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Bacopa monnieri extracts prevent hydrogen peroxide- induced oxidative damage in a cellular model of neuroblastoma IMR32 cells

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Chinese Journal of Natural Medicines 2017年第11期15卷 834-846页

作者： Gaurav bhatia Vikram Dhuna Kshitija Dhuna Manpreet Kaur Jatinder Singh Department of Molecular Biology and Biochemistry Guru Nanak Dev University Amritsar-143005 Punjab India Department of Biotechnology DAV College Amritsar-143006 Punjab India Department of Human Genetics Guru Nanak Dev University Amritsar-143005 Punjab India

Neurodegenerative diseases are the consequences of imbalance between the production of oxidative stress and its nullification by cellular defense mechanisms. Hydrogen peroxide(H_2O_2), a precursor of deleterious reactive oxygen species, elicits oxidative stress, resulting in severe brain injuries. Bacopa monnieri is well known for its nerve relaxing and memory enhancing properties. The present study was designed to evaluate the protective effects of extracts from Bacopa monnieri against H_2O_2 induced oxidative stress using a cellular model, neuroblastoma IMR32 cell line. The protective potential of methanolic, ethanolic, and water extracts of B. monnieri(BM-MEx, BM-EEx, and BM-WEx) was evaluated using MTT assay. Although, all the B. monnieri extracts were found to protect cells against H_2O_2-mediated stress but BM-MEx showed significantly greater protection. UPLC analysis of BM-MEx revealed various polyphenols, including quercetin, catechin, umbelliferone, and caffeic acid predominance. Further, BM-MEx was found to possess considerable greater neuroprotective potential in comparison to the standard polyphenols such as quercetin, catechin, umbelliferone, and caffeic acid. The levels of antioxidant enzymes were significantly elevated after the pretreatment of BM-MEx and quercetin. The expression levels of oxidative stress markers, such as NF200, HSP70, and mortalin, were significantly alleviated after the pretreatment of BM-MEx as shown by immunofluorescence and RT-PCR. In conclusion, the present study demonstrated the protective effects of BM-MEx, suggesting that it could be a candidate for the development of neuropathological therapeutics.

关键词： Antioxidant enzymes Bacopa monnieri H2O2 IMR32 neuroblastoma NF200 HSP70 Mortalin

Titanium nanoparticles attenuates arsenic toxicity by up-regulating expressions of defensive genes in Vigna radiata L

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Journal of Environmental Sciences 2020年第6期32卷 18-27页

作者： Priya Katiyar Bhumika Yadu jyoti Korram Manmohan L.Satnami Meetul Kumar S.Keshavkant School of Studies in Biotechnology Pt.Ravishankar Shukla UniversityRaipur 492010India School of Studies in Chemistry Pt.Ravishankar Shukla UniversityRaipur 492010India Directorate of International Cooperation Defence Research and Development OrganizationNew Delhi 110001India

Arsenic(As)-toxicity is recognized as one of the major environmental problems,affecting productivity of crops worldwide,thereby threatening sustainable agriculture and food *** in nanotechnology and its impacts have brought up concerns about the application of engineered nanoparticles(NPs)in various sectors of the economy,including the field of *** various NPs,there has been a rising amount of interest regarding the effects of titanium NPs(TiNPs)on plants growth and development,and their fate of abiotic stress ***,the present study was aimed to assess the ameliorative potentialities of chemically and biologically/green synthesized TiNPs to alleviate As-induced toxic responses in Vigna radiata *** results revealed that exposure to As hindered the growth indices(radicle length and biomass)and membrane integrity,while were improved with the application of chemical and green synthesized *** addition,treatment of As provoked the accretion of reactive oxygen species(superoxide and hydrogen peroxide)and malondialdehyde(a lipid per oxidized product),but were diminished by the supplementation of chemical and green manufactured *** experimental data also signified that exogenous application of chemical and green synthesized TiNPs conferred tolerance to As-induced oxidative injuries via perking-up the expressions of antioxidant genes and enzyme systems viz;superoxide dismutase and ***,the present study inferred that chemically and green synthesized TiNPs,particularly green manufactured,effectively mitigated the adverse impacts of As by augmenting antioxidant machinery,thereby proving its potentiality in the alleviation of As-toxicity,at least in Vignaradiata L.

