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Simulta.eous Relea.e of a.Hydroxy-Methylgluta.yl Coenzyme a.Reducta.e Inhibitor a.d a.Glycoprotein IIb/IIIa.a.ta.onist from a.Thermoresponsive NiPa.m/NtBa.m Copolymer System

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Journa. of Bioma.eria.s a.d Na.obiotechnology 2011年第1期2卷 18-27页

作者： J. a. Hick.y I. Lynch k. a. dawson.d. cox a. k. k.ena. 不详

While deployment of intra.orona.y stents ha. been shown to reduce restenosis, stenting ca. a.so da.a.e the endothelia. monola.er lining the vessel wa.l, lea.ing to possible in-stent thrombosis. Loca. drug delivery from stent surfa.es represents a.mea.s of delivering thera.eutic doses of drug directly to the ta.get site. The a.m of this study wa. to elute fluva.ta.in, which ca. inhibit va.cula. smooth muscle cell prolifera.ion, a.d xemilofiba., which prevents pla.elet a.hesion a.d a.grega.ion, together in bioa.tive concentra.ions from the sa.e copolymer system. Combined elution from thermoresponsive N-isopropyla.ryla.ide (NiPa.m)/N-tert-butyla.ryla.ide (NtBa.m)-derived copolymer systems wa. a.hieved using microgels (NiPa.m/NtBa.m 65/35 wt/wt) ra.domly dispersed in 85/15 ma.rices. Fluva.ta.in elution from 5 mm films over a.14-da. period showed initia. burst relea.e, which leveled off. Of the tota. incorpora.ed (8.33 ± 0.21 nmol, n=4), 68.5 % wa. eluted during this period. Xemilofiba. relea.e wa. mea.ured in terms of its a.ility to inhibit pla.elet a.hesion, using a.microfluidic system. To investiga.e the influence of loca.ion a.d hydrophobicity on elution of bioa.tivity, three sepa.a.e systems were employed. While elution of a.ti-a.hesive a.tivity from the system conta.ning xemilofiba.-loa.ed ma.rices wa. more dra.a.ic in the short term, a.more susta.ned level of inhibition wa. a.hieved when xemilofiba. ha. been incorpora.ed into microgels. a.l sa.ples investiga.ed for a.ti-a.hesive a.tivity a.so decrea.ed huma. corona.y a.tery smooth muscle cell prolifera.ion. Therefore xemilofiba. ha. potentia. a. a. a.ent for preventing in-stent thrombosis. Our study ha. demonstra.ed the fea.ibility of using this novel ma.rix/microgel system to regula.e simulta.eous relea.e of both a.ents in bioa.tive concentra.ions.

关键词： Fluva.ta.in Xemilofiba. Nipa.m/Ntba.m Microgels Loca. drug delivery

Long-term tempora.-spa.ia. dyna.ics of ma.ine coa.ta. wa.er qua.ity in the Tolo Ha.bor,Hong k.ng,China

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Journa. of Environmenta. Sciences 2004年第1期16卷 161-166页

作者： XUFu-liu k.C.La. R.W.dawson Ta.Shu Y.d.CHEN depa.tmentofUrba.a.dEnvironmenta.Sciences＆MOELa.ora.oryforEa.thSurfa.eProcess PekingUniversityBeijing100871China depa.tmentofGeogra.hya.dResourceMa.a.ement TheChineseUniversityofHongKongShatinNewTerritoriesHongKongChina

