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Multi-omic Analyses Shed Light on The Genetic Control of High-altitude Adaptation in Sheep

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 43-56页

作者： Chao Li Bingchun Chen Suo Langda Peng Pu Xiaojia Zhu Shiwei Zhou Peter Kalds Ke Zhang Meenu bhati Alexander Leonard Shuhong Huang Ran Li Awang Cuoji Xiran Wang Haolin Zhu Yujiang Wu Renqin Cuomu Ba Gui Ming Li Yutao Wang Yan Li Wenwen Fang Ting Jia Tianchun Pu Xiangyu Pan Yudong Cai Chong He Liming Wang Yu Jiang Jian-Lin Han Yulin Chen Ping Zhou Hubert Pausch Xiaolong Wang International Joint Agriculture Research Center for Animal Bio-Breeding Ministry of Agriculture and Rural Affairs/Key Laboratory of Animal GeneticsBreeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Animal Genomics ETH ZürichZürich 8092Switzerland Institute of Animal Science Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China School of Biological and Pharmaceutical Engineering Lanzhou Jiaotong UniversityLanzhou 730070China College of Life Sciences Shaanxi Normal UniversityXi’an 710119China Zoology and Evolutionary Biology Department of BiologyUniversity of Konstanz78457 KonstanzGermany College of Life and Geographic Sciences Kashi UniversityKashi 844000China Beijing Key Laboratory of Captive Wildlife Technologies Beijing ZooBeijing 100044China Department of Medical Research Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Key Laboratory of Agricultural Internet of Things Ministry of Agriculture and Rural Affairs/Shaanxi Key Laboratory of Agricultural Information Perception and Intelligent ServiceCollege of Information EngineeringNorthwest A&F UniversityYangling 712100China Institute of Animal Husbandry and Veterinary Medicine Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China State Key Laboratory of Sheep Genetic Improvement and Healthy Production Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China Livestock Genetics Program International Livestock Research InstituteNairobi 00100Kenya

Sheep were domesticated in the Fertile Crescent and then spread globally,where they have been encountering various environmental *** Tibetan sheep has adapted to high altitudes on the Qinghai-Tibet Plateau over the past 3000 *** explore genomic variants associated with high-altitude adaptation in Tibetan sheep,we analyzed Illumina short-reads of 994 whole genomes representing∼60 sheep breeds/populations at varied altitudes,PacBio High fidelity(HiFi)reads of 13 breeds,and 96 transcriptomes from 12 sheep *** testing between the inhabited altitudes and 34,298,967 variants was conducted to investigate the genetic architecture of altitude *** accurate HiFi reads were used to complement the current ovine reference assembly at the most significantly associatedβ-globin locus and to validate the presence of two haplotypes A and B among 13 sheep *** haplotype A carried two homologous gene clusters:(1)HBE1,HBE2,HBB-like,and HBBC,and(2)HBE1-like,HBE2-like,HBB-like,and HBB;while the haplotype B lacked the first *** high-altitude sheep showed highly frequent or nearly fixed haplotype A,while the low-altitude sheep dominated by haplotype *** further demonstrated that sheep with haplotype A had an increased hemoglobin–O2 affinity compared with those carrying haplotype *** highly associated genomic region contained the EGLN1 gene which showed varied expression between high-altitude and low-altitude *** results provide evidence that the rapid adaptive evolution of advantageous alleles play an important role in facilitating the environmental adaptation of Tibetan sheep.

关键词： Environmental adaptation High altitude Hypoxia Selection signature Sheep

Bulk scale production of carbon nanofibers in an economical way

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Frontiers of Materials Science 2012年第4期6卷 319-325页

作者： Ravindra RAJARAO Badekai Ramachandra bhati Catalysis and Materials Laboratory Department of ChemistryNational Institute of Technology KarnatakaSurathkalMangalore-575025India

An economical route for the scalable production of carbon nanofibers （CNFs） on a sodium chloride support has been developed. CNFs have been synthesized by chemical vapor deposition （CVD） method by using metal formate as catalyst precursors at 680℃. Products were characterized by SEM, TEM, Raman spectroscopy and XRD method. By thermal analysis, the purity of the as grown products and purified products were determined. This method avoids calcination and reduction process which was employed in commercial catalysts such as metal oxide or nitrate. The problems such as detrimental effect, environmental and even cost have been overcome by using sodium chloride as support. The yield of CNFs up to 7800 wt.% relative to the nickel catalyst has been achieved in the growth time of 15 min. The advantage of this synthesis technique is the simplicity and use of easily available low cost precursors.