关键词： Antioxidants Arsenic Gene expression Titanium nanoparticles(TiNPs) Reactive oxygen species(ROS) Vigna radiata L

Contribution of Community Forestry in Poverty Reduction: Case Study of Multiple Community Forests of Bajhang District, Nepal

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Journal of Resources and Ecology 2019年第6期10卷 632-640页

作者： Dhruba Bijaya GC BHANDARI jyoti XU Zengrang LI Can Provincial Key Laboratory for Rare Animals and Economic Insects of the mountains of Guizhou Province School of Biological and Environmental EngineeringGuiyang CollegeGuiyang 550005China Institute of Forestry Tribhuvan UniversityPokhara Campus 43PokharaNepal Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101.China

In Nepal,nearly half of the total land is covered by forest,which holds a potentially important position in promoting rural livelihoods and in alleviating rural *** rural landscape that encompasses an agrarian economy,a fragile ecology,and a complex and differentiated society is changing rapidly in Nepal *** poverty alleviation has been one of the top priorities for national development since 1976,poverty still remains widespread,persistent and it is also an acute problem in Nepal,where people are in a state of deprivation with regard to incomes,clothing,housing,healthcare,education,sanitary facilities and human ***,Nepal is considered as one of the poorest countries in South-Asia,with 25.2%people living below the poverty *** objective of this study was to assess changes in poverty of forest users brought on by the community forestry program,in order to analyze the level of participation in community forestry management *** this study,Bajhang district was chosen as the study site,which is one of the poorest and most remote districts in the country of *** Participatory Rural Appraisal methods such as face-to face interviews,focus group discussions and key informants’interviews including secondary data were used to gather *** findings showed that the forest users'participation in meetings,discussion and other activities,like community forestry management or silvicultural operation related to community forestry,was *** assessment found that 42.3%,32.6%and 25.1%of respondents strongly agreed,agreed and were neutral,respectively,towards the idea that poverty reduction from community forests had *** results showed almost all the respondents were depended upon agriculture and/or forest resources for their *** ecosystem services such as ethnomedicines,aesthetic value and ecotourism,control of soil erosion/land-slides,water recharge and soil fertility have increased due to the

关键词： community forests poverty Bajhang district aesthetic value ecotourism

Development and evaluation of robust tree biomass equations for rubber tree (Hevea brasiliensis) plantations in India

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Forest Ecosystems 2017年第3期4卷 241-250页

作者： Biplab Brahma Gudeta W.Sileshi Arun jyoti Nath Ashesh Kumar Das Department of Ecology and Environmental Science Assam University

Background： In India, rubber（Hevea brasiliensis） plantations cover -0.8 million ha of land, emphasizing its significant role in the Earth＇s carbon dynamics. Therefore, it is important to estimate the biomass stocks of plantations precisely in the context of carbon management. Previous studies in India have focused on development of allometric equations for estimating aboveground biomass（AGB） through harvesting younger trees（up to 14 yr）only or on studies with small sample sizes without assessing model bias. The objective of this study was to develop biomass estimation models for different tree components in rubber plantations and assess model predictive performance at the stand ***： A total of 67 trees were harvested from plantations of different ages（6, 15, 27 and 34 yr） in North East India and their diameter at 200 cm（D）, height and dry weights of different tree components were recorded. The data were used for evaluation of H-D and biomass estimation models at the stand ***： The Michaelis-Menten function was found to be the most appropriate model for estimating tree height among 10 commonly used H-D models. For estimation of AGB and coarse root biomass, a model that involves tree volume（i.e. D2 H） was found to provide better prediction than either D or H alone or a model that combines H, D and stand density. The estimated AGB varied from 28 Mg·ha-（-1） in 6 yr. old plantation to 169 Mg·ha-（-1） in 34 yr. old *** coarse root biomass was estimated at 4 Mg·ha-（-1） for 6 yr. old plantation and 12 Mg·ha-（-1） for 34 yr. old ***： It is concluded that models involving tree volume are more appropriate for regional level biomass estimation than simple power-law models for individual stands. We recommend that the power-law model should not be used for estimation of AGB in plantations at different growth stages because power-law parameters can be biased due to data truncation.

关键词： Aboveground biomass Data truncation Michaelis-Menten function Power-law

Performance prediction of switched reluctance generator with time average and small signal models

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Frontiers in Energy 2013年第1期7卷 56-68页

作者： jyoti KOUJALAGI B. UMAMAHESWARI R. ARUMUGAM Department of Electrical Engineering Dr. Ambedkar Institute of Technology Bangalore 560056 India Department of Electrical Engineering CEG Campus Anna University Chennai 600025 India Department of Electrical Engineering SSN Engineering of CollegeChennai 603110 India

This paper presents the complete mathematical model and predicts the performance of switched reluctance generator with time average and small signal models. The complete mathematical model is developed in three stages. First, a switching model is developed based on quasi-linear inductance profile. Next, based on the switching behaviour, a time average model is obtained to measure the difference between the excitation and generation time in each switching cycle. Finally, to track control voltage and current wave shapes, a small signal model is designed. The effectiveness of the complete multilevel model combining electrical machine, power converter, load and control with programming language is demonstrated through simulations. A PI controller is used for controlling the voltage of the generator. The results presented show that the controller exhibits accurate tracking control of load voltage under different operating conditions. This demonstrates that the proposed model is able to perform an accurate control of the generated output voltage even in transient situations. The simulation is performed to choose the control parameters and study the performance of switched reluctance generator prior to its actual implementation. Initial experimental results are presented using NI-Data acquisition card to control the output power according to load requirements.

