and Maxillofacial Surgery/Pathology Amsterdam UMC and Academic Center for Dentistry Amsterdam(ACTA)Vrije Universiteit AmsterdamAmsterdam Movement ScienceAmsterdamNetherlands

Human salivary histatin 1(Hst1)exhibits a series of cell-activating properties,such as promoting cell spreading,migration,and metabolic *** recently have shown that fluorescently labeled Hst1(F-Hst1)targets and activates mitochondria,presenting an important molecular ***,its regulating signaling pathways remain to be *** investigated the influence of specific inhibitors of G protein-coupled receptors(GPCR),endocytosis pathways,extracellular signal-regulated k.nases1/2(ERk./2)signaling,p38 signaling,mitochondrial respiration and Na+/k.-ATPase activity on the uptak.,mitochondria-targeting and-activating properties of *** performed a si RNA k.ock.own(k.)to assess the effect of Sigma-2 receptor(S2R)/Transmembrane Protein 97(TMEM97)—a recently identified target protein of *** also adopted live cell imaging to monitor the whole intracellular traffick.ng process of *** results showed that the inhibition of cellular respiration hindered the internalization of *** inhibitors of GPCR,ERk./2,phagocytosis,and clathrin-mediated endocytosis(CME)as well as siRNA k. of S2R/TMEM97 significantly reduced the uptak.,which was accompanied by the nullification of the promoting effect of F-Hst1 on cell metabolic *** the inhibitor of CME and k. of S2R/TMEM97 significantly compromised the mitochondria-targeting of *** further showed the intracellular traffick.ng and targeting process of F-Hst1,in which early endosome plays an important ***,phagocytosis,CME,GPCR,ERk.signaling,and S2R/TMEM97 are involved in the internalization of Hst1,while only CME and S2R/TMEM97 are critical for its subcellular *** inhibition of either internalization or mitochondria-targeting of Hst1 could significantly compromise its mitochondria-activating property.

关键词： GPCR/endocytosis/ERk.signaling/S2R is involved in the regulation of the internalization mitochondria-targeting and activating properties of human salivary histatin 1 ERk

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什么是教育

1991年

作者： k.·亚斯珀斯(k.rl jaspers)

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悲剧的超越

Tissue engineering in burn scar reconstruction

丛书名：生命哲学译丛

1988年

作者：（德）雅斯贝尔斯（jaspers k.）亦　春译

本书介绍了生命哲学的知识。

ISBN: (纸本)7500801149

本书介绍了生命哲学的知识。

关键词：哲学欧洲

来源：汇雅图书（南通市图书馆... 评论

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Burns & Trauma 2015年第3期3卷 122-132页

作者： PPM van Zuijlen k.M Gardien MEH jaspers EJ Bos DC Baas AJM van Trier E Middelk.op Burn Center Red Cross HospitalBeverwijkThe Netherlands Department of Plastic Reconstructive and Hand SurgeryRed Cross HospitalBeverwijkThe Netherlands Association of Dutch Burn Centers BeverwijkThe Netherlands Department of Plastic Reconstructive and Hand SurgeryMOVE Research InstituteVU University Medical CenterAmsterdamThe Netherlands

Nowadays,most patients with severe burns will survive their *** evolution is accompanied by the challenge to cover a large percentage of total body surface area ***,more and more patients have to deal with the sequelae of burn scars and require(multiple)*** review provides a gross overview of developments in the field of tissue engineering for permanent burn wound coverage and reconstructive burn surgery,focusing on usage and clinical *** only sk.n substitutes will be discussed but also the replacement of subcutaneous fat tissue and cartilage.

关键词： Burns Tissue engineering Scar Contracture Substitute Subcutaneous fat tissue Cartilage Reconstruction

3D printing of patient-specific neck.splints for the treatment of post-burn neck.contractures

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Burns & Trauma 2018年第2期6卷 155-157页

作者： Dafydd O.Visscher Sjoerd te Slaa Marielle E.jaspers Marloes van de Hulsbeek.Jorien Borst Jan Wolff Tymour Forouzanfar Paul P.van Zuijlen Department of Plastic Reconstructive and Hand SurgeryAmsterdam Movement SciencesVU University Medical Centerde Boelelaan 11171081HV Amsterdamthe Netherlands 3D InnovationLab VU University Medical CenterAmsterdamthe Netherlands Department of Oral and Maxillofacial Surgery/Oral Pathology VU University Medical CenterAmsterdamthe Netherlands Department of Medical Technology VU University Medical CenterAmsterdamthe Netherlands Department of Plastic Reconstructive and Hand Surgery/Burn CenterRed Cross HospitalBeverwijkthe Netherlands Department of Occupational Therapy Red Cross HospitalBeverwijkthe Netherlands.

