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How good is endoscopic ultrasound for TNM staging of gastric cancers? A meta-analysis and systematic review

World Journal of Gastroenterology 2008年第25期14卷 4011-4019页

作者： Srinivas reddy Puli jyotsna batapati krishna reddy Matthew L Bechtold Mainor R Antillon Jamal A Ibdah Division of Gastroenterology and Hepatology University of Missouri-Columbia

AIM: To evaluate the accuracy of endoscopic ultrasound (EUS) for staging of gastric cancers. METHODS: Only EUS studies confirmed by surgery were selected. Only studies from which a 2 × 2 table could be constructed for true positive, false negative, false positive and true negative values were included. Articles were searched in Medline, Pubmed, Ovid journals, Cumulative index for nursing & allied health literature, International pharmaceutical abstracts, old Medline, Medline nonindexed citations, and Cochrane control trial registry. Two reviewers independently searched and extracted data. The differences were resolved by mutual agreement. 2 × 2 tables were constructed with the data extracted from each study. Meta-analysis for the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specifi city, likelihood ratios, and diagnostic odds ratio. Pooling was conducted by both the Mantel-Haenszel method (fi xed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran's Q test based upon inverse variance weights. RESULTS: Initial search identified 1620 reference articles and of these, 376 relevant articles were selected and reviewed. Twenty-two studies (n = 1896) which met the inclusion criteria were included in this analysis. Pooled sensitivity of T1 was 88.1% (95% CI: 84.5-91.1) and T2 was 82.3% (95% CI: 78.2-86.0). For T3, pooled sensitivity was 89.7% (95% CI: 87.1-92.0). T4 hada pooled sensitivity of 99.2% (95% CI: 97.1-99.9). For nodal staging, the pooled sensitivity for N1 was 58.2% (95% CI: 53.5-62.8) and N2 was 64.9% (95% CI: 60.8-68.8). Pooled sensitivity to diagnose distant metastasis was 73.2% (95% CI: 63.2-81.7). The P for chi-squared heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION: EUS results are more accurate with advanced disease than early disease. If EUS diagnoses advanced disease, such as T4 disease, the patient is 500 times more likely to h

关键词： Gastric cancer Staging Meta-analysis Endoscopic ultrasound

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Endoscopic ultrasound:It’s accuracy in evaluating mediastinal lymphadenopathy? A meta-analysis and systematic review

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World Journal of Gastroenterology 2008年第19期14卷 3028-3037页

作者： Srinivas R Puli jyotsna batapati krishna reddy Matthew L Bechtold Jamal A Ibdah Daphne Antillon Shailender Singh Mojtaba Olyaee Mainor R Antillon Division of Gastroenterology and Hepatology University of Missouri- Columbia Division of Gastroenterology and Hepatology University of Kansas School of Medicine

AIM:To evaluate the accuracy of endoscopic ultrasound (EUS), EUS-fine needle aspiration (FNA) in evaluating mediastinal lymphadenopathy. METHODS:Only EUS and EUS-FNA studies confirmed by surgery or with appropriate follow-up were selected. Articles were searched in Medline, Pubmed, and Cochrane control trial registry. Only studies from which a 2 × 2 table could be constructed for true positive, false negative, false positive and true negative values were included. Two reviewers independently searched and extracted data. The differences were resolved by mutual agreement. Meta-analysis for the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specificity, likelihood ratios, and diagnostic odds ratios. Pooling was conducted by both Mantel-Haenszel method (fixed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran’s Q test based upon inverse variance weights. RESULTS:Data was extracted from 76 studies (n = 9310) which met the inclusion criteria. Of these, 44 studies used EUS alone and 32 studies used EUS-FNA. FNA improved the sensitivity of EUS from 84.7% (95% CI:82.9-86.4) to 88.0% (95% CI:85.8-90.0). With FNA, the specificity of EUS improved from 84.6% (95% CI:83.2-85.9) to 96.4% (95% CI:95.3-97.4). The P forchi-squared heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION:EUS is highly sensitive and specific for the evaluation of mediastinal lymphadenopathy and FNA substantially improves this. EUS with FNA should be the diagnostic test of choice for evaluating mediastinal lymphadenopathy.

