检索结果-南通市图书馆

Liposome based drug delivery as a potential treatment option for Alzheimer’s disease

Neural Regeneration Research 2022年第6期17卷 1190-1198页

作者： Carely Hernandez Surabhi shukla Department of Pharmaceutical Sciences College of PharmacyLarkin UniversityMiamiFLUSA

Alzheimer’s disease is a neurodegenerative condition leading to atrophy of the brain and robbing nearly 5.8 million individuals in the United States age 65 and older of their cognitive ***’s disease is associated with dementia and a progressive decline in memory,thinking,and social skills,eventually leading to a point that the individual can no longer perform daily activities *** available drugs on the market temporarily alleviate the symptoms,however,they are not successful in slowing down the progression of Alzheimer’s *** and cures have been constricted due to the difficulty of drug delivery to the blood-brain *** studies have led to identification of vesicles to transport the necessary drugs through the blood-brain barrier that would typically not achieve the targeted area through systemic delivered ***,liposomes have emerged as a viable drug delivery agent to transport drugs that are not able to cross the blood-brain *** are being used as a component of nanoparticle drug delivery;due to their biocompatible nature;and possessing the capability to carry both lipophilic and hydrophilic therapeutic agents across the blood brain barrier into the brain *** indicate the importance of liposomal based drug delivery in treatment of neurodegenerative *** idea is to encapsulate the drugs inside the properly engineered liposome to generate a response of *** are engineered to target specific diseased moieties and also several surface modifications of liposomes are under research to create a clinical path to the management of Alzheimer’s *** review deals with Alzheimer’s disease and emphasize on challenges associated with drug delivery to the brain,and how liposomal drug delivery can play an important role as a drug delivery method for the treatment of Alzheimer’s *** review also sheds some light on variation of ***

关键词： Alzheimer’s disease beta-amyloid blood-brain barrier brain delivery drug delivery systems encapsulated drugs liposomes nanoparticles neurodegenerative diseases PEGylation targeted delivery tau

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mammogram Classification with HanmanNets Using Hanman Transform Classifier

引用

Journal of Modern Physics（现代物理） 2024年第7期 1045页

作者： jyoti Dabass Madasu Hanmandlu Rekha Vig Shantaram Vasikarla

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Acclimation and Tolerance Strategies of Rice under Drought Stress

引用

Rice science 2015年第4期22卷 147-161页

作者： Veena PANDEY Alok shukla Department of Plant Physiology College of Basic Sciences and HumanitiesGovind Ballabh Pant University of Agriculture & Technology

Rice （Oryza sativa L.） is an important food crop and requires larger amount of water throughout its life cycle as compared to other crops. Hence, water related stress cause severe threat to rice production. Drought is a major challenge limiting rice production. It affects rice at morphological （reduced germination, plant height, plant biomass, number of tillers, various root and leaf traits）, physiological （reduced photosynthesis, transpiration, stomatal conductance, water use efficiency, relative water content, chlorophyll content, photosystem II activity, membrane stability, carbon isotope discrimination and abscisic acid content）, biochemical （accumulation of osmoprotectant like proline, sugars, polyamines and antioxidants） and molecular （altered expression of genes which encode transcription factors and defence related proteins） levels and thereby affects its yield. To facilitate the selection or development of drought tolerant rice varieties, a thorough understanding of the various mechanisms that govern the yield of rice under water stress condition is a prerequisite. Thus, this review is focused mainly on recent information about the effects of drought on rice, rice responses as well as adaptation mechanisms to drought stress.