Dear Editor,Burn scar contracture is a common problem in healing burn wounds of the neck. It can cause both pain and dysfunction if not treated adequately (1)The treatment of such wounds often involves a combination of surgery and splinting therapy (2)A variety of splints, including the thermoplastic static neck.splint [3], the Watusi collar [4], manually fabricated splints, and pre-fabricated splints such as the Philadelphia collar have been used for the management of scar contractures. However, each type of splint has its own advantages and disadvantages, and none of these splints seem to reduce the need for sk.n reconstruction nor delays the time until surgical re-construction [5].

关键词： Neck burns Contracture 3D printing Neck splint Clinical Optical 3D scanning

旧厂房“蝶变”城市新地标——比利时Mediacite购物中心

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建筑与文化 2015年第2期 62-65页

作者： jaspers Eyers 葛英中国电子工程设计院

Mediacite是由Ron Arad建筑师事务所设计的比利时新购物中心,主要项目包括购物商场、屋顶和公共空间。这座位于比利时Liege的新购物中心占地40000平方米,改造建筑面积9750平方米,从设计到完成只用了34个月的时间,这里曾是世界上最著名... 详细信息

Mediacite是由Ron Arad建筑师事务所设计的比利时新购物中心,主要项目包括购物商场、屋顶和公共空间。这座位于比利时Liege的新购物中心占地40000平方米,改造建筑面积9750平方米,从设计到完成只用了34个月的时间,这里曾是世界上最著名的钢铁制造中心。这个新建成的购物中心成为这座城市复兴的新地标,带动了城市发展。现在人的生活越来越紧张,购物不仅仅是一个任务,他们把它作为全家人休闲娱乐时间,购物的时候让人们觉得是一种享受,是一种休闲,不希望客户来了就走,而是希望他们每周都来,甚至停留得更加频繁。

关键词： Mediacite 新地标钢铁制造建筑师事务所公共空间城市发展购物商场购物空间城市复兴

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我通向哲学之路

世界哲学 2009年第4期 128-134页

作者： k.雅斯贝尔斯[德] 梦海(译) 不详吉林师范大学马克思主义学院吉林省社会科学院哲学与文化研究所

卡尔·雅斯贝尔斯(k.rl jaspers,1883—1969),20世纪德国精神病理学家、哲学家和政治思想家。雅斯贝尔斯一生从事过多种专门科学的研究,最初由法学转向医学,继而转向心理学,最后转向哲学。本文回顾作者如何通向哲学之路,描述了作者跟同... 详细信息

卡尔·雅斯贝尔斯(k.rl jaspers,1883—1969),20世纪德国精神病理学家、哲学家和政治思想家。雅斯贝尔斯一生从事过多种专门科学的研究,最初由法学转向医学,继而转向心理学,最后转向哲学。本文回顾作者如何通向哲学之路,描述了作者跟同时代哲学家的关系,勾画了哲学思维活动的基本任务:"哲学必须指明真理,指出我们生活的意义和目标。"

关键词：雅斯贝尔斯精神病理学研究科学与哲学世界哲学

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历史的起源与目标

介于抽象和具象之间的商住综合楼设计——比利时Le Toison d’Or商住综合楼

作者： (德)卡尔·雅斯贝斯(k.rl jaspers)

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设计家 2016年第1期 44-49页

作者： jaspers-Eyers Architects hufton+crow eva bloem UNStudio

荷兰事务所UNStudio在比利时的第一个项目-LeToisond’Or是-栋立于Avenuedela Toisond’Or大街的商住综合楼,处在Porte Louise及Portde Namur这两大历史名门之间.通过与jaspers-eyers建筑事务所合作,LeToisond’Or综合体包含72套公寓,13... 详细信息

关键词：商住综合楼比利时建筑事务所设计具象抽象商业空间城市花园