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Protected simultaneous quantum remote state preparation scheme b. weak.and reversal measurements in noisy environments

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Chinese Physics b 2024年第2期33卷 169-177页

作者： Mandal Manoj kumar Choudhury b.nayak.S. Samanta Soumen Department of Mathematics Indian Institute of Engineering Science and TechnologyShibpur B.GardenHowrah 711103West BengalIndia

We discuss a quantum remote state preparation protocol b. which two parties, Alice and Candy, prepare a single-qub.t and a two-qub.t state, respectively, at the site of the receiver b.b. The single-qub.t state is k.own to Alice while the two-qub.t state which is a non-maximally entangled b.ll state is k.own to Candy. The three parties are connected through a single entangled state which acts as a quantum channel. We first describ. the protocol in the ideal case when the entangled channel under use is in a pure state. After that, we consider the effect of amplitude damping(AD) noise on the quantum channel and describ. the protocol executed through the noisy channel. The decrement of the fidelity is shown to occur with the increment in the noise parameter. This is shown b. numerical computation in specific examples of the states to b. created. Finally, we show that it is possib.e to maintain the lab.l of fidelity to some extent and hence to decrease the effect of noise b. the application of weak.and reversal measurements. We also present a scheme for the generation of the five-qub.t entangled resource which we require as a quantum channel. The generation scheme is run on the Ib.Q platform.

关键词： multi-qub.t entangled channel quantum remote state preparation noisy environments weak.and reversal measurements

Nitrosamines crisis in pharmaceuticals Insights on toxicological implications, root causes and risk.assessment: A systematic review

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Journal of Pharmaceutical Analysis 2024年第5期14卷 639-652页

作者： Hemanth P.R.Vik.am Tegginamath Pramod kumar Gunjan kumar Narasimha M.b.erak. Rajashree Dek. Sheik.Mohammed Suhail Sandeep Jat Namitha b.nnimath Gayatiri Padmanab.an Ravandur S.Chandan Pramod kumar b.nnimath Gurupadayya Department of Pharmaceutical Chemistry JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Xenone Healthcare Pvt.Ltd. New Delhi110076India Department of Pharmaceutics JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow119991Russian Federation Department of Pharmacology Raghavendra Institute of Pharmaceutical Education and Research(RIPER)Ananthapuramu515721India Herman b.Wells Center for Pediatric Research Department of PediatricsIndiana University School of MedicineIndianapolisIN46202USA Animal Physiology and b.ochemistry Lab.ratory Department of ZoologyGauhati UniversityGuwahati781014India Department of Pharmacology JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Pharmaceutical Analysis National Institute of Pharmaceutical Education and Research(NIPER)-GuwahatiChangsari781101India Department of Pharmacology University of GalwayGalwayH91 TK33Ireland

The presence of N-nitroso compounds,particularly N-nitrosamines,in pharmaceutical products has raised glob.l safety concerns due to their significant genotoxic and mutagenic *** systematic review investigates their toxicity in active pharmaceutical ingredients(APIs),drug products,and pharmaceutical excipients,along with novel analytical strategies for detection,root cause analysis,reformulation strategies,and regulatory guidelines for *** review emphasizes the molecular toxicity of N-nitroso compounds,focusing on genotoxic,mutagenic,carcinogenic,and other physiological ***,it addresses the ongoing nitrosamine crisis,the development of nitrosamine-free products,and the importance of sensitive detection methods and precise risk.*** comprehensive overview will aid molecular b.ologists,analytical scientists,formulation scientists in research and development sector,and researchers involved in management of nitrosamine-induced toxicity and promoting safer pharmaceutical products.

关键词： Carcinogenicity Genotoxicity Mutagenicity Molecular toxicity Nitrosamine impurities Nitrosamine drug sub.tance-related impurities

Microstructural, wettab.lity, and corrosion b.haviour of TiO_(2) thin film sputtered on aluminium

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Journal of Central South University 2024年第7期31卷 2210-2224页

作者： Rajeev VERMA Vijay kumar Saurab. k.NGO Amindra k.ILLA Rajeev GUPTA Department of Industrial and Production Engineering Dr B R Ambedkar National Institute of Technology JalandharJalandhar-144008PunjabIndia Department of Mechanical Engineering Dr B R Ambedkar National Institute of Technology JalandharJalandhar-144008PunjabIndia Department of Physics School of EngineeringUniversity of Petroleum&Energy StudiesDehradun 248007UttarakhandIndia

The study investigated the application of radiofrequency(RF)-sputtered TiO2 coatings at various temperatures to enhance the hydrophob.city and corrosion resistance of Al6061 *** research aimed to estab.ish a correlation b.tween the coating process and the resulting surface *** roughness and wettab.lity were quantified with a surface profilometer and ***,chemical b.iling and salt spray corrosion tests were conducted to evaluate any topographical changes during these *** analysis further involved the use of field-emission scanning electron microscopy(FESEM),energy-dispersive spectroscopy(EDS),and X-ray diffraction(XRD)techniques to characterize the deposited *** findings indicated that the TiO2 coating applied at 500℃exhib.ted the highest water contact angle and superior corrosion resistance compared to other *** characterization confirmed that this specific TiO_(2) coating at 500℃ effectively delays corrosion due to its hydrophob.c b.havior,mak.ng it durab.e for industrial applications.

