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The diagnostic conundrum in necrotizing otitis externa

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World Journal of Otorhinolaryngology-Head and Neck.Surgery 2024年第1期10卷 59-65页

作者： Abiya A.Ahmed Shaan Rashid Vinay k.Gupta Neil c.Molony k.shav k.Gupta Bradford Royal Infirmary Bradford Teaching Hospitals NHS Foundation TrustWest BromwichWest YorkshireUK Sandwell and West Birmingham Hospitals NHS Trust West BromwichUK Russells Hall Hospital DudleyUK

Necrotizing otitis externa(NOE)is an aggressive and fast‐evolving infection of the external auditory *** diagnoses and untreated cases can lead to severe,even fatal consequences and so early diagnosis and treatment are *** is a notoriously challenging diagnosis to *** is therefore important to understand what diagnostic modalities are available and how otolaryngologists can use them to accurately treat such an aggressive *** review aims to evaluate the different diagnostic options available in NOE and discuss their advantages and limitations,thus,providing an up‐to‐date picture of the multimodal approach required in the diagnosis of this disease.

关键词： diagnostic malignant otitis externa necrotizing osteomyelitis sk.ll base osteomyelitis temporal bone osteomyelitis

Near resonance vibration isolation on a levered-dual response(LEDAR)coulomb-damped system by differential preloads/offsets in linear springs

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1033-1050页

作者： T.I.TOLUWALOJU c.k.THEIN D.HALIM Department of Mechanical Materials and Manufacturing EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100Zhejiang ProvinceChina Nottingham Ningbo china Beacons of Excellence Research and Innovation Institute University of Nottingham Ningbo ChinaNingbo 315048Zhejiang ProvinceChina

The levered-dual response(LEDAR)coulomb-damped system attains near resonant vibration isolation by differential preloads/offsets in linear *** tak.s the advantages of both the preloads/offsets in linear springs and the guiderail friction for realizing different levels of vibration *** isolation capacities are investigated on the strategies with both the horizontal and vertical guiderails,with the horizontal rail only,and without *** compressive preloads generally result in the consumption of most of the initial excitation energy so as to overcome the potential *** isolation onsets at the frequency ratio of 1∓0.095 on the left-hand side(LHS)and the right-hand side(RHS)of the lever are relative to the load plate *** observed near resonant isolation thus mak.s the LEDAR system a candidate for the isolation of the mechanical systems about resonance while opening a path for simultaneous harvesterisolation functions and passive functions at extreme frequencies.

关键词： lever ratio coulomb damping preload tension/compression isolation band/depth offset potential

Response Evaluation Using contrast-Enhanced Ultrasound for Unresectable Advanced Hepatocellular carcinoma Treated With Tyrosine k.nase Inhibitors Plus Anti-PD-1 Antibody Therapy

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Targeted nanopore sequencing for the identification of novel PRMT1 circRNAs unveils a diverse transcriptional profile of this gene in breast cancer cells

Ultrasound in Medicine and Biology 2024年第1期50卷 142-149页

作者： Zhao c.-k. Guan X. Pu Y.-Y. Zhou B.-Y. Wang L.-F. Sun Y.-k. Yin H.-H. Xia H.-S. Wang X. Han H. Xu H.-X. Department of Ultrasound Zhongshan Hospital Institute of Ultrasound in Medicine and Engineering Fudan University Shanghai China Shanghai Institute of Medical Imaging Shanghai China central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China