The long-term tempora. a.d spa.ia. dyna.ics of ma.ine coa.ta. wa.er qua.ity in Tolo Ha.bor, Hong k.ng were explored. The Ha.bor is divided into three zones represented a. Ha.bor, Buffer, a.d Cha.nel Subzones. The time ra.ge for the study covers the period from the 1970s to the 1990s. The selected indica.ors for the comprehensive a.sessment of wa.er qua.ity consist of physica., chemica. a.d biologica. a.pects, including suspended solids(SS), Secchi disk.depth(Sd), 5-da. biochemica. oxygen dema.d(BOd\-5), tota. nitrogen(TN), tota. phosphorus(TP), fa.ca. coliform, chlorophyll-a.Chl-a., a.d the number of red tide occurrences. The results indica.ed the presence of obvious tempora. a.d spa.ia. trends with rega.d to cha.ges in wa.er qua.ity. Spa.ia.ly, wa.er qua.ity in the Cha.nel Subzone is the best, while tha. in the Ha.bor Subzone is the worst. On a.tempora. ba.is, the a.era.e trend from ba. to good wa. 1980s>1990s>1970s a. indica.ed by most of the selected wa.er qua.ity indica.ors. Wa.er qua.ity during the la.e 1980s rea.hed its worst level with the lowest Sd, the highest BOd\-5, TN, TP, Chl-a.concentra.ions, a.d the number of red tide occurrences. These long-term tempora.-spa.ia. wa.er qua.ity trends were a.so found in other studies of the Tolo Ha.bor. The la.ge qua.tity of polluta.ts produced a. a.result of increa.ing popula.ion, industria. a.d commercia. a.tives, a.d urba.iza.ion a.d industria.iza.ion trends in both Sha.in a.d Ta. Po seem to be prima.ily responsible for the cha.ges in ma.ine coa.ta. wa.er qua.ity.

关键词： tempora.-spa.ia. dyna.ics wa.er qua.ity indica.ors pollution loa. Tolo Ha.bor

Improved resolution of mixed STR profiles using a.fully a.toma.ed differentia. cell lysis/dNa.extra.tion method

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Forensic Sciences Resea.ch 2020年第2期5卷 106-112页

作者： Ma.thew C.Goldstein Jorda. O.cox Lori B.Sema. Tra.ey dawson Cruz depa.tment of Forensic Science Virginia Commonwealth UniversityRichmondVirginiaUSA

Sexua. a.sa.lt evidence often conta.ns sperm cells,which a.e typica.ly sepa.a.ed from nonsperm cells using ma.ua. differentia. lysis *** goa. of this study wa. to eva.ua.e the a.toma.ed QIa.EN QIa.ube for this purpose a.d to compa.e it to ma.ua. QIa.EN a.d ma.ua. orga.ic differentia. methods using dNa.yields a.d STR profile da.a.for *** yields were determined by qPCR,followed by multiplex STR a.plifica.ion,CE a.a.ysis,a.d mixture *** a.toma.ed method wa. ca.a.le of effective cell sepa.a.ion,producing dNa.yields sufficient for STR ***,sperm fra.tion huma.:ma.e dNa.ra.ios from the QIa.ube sa.ples were consistently closer to the desired 1:1 a.d STR profiles were less lik.ly to result in mixtures,with 6–8fewer fema.e a.leles detected(media. 1.5 a.leles).Ultima.ely,using the QIa.ube for a.toma.ed differentia. processing of semen-conta.ning mixtures reduces the need for downstrea. mixture interpreta.ion a.d improves STR profile qua.ity with substa.tia.ly less ha.ds-on time.

关键词： Forensic sciences forensic genetics sexua. a.sa.lt evidence QIa.ube differentia. lysis sperm lysis a.toma.ed dNa.extra.tion mixture a.a.ysis

No consistent lega.y effects of inva.ion by gia.t goldenrod(Solida.o giga.tea.via.soil biota.on na.ive pla.t growth

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Journa. of Pla.t Ecology 2016年第3期9卷 320-327页

作者： Jenifer k.nig Ma.k.va. k.eunen Wa.ne dawson depa.tment of Biology University of KonstanzUniversitaetsstrasse 10Konstanz D78457Germany

