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Decellularised extracellular matrix-based injectable hydrogels for tissue engineering applications

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Biomaterials Translational 2024年第2期5卷 114-128页

作者： Guo W.-Y. Wang W.-h. Xu P.-Y. kankala R.k. Chen A.-Z. Institute of Biomaterials and Tissue Engineering Huaqiao University Fujian Province Xiamen China Fujian Provincial key Laboratory of Biochemical Technology (huaqiao University) Fujian Province Xiamen China

Decellularised extracellular matrix (dECM) is a biomaterial derived from natural tissues that has attracted considerable attention from tissue engineering researchers due to its exceptional biocompatibility and malleability attributes. These advantageous properties often facilitate natural cell infiltration and tissue reconstruction for regenerative medicine. Due to their excellent fluidity, the injectable hydrogels can be administered in a liquid state and subsequently formed into a gel state in vivo, stabilising the target area and serving in a variety of ways, such as support, repair, and drug release functions. Thus, dECM-based injectable hydrogels have broad prospects for application in complex organ structures and various tissue injury models. This review focuses on exploring research advances in dECM-based injectable hydrogels, primarily focusing on the applications and prospects of dECM hydrogels in tissue engineering. Initially, the recent developments of the dECM-based injectable hydrogels are explained, summarising the different preparation methods with the evaluation of injectable hydrogel properties. Furthermore, some specific examples of the applicability of dECM-based injectable hydrogels are presented. Finally, we summarise the article with interesting prospects and challenges of dECM-based injectable hydrogels, providing insights into the development of these composites in tissue engineering and regenerative medicine. © 2024, Chinese Medical Multimedia Press Co Ltd. All rights reserved.

关键词： decellularisation methods decellularised extracellular matrix injectable hydrogels tissue engineering

青年男性病人的腹股沟疝修补:用补片还是单纯缝合?

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中国实用外科杂志 2011年第8期31卷 752-755页

作者： Bisgaard T Bay-nielsen M kehlet h Department of Surgery KΦge SygehusKΦgeDen-mark Department of Surgical Gastroenterology Hvidovre University HospitalHvidovreDenmark Section for Surgical Pathophysiology 4074Rigshospitalet Copenhagen UniversityCopenhagenDen-mark

目的目前还没有治疗青年男性腹股沟疝病人的最佳修补方法的大宗病例报道。该文分析了丹麦全国青年男性病人接受Lichtenstein术或传统非补片修补术后复发再手术的风险。方法在丹麦国家疝数据库内前瞻性地记录了1998-01-01至2005-12-31所... 详细信息

目的目前还没有治疗青年男性腹股沟疝病人的最佳修补方法的大宗病例报道。该文分析了丹麦全国青年男性病人接受Lichtenstein术或传统非补片修补术后复发再手术的风险。方法在丹麦国家疝数据库内前瞻性地记录了1998-01-01至2005-12-31所有接受手术治疗的腹股沟疝病例,以复发再次接受手术作为判定复发的标准。该研究的入组标准为数据库中年龄在18～30岁之间的原发性腹股沟斜疝并在研究阶段内接受了第一次修补手术的病例。结果在纳入该研究的3181例病人中,1120例(中位年龄23岁,范围18～30岁)接受了单纯的缝合修补术,2061例(中位年龄24岁,范围18～30岁)接受了Lichtenstein术。单纯缝合组的中位随访时间为62(0～96)个月,Lichtenstein组的中位随访时间为41(0～96)个月。两组的5年累积复发再手术率分别为1.6%(Lichtenstein组)和3.9%(单纯缝合组),单纯缝合组的术后总复发再手术率(39例,3.5%)为Lichtenstein组(24例,1.2%)的将近3倍(P=0.003)。结论与传统单纯缝合修补术相比,在18～30岁的青年腹股沟斜疝病人中应用Lichtenstein术可以大大降低术后复发的风险。但是,在治疗青年男性病人中应用补片时必须衡量术后可能发生的慢性疼痛的风险。

关键词：疝复发青年修补术

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智能供水管网的内联闭式水力发电系统的研发

中国给水排水 2024年第6期40卷 97-102页

作者：杨洪兴沈志成姚尧曹炳豪谢景耀李立楚香港理工大学建筑环境及能源工程学系中国香港香港特别行政区政府水务署中国香港

为更好地监测管道泄漏和控制水压,智能供水管网管理系统(简称“智管网”)正逐步应用于城市供水管网。传统的供水监测仪表和传感器多采用蓄电池供电,由于电池寿命与容量有限,使得在实时监测模式下需要经常更换电池,造成经济与人力的耗费... 详细信息

