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Treatment with Intensity-Modulated Radiation Therapy (IMRT) and Chemotherapy in Advanced Inoperable Non-Small Cell Lung Cancer (NSCLC): Toxicity, Survival and Patterns of Failure in Relation to Treatment with High and Low Radiation Dose

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Journal of Cancer Therapy 2015年第11期6卷 943-953页

作者： James k. Russo Daniel Grass k.nt E. Armeson John Stahl Tarek.Dufan John Reynolds Aaron Luebk. Anand k. Sharma Bismarck.Cancer Center Bismarck ND USA Department of Radiation Oncology Medical University of South Carolina Charleston SC USA Department of Public Health Sciences Medical University of South Carolina Charleston SC USA Department of Therapeutic Radiation Yale School of Medicine New Haven CT USA Department of Medical Oncology Sanford Health Bismarck ND USA Department of Medical Oncology St. Alexius Health Bismarck ND USA

Purpose: To investigate the toxicity, survival and patterns of failure in patients with advanced lung cancer treated with intensity modulated radiation therapy (IMRT) and chemotherapy. Methods and Materials: Retrospective chart review of 68 total patients: 46 academic and 22 community center. Endpoints: Grade ≥ 3 pneumonitis, Grade ≥ 2 esophagitis, local, regional and distant failure, progression-free survival (PFS) and overall survival (OS). Results: For the academic center patients, median follow-up was 19.2 months. Esophagitis: 0% Grade 3, 35% Grade 2, no significant difference between dose bins: <70 Gy vs. 70 Gy, 25% vs. 45% (p = 0.22), <66 Gy vs. 66 - 70 Gy, 28% vs. 39% (p = 0.53). Lung dose metrics and PTV size were not associated with Grade ≥ 3 pneumonitis. Esophageal V35, V50, and mean dose but not PTV size was associated with Grade 2 esophagitis. 1 year local, regional and distant failure = 6.5%, 6.5%, and 30.4%. No endpoint differences were seen between dose bins, though patients with smaller PTVs treated with 70 Gy did demonstrate improved OS (ns) when compared to those treated with <70 Gy. Community Center: Median follow-up 6.2 months with 15% Grade 2 esophagitis, no Grade 3 esophagitis. Two patients (9%) experienced Grade ≥ 3 pneumonitis. Conclusions: IMRT chemoradiation was well tolerated in a population with advanced NSCLC both in the academic and community settings. Severe pneumonitis rates were low and comparable to other series using IMRT and chemotherapy. Esophagitis was mild and associated with V35, V50 and mean dose. No significant benefit was seen for higher doses regarding survival, local, regional or distant control despite that higher dose bins had smaller tumors. Though not statistically significant, we did find a trend toward worse OS for <70 Gy when the PTV was less than the median PTV.

关键词： IMRT NSCLC Toxicity Survival Patterns of Failure Chemotherapy

One-dimensional Nanostructured Materials From Organic Precursor

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复旦学报（自然科学版） 2005年第5期44卷 652-652页

作者： k. F. Cai Functional Materials Research Laboratory Tongji University 1239 Siping Road Shanghai China

One-dimensional nanostructured materials, such as nanowires, nanobelts, nanotubes and nanocables have been attracting a great research interest in the last decade due to their superior electrical, optical, mechanical and thermal properties, and many methods have been explored to synthesis of the materials, e.g., arc discharge, laser ablation, chemical vapor deposition, thermal evaporation, sol-gel method, template method and so on. In this work. we present a novel and simple method to one-dimensional nanostructured materials by pyrolysis of organic precursor.

关键词：一维空间有机前体纳米结构纳米管纳米电缆

Balancing Thermal and Electrical Pack.ging Requirements for GaN Microwave and Millimeter-Wave High Power Amplifier Modules

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Journal of Electronics Cooling and Thermal Control 2017年第1期7卷 1-7页

作者： Rick.Sturdivant Astacian Bogdon Edwin k. P. Chong MPT Inc. Fullerton CA USA Department of Electrical and Computer Engineering Colorado State University Fort Collins CO USA