关键词： Endoscopic ultrasound EUS-fine needleaspiration Mediastinal lymphadenopathy

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Enhanced saturation magnetization in La^(3+) doped NiCo ferrites prepared by sol-gel auto-combustion method

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Journal of Rare Earths 2024年第8期42卷 1546-1554,I0005页

作者： Maddileti Jelli Vidyasagar Thopudurthy krishna reddy C.V. Department of Physics Rayalaseema UniversityKurnoolA.P518007.Iindia Department of Physics Government PolytechnicRayachotiA.P516269India

Lanthanum doped nickel-cobalt nano ferrites with chemical formula Ni_(0.5)Co_(0.5)LaxFe_(2-x)O_(4)(x=0.05,0,10,0.15 and 0,20) were prepared using a simple sol-gel auto combustion *** basic structural properties were determined by X-ray diffraction method and the formation of single phased spinel ferrite was *** crystalline size decreased from 25 to 11 nm and lattice parameter a increases with increase of La *** surface morphology of these ferrites was observed by field-emission scanning electron microscopy(FESEM) and agglomerated irregular grains are observed with increase of the rare earth element La ***-dispersive X-ray spectroscopy(EDX) result confirms the presence of the required *** Fourier transform infrared spectroscopy(FTIR) spectrum indicates the formation of the spinel ferrite structure with M-O *** direct band measurements from ultraviolet-visible spectroscopy(UV-Vis) spectroscopy indicate that the direct band gap decreases from 1.39 to 1.19 eV for x=0.05 to x=0.15,then increases to 1.28 eV for x=*** room temperature magnetic properties of these ferrites were studied by a vibrating sample magnetometer(VSM).The enhanced saturation magnetization of 49.73 emu/g is observed for x=0.10 and then saturation magnetizations are gradually decreased for x=0.15 and x=*** the remanent magnetization and coercivity also follow the same trend.

关键词： Ferrites Sol-gel auto combustion La doping Magnetic properties Rare earths

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IoT Task Offloading in Edge Computing Using Non-Cooperative Game Theory for Healthcare Systems

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1487-1503页

作者： Dinesh Mavaluru Chettupally Anil Carie Ahmed I.Alutaibi Satish Anamalamudi Bayapa reddy Narapureddy Murali krishna Enduri Md Ezaz Ahmed School of Computing and Informatics Saudi Electronic UniversityRiyadhSaudi Arabia Department of Computer Engineering SRM University APGunturIndia College of Computer and Information Sciences Majmaah UniversityAl Majma’ahSaudi Arabia Department of Public Health College of Applied Medical SciencesKing Khalid UniversityAbhaSaudi Arabia

In this paper,we present a comprehensive system model for Industrial Internet of Things(IIoT)networks empowered by Non-Orthogonal Multiple Access(NOMA)and Mobile Edge Computing(MEC)*** network comprises essential components such as base stations,edge servers,and numerous IIoT devices characterized by limited energy and computing *** central challenge addressed is the optimization of resource allocation and task distribution while adhering to stringent queueing delay constraints and minimizing overall energy *** system operates in discrete time slots and employs a quasi-static approach,with a specific focus on the complexities of task partitioning and the management of constrained resources within the IIoT *** study makes valuable contributions to the field by enhancing the understanding of resourceefficient management and task allocation,particularly relevant in real-time industrial *** results indicate that our proposed algorithmsignificantly outperforms existing approaches,reducing queue backlog by 45.32% and 17.25% compared to SMRA and ACRA while achieving a 27.31% and 74.12% improvement in Qn ***,the algorithmeffectively balances complexity and network performance,as demonstratedwhen reducing the number of devices in each group(Ng)from 200 to 50,resulting in a 97.21% reduction in complexity with only a 7.35% increase in energy *** research offers a practical solution for optimizing IIoT networks in real-time industrial settings.

