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Current status of esophageal cancer treatment

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Chinese Journal of Cancer Research 2020年第3期32卷 271-286页

作者： Tania Triantafyllou bas P L Wijnhoven Department of Surgery Hippocration General Hospital of AthensNational and Kapodistrian University of AthensAthens 11527Greece Department of Surgery Erasmus University Medical CenterRotterdam 3000the Netherlands

Esophageal cancer(EC) remains one of the most common and aggressive diseases *** review discusses some debates in the modern management of the *** procedures for early cancer(T1a-b) are now embedded in routine care and the challenge will be to more accurately select patients for endoscopic resection with or without adjuvant *** multimodal therapies are associated with improved survival compared to surgery alone for locally advanced esophageal ***, there is no global consensus on the optimal ***, histological subtype(adenocarcinoma *** cell cancer) plays a role in the choice for *** studies are underway to resolve some *** extent of the lymphadenectomy during esophagectomy remains controversial especially after neoadjuvant *** ideal operation balances between limiting surgical trauma and optimizing *** invasive esophagectomy and enhanced recovery pathways are associated with decreased morbidity and faster recovery albeit there is no consensus yet what approach should be ***, immune check.oint inhibitors present promising preliminary results in the novel treatment of advanced or metastatic EC but their widespread application in clinical practice is still awaited.

关键词： Esophageal cancer endoscopic resection minimally invasive esophagectomy multimodal treatment fast-track.protocols

Fully invertible hyperbolic neural network. for segmenting large-scale surface and sub-surface data

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Artificial Intelligence in Geosciences

Artificial Intelligence in Geosciences 2024年第1期5卷 269-281页

作者： bas Peters Eldad Haber k.egan Lensink Computational Geosciences Inc. VancouverV6H 3Y4BCCanada The University of British Columbia Department of EarthOceanand Atmospheric SciencesVancouverV6T 1Z4BCCanada

The large spatial/temporal/frequency scale of geoscience and remote-sensing datasets causes memory issues when using convolutional neural network. for(sub-)surface data *** developed fully reversible or fully invertible network. can mostly avoid memory limitations by recomputing the states during the back.ard pass through the *** results in a low and fixed memory requirement for storing network.states,as opposed to the typical linear memory growth with network.*** work.focuses on a fully invertible network.based on the telegraph *** reversibility saves the major amount of memory used in deep network. by the data,the convolutional k.rnels can tak. up most memory if fully invertible network. contain multiple invertible pooling/coarsening *** address the explosion of the number of convolutional k.rnels by combining fully invertible network. with layers that contain the convolutional k.rnels in a compressed form directly.A second challenge is that invertible network. output a tensor the same size as its *** property prevents the straightforward application of invertible network. to applications that map between different input-output dimensions,need to map to outputs with more channels than present in the input data,or desire outputs that decrease/increase the resolution compared to the input ***,we show that by employing invertible network. in a non-standard fashion,we can still use them for these *** in hyperspectral land-use classification,airborne geophysical surveying,and seismic imaging illustrate that we can input large data volumes in one chunk.and do not need to work.on small patches,use dimensionality reduction,or employ methods that classify a patch to a single central pixel.

关键词： Invertible neural network. Large scale deep learning Memory efficient deep learning

Diagnosis and management of pediatric adrenal insufficiency

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World Journal of Pediatrics 2016年第3期12卷 261-274页

作者： Ahmet Ucar Firdevs bas Nurcin Sak. Growth-Development and Pediatric Endocrine Unit Istanbul School of MedicineIstanbul UniversityTurkey

Back.round:Adrenal insufficiency(AI)is a wellk.own cause of potentially life-threatening *** at each level of the hypothalamic-pituitary-adrenal axis can impair adrenal function,leading to varying degrees of glucocorticoid(GC)*** AI induced by exogenous GCs is the most common cause of *** criteria for the diagnosis and management of iatrogenic AI,neonatal AI,and critical illness-related corticosteroid insuffi ciency(CIRCI)are not *** sources:We reviewed the recent original publications and classical data from the literature,as well as the clinical,diagnostic and management strategies of pediatric ***:Practical points in the diagnosis and management of AI with an emphasis on iatrogenic AI,neonatal AI,and CIRCI are *** the lack.of sensitive and practical biochemical tests for diagnosis of subtle AI,GC treatment has to be tailored to highly suggestive clinical symptoms and *** of adrenal crisis is well standardized and patients almost invariably respond well to *** is mainly the delay in treatment that is responsible for mortality in adrenal ***:Education of patients and health care professionals is mandatory for timely interventions for patients with adrenal crisis.