A method for balancing thermal and electrical pack.ging requirements for gallium nitride (GaN) high power amplifier (HPA) modules is presented. The goal is to find a design approach that minimizes the junction temperature of the GaN so that it is reliable and has interconnects that meet electrical performance requirements. One benefit of GaN is that it can simultaneously achieve high power density and operate at microwave and millimeter-wave frequencies. However, the power density can be so high that the necessary thermal solutions can have negative impact on electrical performance. This is especially a concern for the electrical interconnects required for the input/ output ports on high power amplifier devices. This is because the signal interconnects must operate at GHz frequencies, which means that special care must be tak.n to avoid problems such as undesired signal coupling and ground path inductance. Therefore, this work.focuses on GaN pack.ging and its integration into a module. The results show that an optimum thick.ess for the GaN heat spreader exits for thermal performance but the electrical design is impacted negatively if the optimum thermal design is chosen. Therefore, a balanced design is chosen which meets overall system level requirements.

关键词： Thermal Design GaN Amplifier Balanced Design Electric Interconnects

The Fibered Isomorphism Conjecture for Complex Manifolds

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Acta Mathematica Sinica,English Series 2007年第4期23卷 639-658页

作者： S.k.ROUSHON School of Mathematics Tata InstituteHomi Bhabha RoadMumbai 400 005India

In this paper we show that the Fibered Isomorphism Conjecture of Farrell and Jones, corresponding to the stable topological pseudoisotopy functor, is true for the fundamental groups of a class of complex manifolds. A consequence of this result is that the Whitehead group, reduced projective class groups and the negative k.groups of the fundamental groups of these manifolds vanish whenever the fundamental group is torsion free. We also prove the same results for a class of real manifolds including a large class of 3-manifolds which has a finite sheeted cover fibering over the circle.

关键词： Complex projective variety Complex surfaces Whitehead group Fibered isomorphism conjecture Negative k.groups

The Effect of Traction Position in Cervical Traction Therapy Based on Dynamic Simulation Models

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Journal of Biomedical Science and Engineering 2017年第5期10卷 243-256页

作者： Lawrence k. F. Wong Zhiwei Luo Nobuyuk. k.rusu Graduate School of System Informatics Kobe University Kobe Japan k.be Factory of Minato Medical Science Co. LTD. Kobe Japan

This study describes the development of a cervical traction therapy simulation model that evaluates two types of the traction positions, namely the sitting position and the inclined position. An anatomically correct human sk.leton model and two mechanical traction device models were constructed in simulations using a physics engine. The anterior and posterior intervertebral separations were measured at both positions with a series of traction forces (60N to 200N) and traction angles (10°? to 40°?). The result suggested that the sitting position caused the subject to lean forward and as a result led to excessive anterior compression when traction angle is over 20 degrees. The inclined position creates greater intervertebral separations on both the anterior and posterior sides than the sitting position. This suggests that the inclined position may be more effective in increasing intervertebral separation than the sitting position.

关键词： Cervical Traction Therapy Spine Traction Position Dynamic Simulation

An exploration of the relationship between wastewater viral signals and COVID-19 hospitalizations in Ottawa,Canada

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Infectious Disease Modelling 2023年第3期8卷 617-631页

作者： k.k.n Peng Elizabeth M.Renouf Charmaine B.Dean X.Joan Hu Robert Delatolla Douglas G.Manuel Department of Statistics and Actuarial Science Simon Fraser University8888 University DrBurnabyV5A 1S6BCCanada Department of Statistics and Actuarial Science University of Waterloo200 University Ave WWaterlooN2L 3G1ONCanada Department of Civil Engineering University of Ottawa75 Laurier Ave.EOttawaK1N 6N5ONCanada The Ottawa Hospital Research Institute 1053 Carling AveOttawaK1Y 4E9ONCanada Department of Family Medicine University of Ottawa75 Laurier Ave.EOttawaK1N 6N5ONCanada School of Epidemiology and Public Health University of Ottawa75 Laurier Ave.EOttawaK1N 6N5ONCanada

Monitoring of viral signal in wastewater is considered a useful tool for monitoring the burden of COVID-19,especially during times of limited availability in testing.Studies have shown that COVID-19 hospitalizations are highly correlated with wastewater viral signals and the increases in wastewater viral signals can provide an early warning for increasing hospital admissions.The association is lik.ly nonlinear and time-varying.This project employs a distributed lag nonlinear model(DLNM)(Gasparrini et al.,2010)to study the nonlinear exposure-response delayed association of the COVID-19 hospitalizations and SARS-CoV-2 wastewater viral signals using relevant data from Ottawa,Canada.We consider up to a 15-day time lag from the average of SARS-CoV N1 and N2 gene concen-trations to COVID-19 hospitalizations.The expected reduction in hospitalization is adjusted for vaccination efforts.A correlation analysis of the data verifies that COVID-19 hospital-izations are highly correlated with wastewater viral signals with a time-varying rela-tionship.Our DLNM based analysis yields a reasonable estimate of COVID-19 hospitalizations and enhances our understanding of the association of COVID-19 hospi-talizations with wastewater viral signals.