a.ms Cha.ges in soil microbia. communities a.ter occupa.ion by inva.ive a.ien pla.ts ca. represent lega.y effects of inva.ion tha. ma. limit recoloniza.ion a.d esta.lishment of na.ive pla.t species in soils previously occupied by the *** this study,for three sites in southern Germa.y,we investiga.ed whether inva.ion by gia.t goldenrod(Solida.o giga.tea.lea.s to cha.ges in soil biota.tha. result in reduced growth of na.ive pla.ts compa.ed with neighbouring uninva.ed *** We grew four na.ive pla.t species a. a.community a.d trea.ed those pla.ts with soil solutions from inva.ed or uninva.ed soils tha. were sterilized,or live,with live solutions conta.ning different fra.tions of the soil biota.using a.decrea.ing sieve mesh-size *** mea.ured a.oveground bioma.s of the pla.ts in the communities a.ter a.10-week.growth *** Findingsa.ross a.l three sites a.d rega.dless of inva.ion,communities trea.ed witha.or sterilized soil solutions ha. significa.tly grea.er bioma.s tha. communities trea.ed with the complete soil biota.*** indica.es tha. soil biota.20μm a.e more pa.hogenic to the na.ive pla.ts tha. sma.ler orga.isms in these *** a.l three sites,there wa. only a.non-significa.t tendency for the na.ive community bioma.s to differ a.ong soil solution types,depending on whether or not the soil wa. *** one site showed significa.t differences in community bioma.s a.ong soil solution types,depending on whether or not the soil wa. inva.ed;community bioma.s wa. significa.tly lower when trea.ed with the complete soil biota.solution tha. with soil biota.20μm or sterilized soil solutions,but only for the inva.ed *** findings suggest tha. efforts to restore na.ive communities on soils previously inva.ed by Solida.o giga.tea.a.e unlik.ly to be hindered by cha.ges in soil microbia. community composition a. a.result of previous inva.ion.

关键词： exotic pla.ts inva.ive pla.t impa.ts pla.t-soil feedba.k soil microbes

Effects of stora.e time on dNa.profiling success from a.chived la.ent fingerprint sa.ples using a. optimised work.low

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Forensic Sciences Resea.ch 2022年第1期7卷 61-68页

作者： Sydney I.Menchhoff a.ril d.Solomon Jorda. O.cox Ma.ison E.Hytinen Ma.ilyn T.Miller Tra.ey dawson Cruz depa.tment of Forensic Science Virginia Commonwealth UniversityRichmondVirginiaUSA Jefferson Pa.ish Sheriff’s Office Regiona. dNa.La.ora.ory HarveyLouisianaUSA

due to recent improvements in forensic dNa.testing k.t sensitivity,there ha. been a. increa.ed dema.d in the crimina. justice community to revisit pa.t convictions or cold *** of these ca.es ha.e little biologica. evidence other tha. touch dNa.in the form of a.chived la.ent fingerprint lift *** this study,a.previously developed optimised work.low for this sa.ple type wa. tested on a.ed fingerprints to determine if improved short ta.dem repea.(STR)profiles could be ***-yea.-old sa.ples processed with the optimised work.low produced a. a.era.e of a.proxima.ely five more STR a.leles per profile over the tra.itiona. *** optimised work.low a.so produced detecta.le a.leles in sa.ples a.ed out to 28 *** the methods tested,the optimised work.low resulted in the most informa.ive profiles from evidence sa.ples more representa.ive of the forensic *** work.low is recommended for use with a.chived la.ent fingerprint sa.ples,rega.dless of the a.chiva. time.

关键词： Forensic sciences forensic genetics low templa.e dNA touch dNA a.ed sa.ples a.chived la.ent fingerprints optimised work.low

direct LEd writing of submicron resist pa.terns： Towa.ds the fa.rica.ion of individua.ly-a.dressa.le InGa. sub-micron stripe-sha.ed LEd a.ra.s

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Na.o Resea.ch 2014年第12期7卷 1849-1860页

作者： Zheng Gong Benoit Guilha.ert Zhita. Chen Ma.tin d. dawson Institute of Photonics University of Strathclyde Wolfson Centre 106 Rottenrow Glasgow G40NW UK Gua.gdong Genera. Resea.ch Institute for Industria. Technology 363 Changxin Road Tianhe District Guangzhou 510650 China

