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The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan

Cancer Biology & Medicine 2024年第1期21卷 29-44页

作者： Teruhiko Yoshida Yasushi Yatabe ken kato Genichiro Ishii Akinobu hamada Hiroyuki Mano kuniko Sunami Noboru Yamamoto Takashi kohno Department of Genetic Medicine and Services National Cancer Center HospitalTokyo 104-0045Japan Department of Diagnostic Pathology National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce Clinical Research Coordinating SectionBiobank Translational Research Support SectionNational Cancer Center HospitalTokyo 104-0045Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastChiba 277-8577Japan Division of Molecular Pharmacology National Cancer Center Research InstituteTokyo 104-0045Japan National Cancer Center Research Institute Tokyo 104-0045Japan Department of Laboratory Medicine National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan Division of Genome Biology National Cancer Center Research InstituteTokyo 104-0045Japan

The journey to implement cancer genomic medicine(CGM)in oncology practice began in the 1980s,which is considered the dawn of genetic and genomic cancer *** the time,a variety of activating oncogenic alterations and their functional significance were unveiled in cancer cells,which led to the development of molecular targeted therapies in the 2000s and *** CGM is still a relatively new discipline and it is difficult to predict to what extent CGM will benefit the diverse pool of cancer patients,the National Cancer Center(NCC)of Japan has already contributed considerably to CGM advancement for the conquest of *** back at these past achievements of the NCC,we predict that the future of CGM will involve the following:1)A biobank of paired cancerous and non-cancerous tissues and cells from various cancer types and stages will be *** quantity and quality of these samples will be compatible with omics *** biobank samples will be linked to longitudinal clinical information.2)New technologies,such as whole-genome sequencing and artificial intelligence,will be introduced and new bioresources for functional and pharmacologic analyses(e.g.,a patient-derived xenograft library)will be systematically deployed.3)Fast and bidirectional translational research(bench-to-bedside and bedside-to-bench)performed by basic researchers and clinical investigators,preferably working alongside each other at the same institution,will be implemented;4)Close collaborations between academia,industry,regulatory bodies,and funding agencies will be established.5)There will be an investment in the other branch of CGM,personalized preventive medicine,based on the individual's genetic predisposition to cancer.

关键词： Cancer genomic medicine biobank patient-derived xenograft multi-gene panel test whole genome sequencing

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Observation of Magnetic Domain Structures of Magnetic Thin Films by the Lorentz Electron Microscopy

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International Journal of Minerals,Metallurgy and Materials 1999年第2期13卷 119-124页

作者： A. Okada M Chimura k hamada M Arita I. Ishida(Advanced Materials Science Laboratory, Division of Electronics and information Engineering, Graduate School of Engineering, Hokkaido University,Sapporo 060-8628, Japan) Division of Electronics and Information Engineering Graduate School of Engineering Hokkaido University Sapporo 060-8628 Japan

The microstructure change in thin NiFe/Cu/NiFe films during the magnetization process was observed by the Lorentz electronmicroscopy. TWo types of films were prepared: (1) one NiFe layer with anisotropy and the other layer without, and (2) both NiFe layershave anisotropy normal each other. The domain wall migration and magnetization rotation processes in each of NiFe layers could be observed separately. The presence of magnetic anisotropy in the magnetic layer effectively controls the behavior of magnetic domains. Theinteraction between the two NiFe layers of the film could be observed not so strong in the present experiment.

关键词： magnetic domain domain wall Lorentz microscopy multi-layers thin films hysteresis loop permalloy film

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Genomic medicine in clinical practice:national genomic medicine program in Japan

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Cancer Biology & Medicine 2024年第1期21卷 4-9页

Cancer statistics in Japan Cancer is the most common cause of death in Japan based on Statistics 2021~*** statistics were first gathered,infectious diseases,such as tuberculosis,and cerebrovascular disease have been the main causes of death in *** surpassed cerebrovascular disease as the main cause of death in 1981,and the number of cancer deaths has *** 38,000 people died of cancer in *** National Cancer Center(NCC)reported that the 5-year survival rate for patients with cancer was improving(62%for males and 66.9%for females)in a population-based cancer registry.

关键词： Cancer cancer death

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SILk DYEING IN A MIXTURE OF ACID DYES

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苏州大学学报（工科版） 1992年第S2期17卷 51-57页

作者：三石贤 M. Mitsuishi T. Yagi k. hamada T. Ishiwatari

The equilibrium and kinetic studies for the mixture dyeing of silk with acid dyes have been made. The results of the binary mixture dyeing of silk suggested that so-called”blocking phenomenon”took place in the similar manner to the nylon dyeing. The rate constants of silk dyeing and diffusion coefficient of the dye in silk were obtained. the presence of sodium slkysulfate in the dyeing was found to slow the dyeing rate,but accelerat thedye diffusion.

关键词： silk dyeing mixture dyeing

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High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1487-1496页

作者： Nao Furuya Atsushi Yamaguchi Naohiro kato Syuhei Sugata Takuro hamada Takeshi Mizumoto Yuzuru Tamaru Ryusaku kusunoki Toshio kuwai Hirotaka kouno kazuya kuraoka Yoshiyuki Shibata Sho Tazuma Takeshi Sudo Hiroshi kohno Shiro Oka Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Gastroenterology Hiroshima University HospitalHiroshima 734-8551HiroshimaJapan Department of Pathology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan

BACkGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination ***,it can be diagnosed by pancreatic juice cytology from indirect *** previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic *** revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD ***,course observation was *** 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic *** performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology *** performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade *** parenchyma invasion was not observed,and curative resection was *** High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation.