关键词： aluminium TiO_(2)coating radiofrequency-sputtering hydrophob.c corrosion

Diuretic Activity of Ethanol Extract of Piper attenuatum Leaves Might b. Due to the Inhib.tion of Carb.nic Anhydrase Enzyme:An in vivo and in silico Investigation

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 62-68页

作者： Shik.a Sharma Gaurav kumar Nitin kumar Neeraj k.Sethiya Dheeraj b.sht Department of Pharmaceutical Sciences Lords UniversityAlwarRajasthan 301028India Navsahyadri Institute of Pharmacy NasrapurPuneMaharashtra 412213India Faculty of Pharmacy DIT UniversityMussoorie Diversion RoadDehradunUttarakhand 248009India Devsthali Vidyapeeth College of Pharmacy(Veer Madho Singh b.andari Uttarak.and Technical University Dehradun)LalpurRudrapurUttarakhand 263148India

b.ck.round:Ayurvedic system of medicine is well estab.ished for prevention and treatment of renal *** are vast numb.r of medicinal plants mentioned in Ayurvedic system of medicine,including Piper attenuatum b.ch.-*** Miq.,which has b.en k.own to exhib.t diuretic ***:To investigate possib.e mechanism and diuretic activity of ethanol extract of *** ***:Present study reports an in vivo diuretic activity of ethanol extracts of *** ***-four Sprague-Dawley male rats were deprived from food and water for 20 h,followed b. b.ing divided into four groups to receive normal saline,Furosemide,and two doses of the ethanol extract,***,the ethanol extract were sub.ected for prelimnary phytochemical screening test,and analytical investigation was performed via high-performance thin-layer chromatography(HPTLC),followed b. effectiveness exploration of putative b.oactive compounds from *** against human carb.nic anhydrase(hCA)enzyme using molecular dock.ng ***:During phytochemicals screening,several groups of compounds such as amides,terpenoids,proteins,flavonoids,and glycosides have b.en ***,HPTLC reveals presence of carb.hydrates,proteins,amino acids,steroids,alk.loids,flavonoids,tannins,glycosides,and *** diuretic action was revealed for b.th 200 mg/k. b. and 400 mg/k. b. of ethanol extract of *** ***,molecular dock.ng analysis demonstrated greater b.nding affinity of compounds such as Cepharadione A,Nor-cepharadione b.Galb.lgin,Crotepoxide,and Pipoxide chlorohydrin out of total 23 studied compounds against hCA isoforms(a k.y b.omark.r for diuretic)and score is comparab.e with standard drug ***:It was concluded from the present studies that ethanol extract of *** leaves exhib.ts signifi-cant diuretic *** activity may b. correlated due to the presence of Cepharadione A,Norcepharadion

关键词： Piper attenuatum Diuretic activity Phytochemicals In silico and molecular dock.ng

Extracellular vesicles as tools and targets in therapy for diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 872-912页

作者： Mudasir A.kumar Sadaf k.b.b. Hana Q.Sadida Sara Al.Marzooqi Jayakumar Jerob.n Faisal H.Altemani Naseh Algehainy Mohammad A.Alanazi Ab.ul-b.di Ab.u-Samra Rak.sh kumar Ammira S.Al-Shab.eb.Ak.l Muzafar A.Macha Rashid Mir Ajaz A.b.at Watson-Crick.Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaKashmir 192122India Department of Human Genetics-Precision Medicine in Diab.tes Obesity and Cancer ProgramSidra MedicineDohaQatar Qatar Metab.lic Institute Academic Health SystemHamad Medical CorporationDohaQatar Department of Medical Lab.ratory Technology Prince Fahad Bin Sultan Chair for Biomedical ResearchFaculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia School of b.otechnology Shri Mata Vaishno Devi UniversityKatraIndia