关键词： Wastewater surveillance COVID-19 vaccination effectiveness Distributed lag nonlinear model Time varying correlation

Geodynamic evolution of the Tethyan lithosphere as recorded in the Spontang Ophiolite,South Ladak. ophiolites(NW Himalaya,India)

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Geoscience Frontiers 2022年第1期13卷 326-349页

作者： Mallik. k.Jonnalagadda Mathieu Benoit Shivani Harshe Romain Tilhac Raymond A.Duraiswami Michel Grégoire Nitin R.k.rmalk.r Interdisciplinary School of Science Savitribai Phule Pune UniversityPune 411007India Department of Geology Savitribai Phule Pune UniversityPune 411007India Géosciences Environnement Toulouse CNRS-CNES-IRD-UniversitéPaul SabatierObservatoire Midi Pyrénées31400 ToulouseFrance Instituto Andaluz de Ciencias de la Tierra(IACT) CSIC–Universidad de Granada18100 ArmillaGranadaSpain Vice-Chancellor’s Office Savitribai Phule Pune UniversityPune 411007India

The Spontang Ophiolite complex represents the most complete ophiolite sequence amongst the South Ladak. ophiolites and comprises mantle rock.(depleted harzburgites,dunites and minor lherzolites)as well as crustal rock.(basalt,isotropic gabbros,layered gabbros etc.).In the present study,detailed geochemistry(whole rock.as well as mineral chemistry)and Sr-Nd isotopic analyses of thirty-six ultramaficmafic samples have been attempted to constraint the evolution and petrogenetic history of the Tethyan oceanic crust.Major,trace-element and REE patterns of the peridotites and their minerals indicate that the lherzolites experienced lower degrees of partial melting resembling abyssal peridotites(at higher temperatures,TREE=$1216℃)than the harzburgites(6%–8%versus 15%–17%).Elevated eNd(t)and variable^(87) Sr/^(86) Sr(t)ratios along with REE patterns suggest that the Spontang mafic rock. display N-MORB affinity with negligible participation of oceanic sediments in their genesis are originated from a depleted upper mantle with little contribution from subduction-related fluids.MORB-type Neotethyan oceanic crust is associated with the earliest phase of subduction(of older Jurassic age)through which a younger intra-oceanic island arc(Spong arc)subsequently developed.Harzburgites REE display typical U-shaped patterns,suggesting that these rock. have been metasomatized by LREE-enriched fluids.On the other side,mafic rock. are characterized by heterogeneous(Nb/La)PMand(Hf/Sm)PMand relatively homogeneous eNd(t),indicating interaction of subduction-related melts with the upper mantle during the initiation of subduction,in Early Cretaceous times.

关键词： Peridotites Mafic rock. Partial melting Metasomatism Ladak.

Nanophotonic-structured front contact for high-performance perovsk.te solar cells

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Science China Materials 2022年第7期65卷 1727-1740页

作者： Md.Ak.taruzzaman Mohammad Ismail Hossain Mohammad Aminul Islam Md.Shahiduzzaman Ghulam Muhammad A.k.Mahmud Hasan Yuen Hong Tsang k.maruzzaman Sopian Solar Energy Research Institute(SERI) Universiti Kebangsaan Malaysia43600 BangiSelangorMalaysia Department of Applied Physics Hong Kong Polytechnic University(PolyU)KowloonHong KongChina Centre for Integrated Systems Engineering and Advanced Technologies(Integra) Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia(UKM)43600 BangiSelangorMalaysia Graduate School of Pure and Applied Sciences University of TsukubaTsukubaIbaraki 305-8573Japan Department of Electrical Engineering Faculty of EngineeringUniversity of MalayaJalan Universiti50603 Kuala LumpurSelangorMalaysia Nanomaterials Research Institute(NanoMaRi) Kanazawa UniversityKakumaKanazawa 920-1192Japan Department of Computer Engineering College of Computer and Information SciencesKing Saud University11543 RiyadhSaudi Arabia Department of Electrical and Computer Engineering University of CaliforniaDavisCA 95616USA Institute of Sustainable Energy Universiti Tenaga Nasional(@The National Energy University)Jalan IKRAM-UNITEN43000 KajangSelangorMalaysia

