检索结果-南通市图书馆

Effects of P301L-Ta. on post-tra.sla.iona. modifica.ions of microtubules in huma. iPSC-derived cortica. neurons a.d Ta. tra.sgenic mice

引用

Neura. Regenera.ion Resea.ch 2025年第8期20卷 2348-2360页

作者： Moha.ed a.hya. a. k.bba.i Christoph k.hler Ha.s Zempel Institute of Huma. Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecula. Medicine Cologne(CMMC) University of CologneCologneGermany Center a.a.omy Department ⅡMedical FacultyUniversity of CologneCologneGermany

Ta. is a.microtubule-a.socia.ed protein tha. promotes microtubule a.sembly a.d sta.ility in the *** is missorted a.d a.grega.ed in a. a.ra. of disea.es k.own a. *** a.e essentia. for neurona. function a.d regula.ed via.a.complex set of post-tra.sla.iona. modifica.ions,cha.ges of which a.fect microtubule sta.ility a.d dyna.ics,microtubule intera.tion with other proteins a.d cellula. structures,a.d media.e recruitment of microtubule-severing *** impa.rment of microtubule dyna.ics ca.ses neurona. dysfunction,we hypothesize cognitive impa.rment in huma. disea.e to be impa.ted by impa.rment of microtubule *** therefore a.med to study the effects of a.disea.e-ca.sing muta.ion of Ta.(P301L)on the levels a.d loca.iza.ion of microtubule post-tra.sla.iona. modifica.ions indica.ive of microtubule sta.ility a.d dyna.ics,to a.sess whether P301L-Ta. ca.ses sta.ility-cha.ging modifica.ions to *** investiga.e Ta. loca.iza.ion,phosphoryla.ion,a.d effects on tubulin post-tra.sla.iona. modifica.ions,we expressed wild-type or P301L-Ta. in huma. Ma.T-k. induced pluripotent stem cell-derived neurons(i Neurons)a.d studied Ta. in neurons in the hippoca.pus of mice tra.sgenic for huma. P301L-Ta.(p R5 mice).Huma. neurons expressing the longest Ta. isoform(2N4R)with the P301L muta.ion showed increa.ed Ta. phosphoryla.ion a. the a.8,but not the p-Ser-262 epitope,a.d increa.ed polygluta.yla.ion a.d a.etyla.ion of microtubules compa.ed with endogenous Ta.-expressing neurons.P301L-Ta. showed pronounced soma.odendritic presence,but a.so successful a.ona. enrichment a.d a.simila. a.odendritic distribution compa.a.le to exogenously expressed 2N4R-wildtype-Ta..P301L-Ta.-expressing hippoca.pa. neurons in tra.sgenic mice showed prominent missorting a.d ta.opa.hy-typica. a.8-phosphoryla.ion of Ta. a.d increa.ed polygluta.yla.ion,but reduced a.etyla.ion,of microtubules compa.ed with non-tra.sgenic *** sum,P301L-Ta. results in cha.ges in micr

关键词： huma. induced pluripotent stem cell microtubules P301L pR5 mice Ta. ta.opa.hy tubulin code

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sta.us a.d prospects for symmetric orga.ic redox flow ba.teries

引用

Journa. of Energy Chemistry 2025年第1期100卷 125-143页

作者： Md a. Ra.ha. C.a.a. Dyk.r Depa.tment of Chemistry University of New Brunswick

a. environmenta. concerns from fossil fuel consumption intensify, la.ge-sca.e energy stora.e becomes impera.ive for the integra.ion of renewa.le sources lik. wind, hydro, a.d sola. with the electrica. *** flow ba.teries, pa.ticula.ly those employing orga.ic molecules, a.e positioned a. a.k.y technology for this purpose. This review explores the growing field of symmetric orga.ic redox flow ba.teries(ORFBs) within this context. Unlik. tra.itiona. a.ymmetric designs ba.ed on unique a.tive ma.eria.s for ea.h electrode, symmetric ORFBs involve a.single bipola. species for both electrodes. This review highlights the benefits of a.symmetric design, a.d ca.egorizes five distinct cla.ses of orga.ic bipola. molecules used in both a.ueous a.d non-a.ueous solvents. By providing a.comprehensive overview of their cell cycling a.d performa.ce cha.a.teristics, the strengths a.d wea.0}esses of the diverse ca.egories of bipola. molecules a.e highlighted for both solvent systems, a. a.e opportunities for future development. This should guide new resea.ch directions a.d a.va.ce the development of pra.tica. symmetric ORFBs.

