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Overcoming antibiotic-resistant Helicobacter pylori infection:Current challenges and emerging approaches

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World Journal of Gastroenterology 2025年第10期31卷 7-29页

作者： Gabriel Reis rocha Fabian Fellipe Bueno Lemos Luis Guilherme de Oliveira Silva Marcel Silva Luz Gabriel Lima Correa Santos Samuel Luca rocha Pinheiro Mariana Santos Calmon Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Recent studies have shown a noticeable increase in global Helicobacter pylori(***)resistance,with clarithromycin resistance surpassing 15%in various ***,inadequate epidemiological monitoring,especially in developing countries,and the absence of uniform testing methods lead to discrepancies between regions and a possible underestimation of resistance *** complexity of treating *** is driven by its highly dynamic genome,which is prone to frequent mutations contributing to phenotypical *** usual course of action in empirical treatment involves using a combination of various drugs simultaneously,leading to significant resistance selection pressure and potential side *** emergence of *** strains resistant to multiple drugs is closely tied to failures in first-line treatment,highlighting the need to prevent further resistance by using optimal initial empirical therapy or regimens guided by antibiotic susceptibility testing,requiring a collection of mixed samples and multiple isolates for accurate *** emergence of new treatments like potassium-competitive acid blockers offers a hopeful approach to decrease antimicrobial usage while still ensuring effectiveness in comparison to traditional therapies with proton pump ***,the use of probiotics is under investigation to identify specific strains and formulations that may mitigate therapy-associated adverse effects.

关键词： Helicobacter pylori Antibiotic resistance Multidrug resistance Heteroresistance Empirical treatment Antimicrobial susceptibility testing

Combined Effect of Honey from Central West Brazil on Bacterial Membrane Permeability

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Journal of Biosciences and Medicines 2025年第1期13卷 316-337页

作者： Mariana Lenina Menezes Aleixo Joziane da Cruz Mendonça Rafael Bruno rocha Benevides Larissa Maria Scalon Lemos Carla Galbiati Graduate Program in Environmental Sciences (PPGCA) Office of Research and Graduate Studies State University of Mato Grosso (UNEMAT) Cceres Mato Grosso Brazil Faculty of Agrarian Sciences State University of Mato Grosso (UNEMAT) Cceres Mato Grosso Brazil Departament of Nursing Faculty of Health Sciences State University of Mato Grosso (UNEMAT) Cceres Mato Grosso Brazil

Honey, an apicultural product with a complex chemical composition, contains numerous bioactive compounds with potential antimicrobial effects. This study investigated the effect of Apis mellifera honey from Brazil’s Central-West Region, combined with antibiotics, on bacterial membrane permeability, exploring the contributions of bioactive compounds and the botanical origin of honey. Six fresh Apis mellifera honey samples and their fractions (hexane and ethyl acetate) were analyzed, for a total of 18 samples. The bacteria Staphylococcus epidermidis, Helicobacter pylori and Enterococcus faecalis were used for antibacterial activity tests, which included minimum inhibitory concentration (MIC) determination and synergistic effect (checkerboard) assays. The total polyphenol and flavonoid contents were quantified, and the botanical origin was determined based on pollen analysis. The tested honey samples significantly affected bacterial membrane permeability when combined with rifampicin and clarithromycin. Although many honey-derived bioactive compounds, when isolated, did not exhibit significant activity against these bacteria, the additive or synergistic effect of multiple compounds acting on different targets appears to potentiate the antibacterial action. Descriptive statistical analysis, including means and 95% confidence intervals, confirmed the relevance of the findings. This study has provided an important discovery: Honey has an effect on bacterial membrane permeability, although the specific mechanisms involved in this process require further investigation.

关键词： Honey Mechanism of Action Antibacterial Bacterial Membrane Permeability Bioactive Compounds

Dynamics of air transport networks：A review from a complex systems perspective

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Chinese Journal of Aeronautics 2017年第2期30卷 469-478页

作者： Luis E.C.rocha Department of Public Health Sciences Karolinska Institutet Stockholm 17177 Sweden Department of Mathematics University of Namur 5000 Belgium

Air transport systems are highly dynamic at temporal scales from minutes to *** dynamic behavior not only characterizes the evolution of the system but also affect the system＇s *** the evolutionary mechanisms is thus fundamental in order to better design optimal air transport networks that benefits companies,passengers and the *** this review,we briefly present and discuss the state-of-the-art on time-evolving air transport *** distinguish the structural analysis of sequences of network snapshots,ideal for long-term network evolution（*** evolution）,and temporal paths,preferred for short-term dynamics（*** evolution）.We emphasize that most previous research focused on the first modeling approach（***-term） whereas only a few studies look at high-resolution temporal *** conclude the review highlighting that much research remains to be done,both to apply already available methods and to develop new measures for temporal paths on air transport *** particular,we identify that the study of delays,network resilience and optimization of resources（aircraft and crew） are critical topics.