关键词： metal formate carbon nanofiber (CNF) chemical vapor deposition (CVD),high yield sodium chloride support environmental friendly route

MicroProteins:Expanding functions and novel modes of regulation

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Molecular Plant 2021年第5期14卷 705-707页

作者： Kaushal Kumar bhati Ulla Dolde Stephan Wenkel Louvain Institute of Biomolecular Sciences Catholic University of LouvainLouvain la Neuve 1348Belgium Plant Science Research Laboratory(LRSV) UMR5546 CNRS/Universite Toulouse 331320 Castanet-TolosanFrance Copenhagen Plant Science Centre Department of Plant&Environmental SciencesUniversity of CopenhagenThorvaldsensvej 401871 Frederiksberg CDenmark

MicroProteins are small,5-15-kDa single-domain proteins that are evolutionarily related to multi-domain proteins with sequence homology(Eguen et al.,2015).The single domain of microProteins is often a protein-protein interaction(PPI)-domain,through which they can interact with their multi-domain protein targets(Figure 1).The first experimental insight that microProteins exist and how they act came from the identification of the regulatory feedback mechanism of class III homeodomain-leucine zipper(HD-ZIPIII)transcription factors by LITTLE ZIPPER(ZPR)microProteins(Wenkel et al.,2007;Kim et al.,2008).In Arabidopsis,the LITTLE ZIPPER microProtein family consists of four members(ZPR1-4)containing only a leucine zipper *** HD-ZIPIII transcription factor REVOLUTA directly transcriptionally upregu-lates multiple ZPR *** proteins physically interact with their HD-ZIPIII targets and suppress their DNA binding ability.

关键词： domain. Figure insight

Control of flowering in rice through synthetic microProteins

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Journal of Integrative Plant Biology 2020年第6期62卷 730-736页

作者： Tenai Eguen Jorge Gomez Ariza Vittoria Brambilla Bin Sun Kaushal Kumar bhati Fabio Fornara Stephan Wenkel Copenhagen Plant Science Centre University of Copenhagen1871Frederiksberg CDenmark Department of Plant and Environmental Sciences University of Copenhagen1871Frederiksberg CDenmark Department of Biosciences Universitàdegli Studi di Milano20133MilanoItaly

Photoperiod-dependent flowering in rice is regulated by HEADING DATE 1(Hd1),which acts as both an activator and repressor of flowering in a daylengthdependent *** investigate the use of microProteins as a tool to modify rice sensitivity to the photoperiod,we designed a synthetic Hd1 micro Protein(Hd1miP)capable of interacting with Hd1 protein,and overexpressed it in *** OX-Hd1 miP plants flowered significantly earlier than wild type plants when Breakt grown in non-inductive long day *** results show the potential of microProteins to serve as powerful tools for modulating crop traits and unraveling protein function.

关键词： function. inductive flowering

A Modified Approach to Analyze Thermal Comfort Classification

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Atmospheric and Climate Sciences 2014年第1期4卷 7-19页

作者： Manju Mohan Anuj Gupta Shweta bhati Centre for Atmospheric Sciences Indian Institute of Technology Delhi New Delhi India Department of Chemical Engineering Indian Institute of Technology Delhi New Delhi India

A thermal stress index of a geographic location over a period of time can provide knowledge of overall climate perceptible to the general public. Out of the three approaches to assessing thermal comfort namely, rational, empirical and direct, the direct approach is being used in the present study because of easy availability of all inputs and reasonable comprehension of the assessments. Assessment and ranking of cities using this approach based on the percentage of comfortable hours alone may however be erroneous and misleading as this approach does not consider the percentages of uncomfortable classes which could often be substantially high. The modified approach for thermal comfort classification demonstrates cumulative representation of all classes of thermal comfort including uncomfortablity and provides relative ranking of cities. Analysis of the results is presented here for five megacities (Delhi, Mumbai, Chennai, Kolkata and Hyderabad) representing varying geographical and climatic locations of India. These cities are ranked based on the routine and modified approaches and results are discussed in detail on monthly, seasonal and annual average basis. When the cities are compared only on the basis of comfortable hours, the decreasing order of comfortability is Hyderabad, Kolkata, Delhi, Chennai and Mumbai. However, considering the second methodology, it is revealed that the contribution of uncomfortable hours is greater in Kolkata and Chennai in comparison to Mumbai. The proposed methodology could be an improvement over the current practices and provides a more rational method for relative ranking of cities that could be used for tourism and energy demands.

关键词： Comfort Index Heat Index Wind Chill Effective Comfortability Relative Ranking of Cities Thermal Stress

Distribution of Geometrically Weighted Sum of Bernoulli Random Variables

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Applied Mathematics 2011年第11期2卷 1382-1386页

作者： Deepesh bhati Phazamile Kgosi Ranganath Narayanacharya Rattihalli 不详

A new class of distributions over (0,1) is obtained by considering geometrically weighted sum of independent identically distributed (i.i.d.) Bernoulli random variables. An expression for the distribution function (d.... 详细信息

关键词： Binary Representation Probability Mass Function Distribution Function Characteristic Function

Right versus left fully robotic live donor nephrectomy and open kidney transplantation:Does the laterality of the donor kidney really matter?