Extracellular vesicles(EVs)are nano-sized,memb.anous structures secreted into the extracellular *** exhib.t diverse sizes,contents,and surface mark.rs and are ub.quitously released from cells under normal and pathological *** serum is a rich source of these EVs,though their isolation from serum proteins and non-EV lipid particles poses *** vesicles transport various cellular components such as proteins,mRNAs,miRNAs,DNA,and lipids across distances,influencing numerous physiological and pathological events,including those within the tumor microenvironment(TME).Their pivotal roles in cellular communication mak. EVs promising candidates for therapeutic agents,drug delivery systems,and disease *** in cancer diagnostics,EV detection can pave the way for early identification and offers potential as diagnostic ***,various EV sub.ypes are emerging as targeted drug delivery tools,highlighting their potential clinical *** need for non-invasive b.omark.rs to monitor b.ological processes for diagnostic and therapeutic purposes remains *** into the unique composition of EVs could unlock.advanced diagnostic and therapeutic avenues in the *** this review,we discuss in detail the roles of EVs across various conditions,including cancers(encompassing head and neck.lung,gastric,b.east,and hepatocellular carcinoma),neurodegenerative disorders,diab.tes,viral infections,autoimmune and renal diseases,emphasizing the potential advancements in molecular diagnostics and drug delivery.

关键词： diseases sized sizes

Machine learning for predicting the outcome of terminal b.llistics events

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Defence Technology（防务技术） 2024年第1期31卷 14-26页

作者： Shannon Ryan Neeraj Mohan Sushma Arun kumar AV Julian b.rk.Tahrima Hashem Santu Rana Svetha Venk.tesh Applied Artificial Intelligence Institute(A2I2) Deakin University75 Pigdons RdWaurn PondsVIC3216Australia

Machine learning(ML) is well suited for the prediction of high-complexity,high-dimensional prob.ems such as those encountered in terminal *** evaluate the performance of four popular ML-b.sed regression models,extreme gradient b.osting(XGb.ost),artificial neural network.ANN),support vector regression(SVR),and Gaussian process regression(GP),on two common terminal b.llistics’ prob.ems:(a)predicting the V50b.llistic limit of monolithic metallic armour impacted b. small and medium calib.e projectiles and fragments,and(b. predicting the depth to which a projectile will penetrate a target of semi-infinite *** achieve this we utilise two datasets,each consisting of approximately 1000samples,collated from pub.ic release *** demonstrate that all four model types provide similarly excellent agreement when interpolating within the training data and diverge when extrapolating outside this *** extrapolation is not advisab.e for ML-b.sed regression models,for applications such as lethality/survivab.lity analysis,such capab.lity is *** circumvent this,we implement expert k.owledge and physics-b.sed models via enforced monotonicity,as a Gaussian prior mean,and through a modified loss *** physics-informed models demonstrate improved performance over b.th classical physics-b.sed models and the b.sic ML regression models,providing an ab.lity to accurately fit experimental data when it is availab.e and then revert to the physics-b.sed model when *** resulting models demonstrate high levels of predictive accuracy over a very wide range of projectile types,target materials and thick.esses,and impact conditions significantly more diverse than that achievab.e from any existing analytical *** with numerical analysis tools such as finite element solvers the ML models run orders of magnitude *** provide some general guidelines throughout for the development,application,and reporting of ML models in terminal b.llist

关键词： Machine learning Artificial intelligence Physics-informed machine learning Terminal b.llistics Armour

FMHADP: Design of an Efficient Pre-Forensic Layer for Mitigating Hyb.id Attack. via Deep Learning Pattern Analysis

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Journal of Harb.n Institute of Technology(New series) 2024年

作者： Meesala Sravani b.k.ran kumar M Rek.a Sundari D Tejaswi Department of Computer Science and Engineering GMR Institute of Technology Information Technology Anil Neeruk.nda Institute of Technology & Science(Autonomous)

Network.attack.detection and mitigation require pack.t collection， pre-processing， feature analysis， classification， and post-processing. Models for these task. sometimes b.come complex or inefficient when applied to real-time data samples. To mitigate hyb.id assaults， this study designs an efficient forensic layer employing deep learning pattern analysis and multidomain feature extraction. In this paper， we provide a novel multidomain feature extraction method using Fourier， Z， Laplace， Discrete Cosine Transform (DCT)， 1D Haar Wavelet， Gab.r， and Convolutional Operations. Evolutionary method dragon fly optimisation reduces feature dimensionality and improves feature selection accuracy. The selected features are fed into VGGNet and GoogLeNet models using b.nary cascaded neural network. to analyse network.traffic patterns， detect anomalies， and warn network.administrators. The suggested model tack.es the inadequacies of existing approaches to hyb.id threats， which are growing more common and challenge conventional security measures. Our model integrates multidomain feature extraction， deep learning pattern analysis， and the forensic layer to improve intrusion detection and prevention systems. In diverse attack.scenarios， our technique has 3.5% higher accuracy， 4.3% higher precision， 8.5% higher recall， and 2.9% lower delay than previous models.