关键词： Redox flow ba.tery Symmetric ba.tery Orga.ic ba.tery a.ueous electrolyte Non-a.ueous electrolyte

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Na.osecond pulse a.d dua.-wa.elength Q-switched 1.5 μm fiber la.er using Ma. pha.e Cr2Tia.C2 sa.ura.le a.sorber

引用

Optoelectronics Letters 2025年第1期21卷 7-12页

作者： a.med Sha.0}r a.-HITI Hiba.Ha.Sa. Depa.tment of Electrica. Engineering Faculty of Engineering University of Anbar Depa.tment of La.er a.d Optoelectronics Engineering University of Technology-Iraq

We demonstra.ed a.new type of Ma. pha.e ma.eria., chromium tita.ium a.uminum ca.bide（Cr2Tia.C2） polymer film, to genera.e a.pa.sively Q-switched erbium-doped fiber la.er（EDFL）. The film thick.ess wa. mea.ured to be a.ound 45 μm, which wa. fa.rica.ed using the embedding method with polyvinyl a.cohol（PVa. polymer a. hoster. The sa.ura.le a.sorber（Sa. film demonstra.es a.dua.-wa.elength pa.sively Q-switched EDFL which opera.es a. 1 531 nm a.d 1 560.19 nm, respectively. The Q-switching pulse dura.ion could be va.ied from 2.46 μs to 770 ns, while the repetition ra.e va.ied from 92.76 k.z to 106.6 k.z with a. increa.ing input pumping ra.ge from 154 mW to 300 mW. The ma.imum output power a.d pulse energy of 15.05 mW a.d 141.18 nJ were obta.ned a. the ma.imum input power of 300 mW, respectively.

关键词： Sa.ura.le a.sorbers

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

a.mild, configura.le, flexible CoNi-LDH（v）/Zn ba.tery ba.ed on H-va.a.cy-induced reversible Zn2+ interca.a.ion

引用

Journa. of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue Cheng Dingsheng Wu Ha. Ga. Qingqing Wa.g Pengfei Lv sam S.Yoon Qufu Wei k.y La.ora.ory of Eco-textiles Ministry of Education Jiangnan University School of Mecha.ica. Engineering Korea University

Flexible Zn-ba.ed ba.teries ha.e a.tra.ted increa.ing resea.ch interest a. essentia. components of wea.a.le energy stora.e ***,the a.va.cement of flexible a.ueous Zn-ba.ed ba.teries ba.ed on Co-Ni la.ered double hydroxide （CoNi-LDH） a. the ca.hode ma.eria. is ha.pered by their poor cycling sta.ility a.d the corrosiveness of a.k.line ***,CoNi-LDH na.osheets enriched with H va.a.cies (CoNi-LDH（v）) were constructed on a.flexible ca.bon cloth （CC） substra.e via.electrochemica. deposition a.d *** Zn-ba.ed ba.tery comprising CoNi-LDH（v）@CC a. the ca.hode exhibited highly reversible conversion rea.tions a.d sta.le opera.ion in 3 M ZnSO4electrolyte （pH=4）.The ba.tery delivered a. excellent specific ca.a.ity (225 ma.h g-1,0.26 ma.h cm-2),a.cepta.le cycling sta.ility（53.9%,900 cycles）,a.d high discha.ging *** a.unda.t H va.a.cies served a. a.tive sites for the reversible interca.a.ion of Zn2+a.d the extra.a.a.ion of NO3-genera.ed cha.nels a.d spa.e for Zn2+tra.sport a.d stora.e,together ena.ling a. excellent Zn2+stora.e ***,a.sa.dwich-structured solid-sta.e CoNi-LDH（v）@CC//Zn@CC ba.tery wa. fa.rica.ed a.d wa. found to exhibit a.noteworthy electrochemica. performa.ce a.d mecha.ica. *** a.proof of concept,the unenca.sula.ed ba.tery powered a.digita. wa.ch under va.ious deforma.ion conditions a.d opera.ed sta.ly for 80 ***,the flexible ba.tery displa.ed outsta.ding customiza.ility,ma.nta.ning a. open-circuit volta.e of 1.42 V even a.ter being cut *** proposed engineering stra.egy contributes to the rea.iza.ion of textiles with truly wea.a.le energy-stora.e devices.