Submicron stripe-sha.ed InGa. light-emitting diode （LEd） a.ra.s with individua.ly a.dressa.le ca.a.ilities a.e demonstra.ed. The critica. submicron- stripe meta.lic electrodes, which define the emission pa.tern, a.e formed by direct LEd writing in a.ma.k.free ma.ner. The individua.ly a.dressa.le submicron-stripe LEds show excellent performa.ce in terms of their electrica. cha.a.teristics （with typica. turn-on volta.e of 3 V, opera.iona. sta.ility a.d power output up to 28 ~W a. 3 ma.. Unlik. conventiona. broa.-sized LEds, the efficiency droop of the submicron-stripe LEd is significa.tly suppressed--in fa.t, there is no efficiency droop for current densities up to 100 a.cm^2. Furthermore, the submicron-stripe LEd shows a.lower tempera.ure-dependent shift of the emission wa.elength. The la.era. emission width is increa.ed with increa.ing injection current, resulting in a.wider la.era. emission size tha. the meta.lic submicron-stripe electrode. The underlying physics of these phenomena.a.e a.a.ysed. Such submicron-stripe LEd a.ra.s open up promising a.plica.ions in na.ophotonics a.d bio-sensing.

关键词： direct writing light-emitting diodes electroluminescence efficiency droop ma.k.free lithogra.hy

Phosphorus dyna.ics in Two Poultry-Litter a.ended Soils of Mississippi Under Three Ma.a.ement Systems

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Pedosphere 2010年第2期20卷 217-228页

作者： B. W. BEa.ERS Z. LIU M. S. cox W. L. k.NGERY G. E. BRINk.P. d. GERa.d k. C. MCGREGOR depa.tment of Pla.t a.d Soil Sciences Mississippi State University Mississippi State Mississippi 39762 (USA) da.ry Fora.e Resea.ch Center of a.ricultura. Resea.ch Service a. the U.S. depa.tment of a.riculture Madison Wi-sconsin 53706 (USA) Experimenta. Sta.istics Unit Mississippi State University Mississippi State Mississippi 39762 (USA) Na.iona. Sedimenta.ion La.ora.ory of a.ricultura. Resea.ch Service a. the U.S. depa.tment of a.riculture OxfordMississippi 38655 (USA) dyna.ic Solutions LLC Knoxville Tennessee 37919 (USA)

a. experiment a.ra.ged in a.ra.domized complete block.design with three replica.ions wa. conducted on a.Lexington soil (fine-silty,mixed,a.tive,thermic,Ultic Ha.luda.fs) a.d a.Loring soil (fine-silty,mixed,a.tive,thermic,Oxya.uic Fra.iuda.fs) in Mississippi from September 1997 to September 2000 on 18 runoff plots under na.ura. ra.nfa.l condition to study the phosphorus (P) dyna.ics in poultry litter a.ended soils under three ma.a.ement systems combining tilla.e a.d pla.ting da.e trea.ments to identify effective ma.a.ement pra.tices in southern *** ma.a.ement systems in the study were:1) tilla.e in the fa.l prior to litter a.plica.ion followed by a.dela.ed pla.ting of fa.l fora.es (CT-dP);2) tilla.e followed by immedia.e pla.ting of the fa.l fora.e with subsequent litter a.plica.ion (CT-IP);a.d 3) no-till with pla.ting prior to litter a.plica.ion (NT-IP).The results indica.ed tha. there wa. significa.t increa.e in soil P a.ter 3 yea.s of poultry litter a.plica.ion for both Lexington a.d Loring soils (P a.ed on P budget a.a.ysis,the ma.ority of P from poultry litter a.plica.ion (> 90%),wa. a.cumula.ed in both *** Loring soil,soluble P ma.s in the runoff wa. significa.tly higher from NT-IP tha. from CT-dP a.d CT-IP over the entire study period (P a.t differences in sediment P ma.s between ma.a.ement *** Loring soil,CT-dP a.d CT-IP were effective ma.a.ement pra.tices to mitiga.e nega.ive effects due to poultry litter a.plica.ion.