关键词： Internet of Things edge computing offloading NOMA

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Paleo-Mesoarchean sedimentary record in the Dharwar Craton,India:Implications for Archean ocean oxygenation

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Geoscience Frontiers 2024年第1期15卷 126-154页

作者： G.Harshitha C.Manikyamba M.Santosh Cheng-Xue Yang A.Keshav krishna V.V.Sesha Sai I.Panduranga reddy CSIR-National Geophysical Research Institute(NGRI) Uppal RoadHyderabad 500007India Department of Geology Osmania UniversityHyderabad 500007India School of Earth Science and Resources China University of GeosciencesBeijing 100083China Department of Earth Science University of AdelaideAdelaide SA5005Australia Yonsei Frontier Lab Yonsei UniversitySeoul 03722Republic of Korea Geological Survey of India State UnitNagpurIndia

The early Archean oceans were marked by significant redox changes which have subsequently shaped the Earth’s *** chemical sediments of banded Iron and Manganese formations provide important geochemical proxies for these historical shifts in the redox conditions and to trace the ancient sedimentation patterns and *** this study,we investigate the proto-ore of the Archean Mn-formations of the Sandur,Chitradurga and Shimoga greenstone belts of Dharwar Craton of southern Peninsular India,which is geochemically characterised as quartz arenites,Mn-arenites,Fe-arenites,Mn-argillites and *** geochemical systematics suggest their deposition in shallow to deeper shelf in the Archean *** detrital zircon U-Pb systematics of Mn arenites and argillites indicate their maximum depositional age of 3230±52 Ma representing the oldest onset of sedimentation during the Paleo-Mesoarchean timeframe in the Chitradurga Group of Dharwar *** detrital influx proxies suggest variations in sedimentation rates associated with the Archean transgressive-regressive cycles and fluctuating hydrodynamic conditions,together reflecting an increasing trend in the contributions of recycled sediment from Sandur to Chitradurga and Shimoga greenstone *** available detrital zircon ages of the Mn arenites and argillites from these greenstone belts indicate a~600 Ma prolonged period of Mn deposition for which high-T hydrothermal fluids from Archean mid-oceanic ridges supplied the *** trace element compositions of the concordant detrital zircons suggest 3.3-3.1 Ga Dharwar basement TTG/granitoid source which is corroborated by the zircon crystallization temperatures of 690-820℃.The source-normalisedα-dose rates of the detrital zircons signify greater degrees of sediment transport and multi-cycle nature which correspond to the earliest episode of crustal growth in the Indian sub-continent associated with the Mesoarchean Ur supercontinent.T

关键词： Mn-arenites-argillites Dharwar Craton Zircon U-Pb geochronology Passive margin sediments Ocean oxygenation

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Dietary Green Tea Extract and Antioxidants Improve Insulin Secretory Functions of Pancreatic β-Cells in Mild and Severe Experimental Rodent Model of Chronic Pancreatitis

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Open Journal of Endocrine and Metabolic Diseases 2024年第2期14卷 53-72页

作者： Galande Sheethal Ranjeet K. Tokala Pavan Pondugala krishna Vemula Vijayalakshmi Venkatesan Pothani Suresh Surya Satyanarayana Singh Guduru Venkat Rao Duvvur Nageshwar reddy Mitnala Sasikala Basic Science and Translational Research Division Asian Healthcare Foundation AIG Hospitals Hyderabad India Division of Cell and Molecular Biology National institute of Nutrition Hyderabad India National Animal Resource Facility for Biomedical Research Hyderabad India Department of Biochemistry Osmania University Hyderabad India Department of Surgical Gastroenterology Asian Institute of Gastroenterology Hyderabad India Department of Gastroenterology Asian Institute of Gastroenterology Hyderabad India