关键词： Air transport Airport network Complex network Dynamic network Temporal network

First Occurrence of Paragordius varius in Different Species of Acrididae in Irapuato, Guanajuato, Mexico

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Advances in Entomology 2025年第1期13卷 120-125页

作者： Manuel Dario Salas-Araiza Ilse Alejandra Huerta-Arredondo Rafael Guzmán-Mendoza Itzel Berenice Aguilar-Campos Daniela de Jesús Bustos-Gallaga Miguel Angel rocha-García David Isaías Rodríguez-Vázquez Agronomy Department Life Sciences Division University of Guanajuato Irapuato Mexico

Acridid populations have increased significantly in recent years, causing damage to crops. Having biocontrol tools is important as it will help reduce the use of insecticides. This study reports the presence of Paragordius varius in grasshoppers for the first time in Irapuato, Guanajuato, Mexico. Samples were taken from the grass around a water pond. A total of 1,225 grasshoppers were dissected to observe the presence of the worm. Seven species of grasshoppers were identified, with the most abundant species being Melanoplus differentialis. The parasitoid Paragordius varius, a nematomorph, parasitized male M. differentialis in greater numbers. This work is the first record of this parasitoid in Mexico and contributes to the knowledge of the biological control of acridids in Mexico.

关键词： Grasshoppers Paragordius varius Parasitism Nematomorph Biological Control

Pesticides in a temperate coastal lagoon in southwest Europe (Ria de Aveiro, Portugal) – Risk assessment and acute assays with Artemia and Daphnia

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Emerging Contaminants 2024年第2期10卷 40-56页

作者： Maria João rocha Eduardo rocha Laboratory of Histology and Embryology Department of MicroscopyICBAS-School of Medicine and Biomedical SciencesUniversity of Porto(U.Porto)Portugal Team of Animal Morphology and Toxicology Interdisciplinary Centre of Marine and Environmental Research(CIIMAR/CIMAR)U.PortoPortugal

The Ria de Aveiro lagoon has been considered one of the most important Southern European long-term monitoring sites(LTER-site)concerning climate change and anthropogenic ***,studies concerning pesticide contamination herein are few and mostly ***,56 pesticides dissolved in the aqueous phase(DAP)and suspended particulate matter(SPM)were examined to fill the knowledge gap,considering the hydrophobic nature of most evaluated *** samples were taken seasonally from eight sites,and both DAP and SPM fractions were analysed by gas-chromatography-mass *** annual average concentrations of fungicides,herbicides and insecticides were≈57 ng/L,≈409 ng/L and≈1058 ng/L in DAP and≈7μg/g,≈28μg/g and≈67μg/g in *** pesticides and the excessive phosphate concentrations suggest that the lagoon's water quality may be hazardous to biota and *** were identified as the most threatened trophic level using deterministic risk assessment,with chlorpyriphos and chlorfenvinphos being the primary *** experiments with Artemia and Daphnia supported the suppositions.

关键词： Coastal lagoon Invertebrate bioassays Risk evaluation Waterborne pesticides

Glucagon-like peptide-1 and impaired counterregulatory responses to hypoglycemia in type 1 diabetes

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World Journal of Diabetes 2025年第2期16卷 297-304页

作者： Gabriel Reis rocha Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45065-430BahiaBrazil

This letter comments on a study by Jin et al,published recently in the World Journal of *** is a significant complication of diabetes,with primary defense mechanisms involving the stimulation of glucagon secretion inα-cells and the inhibition of insulin secretion in pancreaticβ-cells,which are often compromised in type 1 diabetes mellitus(T1DM)and advanced type 2 diabetes *** hypoglycemia predisposes the development of impaired hypoglycemia awareness,a condition underpinned by complex pathophysiological processes,encompassing central nervous system adaptations and several hormonal interactions,including a potential role for glucagon-like peptide-1(GLP-1)in paracrine and endocrine *** evidence indicates that GLP-1 may impair hypoglycemic counterregulation by disrupting the sympathoadrenal system and promoting somatostatin release in pancreaticδ-cells,which inhibits glucagon secretion from neighboringα-***,current trials evaluating GLP-1 receptor agonists(GLP-1 RAs)in T1DM patients have shown promising benefits in reducing insulin requirements and body weight,without increasing the risk of *** research is essential to elucidate the specific roles of GLP-1 and GLP-1 RAs in modulating glucagon secretion and the sympathetic-adrenal reflex,and their impact on hypoglycemia unawareness in T1DM patients.