关键词： Pancreatic cancer Pancreatic intraepithelial neoplasm High-grade pancreatic intraepithelial neoplasm Magnetic resonance cholangiopancreatography Carcinoma in situ Case report

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波拉型电解质对蚕丝纤维吸附酸性染料的影响

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国外纺织技术（纺织针织服装化纤染整） 2000年第4期 11-14页

作者： k.hamada 蔡翔沈煜如

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波拉型电解质对蚕丝纤维吸附酸性染料的影响

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国外纺织技术 2000年第4期 11-14页

作者： k.hamada 蔡翔沈煜如

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Positive Effect of Transcranial Direct Current Stimulation on Visual Verbal Working Memory in Patients with Attention-Deficit/Hyperactivity Disorder

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Open Journal of Psychiatry 2024年第4期14卷 334-346页

作者： Tomoko Uchida Daisuke Matsuzawa Tadashi Shiohama katsunori Fujii Akihiro Shiina Masamitsu Naka katsuo Sugita Eiji Shimizu Naoki Shimojo Hiromichi hamada Department of Pediatrics Graduate School of Medicine Chiba University Chiba Japan Research Center for Child Mental Development Chiba University Chiba Japan Division of Medical Care and Treatment Center for Forensic Mental Health Chiba University Chiba Japan Department of Cognitive Behavioral Physiology Graduate School of Medicine Chiba University Chiba Japan

Background: Working memory is an executive function that plays an important role in many aspects of daily life, and its impairment in patients with attention-deficit/hyperactivity disorder (ADHD) affects quality of life. The dorsolateral prefrontal cortex (DLPFC) has been a good target site for transcranial direct current stimulation (tDCS) due to its intense involvement in working memory. In our 2018 study, tDCS improved visual-verbal working memory in healthy subjects. Objective: This study examines the effects of tDCS on ADHD patients, particularly on verbal working memory. Methods: We conducted an experiment involving verbal working memory of two modalities, visual and auditory, and a sustained attention task that could affect working memory in 9 ADHD patients. Active or sham tDCS was applied to the left DLPFC in a single-blind crossover design. Results: tDCS significantly improved the accuracy of visual-verbal working memory. In contrast, tDCS did not affect auditory-verbal working memory and sustained attention. Conclusion: tDCS to the left DLPFC improved visual-verbal working memory in ADHD patients, with important implications for potential ADHD treatments.

关键词： Working Memory Attention-Deficit/Hyperactivity Disorder Dorsolateral Prefrontal Cortex Transcranial Direct Current Stimulation

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伊藤町零碳酒店

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世界建筑导报 2024年第1期39卷 114-117页

作者： Minoru Yokoo Takumi Saikawa Masaki hamada(kkpo)(摄影) 不详

我们设计了一家零能耗酒店,作为西条市的社区中心。西条市是著名的“Uchinuki”井水产地,水源来自被视为圣山的石锤山。2016年,东京大学隈研吾实验室开始与各地的合作伙伴密切合作,以水为主题制定名为“伊藤町项目”的新型环保城市总体... 详细信息

我们设计了一家零能耗酒店,作为西条市的社区中心。西条市是著名的“Uchinuki”井水产地,水源来自被视为圣山的石锤山。2016年,东京大学隈研吾实验室开始与各地的合作伙伴密切合作,以水为主题制定名为“伊藤町项目”的新型环保城市总体规划。与当地居民举办了研讨会,为年轻建筑师举办了个人建筑竞赛,并在此基础上建立了“伊藤町”网络。

关键词：城市总体规划东京大学零能耗隈研吾酒店零碳当地居民建筑师

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Dynamics of 7Li breakup and its influence on elastic scattering: a study of 7Li + 144Sm system

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Chinese Physics C 2024年第2期48卷 124-134页

作者： A.Morzabayev N.Amangeldi Awad A.Ibraheem D.Soldatkhan G.Yergaliuly B.Mauyey Anuar.A.Orazalievna Sh.hamada L.N.Gumilyov eurasian national university astanakazakhstan Institute of nuclear physics almatykazakhstan Physics department king khalid universityabhasaudi arabia Faculty of science tanta universitytantaegypt

The angular distributions of 7Li+144Sm elastic scattering over the energy range of 21.6–52 MeV are reanalyzed utilizing various interaction *** analysis aims to study the consistency of the implemented potentials in representing the considered data and investigate the cluster nature of the weakly bound 7Li *** will aid in the better understanding the impacts of 7Li breakup on the elastic scattering *** coupling to the breakup channel has a substantial impact on the elastic data and reproduces a repulsive dynamical polarization potential,which drastically diminishes the real potential *** reported impact was simulated by introducing a semi-microscopic repulsive DPP and by implementing the method of continuum discretized coupled *** analysis was also extended to understand the impact of triton transfer on the elastic scattering data.

关键词： phenomenological and semi-microscopic potentials cluster folding dynamic polarization

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