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Asian Journal of Urology 2023年第4期10卷 453-460页

作者： Brianna Ruch Deki Tsering Chandra bhati Dhiren Kumar Muhammad Saeed Seung Duk Lee Aamir Khan Daisuke Imai David Bruno Marlon Levy Adrian Cotterell Amit Sharma Hume-Lee Transplant Center Virginia Commonwealth UniversityRichmondVAUSA Division of Transplant Surgery University of MarylandBaltimoreMDUSA

Objective Robotic-assisted live donor nephrectomy(LDN)is being gradually adopted across transplant *** left donor kidney is preferred over right due to anatomical factors and ease of *** aimed to study donor and recipient outcomes after robotic procurement and subsequent open implantation of right and left *** All fully robotic LDNs and their corresponding open kidney transplants performed at our center between February 2016 and December 2021 were retrospectively *** Out of 196 robotic LDN(49[right]vs.147[left]),10(5.1%)donors had intra-operative events(6.1%[right]vs.4.8%[left],p=0.71).None of the LDN required conversion to open *** operative times were comparable for the two ***(13.3%)was the most common post-operative *** was no mortality in either LDN ***,we report our outcomes on 156 recipients(39 right and 117 left allografts)excluding robotic implants,exports,and pediatric *** were no significant differences between right and left kidney recipients with respect to 1-year post-transplant patient survival(100.0%vs.98.1%,p=0.45)or graft survival(93.9%vs.97.1%,p=0.11),or delayed graft function(7.7%vs.5.1%,p=0.55).Conclusion Non-hand-assisted robotic live donor nephrectomies can be safely performed with excellent *** LDN was not associated with higher incidence of complications compared to left *** implantation of robotically procured right renal allografts was not associated with higher risk of recipient complications.

关键词： Robotics Laparoscopy Donor nephrectomy Complication Renal transplant Outcome

A Generalized Analytical Model of a Multispecies Plasma Immersion Ion Implantation Process in a Collisionless System

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材料科学与工程（中英文B版） 2011年第3期1卷 372-377页

作者： Dushyant Gupta B. Prasad jyotika Jogi P.J. George Electronics Dept. University College Kurukshetra University Kurukshetra 136119 India Department of Electronics Kurukshetra University India Department of Physics ＆ Electronics ARSD College University of DelhL Delhi India KITM Kurukshetra University India

Plasma immersion ion implantation (PIII) is a high-dose rate implantation technique with wide range of applications in the area of semiconductor devices fabrication viz., ultra shallow junctions, synthesis of silicon-on-insulator (SOI) structures, processing of flat panel display materials, metallization. In this technique, the target is immersed in plasma and the implantation is done by accelerating the ions with a negative pulse voltage, applied to the target. In this paper, for the application of PIII process with multispecies plasma, a generalised analytical model in a collisionless regime is suggested which estimates various parameters like sheath expansion, total implant ion current, net implant dose and the individual ion doping contributions of different species. To illustrate the model, combined plasma of He and Ar species has been investigated when a negative pulse of potential 10 KV and with pulse time of 10 μs is applied to the sample.

关键词：等离子体浸没离子注入碰撞系统模型广义多种群 PIII 脉冲电压设备制造

Enhanced osseointegration of drug eluting nanotubular dental implants: An in vitro and in vivo study

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Bioactive Materials 2023年第10期28卷 432-447页

作者： Pankaj Chauhan Alok Srivastava Pooja bhati Manish Chaturvedi Vinay Patil Sriram Kunnoth Nisha Kumari Vedpal Arya Madhur Pandya Mohit Agarwal Smiti Bhardwaj Farrukh Faraz Sanjay Chauhan Mahesh Verma Veena Koul Naresh Bhatnagar Homi Bhabha Cancer Hospital and Research Centre VizagAndhra PradeshIndia Centre for Biomedical Engineering Indian Institute of Technology DelhiIndia Department of Mechanical Engineering Indian Institute of Technology DelhiIndia Mechanical&Automation Engineering Indira Gandhi Delhi Technical University for WomenNew DelhiIndia Rajasthan Technical University Kota RajasthanIndia Applied Mechanics Indian Institute of Technology DelhiIndia National University of Singapore Singapore Department of Periodontics Maulana Azad Institute of Dental SciencesNew DelhiIndia Rajasthan Dental College and Hospital JaipurRajasthanIndia Department of Prosthodontics Maulana Azad Institute of Dental SciencesNew DelhiIndia

Faster and predictable osseointegration is crucial for the success of dental implants, especially in patients with compromised local or systemic conditions. Despite various surface modifications on the commercially available Titanium (Ti) dental implants, the bioactivity of Ti is still low. Thus, to achieve both biological and therapeutic activity on titanium surfaces, surface modification techniques such as titanium nanotubes have been studied as nanotube surfaces can hold therapeutic drugs and molecules. The main aim of the present research work is to study the early osseointegration around the novel Simvastatin drug eluting nanotubular dental implant. In the present research, the titanium nanotubes were fabricated on the screw-shaped dental implant surface and the Simvastatin drug was loaded into the nanotubes using the ultrasonication dip method. In vitro and In vivo studies were carried out on the modified dental implants. In vitro cell culture study reported enhanced osteogenic activity on the drug-loaded nanotube surface implants. The in vivo animal studies were evaluated by micro-CT, histopathology, and reverse torque removal analysis methods. The test results showed faster osseointegration with the strong interface on the Simvastatin drug-loaded implant surface at 4 weeks of healing as compared to the control implants.

关键词： Titanium Biocompatibility Simvastatin Nanotube Micro CT Histopathology Nanoscale