关键词： adrenal insuffi ciency critical illness hypothalamo-pituitary-adrenal axis iatrogenic steroids

Inhibition of hypoxia-inducible factor 1 with acriflavine sensitizes hypoxic tumor cells to photodynamic therapy with zinc phthalocyanine-encapsulating cationic liposomes

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Nano Research 2016年第6期9卷 1639-1662页

作者： Mans Broek.aarden Ruud Weijer Massis k.ek.rian bas van den IJssel Milan k.s Lindy k. Alles Albert C. van Wijk. Zsolt Bik.di Eszter Hazai Thomas M. van Gulik.Michal Heger Department of Experimental Surgery Academic Medical Center University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam the Netherlands Virtua Drug Ltd. Csalogany 4C H-1015 Budapest Hungary

Photodynamic therapy （PDT） is a tumor treatment modality in which a tumor- localized photosensitizer is excited with light, which results in local production of reactive oxygen species, destruction of tumor vasculature, tumor hypoxia, tumor cell death, and induction of an anti-tumor immune response. However, pre-existing tumor hypoxia may desensitize tumors to PDT by activating the hypoxia-inducible factor 1 （HIF-1） survival pathway. Therefore, we hypothesized that inhibition of HIF-1 with acriflavine （ACF） would exacerbate cell death in human epidermoid carcinoma （A431） cells. PDT of A431 tumor cells was per- formed using newly developed and optimized PEGylated cationic liposomes containing the photosensitizer zinc phthalocyanine （ZnPC）. Molecular dock.ng revealed that ACF binds to the dimerization domain of HIF-la, and confocal microscopy confirmed translocation of ACF from the cytosol to the nucleus under hypoxia. HIF-1 was stabilized in hypoxic, but not normoxic, A431 cells following PDT. Inhibition of HIF-1 with ACF increased the extent of PDT-induced cell death under hypoxic conditions and reduced the expression of the HIF-1 target genes VEGF, PTGS2, and EDN1. Moreover, co-encapsulation of ACF in the aqueous core of ZnPC-containing liposomes yielded an adjuvant effect on PDT efficacy that was comparable to non-encapsulated ACF. In conclusion, HIF-1 contributes to A431 tumor cell survival following PDT with liposomal ZnPC. Inhibition of HIF-1 with free or liposomal ACF improves PDT efficacy.

关键词： cancer therapy confocal microscopy drug delivery system glucose metabolism hypoxia

Evolution of laparoscopic gastrectomy for cancer in the East and West

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Chinese Journal of Cancer Research 2022年第6期34卷 579-586页

作者： Eider Talavera-Urquijo bas P.L.Wijnhoven Department of Surgery University Hospital of DonostiaDonostia-San Sebastian 20014Spain Department of Surgery Erasmus University Medical Centre RotterdamRotterdam 3000the Netherlands

Laparoscopic gastrectomy has evolved differently in Eastern and Western ***,safety and oncological outcomes of laparoscopic gastrectomy were addressed step-by-step by several randomized controlled trials from the *** phase III studies were published from the West that largely did not show a difference between the laparoscopic and open *** this,laparoscopic gastrectomy is seen as the standard for the surgical treatment of early and advanced gastric cancer in many European ***,we review and comment on some important studies on laparoscopic gastrectomy for gastric cancer from Eastern and Western countries and also comment on current and future challenges.

