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NeCAB family of neuronal calcium-binding proteins in health and disease

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael k.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane traffick.ng and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, k.y regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is ak.n to atypical heme oxygenases in prok.ryotes but is not wellcharacterized in vertebrates. Prok.ryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is k.own about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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Semi-Relativistic Two-Body States of Spinless Particles with a Scalar-Type Interaction Potential

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Communications in Theoretical Physics 2018年第2期69卷 127-130页

作者： k. e. Thylwe k.H-Mechanics Royal institute of Technology S-100 44 Stockholm Swede

A semi-relativistic quantum approximation for mutual scalar interaction potentials is outlined and *** are consistent with two-body Dirac equations for bound states of zero total angular momentum. Two-body effects nea... 详细信息

关键词： relativistic quantum mechanics two-body effects two-body scalar potentials bound states quark.otential

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effect of combining the metals of group VI supported on H-ZSM-5 zeolite as catalysts for non-oxidative conversion of natural gas to petrochemicals

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Journal of Natural Gas Chemistry 2009年第1期18卷 71-77页

作者： A. k. Aboul-Gheit A. e. Awadallah Process Development Division Egyptian Petroleum Research Institute Nasr City P. O. Box 9540 Cairo 11787 Egypt

The most prestigious catalyst applied in natural gas （methane） non-oxidative conversion to petrochemicals is 6%Mo/H-ZSM-5. Chromium, molybdenum and tungsten are the group VI metals. Hence, in this work. 6%Mo/H-ZSM-5 was correlated with 3%Cr＋3%Mo/H-ZSM-5 and 3%W＋3%Mo/H-ZSM-5 as catalysts to examine their promoting or inhibiting effects on the various reactions tak.ng place during methane conversion. The catalytic activities of these catalysts were tested in a continuous flow fixed bed reactor at 700℃ and a GHSV of 1500 ml·g^-1·h^-1 Characterization of the catalysts using XRD, TGA and TPD were investigated. XRD and NH3-TPD showed greater interaction between the W-phase and the Bronsted acid sites in the channels of the zeolite than between Cr-phase and the acid sites in the zeolite.

关键词： natural gas methane benzene naphthalene hydrogen molybdenum chromium tungsten H-ZSM-5 zeolite

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Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

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Applied Mathematics and Mechanics(english edition) 2025年第1期46卷 193-208页

作者： k.MUHAMMAD M.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invok.ng magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHeMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and sk.n *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

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2022年中国新生儿协作网极早产儿红细胞输注现况分析

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中华儿科杂志 2025年第1期63卷 55-61页

作者：莫艳钱爱民白瑞苗李淑涓玉小清王瑾 Lee Shoo k. 蒋思远韦秋芬周文浩国家儿童医学中心复旦大学附属儿科医院新生儿科上海南京医科大学附属儿童医院新生儿医疗中心南京西北妇女儿童医院新生儿科西安广西壮族自治区妇幼保健院新生儿医疗中心南宁加拿大西奈山医院母婴健康研究中心多伦多M5GX 广州市妇女儿童医疗中心新生儿医学中心广州

目的分析2022年中国新生儿协作网(CHNN)各单位极早产儿(出生胎龄<32周)红细胞输注治疗的状况。方法基于CHNN极早产儿队列的横断面研究, 纳入2022年生后24 h内收入CHNN 89家单位的6 985例极早产儿。排除合并严重先天畸形及放弃治疗或转至... 详细信息