关键词： rice water drought stress yield attribute morphological characteristic physiological characteristic biochemical characteristic molecular level

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamic scheduling of market price-based combined heat–power-constrained renewable microgrid

引用

Clean Energy 2023年第4期7卷 859-872页

作者： Sunita shukla Manjaree Pandit Department of Electrical Engineering Madhav Institute of Technology&ScienceGwalior 474005India

In this paper,a market price-based combined heat–power dynamic dispatch model for a microgrid is *** microgrid comprises cogeneration units and wind and solar power-generation units.A battery and a heat storage tank are incorporated to optimally balance variations in heat-and-power load *** proposed model explores the impact of market prices of electricity,heat supply and load variability on the optimal schedule such that profit maximizes and emission,loss and waste heat are *** Weibull probability distribution function is applied to characterize the uncertain renewable power variable in the model and to find the over-and under-scheduling *** problem is solved using an improved differential evolution algorithm in which a fuzzy membership module is appended to obtain a solution having the highest attainment for the selected multiple *** results show that the proposed model can handle uncertain heat–power demand and price scenarios to produce feasible and optimal schedules with owner profits,heat utilization and renewable share varying between 10.55–115.97%,72.51–90.39%and 26.82–38.05%,respectively.

关键词： renewable energy combined heat power(CHP) microgrid(MG) economic dispatch MG profit

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Electron Paramagnetic Resonance and Optical Absorption of VO2+Doped Ammonium Selenate Single Crystals

引用

Chinese Physics Letters 2011年第3期28卷 203-206页

作者： Ram Kripal Ashutosh Kumar shukla Department of Physics University of AllahabadAllahabad 211002India Department of Physics Ewing Christian CollegeAllahabad 211003India

An electron paramagnetic resonance study of vanadyl ions doped in ammonium selenate single crystals is carried out at room *** is found that the VO^(2+)ion takes up an interstitial *** spin Hamiltonian parameters obtained from the crystal rotations are g‖=1.9576±0.0002,g⊥=1.9889±0.0002,A‖=203±2 G,A⊥=78±2 *** optical absorption study is also carried out to evaluate various bonding *** the basis of these parameters the nature of bonding in the complex is discussed.

关键词： temperature parameters bonding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecules against COVID-19:An in Silico Approach for Drug Development

引用

Journal of Electronic Science and Technology 2021年第1期19卷 14-24页

作者： Rhythm Bharti Sandeep Kumar shukla the Sri Venkateswara College University of DelhiNew Delhi 110021. The Institute of Nuclear Medicine and Allied Sciences Defence Research and Development OrganizationDelhi 110054

A large number of deaths have been caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)worldwide,turning it into a serious and momentous threat to public *** study tends to contribute to the development of effective treatment strategies through a computational approach,investigating the mechanisms in relation to the binding and subsequent inhibition of SARS-CoV-2 ribonucleic acid(RNA)-dependent RNA polymerase(RdRp).Molecular docking was performed to screen six naturally occurring molecules with antineoplastic properties(Ellipticine,Ecteinascidin,Homoharringtonine,Dolastatin 10,Halichondrin,and Plicamycin).Absorption,distribution,metabolism,and excretion(ADME)investigation was also conducted to analyze the druglike properties of these *** docked results have clearly shown binding of ligands to the SARS-CoV-2 RdRp ***,all ligands were found to obey Lipinski’s rule of *** results provide a basis for repurposing and using molecules,derived from plants and animals,as a potential treatment for the coronavirus disease 2019(COVID-19)infection as they could be effective therapeutics for the same.

关键词： Coronavirus disease 2019(COVID-19) drug repurposing,molecular docking natural therapeutics RNA-dependent RNA polymerase(RdRp) severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bifurcation analysis and optimal control of an epidemic model with limited number of hospital beds

引用

International Journal of Biomathematics 2023年第4期16卷 229-253页

作者： A.K.Misra jyoti Maurya Department of Mathematics Institute of Science Banaras Hindu UniversityVaranasi 221005India

This paper deals with a three-dimensional nonlinear mathematical model to analyze an epidemic's future course when the public healthcare facilities,specifically the number of hospital beds,are *** feasibility and stability of the obtained equilibria are analyzed,and the basic reproduction number(Ro)is *** show that the system exhibits transcritical *** show the existence of Bogdanov-Takens bifurcation,we have derived the normal *** have also discussed a generalized Hopf(or Bautin)bifurcation at which the first Lyapunov coefficient *** show the existence of saddle-node bifurcation,we used Sotomayor's ***,we have identified an optimal layout of hospital beds in order to control the disease with minimum possible *** optimal control setting is studied analytically using optimal control theory,and numerical simulations of the optimal regimen are presented as well.