关键词： CoNi/Zn ba.tery H va.a.cies Mild a.ueous electrolyte Ta.lora.le ba.tery Wea.a.le energy stora.e device

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Compa.a.ive chemica. sensor for detection of chromium(Ⅵ) in a.ueous solution

引用

Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura.H.a.-REk.BI a.a.a.Wa.IB Electrica. Technique Depa.tment Al Suwayrah Technical Institute Middle Technical University La.er a.d Optoelectronics Depa.tment University of Technology-Iraq

a.process for purifying a.ueous solutions conta.ning hea.y a.d toxic meta.s such a. chromium（Cr） ha. been investiga.ed. One of the extremely ha.mful polluta.ts in rivers a.d sea.a.er is the hea.y meta. ions due to their direct impa.ts on huma., a.ima.s a.d pla.ts a.e hexa.a.ent Cr（Ⅵ）. Consequently, highly sensitive sensor to detect Cr is essentia.. Surfa.e pla.mon resona.ce（SPR） technique ha. a.tra.ted huge resea.ch interest in detecting hea.y meta.s specifica.ly. In this study, three types of prism-ba.ed SPR sensor, gold（a.）/silver（a.）, a./polya.iline（Pa.I） a.d a./tita.ium dioxide（TiO2） na.ostructured films, a.e investiga.ed a. potentia. sensing ma.eria. to detect the presence of Cr（Ⅵ） ions in wa.er. The ba.e a. la.er with thick.ess of 48.3 nm is deposited on a.gla.s slide for a.l sensors. For a./a., a./Pa.I na.ofibers a.d a./TiO2sensor films, the Cr（Ⅵ） concentra.ion is va.ied from 1 ppm to 15 ppm with sensitivity of 0.270 °ppm-1, 0.082 °ppm-1a.d 0.039 °ppm-1, respectively. Ba.ed on these results, the a./Pa.I na.ofibers a.e the most sensitive to Cr（Ⅵ） a.ong the tested sensing ma.eria.s.

关键词： Tita.ium dioxide

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Intrumer:a.Multi Module Distributed Expla.na.le IDS/IPS for Securing Cloud Environment

引用

Computers, Ma.eria.s & Continua 2025年第1期82卷 579-607页

作者： Na.reen Ba.u a.S.k.B.Sa.geetha Depa.tment of Computer Science a.d Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increa.ing use of cloud-ba.ed devices ha. rea.hed the critica. point of cybersecurity a.d unwa.ted network.*** environments pose significa.t cha.lenges in ma.nta.ning priva.y a.d *** a.proa.hes,such a. IDS,ha.e been developed to ta.k.e these ***,most conventiona. Intrusion Detection System(IDS)models struggle with unseen cybera.ta.k. a.d complex high-dimensiona. *** fa.t,this pa.er introduces the idea.of a.novel distributed expla.na.le a.d heterogeneous tra.sformer-ba.ed intrusion detection system,na.ed INTRUMER,which offers ba.a.ced a.cura.y,relia.ility,a.d security in cloud settings bymultiplemoduleswork.ng together within *** tra.fic ca.tured from cloud devices is first pa.sed to the TC&TM module in which the Fa.con Optimiza.ion a.gorithm optimizes the fea.ure selection process,a.d Na.e Ba.es a.gorithm performs the cla.sifica.ion of *** selected fea.ures a.e cla.sified further a.d a.e forwa.ded to the Heterogeneous a.tention Tra.sformer(Ha.)*** this module,the contextua. intera.tions of the network.tra.fic a.e ta.0}n into a.count to cla.sify them a. norma. or ma.icious *** cla.sified results a.e further a.a.yzed by the Expla.na.le Prevention Module(XPM)to ensure trustworthiness by providing interpreta.le *** the expla.a.ions fromthe cla.sifier,emergency a.a.ms a.e tra.smitted to nea.by IDSmodules,servers,a.d underlying cloud devices for the enha.cement of preventive *** experiments on benchma.k.IDS da.a.ets CICIDS 2017,Honeypots,a.d NSL-k.D were conducted to demonstra.e the efficiency of the INTRUMER model in detecting network.tra.ficwith high a.cura.y for different *** outperforms sta.e-of-the-a.t a.proa.hes,obta.ning better performa.ce metrics:98.7%a.cura.y,97.5%precision,96.3%reca.l,a.d 97.8%*** results va.ida.e the robustness a.d effectiveness of INTRUMER in securing diverse cloud environments a.a.nst sophistica.ed cyber threa.s.

关键词： Cloud computing intrusion detection system tra.sformers a.d expla.na.le a.tificia. intelligence(Xa.)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Flexura. response of doubly curved la.ina.ed composite shells

引用

Science China.Physics,Mecha.ics & a.tronomy) 2013年第4期56卷 812-817页

作者： SHa.Ma.a.buj UPa.HYa. a. k. SHUk.a.k. k. Depa.tment of a.plied Mecha.ics MNNIT Allahabad-211004 India

In the present work. a.a.ytica. solutions for la.ina.ed composite doubly curved pa.els on recta.gula. pla. form undergoing sma.l deforma.ions a.d subjected to uniformly distributed tra.sverse loa. ha.e been obta.ned. The problem is formula.ed using first order shea. deforma.ion theory. The spa.ia. descretiza.ion of the linea. differentia. equa.ions is ca.ried out using fa.t converging finite double Chebyshev series. The effect of pa.el thick.ess, curva.ure, bounda.y conditions, la.ina.ion scheme a. well a. ma.eria. property on the sta.ic response of pa.el ha. been investiga.ed in deta.l.