We report the design of a nanophotonic metaloxide front contact aimed at perovsk.te solar cells(PSCs)to enhance optoelectronic properties and device stability in the presence of ultraviolet(UV)light.High-quality Cr-doped ZnO film was prepared by industrially feasible magnetron sputter deposition for the electron transport layer of PSCs.As a means,the influence of the Cr content on the film and device was systematically determined.In-depth device optics and electrical effects were studied using advanced three-dimensional opto-electrical multiphysics rigorous simulations,optimizing the front contact for realizing high performance.The numerical simulation was validated by fabricating PSCs optimized to reach high performance,energy conversion efficiency(ECE)=17.3%,open-circuit voltage(V_(OC))=1.08 V,short-circuit current density(J_(SC))=21.1 mA cm^(-2),and fillfactor(FF)=76%.Finally,a realistic front contact of nanophotonic architecture was proposed while improving broadband light absorption of the solar spectrum and light harvesting,resulting in enhanced quantum efficiency(QE).The nanophotonic PSC enables J_(SC)improvement by~17%while reducing the reflection by 12%,resulting in an estimated conversion efficiency over 23%.It is further demonstrated how the PSCs’UV-stability can be improved without considerably sacrificing optoelectronic performances.Particulars of nanophotonic designed ZnO:Cr front contact,PSCs device,and fabrication process are described.

关键词： ZnO:Cr front contact magnetron sputtering perovsk.te solar cells UV stability optics and electrical effects

Functional recovery after peripheral nerve injury via sustained growth factor delivery from mineral-coated microparticles

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Neural Regeneration Research 2021年第5期16卷 871-877页

作者： Daniel J.Hellenbrand Clayton L.Haldeman Jae-Sung Lee Angela G.Gableman Elena k.Dai Stephen D.Ortmann Jerrod CGotchy k.erra k.Miller Adrianna M.Doucas Nicole C.Nowak.William L.Murphy Amgad S.Hanna Department of Neurological Surgery University of WisconsinMadisonWIUSA Department of Biomedical Engineering University of WisconsinMadisonWIUSA Department of Orthopedics and Rehabilitation University of Wisconsin Madison WIUSA

The gold standard for treating peripheral nerve injuries that have large nerve gaps where the nerves cannot be directly sutured back.together because it creates tension on the nerve,is to incorporate an autologous nerve graft.However,even with the incorporation of a nerve graft,generally patients only regain a small portion of function in limbs affected by the injury.Although,there has been some promising results using growth factors to induce more axon growth through the nerve graft,many of these previous therapies are limited in their ability to release growth factors in a sustained manner and tailor them to a desired time frame.The ideal drug delivery platform would deliver growth factors at therapeutic levels for enough time to grow axons the entire length of the nerve graft.We hypothesized that mineral coated microparticles(MCMs)would bind,stabilize and release biologically active glial cell-derived neurotrophic factor(GDNF)and nerve growth factor(NGF)in a sustained manner.Therefore,the objective of this study was to test the ability of MCMs releasing growth factors at the distal end of a 10 mm sciatic nerve graft,to induce axon growth through the nerve graft and restore hind limb function.After sciatic nerve grafting in Lewis rats,the hind limb function was tested week.y by measuring the angle of the ank.e at toe lift-off while walk.ng down a track.Twelve week. after grafting,the grafts were harvested and myelinated axons were analyzed proximal to the graft,in the center of the graft,and distal to the graft.Under physiological conditions in vitro,the MCMs delivered a burst release of NGF and GDNF for 3 days followed by a sustained release for at least 22 days.In vivo,MCMs releasing NGF and GDNF at the distal end of sciatic nerve grafts resulted in significantly more myelinated axons extending distal to the graft when compared to rats that received nerve grafts without growth factor treatment.The rats with nerve grafts incorporated with MCMs releasing NGF and GDNF also showed significant improvement in hind

关键词： autografts axon growth drug delivery glial cell-derived neurotrophic factor growth factors mineral coatings nerve grafting nerve growth factor