关键词： Laparoscopic gastrectomy minimally invasive surgery gastric cancer

The Japanese Clinical Practice Guidelines for intrahepatic cholangiocarcinoma: a comparison with Western guidelines

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 244-247页

作者： Stefan Buettner bas Groot k.erk.mp Department of Surgery Erasmus MC University Medical CenterRotterdamThe Netherlands

The Liver Cancer Study Group of Japan(LCSGJ)recently published the first version of the clinical practice guidelines for intrahepatic cholangiocarcinoma(iCCA)(1).The study group followed the GRADE methodology for evidence-based *** is a world leader in the treatment of cholangiocarcinoma,with Japanese medical centers realizing superior results compared to other developed countries and many landmark.articles originating from these *** there are differences between the Japanese iCCA population and patients in other countries,these guidelines contain important lessons for healthcare providers across the world.

关键词： Intrahepatic cholangiocarcinoma treatment guideline

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吸力式基础设计（英文）

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2018年第8期19卷 579-599页

作者： bas van DIJk Fugro

目的:吸力式基础具有投资费用低、施工时间短、无噪音和可重复使用等优点,因此被广泛应用在海洋工程领域。本文针对吸力式基础设计中的关键问题,主要综述现有设计理论,指出理论缺陷,并给出设计建议。创新点:综述砂土、粘土和成层土中吸... 详细信息

目的:吸力式基础具有投资费用低、施工时间短、无噪音和可重复使用等优点,因此被广泛应用在海洋工程领域。本文针对吸力式基础设计中的关键问题,主要综述现有设计理论,指出理论缺陷,并给出设计建议。创新点:综述砂土、粘土和成层土中吸力式基础的安装、回收、基础承载力、基础沉降和服役性能中的关键科学问题和现有设计理论。方法:1.基于文献报道的现场试验和模型试验,针对吸力式基础安装过程中的沉贯阻力、临界吸力和土塞效应,评估现有设计理论的准确性;2.分析粘土和砂土中吸力式基础的完全排水、完全不排水和部分排水条件下静力和循环承载力计算理论;3.针对吸力式基础的长期服役性能,分析荷载引起的基础变形、固结沉降、循环再固结沉降和极端荷载下的"棘轮效应"。结论:1.现有的吸力式基础安装中沉贯阻力计算理论没有普适性;对于临界吸力的计算,由于没有考虑"土拱效应",理论计算值均低估了安装吸力。2.对于粘土中吸力式基础承载力的计算需要考虑循环作用下土体的强度弱化和基础-土间空隙引起的承载力降低,而砂土中基础承载力计算需要考虑排水条件的影响。3.对于吸力式基础的长期服役性能,特别是基础变形的计算,目前还缺少成熟的计算理论。

关键词：吸力式基础安装承载力变形

Re-interpretation of zircon date in a carbonatite dyk. at the Bayan Obo giant REE-Fe-Nb deposit,China

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岩石学报 2006年第2期22卷 517-518页

作者： Le bas MJ Department of Mineralogy Natural History Museum LondonSW7 5BDUK

Recent ce-valuation of the dating of the carbonatite dyk.s associated with the REE-Re-Nb giant deposit at Bayan Obo

关键词： REE Re-interpretation of zircon date in a carbonatite dyk. at the Bayan Obo giant REE-Fe-Nb deposit,China Fe

Structural effects on the magnetic hyperthermia properties of iron oxide nanoparticles

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Progress in Natural Science:Materials International 2016年第5期26卷 440-448页

作者： Eric C.Abenojar Sameera Wick.amasinghe Jesbaniris bas-Concepcion Anna Cristina S.Samia Department of Chemistry Case Western Reserve University Chemistry Department University of Puerto Rico Rio Piedras Campus

Magnetic iron oxide nanoparticles(IONPs) are heavily explored as diagnostic and therapeutic agents due to their low cost, tunable properties, and biocompatibility. In particular, upon excitation with an alternating current(AC) magnetic field, the NPs generate localized heat that can be exploited for therapeutic hyperthermia treatment of diseased cells or pathogenic microbes. In this review, we focus on how structural changes and inter-particle interactions affect the heating efficiency of iron oxide-based magnetic NPs. Moreover, we present an overview of the different approaches to evaluate the heating performance of IONPs and introduce a new theranostic modality based on magnetic imaging guided–hyperthermia.

关键词： Iron oxide nanoparticles Magnetic hyperthermia Magneto-structural effects Magnetic dipolar interactions Magnetic imaging guided–hyperthermia