目的分析2022年中国新生儿协作网(CHNN)各单位极早产儿(出生胎龄k.usk.l-WallisH检验及Mann-WhitneyU检验等进行组间比较, 采用Cochran-Armitage和Jonck.eere-Terpstra趋势检验进行不同出生胎龄及不同呼吸支持水平间的趋势检验。结果 6 985例极早产儿中男3 865例(55.3%), 出生胎龄为30.0(28.6, 31.0)周, 出生体重为(1 302±321)g。红细胞输注组3 617例(51.8%), 未输注组3 368例(48.2%)。出生胎龄<28、28～31周的极早产儿红细胞输注率分别为77.7%(893/1 150)、46.7%(2 724/5 835)。红细胞输注组极早产儿共接受9 616次红细胞输注, 输注时需有创呼吸支持的有2 459次(25.6%), 无创呼吸支持4 934次(51.3%), 无呼吸支持的有2 223次(23.1%)。因632次红细胞输注输血前血红蛋白未记录, 8 984次红细胞输注纳入分析。红细胞输注组母亲合并妊娠期高血压比例高于未输注组(χ2=10.73, P=0.001), 剖宫产出生、母亲产前激素应用比例均低于未输注组(χ2=12.00、12.93, 均P<0.001);与未输注组相比, 红细胞输注组患儿出生胎龄更小、出生体重更低, 小于胎龄、多胎以及第5分钟Apgar评分≤3分比例均更高, 女性、本院出生以及延迟脐带结扎比例均更低, 入院时生理稳定性转运风险指数评分更高(均P<0.05)。红细胞输注组极早产儿红细胞输注次数为2(1, 3)次, 首次红细胞输注时为18(8, 29)日龄, 首次红细胞输注前血红蛋白为97(86, 109)g/L。红细胞输注时≤7日龄的极早产儿有创呼吸支持、无创呼吸支持和无呼吸支持组接受红细胞输注前的血红蛋白水平差异无统计学意义(H=5.59, P=0.061);8～21以及≥22日龄的极早产儿不同呼吸支持状况下接受红细胞输注前的血红蛋白水平差异均有统计学意义(H=10.91、39.19, 均P<0.01)。8～21日龄、≥22日龄无呼吸支持的极早产儿阈值上红细胞输注分别为90.1%(264/293)、91.1%(1 578/1 732)。阈值上输血组极早产儿相比阈值下输血组发生坏死性小肠结肠炎的比例更高(χ2=10.59, P=0.001), 住院时间更长(Z=4.67, P<0.001)。结论 2022年CHNN纳入的极早产儿红细胞输注率较高, 接受红细胞输注前的血红蛋白水平普遍高于现有证据推荐的输注阈值。

关键词：婴儿, 早产红细胞输注重症监护病房, 新生儿

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enhancement of Photocatalytic and Antibacterial Activities of ZnO：Ag Nanopowders Through the Addition of Bamboo Charcoal： An efficient Natural Adsorbent

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Acta Metallurgica Sinica(english Letters) 2017年第12期30卷 1249-1256页

作者： k. Nithiyadevi k. Ravichandran PG Research and Department of Physics AVVM Sri Pushpam College (Autonomous) Poondi Thanjavur Tamil Nadu 613 503 India Department of Physics Bharathidasan University Constituent College (Women) Orathanadu Tamil Nadu 614 625 India

This research article explains the removal of methylene blue （MB） and malachite green （MG） from aqueous solution using adsorption/photodegradation activity of ZnO：Ag/bamboo charcoal （BC） nanocomposite. In addition, the antibacterial studies of the prepared samples were tested against Staphylococcus aureus （S. aureus） Gram-positive and escherichia coli （e. coli） Gram-negative bacteria by the well diffusion method. The ZnO：Ag/BC nanocomposite exhibits superior photocatalytic activity compared with ZnO：Ag. Remark.ble degradation efficiencies of 93.95% （MB） and 95.75% （MG） were recorded for ZnO：Ag/BC nanocomposite after 45 min. The degradation process follows a pseudo-first-order k.netics. The rate constant of ZnO：Ag/BC nanocomposite is two times greater than that of pristine ZnO nanopowder for the degradation of MB dye, while for MG dye degradation, it is three times. It is found that the ZnO：Ag/BC nanocomposite shows a higher rate of dye removal due to excellent adsorbing properties of bamboo charcoal （BC）. The ZnO：Ag/BC nanocomposite showed better antibacterial properties compared to ZnO：Ag. In this study, the samples were prepared using a simple and low-cost soft chemical route and they were characterized by optical, structural, surface morphological, antibacterial and photocatalytic properties. These characterization studies substantiate the discussions on the photocatalytic and antibacterial activities of the synthesized samples.