关键词： Glucagon-like peptide 1 Type 1 diabetes mellitus Counterregulatory hypoglycemic dysfunction Hypoglycemia unawareness Glucagon Sympathoadrenal system

The Atlas of Brazilian Digital Literature

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Journal of Foreign Languages and Cultures 2022年第2期6卷 19-27页

作者： Rejane rocha Federal University of São Carlos

The Atlas of Brazilian Digital Literature is the first and the only digital archive of digital literature in Brazil to *** reunites the documentation(taxonomic description,images,videos,interviews with the authors,and critical fortune)of 150 works and *** article reports the challenges related to the construction and maintenance of the Atlas,which led to the formation of the Brazilian Digital Literature Observatory,a research group dedicated to follow and critically analyze the production of Brazilian digital literature,to propose alternatives for its preservation,and to discuss the changes in the literary system at a timewhenprintcultureanddigital culturecoexist.

关键词： Brazilian digital literature archive preservation literary system

Rheological and stability analysis of cement pastes incorporating silica-based wastes

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Particuology 2024年第6期89卷 144-152页

作者： Julia da Rosa Martins Janaíde Cavalcante rocha Dachamir Hotza Luciano Senff Graduate Program in Materials Science and Engineering(PPGMAT) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Graduate Program in Civil Engineering(PPGEC) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Graduate Program in Chemical Engineering(POSENQ) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Department of Mobility Engineering Federal University of Santa Catarina(UFSC)Joinville89219-600SCBrazil

This study investigates the influence of waste characteristics,especially zeta potential,on the properties of cement pastes and *** focus is to evaluate the impact of the zeta potential of cement particles and waste materials on the sedimentation speed,rheology,and hardening time of stabilized cement *** Cement II F 40,retarder additive,silica,and fly ash were used in the *** pastes were prepared,and during the stabilization period,their rheological properties and pH were *** zeta potential and sedimentation speed of the cement and waste particles were measured at the pH that the pastes presented during the entire stabilization *** the stabilization period,the pastes were subjected to the hardening time *** zeta potential analyses revealed diverse values for the different powder types,with the cement particles exhibiting a zeta potential of−3.0 mV,the silica particles exhibiting−10.5 mV,and the fly ash particles exhibiting−20.3 *** influence of the high zeta potential modulus was observed on the sedimentation speed,with the solution containing fly ash exhibiting a speed of 40.01μm/s,whereas the solution containing only cement exhibited a speed of 99.38μm/*** the pastes,the results indicate that the presence of fly ash particles with a significantly negative zeta potential led to a 16%reduction in hardening time compared to particles with a lower modulus of zeta *** tests showed that the inclusion of fly ash particles prevented the formation of *** the zeta potential influenced agglomerate formation and hardening time,it was found to have no effect on yield stress or viscosity.

关键词： Wastes Zeta potential Setting time Rheometry

Nickel sulfate solution fluoride separation with hydrous zirconium oxide

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Tungsten 2024年第2期6卷 367-381页

作者： Elbert M.Nigri Ummul k.Sultana André L.A.Santos James W.Vaughan Sonia D.F.rocha Department of Mining Engineering Federal University of Minas GeraisBelo Horizonte 31270-901Brazil School of Chemical Engineering University of QueenslandSt Lucia 4072Australia

Fluoride is an impurity in nickel sulfate production,which is required for electric vehicle *** zirconium oxide(HZO)was evaluated for removing fl uoride from nickel sulfate *** fluoride removal occurred at pH value 4 and optimal pH value is 4–5,considering Zr *** availability decreases with pH due to hydrogen fluoride and zirconium fluoride aqueous *** removal is initially rapid,with 50 wt.%removal in 7 min,followed by slow removal up to 68 wt.%after 72 h and follows second order rate *** removal was dominated by an ion exchange mechanism and resulting Zr–F bonds were observed using Fourier-transform infrared *** presence of nickel sulfate decreased loading capacity compared to a salt-free *** maintained adsorption capacity through five cycles of loading and regeneration.

关键词： Hydrous zirconium oxide Nickel sulfate Fluoride Adsorption Anion exchange