Chronic pancreatitis (CP) is a progressive inflammatory disorder of the pancreas. It is predominantly idiopathic (with an unknown cause) in India and mostly due to alcohol in the West. Diabetes that occur secondary to chronic pancreatitis (T3c Diabetes) is often brittle, and is difficult to attain normoglycemia with conventional treatment requiring multiple doses of insulin. Mild and severe model of CP was induced in mice by repeated intraperitoneal injections of cerulein and L-arginine respectively with an intent to study islet dysfunction and develop therapeutic strategy in animal models of CP. Dietary intervention of epigallocatechin-3-gallate (EGCG) was tested in both the models of CP for its beneficial effects on insulin secretory functions. Pancreata collected upon euthanasia were used to study alterations in the morphology of pancreatic parenchyma and inflammation by staining with H&E and fibrotic changes by Masson’s trichrome and picrosirius staining. Insulin secretory functions of islets were evaluated to test the efficacy of the dietary intervention on β-cell functions. Intraperitoneal glucose tolerance test was performed to monitor the glucose homeostasis before and after the dietary intervention. Both the models resulted in CP with dispersed acini, inflammation and fibrosis. The loss of acini and extent of fibrosis was more in L-arginine model. 2-fold improvement in glucose-stimulated insulin secretory functions of islets was observed with 0.5% EGCG dietary intervention in cerulein model of CP and 1.6-fold in L-arginine model of CP. A further improvement in insulin secretion by 3.2-fold was observed with additional dietary supplements like N-acetyl cysteine, curcumin in combination with EGCG. Our results thus demonstrate and highlight the therapeutic potential of dietary green tea (EGCG) supplementation in reversing islet dysfunction and improving glucose homeostasis in experimental chronic pancreatitis in mice.

关键词： Dietary Intervention C57BL6/J Mice Epigallocatechin-3-Gallate N-Acetyl Cysteine Curcumin Chronic Pancreatitis Islets Glucose Stimulated Insulin Secretion

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Camphor-derived thioureas: Synthesis and application in asymmetric Kabachnik-Fields reaction

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Chinese Chemical Letters 2016年第6期27卷 943-947页

作者： Pogula Sreekanth reddy Motakatla Venkata krishna reddy Peddiahgari Vasu Govardhana reddy Department of Chemistry Yogi Vemana University

A series of camphor-derived thiourea organocatalysts 3a–f were designed and synthesized from（1R,3S）-camphoric acid 1 and applied to the one-pot three-component Kabachnik–Fields reaction. Catalyst 3c was found to be an efficient organocatalyst for the reaction of 2-cyclopropylpyrimidin-4-carbaldehyde 4,various amines 5, and diphenylphosphite 6 to yield the corresponding enantioselective a-aminophosphonates 7a–e in 74%–82% yields and 14%–35% ee.

关键词： Asymmetric organocatalysis (1R 3S)-Camphoric acid Camphor-derived thioureas Chiral a-aminophosphonates Enantioselective Kabachnik-Fields reaction

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Comparison of microwave and autoclave treatment for biomedical waste disinfection

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Systems Microbiology and Biomanufacturing 2022年第4期2卷 732-742页

作者： Vamsi krishna reddy Kollu Parmeshwar Kumar krishna Gautam All India Institute of Medical Sciences New Delhi 110029India Centre for Energy and Environmental Sustainability LucknowUttar Pradesh 226029India

As the world is facing a Covid-19 pandemic,this virus teaches a lesson about the importance of on-site ***-site disinfection/sterilization with real-time monitoring of biomedical waste generated from the medical facilities is mandatory to prevent hospital-acquired infection(HAI).In this study,the life cycle assessment of two technologies,i.e.,microwave(radiation-based)and autoclave(steam-based)were performed to summarize the inside-out evaluation of both technologies in terms of efficiency,efficacy,and *** results of disinfection efficacy indicated a log 10 reduction(almost 100%)in the vegetative load of microorganisms compared to the control,showing a similar level of disinfection efficacy of both ***,both technologies were compared on several parameters,and it was discovered that the autoclave uses more time and resources than the *** total cost of an autoclave to the government is approximately double that of a microwave,while the operational cost of an autoclave is more than double that of a *** findings from this study indicate that MACS may be used as a dry technique of biomedical disinfection,and its portability,tunability,and compactness make it a suitable alternative for biomedical disinfection and sterilization.