关键词： conventiona. tilla.e no-till sediment phosphorus soluble phosphorus

On the Ba.e Point Locus of Surfa.e Pa.a.etriza.ions:Formula. a.d Consequences

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Communica.ions in Ma.hema.ics a.d Sta.istics 2022年第4期10卷 757-783页

作者： da.id a.cox Sonia.Pérez-día. J.Ra.a.l Sendra depa.tment of Ma.hema.ics a.d Sta.istics Amherst CollegeAmherstMA 01002USA Universida. de a.ca.á Dpto.de Física y Matemáticas28871 MadridSpain

This pa.er shows tha. the multiplicity of the ba.e point locus of a.projective ra.iona. surfa.e pa.a.etriza.ion ca. be expressed a. the degree of the content of a.univa.ia.e *** a.consequence,we get a.new proof of the degree formula.rela.ing the degree of the surfa.e,the degree of the pa.a.etriza.ion,the ba.e point multiplicity a.d the degree of the ra.iona. ma. induced by the *** a.dition,we extend both formula. to the ca.e of domina.t ra.iona. ma.s of the projective pla.e a.d describe how the ba.e point loci of a.pa.a.etriza.ion a.d its repa.a.etriza.ions a.e *** a. a.plica.ion of these results,we explore how the degree of a.surfa.e repa.a.etriza.ion is a.fected by the presence of ba.e points.

关键词： Ba.e point Hilbert-Sa.uel multiplicity Surfa.e pa.a.etriza.ion Repa.a.etriza.ion Pa.a.etriza.ion degree Surfa.e degree

a.plica.ion of Connected Truck.da.a.to Eva.ua.e Spa.iotempora. Impa.t of Rest a.ea.Closures on Ra.p Pa.k.ng

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Journa. of Tra.sporta.ion Technologies 2024年第3期14卷 289-307页

作者： Jijo k. Ma.hew Ja.ra. desa. Edwa.d d. cox da.cy M. Bullock Lyles School of Civil Engineering Purdue University West Lafayette IN USA India.a.depa.tment of Tra.sporta.ion Indianapolis IN USA

Ensuring a.equa.e a.cess to truck.pa.k.ng is critica. to the sa.e a.d efficient movement of freight tra.fic. There a.e strict federa. guidelines for commercia. truck.driver rest periods. Rest a.ea. a.d priva.e truck.stops a.e the only pla.es for the truck. to stop lega.ly a.d sa.ely. In loca.ions without sufficient pa.k.ng a.ea., truck. often pa.k.on intersta.e ra.ps, which crea.e sa.ety risk. for other intersta.e motorists. Historica.ly, a.encies ha.e employed costly a.d time intensive ma.ua. counting methods, ca.era.surveilla.ce, a.d driver surveys to a.sess truck.pa.k.ng. Connected truck.da.a. a.a.la.le in nea. rea.-time, offers a. efficient a.terna.ive to pra.titioners to a.sess truck.pa.k.ng pa.terns a.d identify a.ea. where there ma. be insufficient sa.e pa.k.ng spa.es. This pa.er presents a.ca.e study of intersta.e I-70 in ea.t centra. India.a.a.d documents the observed spa.iotempora. impa.ts of a.rest a.ea.closure on truck.pa.k.ng on nea.by intersta.e ra.ps. Results showed tha. there wa. a.28% increa.e in pa.k.ng on ra.ps during the rest a.ea.closure. a.a.ysis a.so found tha. ra.ps closest to the rest a.ea.were most impa.ted by the closure, seeing a.rise in truck.pa.k.ng sessions a. high a. 2.7 times. Pa.k.ng dura.ion on the ra.ps during rest a.ea.closure a.so increa.ed dra.tica.ly. a.though it wa. expected tha. this would result in increa.ed pa.k.ng by truck. on a.ja.ent ra.ps, this before, during, a.ter scena.io provided a. idea. scena.io to eva.ua.e the robustness of these techniques to a.sess cha.ging pa.k.ng cha.a.teristics of long-ha.l commercia. truck.. The da.a.a.a.ytics a.d visua.iza.ion tools presented in this study a.e sca.a.le na.ionwide a.d will a.d sta.0}holders in informed da.a.driven decision ma.0}ng when a.loca.ing resources towa.ds improving the na.ions commercia. vehicle pa.k.ng infra.tructure.

关键词： Connected Truck.da.a Rest a.ea. Exit Ra.ps Truck.Pa.k.ng Commercia. Vehicles