关键词： Hospital beds Hopf-bifurcation saddle-node bifurcation transcritical bifurcation Bogdanov-Takens bifurcation optimal control

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of heat treatment on the structural and optical properties of SrGd_2O_4:Eu^(3+) phosphor

引用

Journal of Rare Earths 2015年第10期33卷 1040-1050页

作者： jyoti Singh Pankaj Kr.Baitha J.Manam Department of Applied Physics Indian School of Mines

Novel red emitting Eu3＋ doped SrGd2O4 phosphors were synthesized by homogeneous precipitation method followed by a subsequent combustion process at various temperatures. A systematic study on the consequent structural evolution and optical properties were investigated as a function of various processing temperatures. With the enhancement of processing temperature, SrGd2O4 phosphor showed a gradual transformation from a mixed phase to monophasic nature, with minimized volatile imptwities. The microscopic images exhibited homogeneous aggregates of varying shapes and sizes with an average length of about 0.5-5μl. Eu3＋ doped SrGd2O4 phosphors prepared at low temperatures, showed miserably low values of red emission upon UV excitation owing to the presence of volatile impurities. The SrGd2O4：Eu3＋ phosphors prepared at relatively high temperature exhibited strong red-orange emissions due to homogeneously occupied Eu3＋ ions in the host lattice. The dominant red to orange （R/O） emission intensity ratios and CIE parameters of EU3＋ ions substantiated the site occupation of higher asymmetry sites of Gd3＋ ions and the strong covalent nature. Dexter theory and critical distance calculation suggested that the dipole-dipole interaction could be responsible for the concentration quenching of Eu3＋（4 mol.%） doped SrGd2O4 phosphors. Elevated physical and chemical durability and stable photoluminescence made these phosphors suitable for white LEDs and other display applications.

关键词： optical materials chemical synthesis X-ray diffraction luminescence rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The general class of Bianchi cosmological models with viscous fluid and particle creation in Brans-Dicke theory

引用

Research in Astronomy and Astrophysics 2014年第5期14卷 533-552页

作者： Raghavendra Chaubey Anjani Kumar shukla DST-Centre for Interdisciplinary Mathematical Sciences Faculty of Science Banaras Hindu University Varanasi India

This paper deals with the general class of Bianchi cosmological models with bulk viscosity and particle creation described by full causal thermodynamics in Brans-Dicke theory. We discuss three types of average scale-factor solutions for the general class of Bianchi cosmological models by using a special law for the deceler- ation parameter which is linear in time with a negative slope. The exact solutions to the corresponding field equations are obtained in quadrature form and solutions to the Einstein field equations are obtained for three different physically viable cosmologies. All the physical parameters are calculated and discussed in each model.

关键词： cosmology theory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deep Neural Network and Pseudo Relevance Feedback Based Query Expansion

引用

Computers, Materials & Continua 2022年第5期71卷 3557-3570页

作者： Abhishek Kumar shukla Sujoy Das Department of Mathematics Bio-Informatics and Computer ApplicationsMaulana Azad National Institute of Technology BhopalBhopalMadhya Pradesh462003India

The neural network has attracted researchers immensely in the last couple of years due to its wide applications in various areas such as Data mining,Natural language processing,Image processing,and Information retrieval *** embedding has been applied by many researchers for Information retrieval *** this paper word embedding-based skip-gram model has been developed for the query expansion *** terms are obtained from the top“k”initially retrieved documents using the Pseudo relevance feedback model and then they are trained using the skip-gram model to find the expansion terms for the user *** performance of the model based on mean average precision is *** proposed model compares with other existing *** improvement of 6.61%,6.93%,and 9.07%on MAP value is observed compare to the Original query,BM25 model,and query expansion with the Chi-Square model *** proposed model also retrieves 84,25,and 81 additional relevant documents compare to the original query,query expansion with Chi-Square model,and BM25 model respectively and thus improves the recall value *** per query analysis reveals that the proposed model performs well in 30,36,and 30 queries compare to the original query,query expansion with Chi-square model,and BM25 model respectively.

关键词： Information retrieval query expansion word embedding neural network deep neural network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：