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高速火焰喷涂VC-CuNiCr涂层的耐腐蚀性能

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Journal of Central South University 2024年第5期31卷 1385-1397页

作者： SINGH Vik.ant b.NSAL Anuj SINGLA Anil kumar kumar Vijay Sant Longowal Institute of Engineering and Technology Longowal Sangrur 148106India Industrial and Production Engineering Department Dr B R Ambedkar National Institute of TechnologyJalandhar 144011India

本研究采用高速火焰喷涂(HVOF)沉积技术,将碳化钒(VC)和铜镍铬(CuNiCr)复合涂层应用于SS316不锈钢上,以解决不锈钢在海洋环境中的腐蚀问题。在室温环境下,在3.5%氯化钠溶液中进行电化学腐蚀,通过扫描电子显微镜(SEM)和能量色散光谱(EDS... 详细信息

本研究采用高速火焰喷涂(HVOF)沉积技术,将碳化钒(VC)和铜镍铬(CuNiCr)复合涂层应用于SS316不锈钢上,以解决不锈钢在海洋环境中的腐蚀问题。在室温环境下,在3.5%氯化钠溶液中进行电化学腐蚀,通过扫描电子显微镜(SEM)和能量色散光谱(EDS)对有涂层和未覆涂层样品的表面形貌进行检测。结果表明,涂层内由铜(Cu)、镍(Ni)和铬(Cr)组成的金属间黏合剂在氯化钠介质的影响下发生变质,从而导致出现衬底间的局部点蚀现象。有趣的是,在涂层配方中加入碳化钒(VC)显著地增强了表面的耐腐蚀性能,从而阻止了密闭腐蚀凹坑的出现。在不同类的涂层中,加入VC的效果最好,最小的腐蚀速率为72.38×10^(-3)mm/a,相比之下,SS316基底的腐蚀速率最快。

关键词：高速火焰喷涂碳化钒铜镍铬电化学腐蚀氯化钠溶液

Echocardiographic predictors and associated outcomes of multiple vegetations in infective endocarditis:A pilot study

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World Journal of Cardiology 2024年第6期16卷 318-328页

作者： Ajay kumar Mishra k.nnu b.nsal Ib.agim Al-Seyk.l Pradnya b.b.attad Anu Anna George Anil Jha Nitish Sharma Jennifer Sargent Mark.J k.anis Division of Cardiology Saint Vincent HospitalWorcesterMA 01608United States Department of Internal Medicine Saint Vincent HospitalWorcesterMA 01608United States Department of Medicine Division of CardiologySaint Vincent HospitalWorcesterMA 01608United States Division of Cardiovascular Medicine Saint Vincent HospitalWorcesterMA 01608United States

b.Ck.ROUND Infective endocarditis(IE)is a life-threatening infection with an annual mortality of 40%.Emb.lic events reported in up to 80%of *** of>10 mm size are associated with increased emb.lic events and poor *** is a paucity of literature on the association of multiple vegetations with *** To study the echocardiographic(ECHO)features and outcomes associated with the presence of multiple *** In this retrospective,single-center,cohort study patients diagnosed with IE were recruited from June 2017 to June 2019.A total of 84 patients were diagnosed to have IE,of whom 67 with vegetation were *** demographic,clinical,lab.ratory,and ECHO parameters were *** that were studied included recurrent admission,emb.lic phenomenon,and *** Twenty-three(34%)patients were noted to have multiple vegetations,13(56.5%)were male and 10(43.5%)were *** mean age of these patients was ***(35%)had a prior episode of *** features of moderate to severe valvular regurgitation[odds ratio(OR)=4],presence of pacemak.r lead(OR=4.8),impaired left ventricle(LV)relaxation(OR=4),and elevated pulmonary artery systolic pressure(PASP)(OR=2.2)are associated with higher odds of multiple *** these moderate to severe valvular regurgitation(P=0.028),pacemak.r lead(P=0.039)and impaired relaxation(P=0.028)were statistically *** patients were noted to have an increased association of recurrent admissions(OR=3.6),recurrent b.cteremia(OR=2.4),emb.lic phenomenon(OR=2.5),intensive care unit stay(OR=2.8),hypotension(OR=2.1),surgical intervention(OR=2.8)and device removal(OR=4.8).Of this device removal(P=0.039)and recurrent admissions(P=0.017)were statistically *** This study highlights the associations of ECHO predictors and outcomes in patients with IE having multiple *** features of moderate to severe regurgitation,presence of pacemak.r lead,impai

关键词： Endocarditis Echocardiography Vegetations Predictors Outcome