关键词： doubly curved pa.el a.a.ytica. Chebyshev sta.ic recta.gula. pla. form

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Elimina.ion of bounda.y effect for la.ina.ed overburden model in pilla. sta.ility a.a.ysis

引用

Journa. of Centra. South University 2016年第6期23卷 1468-1473页

作者：张鹏 k. a. Hea.ley Ca.lson Softwa.e Watertown MA 02472 USA Depa.tment of Mining Engineering West Virginia University WV 26505 USA

The la.ina.ed overburden model(La.Model)ha. been widely used for pilla. design a.d sta.ility *** a.bounda.y element progra.,the La.Model progra. is sensitive to the bounda.y condition,which should be considered before crea.ing the *** elimina.e the bounda.y effect in a.La.Model pilla. sta.ility a.a.ysis,a.suita.le bounda.y buffer zone is needed a.ound the model *** ra.ius of influence(R)a.d the a.utment loa. extent(D)a.e two ma.or fa.tors tha. a.fect the stresses a.d displa.ements ca.cula.ed in La. *** determine the optimum buffer zone extent,a.da.a.a.e of ca.e histories wa. a.a.yzed using the La.Model *** for R a.d D were va.ied until a.buffer zone ha.ing negligible influence on the pilla. sta.ility fa.tor(SF)of the a.tive mining zone(a.Z)wa. determined.

关键词： pilla. sta.ility bounda.y effect La.odel numerica. simula.ion room-a.d-pilla.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Leptosririllumferrooxida.s-sulfide minera. intera.tions with reference to bioflota.ion na. biofloccula.ion

引用

中国有色金属学会会刊：英文版 2008年第6期18卷 1403-1409页

作者： a. VILINSk. k. Ha.UMa.THa.Ra. Division of Minera. Processing Lulea University of Technology SE-971 87 LULEA Sweden

铁的离子的粘附黄铁矿和黄铜矿矿物质上的成年 Leptospirillum ferrooxida.s 房间通过吸附，希腊语的第六个字母潜力和弥漫的反射英尺红外被调查大小。当絮凝行为被 Turbisca. 大小检验时，矿物质 floa.a.ility 上的细菌的种类的影响被 ... 详细信息

铁的离子的粘附黄铁矿和黄铜矿矿物质上的成年 Leptospirillum ferrooxida.s 房间通过吸附，希腊语的第六个字母潜力和弥漫的反射英尺红外被调查大小。当絮凝行为被 Turbisca. 大小检验时，矿物质 floa.a.ility 上的细菌的种类的影响被 Ha.limond 筹款测试决定。矿物质等电位的点(pH 6.5 ? 7.5 ) 在和细菌的房间的相互作用向房间转移了等电位的点以后(pH 3.3 ) ，在矿物质上显示房间吸附的化学性质出现。与细菌的房间对待的矿物质的英尺红外系列显示出所有房间的存在功能的组意味着房间吸附。黄铜矿上的细菌的房间吸附与黄铁矿相比是更高的，它同意了房间与黄铁矿比较的黄铜矿筹款和显著絮凝行为上的更大的萧条效果。

关键词：细菌硫矿絮凝浮选

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Va.ia.ion in phenol, electrica. conductivity, a.d suga. contents in Grewia.oppositifolia.Roxb.

引用

Journa. of Forestry Resea.ch 2013年第1期24卷 121-125页

作者： a. k. Uniya. Depa.tment of Forestry Doon (PG) College of Agri. Sci. & Tech.DehradunUKIndia.

We estima.ed va.ia.ion in the a.loca.ion of meta.olites （phenol, suga., a.d electrica. conducta.ce） in seed, fruit a.d seedling lea.ha.es of 25 popula.ions of Grewia. oppositifolia. Higher qua.tity of phenolics a.d higher electrica. conducta.ce were observed in pla.ts from lower-middle a.titudes but this wa. not correla.ed significa.tly with germina.ion, surviva., or pla.t height. On the other ha.d, suga. content in fruit pulp lea.ha.es wa. grea.est in higher eleva.iona. popula.ions a.d these sources a.so recorded higher germina.ion, surviva., a.d pla.t height under nursery conditions. Thus we recommend tha. germpla.m （seed） should be collected from modera.ely higher eleva.iona. sources for nursery a. well a. future breeding stra.egies of this potentia. a.roforestry tree crop of the centra. Hima.a.a.

关键词： Grewia.oppositifolia phenol electrica. conductivity suga. seed seedling Ga.hwa. Hima.a.a

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：