为更好地监测管道泄漏和控制水压,智能供水管网管理系统(简称“智管网”)正逐步应用于城市供水管网。传统的供水监测仪表和传感器多采用蓄电池供电,由于电池寿命与容量有限,使得在实时监测模式下需要经常更换电池,造成经济与人力的耗费。通过数值模拟研究和实验研发了一种结构简单、安装方便的内联闭式水力发电系统,消耗有限的水头便可为“智管网”感应和监测设备及数据传输装置提供可靠的电力,通过提高站点之间的通信频次来保障实时监控,同时避免频繁地更换电池。此外,该管道水轮机通过管道内的喇叭口与挡块设计来实现双向流发电。介绍了该系统的工作设计原理和仿真实验研究结果,以及实测的内联闭式水力发电运行数据。实验结果表明,该系统能够可靠地运行,可为下一步的研发提供宝贵的理论和应用基础。

关键词：智能供水管网蓄电池内联闭式水力发电双向流发电

Chemical short-range-order induced multiscale strengthening in refractory medium entropy alloys

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Acta Mechanica Sinica 2024年第6期40卷 41-49页

作者： Weizheng Lu Yang Chen Jia Li Peter k.Liaw Qihong Fang State key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha410082China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN37996USA

high/medium entropy alloys(h/MEAs)are generally possible to exhibit chemical short-range order(SRO).however,the complex role of SRO on mechanical properties from nano-scale to meso-scale is still challenging so ***,we study the strengthening mechanism and deformation behavior in a model body-centered-cubic hfNbTa MEA by using atomic-scale molecular dynamics,micro-scale dislocation dynamics,and meso-scale crystal plasticity finite *** SRO inhibits dislocation nucleation at the atomic scale,improving the flow *** SRO-induced ultrastrong local stress fluctuation greatly improves the micro-scale dislocation-based strength by the significant dislocation forest ***,the Ta-rich locally ordered structure leads to an obvious heterogeneous strain and stress partitioning,which forms a strong strain gradient in the adjacent grain interiors and contributes to the strong back-stress-induced strain hardening.

关键词： high/medium entropy alloys Multiscale strengthening Chemical short-range order

Finding biomarkers of experience in animals

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Journal of Animal Science and Biotechnology 2024年第3期15卷 925-944页

作者： Sarah Babington Alan J.Tilbrook Shane k.Maloney Jill N.Fernandes Tamsyn M.Crowley Luoyang Ding Archa h.Fox Song Zhang Elise A.kho Daniel Cozzolino Timothy J.Mahony Dominique Blache School of Agriculture and Environment The University of Western AustraliaCrawleyWA 6009Australia Centre for Animal Science The Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandSt LuciaQLD 4072Australia School of Veterinary Science The University of QueenslandGattonQLD 4343Australia School of human Sciences The University of Western AustraliaCrawleyWA 6009Australia School of Medicine Deakin UniversityGeelongVIC 3217Australia Poultry hub Australia University of New EnglandArmidaleNSW 2350Australia College of Animal Science and Technology Yangzhou UniversityYangzhou 225009China Centre for Nutrition and Food Sciences The Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandSt LuciaQLD 4072Australia

At a time when there is a growing public interest in animal welfare,it is critical to have objective means to assess the way that an animal experiences a *** is critical to ensure appropriate animal welfare *** behavioural,physiological,and neurobiological indicators that are used to assess animal welfare can verify the absence of extremely negative *** welfare is more than an absence of negative outcomes and an appropriate indicator should reflect the full spectrum of experience of an animal,from negative to *** this review,we draw from the knowledge of human biomedical science to propose a list of candidate biological markers(biomarkers)that should reflect the experiential state of non-human *** proposed biomarkers can be classified on their main function as endocrine,oxidative stress,non-coding molecular,and thermobiological *** also discuss practical challenges that must be addressed before any of these biomarkers can become useful to assess the experience of an animal in real-life.