关键词： Biomedical waste management Microwave Disinfection Sterilization COVID-19

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Facile one-step hydrothermal route to MSe/Mo_(3)Se_(4)(M:Zn,Mn,and Ni)-based electrode materials for ultralong-life hybrid supercapacitors

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Journal of Materials Science & Technology 2023年第25期156卷 230-240页

作者： B.N.Vamsi krishna Obula reddy Ankinapalli Ayyaluri Ramakrishna reddy Jae Su Yu Department of Electronics and Information Convergence Engineering Institute for Wearable Convergence ElectronicsKyung Hee UniversityYongin-siGyeonggi-do 17104Republic of Korea

Transition metal selenides have attracted great interest in electrochemical energy storage applications because of their good electrochemical activity and conductivity ***,we reported the metal molybdenum selenide(M Se/Mo_(3)Se_(4)(M:Zn,Mn,and Ni))electrode materials on their morphological and electrochemical properties by varying the metal ions via a facile hydrothermal *** effects of the structural,morphological,and surface area properties of the prepared powder materials on their electrochemical performance were *** to the hierarchical porous and unique interconnected structure,the nickel molybdenum selenide nanosheet spheres(NMS NSSs)-based electrode material delivered an excellent specific capacity value of 252 mAh g^(-1) at a current density of 1 Ag^(-1).Moreover,the optimized NMS NSSs electrode exhibited outstanding cycling stability with a capacity retention of 80%and a corresponding coulombic efficiency of 99%after 80,000 ***,a pouch-type hybrid supercapacitor(HSC)device was assembled using NMS NSSs material as a positive electrode and activated carbon as a negative electrode in 1 M aqueous KOH ***,the assembled HSC device exhibited superior energy and power density values as well as magnificent cycling *** real-time practical applications,light-emitting diodes and a digital display were powered using two series-connected HSC ***,the obtained tremendous results strongly suggest that the NiSe/Mo_(3)Se_(4) NSSs-based materials could be a promising electrode for ultralong-life energy storage applications.

关键词： Nickel selenides Molybdenum selenides Nanosheet spheres Ultralong-life cycling stability

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Influence of Nano-Materials on Mechanical and Permeation Characteristics of High Strength Concrete

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Journal of Wuhan University of Technology(Materials Science) 2022年第3期37卷 416-422页

作者： K V S Gopala krishna Sastry M Srinivasula reddy A Ravitheja Civil Engineering G Pulla Reddy Engineering CollegeKurnoolAPIndia SVR Engineering College NandyalAndhra PradeshIndia

Efforts have been made to evaluate the influences of the addition of nanoparticles on the strength,durability and mineralogical changes of high strength concrete(HSC).Therefore,mixes were prepared for conventional concrete mix(CCM)of M80 ***,various mixes were prepared by replacing cementitious materials initially with 1%Nano-CaCO_(3)(NC),2%NC,3%NC in the CCM,and then 1%NC and Nano-SiO_(2)(NS)NS,2%NC and NS,3%NC and NS(NC and NS were in equal proportion)in the *** developed concretes were then evaluated for mechanical properties,permeation characteristics,and mineralogical *** the studies,it is found that the concrete at 2%NCS possesses superior mechanical and superior permeation characteristics of all the mixes.A clear variation in the mineralogical structure with the addition of nanoparticles has been observed.

关键词： high strength concrete nano silicon dioxide nano calcium carbonate mechanical properties permeation properties

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