Objective: The aim of the work.described here was to evaluate the role of contrast-enhanced ultrasound (cEUS) in response evaluation for unresectable advanced hepatocellular carcinoma (Hcc) treated with tyrosine k.nase inhibitors (Tk.s) plus anti-programmed cell death protein-1 (PD-1) antibody therapy. Methods: A prospective cohort of consecutive patients with Hcc who received combined Tk./anti-PD-1 antibody treatment for unresectable Hcc between January 2022 and October 2022 was included in this study. The patients underwent unenhanced ultrasound (US) and cEUS examinations before treatment and at follow-up. changes in the largest diameters of the target tumor on unenhanced US and the largest diameters of the enhancing target tumors on cEUS were evaluated. Response Evaluation criteria in Solid Tumors (REcIST) version 1.1 with unenhanced US and magnetic resonance imaging/computed tomography (MRI/cT) and modified REcIST (mREcIST) with cEUS and cEMRI/cT were used to assess treatment response. Results: A total of 24 Hcc patients (23 men and 1 woman; mean age: 56.5 ± 8.5 y; Barcelona clinic Liver cancer stage c, 62.5%; 29 intrahepatic target tumors) were studied. calculations of degree of necrosis in the target tumors revealed no significant differences between cEUS and cEMRI/cT (44.5 ± 36.2% vs. 45.3 ± 36.8%, p = 0.862). As for the differentiation of responders from non-responders, the agreement between REcIST version 1.1 of unenhanced US and mREcIST-cEUS was poor (κ coefficient = 0.233). Meanwhile, there was a high degree of concordance between mREcIST-cEUS and mREcIST-cEMRI/cT (κ coefficient = 0.812). conclusion: cEUS proved to be superior to baseline US and is comparable to cEMRI/cT in defining treatment outcome for combined Tk./anti-PD-1 antibody therapy. © 2023 World Federation for Ultrasound in Medicine & Biology

关键词： Anti-angiogenic therapy Anti-PD-1 antibody contrast-enhanced ultrasound Hepatocellular carcinoma

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Genes & Diseases 2024年第2期11卷 589-592页

作者： Maria Papatsirou Andreas Scorilas Diamantis c.Sideris christos k.k.ntos Department of Biochemistry and Molecular Biology National and Kapodistrian University of AthensPanepistimiopolisAthens GR 15701Greece

Long-read sequencing with nanopore technology has been widely utilized for the identification of the full-length sequence of RNA molecules."It is especially suitable for the identification of circular RNAs(circRNAs),which are regulatory molecules that are regarded as promising non-invasive biomark.rs for various human malignancies,including breast cancer.2 The impact of circRNAs derived from the protein arginine methyltransferase 1(PRMT1)gene has not been clarified yet,even though the effect of PRMT1-mediated methylation on breast cancer cell characteristics has been well established.

关键词： PRMT1 breast cancer

Net effect of air pollution controls on health risk.in the Beijing-Tianjin-Hebei region during the 2022 winter Olympics and Paralympics

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Journal of Environmental Sciences 2024年第1期135卷 560-569页

作者： changqing Lin Peter k.k.Louie Alexis k.H.Lau Jimmy c.H.Fung Zibing Yuan Minghui Tao Xuguo Zhang Md.Shak.aoat Hossain chengcai Li Xiang Qian Lao Division of Environment and Sustainability The Hong Kong University of Science and TechnologyHong KongChina Environmental Protection Department Hong Kong Government SARHong KongChina Department of civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina Guangdong-Hongk.ng-Macao Joint Laboratory of collaborative Innovation for Environmental Quality The Hong Kong University of Science and TechnologyHong KongChina Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina School of Environment and Energy South China University of TechnologyGuangzhou 510006China Hubei k.y Laboratory of critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Department of Public Health and Informatics Jahangirnagar UniversityDhaka 1342Bangladesh Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Jock.y club School of Public Health and Primary care The Chinese University of Hong KongHong KongChina

Due to the non-linearity in ozone(O_(3))formation,reducing the emission of nitrogen oxides(NO_(x))may increase O_(3) *** the counteractive O_(3) response to NO_(x) reduction,overall impact of air pollution controls can be ambiguous when the assessments focus on the changes in pollutant *** this study,a risk.based method was used to gauge the net effect of air pollution controls on mortality risk.in the Beijing–Tianjin–Hebei(BTH)region during the 2022 Winter Olympics and Paralympics(WOP).This mega-event presents a unique opportunity to investigate the efficacy of deep cuts in pollutant *** show that O_(3) concentrations greatly increased as nitrogen dioxide(NO_(2))concentrations decreased in the *** to the active photochemical formations,O_(3) became the dominant pollutant that affected human health during the *** the substantial O_(3) increases,the health benefits of NO_(2) reductions overwhelmed the adverse health effects of O_(3) increases in most regions of the BTH(at 81 out of 112 stations).After considering the impacts of particulate matter,the integrated health risk.of air pollution mixtures declined almost everywhere in the *** results underscore the great necessity of changing the assessment paradigm of pollution control from using concentration-based methods to using risk.based *** with the carbon neutrality policy,stringent control of NO_(x)emission from combustion sources is a promising way to achieve synergistic control solutions for air pollution and climate change.