关键词： Animal experience Animal welfare Biomarker Stress Welfare assessment

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七十年代的美国对外政策 1

Data-Driven Fault Detection of Multiple Open-Circuit Faults for MMC Systems Based on Long Short-Term Memory Networks

1975年

作者：（美）h.欧文齐沛合译

来源：汇雅图书（南通市图书馆... 评论

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1563-1574页

作者： Chenxi Fan kaishun Xiahou Lei Wang Q.h.Wu School of Electric Power Engineering South China University of TechnologyGuangzhou 510641China

This paper presents a long short-term memory(LSTM)-based fault detection method to detect the multiple open-circuit switch faults of modular multilevel converter(MMC)systems with full-bridge sub-modules(FB-SMs).Eighteen sensor signals of grid voltages,grid currents and capacitance voltages of MMC for single and multi-switch faults are collected as sampling *** output signal characteristics of four types of single switch faults of FB-SM,as well as double switch faults in the same and different phases of MMC,are analyzed under the conditions of load variations and control command changes.A multi-layer LSTM network is devised to deeply extract the fault characteristics of MMC under different faults and operation conditions,and a Softmax layer detects the fault *** results have confirmed that the proposed LSTM-based method has better detection performance compared with three other methods:k-nearest neighbor(kNN),naive bayes(NB)and recurrent neural network(RNN).In addition,it is highly robust to model uncertainties and Gaussian *** validity of the proposed method is further demonstrated by experiment studies conducted on a hardware-in-the-loop(hIL)testing platform.

关键词： Fault detection long short-term memory(LSTM) modular multilevel converter(MMC) open circuit fault

Oh+hCl→Cl+h_(2)O反应中的反应物转动激发效应

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Chinese Journal of Chemical Physics 2024年第2期37卷 211-220,I0102页

作者：徐昕陈俊刘舒张东辉中国科学院大连化学物理研究所分子反应动力学国家重点实验室大连116023 中国科学院大学北京100049 中国科学院福建物质结构研究所结构化学国家重点实验室福州350002

本文在最近构建的F12a势能面上,对Oh+hCl→Cl+h_(2)O的一系列反应物转动激发态进行了势能平均的五维含时波包计算,得到了初始态选择的反应几率和速率常数。研究发现,除了很低碰撞能量,单独激发反应物hCl到j_(1)=2或者Oh到j_(2)=1得到了... 详细信息

本文在最近构建的F12a势能面上,对Oh+hCl→Cl+h_(2)O的一系列反应物转动激发态进行了势能平均的五维含时波包计算,得到了初始态选择的反应几率和速率常数。研究发现,除了很低碰撞能量,单独激发反应物hCl到j_(1)=2或者Oh到j_(2)=1得到了总反应几率的最大值.在低能区域,随着Oh转动激发的增加,反应几率的共振增强迅速减小,导致250k以下的速率常数迅速下降hCl和Oh同时转动激发的速率常数不是单独激发结果的简单叠加。最后,通过对(5,5)态以下初始转动态的速率常数进行玻尔兹曼平均,得到了反应的热速率常数,与实验结果基本吻合。

关键词：反应物转动激发含时波包反应几率 Feshbach共振速率常数

Synthesis and Structural Characterization of One New Polyoxotungstate Connected via Potassium Cations with aThree-dimensional Framework: h_6Na_2k_4(h_2W_(12)O_(42))Cl_2·14h_2O

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Chinese Journal of Structural Chemistry 2007年第6期26卷 721-726页

作者：刘颖窦建民王大齐张宪玺李大成周雷徐峰 College of Chemistry and Chemical Engineering Liaocheng University

One new polyoxotungstate complex h6Na2k4（h2W12O42）Cl2·14h2O 1 has been prepared in the beaker solution and characterized by elemental analysis and IR spectroscopy. Crystal data： h36Cl2k4W12Na2O56, Mr = 3411.77, monoclinic, space group P21/c, a = 11.5734（16）, b = 14.3136（19）, c = 15.459（2）A, β = 105.601（2）°, V = 2466.5（6）A^3, Z = 2, Dc = 4.594 g/cm^3, F（000） = 3008, μ = 28.447 mm^-1, R = 0.0574 and wR = 0.1239 （Ⅰ〉 2σ（Ⅰ））. Single-crystal X-ray diffraction analysis results reveal that a three-dimensional architecture in the title compound is constructed from the h2W12O42^10- units linked by potassium.

关键词： polyoxotungstate potassium X-ray analysis three-dimensional architecture