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Matrix Metalloproteinases and Tissue Inhibitors of.Matrix Metalloproteinases as Plasma Indicators of.Bovine Cystic Ovarian Disease

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Natural Science 2018年第8期10卷 303-312页

作者： k. f. hentze k. G. Younger A. R. Menino 112 Withycombe Hall Department of Animal and Rangeland Sciences Oregon State University Corvallis Oregon USA

Cystic ovarian disease (COD) is one of.the main causes of.inf.rtility in dairy cattle and has a high economic impact on f.rmers. COD is caused by an endocrine imbalance within the hypothalamic-pituitary-ovarian axis preventing the mature Graaf.an f.llicle f.om ovulating. The cause at the molecular level is not well understood. However, the matrix metalloproteinases (MMP) and plasminogen activator/plasmin f.milies of.extracellular (ECM) matrix-degrading proteinases are involved in Graaf.an f.llicle break.own and oocyte release in the ovulation process. Our research investigated the possibility of.using plasma concentrations of.MMP-2 and -9 and their natural tissue inhibitors (TIMP) -1 and -2 as prognostic indicators of.COD. Plasma samples f.om cystic and non-cystic dairy cows were analyzed using ELISA. Although plasma concentrations of.MMP-2 and -9 were greater and TIMP-2 was lower in non-cystic compared to cystic cows, no signif.cant dif.erences were observed in MMP-2 and -9 and TIMP-1 and -2 due to cyst status. However, the TIMP-1:MMP-9 and TIMP-2:MMP-2 molar ratios were greater, (P = 0.099) and (P = 0.038), respectively, in cystic compared to non-cystic cows, suggesting a proteolytic insuf.iciency in cows with COD that may be a contributing f.ctor to the anovulatory pathology. These data may provide the groundwork.f.r f.ture research and development of.tools f.r dairy f.rmers to selectively choose replacement heif.rs less lik.ly to develop COD.

关键词： MMP TIMP Cattle Ovulation

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