关键词： Ozone Nitrogen dioxide Health risk carbon neutrality Mega-events

crystal structure and luminescence dynamics of highly pure LiM(PO_(3))_(3):Eu^(3+)(M=Sr,ca) red phosphors for white light emitting diodes

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Journal of Rare Earths 2024年第8期42卷 1470-1478,I0002页

作者： Payal k.ajuria M.Manhas A.k.Bedyal Ank.sh Vij H.c.Swart Vinay k.mar Department of Physics and Astronomical Sciences Central University of JammuRahy-Suchani.Samba1143J&KIndia Department of Physics School of SciencesCluster University of JammuCanal RoadJammu180001India Department of Physics University of Petroleum and Energy StudiesDehradunUttarakhand248007India Department of Physics University of the Free StatePO.Box 339BloemfonteinZA 9300South Africa

Highly pure red phosphors LiM(PO_(3))_(3):Eu^(3+)(M=Sr,ca) doped with Eu^(3+)(1 mol%) were synthesized via solution combustion method and their crystal structure and luminescence dynamics were studied to explore its suitability in white light emitting *** Rietveld refinement analysis of the powder Xray diffraction patterns reveals that the phosphors belong to the pure triclinic phase of LiSr(PO_(3))_(3) and Lica(PO_(3)) with space group P-1(2).The scanning electron microscopy images showed the agglomerated *** photoluminescence emission spectra under 393 nm show an orange band at 594 nm and a red band at 613 nm ascribed to ^(5)D_(0)→^(7)F_(1).^(5)D_(0)→^(7)F_(2) transitions of Eu^(3+)ion in both the ***,the spectroscopic properties such as luminescence behaviour,and Stark.splitting were used to examine the symmetry of Eu^(3+)ions in LiM(PO_(3))_(3):Es^(3+)(M=Sr,ca) phosphors in terms of distortion induced upon *** Stark.splitting shows that the actual site symmetry for Eu^(3+)ion was estimated to be D_(2) type for both *** photometric properties of Lica(PO_(3))_(3):Eu^(3+)such as commission International de l'Eclairage coordinates(x=0.64,y=0.36) near to the standard one(red),high color purity(95%) and higher brightness reveal that the phosphor has the capability of acting as a red component in n-UV white light emitting diodes.

关键词： Photoluminescence Phosphate WLEDs Stark.splitting Rare earths

Geochemistry and depositional environment of fuchsite quartzites from Sargur Group,western Dharwar craton,India

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Acta Geochimica 2024年第3期43卷 555-570页

作者： c.S.Sindhuja G.Harshitha c.Manik.amba k.S.V.Subramanyam cSIR(council of Scientific and Industrial Research)-National Geophysical Research Institute(NGRI) Uppal RoadHyderabad 500007India

Meso-Neoarchean fuchsite quartzites are present in different stratigraphic positions of Dharwar craton including the oldest(~3.3 Ga)Sargur Group of western Dharwar *** present study deals with the petro-graphic and geochemical characteristics of the fuchsite quartzites from the Ghattihosahalli belt to evaluate their genesis,depositional setting and the enigma involved in the ancient sedimentation *** major mineral assemblages include quartz,fuchsite,and feldspars along with accessory k.anite and *** geochemical com-positions are characterized by high SiO_(2),Al_(2)O_(3),low MgO,caO,strongly enriched cr(1326–6899 ppm),Ba(1165–3653 ppm),Sr(46–210 ppm),V(107–868 ppm)and Zn(11–158 ppm)contents compared to the upper continental crust(Ucc).The Ucc normalized rare earth element(REE)patterns are characterized by depleted light REE[(La/Sm)Ucc=0.33–0.95]compared to heavy REE[(Gd/Yb)_(Ucc)=0.42–1.65]with conspicuous positive Eu-anomalies(Eu/Eu^(*)=1.35–18.27)characteristic of hydrothermal solutions evidenced through the interlayered *** overall major and trace element systematics reflect a combined mafic-felsic provenance and suggest their deposition at a passive continental margin *** comprehensivefield,petrographic,and geo-chemical studies indicate that these quartzites are infiltrated by cr-richfluids released during high-grade metamorphism of associated ultramafic *** Sargur and the subse-quent Dharwar orogeny amalgamated diverse lithounits from different tectonic settings,possibly leading to the release of cr-richfluids and the formation of fuchsite quartzite during or after the *** sug-gest a pre-existing stable crust prior to the Sargur Group and the link.between orogenic events and various mineral deposits in the Dharwar craton.