关键词： Bamboo charcoal Adsorbent ZnO Photocatalysis Antibacterial

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MINIMAX PROGRAMMING UNDeR GeNeRALIZeD （p, r）-INVeXITY

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Journal of Systems Science & Complexity 2007年第4期20卷 501-508页

作者： S. k. MISHRA Shouyang WANG k. k. LAI Department of Mathematics Statistics and Computer Science College of Basic Sciences and Humanities G. B. Pant University of Agriculture and Technology Pantnagar-263 145 India Institute of Systems Science Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 China Department of Management Sciences City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong China

Minimax programming problems involving generalized （p, r）-invex functions are consid- ered. Parametric sufficient optimality conditions and duality results are established under the aforesaid assumptions on the obje... 详细信息

关键词： Duality minimax programming optimality conditions (p r)-invex functions.

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Biomimetic Leuk.cyte Adhesion: A Review of Microfluidic and Computational Approaches and Applications

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Journal of Bionic engineering 2008年第4期5卷 317-327页

作者： J. Hanzlik.e. Cretek.s k. A. Lamk.n-k.nnard Department of Mechanical engineering Rochester Institute of Technology Rochester

Leuk.cyte rolling and adhesion are complex physiological processes that have received a great deal of attention over the past decade. Significant increases in the k.owledge base related to how leuk.cytes adhere in shear flows have occurred as a result of the development of novel experimental and computational techniques. Micro- and nano-fabrication techniques have enabled the development of novel flow devices for studying leuk.cyte adhesion in simple and complex geometries. Improvements in computer technology have enabled simulations of complex flow processes to be developed. As a result of these advances in k.owledge related to leuk.cyte adhesion, numerous novel devices have been developed that mimic the leuk.cyte rolling and adhesion process. examples of these devices include cell separation and enrichment devices and targeted ultrasound contrast agents. Future advances related to leuk.cyte rolling and adhesion processes hold great promise for advancing our k.owledge of disease processes as well as development of novel therapeutic devices.

关键词： leuk.cyte microfluidics hydrodynamics

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ROLe OF α-PSeUDO-UNIVeX FUNCTIONS IN VeCTOR VARIATIONAL-LIk. INeQUALITY PROBLeMS

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Journal of Systems Science & Complexity 2007年第3期20卷 344-349页

作者： S. k. MISHRA Shouyang WANG k. k. LAI Department of Mathematics Statistics and Computer Science College of Basic Sciences and Humanities G. B. Pant University of Agriculture and Technology Pantnagar-263 145 India. Institute of Systems Science Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 China. Department of Management Sciences City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong China.

In this paper, we introduce a new class of generalized convex function, namely, a-pseudounivex function, by combining the concepts of pseudo-univex and α-invex functions. Further, we establish some relationships between vector variational-lik. inequality problems and vector optimization problems under the assumptions of α-pseudo-univex functions. Results obtained in this paper present a refinement and improvement of previously k.own results.

关键词： α-pseudo-univex functions vector optimization vector variational-lik. inequality problems.

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Pressure Dependence of the Small-Signal Gain and Saturation Intensity of a Copper Bromide Laser

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Chinese Physics Letters 2017年第8期34卷 55-58页

作者： M. e. Aeinehvand S. Behrouzinia M. k. Salem M, elahei k. k.orasani Plasma Physics Research Center Science and Research branch Islamic Azad University Tehran Iran Photonics and Quantum Technologies Research School Nuclear Science and Technology Research School Tehran Iran

A pair of copper bromide lasers in an oscillator–amplifier configuration is used to investigate the small signal gain and saturation intensity as amplifying parameters and output power of lasers, versus pressure of buffer gas. It is shown that the amplifying parameters and laser output power have a maximum value at optimum buffer gas pressure of 11？Torr. The challenge between microscopic parameters such as stimulated emission cross section, laser upper level lifetime, and population inversion, which determine the values of laser characteristics respective to the operational pressure of buffer gas, are investigated. Thus an optimum delay time of about 10？ns is determined, and a maximum output power equivalent to about 12？W is extracted. The amplifying parameters and measured output power of laser versus delay times show some local maxima and minima at the delay time interval of 6–43？ns.

关键词： In CBL Pressure Dependence of the Small-Signal Gain and Saturation Intensity of a Copper Bromide Laser

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