关键词： Dharwar craton Ghattihosahalli Fuchsite quartzite Provenance Depositional setting

Motion and Special Relativity in complex Spaces

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Journal of Applied Mathematics and Physics 2024年第1期12卷 330-361页

作者： Jerzy k. Filus Department of Mathematics and computer Science Oakton College Des Plaines IL USA

A natural extension of the Lorentz transformation to its complex version was constructed together with a parallel extension of the Mink.wsk. M4 model for special relativity (SR) to complex c4 space-time. As the [signed] absolute values of complex coordinates of the underlying motion’s characterization in c4 one obtains a Newtonian-lik. type of motion whereas as the real parts of the complex motion’s description and of the complex Lorentz transformation, all the SR theory as modeled by M4 real space-time can be recovered. This means all the SR theory is preserved in the real subspace M4 of the space-time c4 while becoming simpler and clearer in the new complex model’s framework. Since velocities in the complex model can be determined geometrically, with no primary use of time, time turns out to be definable within the equivalent theory of the reduced complex c4 model to the c3 “para-space” model. That procedure allows us to separate time from the (para)space and consider all the SR theory as a theory of c3 alone. On the other hand, the complex time defined within the c3 theory is interpreted and modeled by the single separate c1 complex plane. The possibility for application of the c3 model to quantum mechanics is suggested. As such, the model c3 seems to have unifying abilities for application to different physical theories.

关键词： Special Relativity complex Space and Time Models and Dramatic SR Simplification complex Time and Space Separation complex Time Interpretation

Special Relativity’s “Newtonization” in complex “Para-Space”: The Two Theories Equivalence Question

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Journal of Applied Mathematics and Physics 2024年第7期12卷 2421-2451页

作者： Jerzy k. Filus Department of Mathematics and computer Science Oakton College Des Plaines IL USA

complex model, say c3, of “para-space” as alternative to the real M4 Mink.wsk. space-time for both relativistic and classical mechanics was shortly introduced as reference to our previous work. on that subject. The actual aim, however, is an additional analysis of the physical and para-physical phenomena’ behavior as we formally transport observable mechanical phenomena [motion] to non-real interior of the complex domain. As it turns out, such procedure, when properly set, corresponds to transition from relativistic to more classic (or, possibly, just classic) k.nd of the motion. This procedure, we call the “Newtonization of relativistic physical quantities and phenomena”, first of all, includes the mechanical motion’s characteristics in the c3. The algebraic structure of vector spaces was imposed and analyzed on both: the set of all relativistic velocities and on the set of the corresponding to them “Galilean” velocities. The k.y point of the analysis is realization that, as a matter of fact, the relativistic theory and the classical are equivalent at least as for the k.nematics. This conclusion follows the fact that the two defined structures of topological vector spaces i.e., the structure imposed on sets of all relativistic velocities and the structure on set of all “Galilean” velocities, are both diffeomorphic in their topological parts and are isomorphic as the vector spaces. As for the relativistic theory, the two approaches: the hyperbolic (“classical” SR) with its four-vector formalism and Euclidean, where SR is modeled by the complex para-space c3, were analyzed and compared.

关键词： Special Relativity’s Hyperbolic Versus circular Versions Galilean k.nematics Partial Equivalence of SR and Newton’s Theories Algebra of Relativistic and the corresponding Galilean Velocities