关键词： generator reluctance switching model small signal model time average model

Novel anti-diabetic agents in non-alcoholic fatty liver disease: a mini-review

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Hepatobiliary & Pancreatic Diseases International 2013年第6期12卷 584-588页

作者： Manhal Olaywi Taruna bhatia Sury Anand Shashideep Singhal Division of Gastroenterology and Hepatology The Brooklyn Hospital Center/New York Presbyterian Healthcare System Division of Digestive and Liver Diseases Columbia University Medical Center

BACKGROUND:Non-alcoholic fatty liver disease(NAFLD)encompasses a spectrum that ranges from simple steatosis to non-alcoholic steatohepatitis(NASH)and to *** recommended treatment for this disease includes measures that target obesity and insulin *** present review summarizes the role of newer anti-diabetic agents in treatment of *** SOURCES:PubMed,MEDLINE and Ovid databases were searched to identify human studies between January 1990and January 2013 using specified key *** studies that enrolled patients with a diagnosis of NAFLD or NASH and involved use of newer classes of anti-diabetic agents for a duration of at least 3 months were ***:Out of the screened articles,four met eligibility criteria and were included in our *** classes of newer anti-diabetic medications described were dipeptidyl peptidase IV inhibitors and glucagon-like peptide-1 ***:Liraglutide and Exenatide showed improvement in transaminases as well as histology in patients with *** showed improvement in transaminases but limited studies are there to access its effect on *** studies are needed to support use of newer anti-diabetic medications in patients with NAFLD.

关键词： non-alcoholic fatty liver disease non-alcoholic steatohepatitis anti-diabetic agents Sitagliptin Exenatide Liraglutide

Improved Multi-Path Routing for QoS on MANET

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Computer Systems Science & Engineering 2023年第6期45卷 2521-2536页

作者： M.Vargheese Surbhi bhatia Shakila Basheer Pankaj Dadheech Department of Computer Science and Engineering PSN College of Engineering and TechnologyTirunelveli627152Tamil NaduIndia Department of Information Systems College of Computer Sciences and Information TechnologyKing Faisal UniversityAl HasaSaudi Arabia Department of Information Systems College of Computer and Information SciencePrincess Nourah bint Abdulrahman UniversityP.O.BOX 84428Riyadh11671Saudi Arabia Department of Computer Science&Engineering Swami Keshvanand Institute of TechnologyManagement&Gramothan(SKIT)Jaipur302017RajasthanIndia

A Mobile Ad hoc NETwork(MANET)is a self-configuring network that is not reliant on *** paper introduces a new multipath routing method based on the Multi-Hop Routing(MHR)*** is the consecutive selection of suitable relay nodes to send information across nodes that are not within direct range of each *** to ensure good MHR leads to several negative consequences,ultimately causing unsuccessful data transmission in a *** research work consists of three *** first to attempt to propose an efficient MHR protocol is the design of Priority Based Dynamic Routing(PBDR)to adapt to the dynamic MANET environment by reducing Node Link Failures(NLF)in the *** is achieved by dynamically considering a node’s mobility parameters like relative velocity and link duration,which enable the next-hop *** method works more efficiently than the traditional *** the second stage is the Improved Multi-Path Dynamic Routing(IMPDR).The enhancement is mainly focused on further improving the Quality of Service(QoS)in MANETs by introducing a QoS timer at every node to help in the QoS routing of *** QoS is the most vital metric that assesses a protocol,its dynamic estimation has improved network performance *** method uses distance,linkability,trust,and QoS as the four parameters for the next-hop *** is compared against traditional routing *** Network Simulator-2(NS2)is used to conduct a simulation analysis of the protocols under *** proposed tests are assessed for the Packet Delivery Ratio(PDR),Packet Loss Rate(PLR),End-to-End Delay(EED),and Network Throughput(NT).

关键词： Multi-path routing quality of service node-link failure packet delivery ratio

Biological analysis of an innovative biodegradable antibiotic eluting bioactive glass/gypsum composite bone cement for treating experimental chronic MRSA osteomyelitis

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Journal of Pharmaceutical Analysis 2022年第1期12卷 164-177页

作者： Surajit Mistry Subhasish Burman Subhasis Roy Nilendu jyoti Maitra Rajiv Roy Abhijit Chanda Department of Periodontics Burdwan Dental College&HospitalBurdwan713101India Department of Oral&Maxillofacial Surgery Burdwan Dental College&HospitalBurdwan713101India Department of Veterinary Clinical Complex(Surgery&Radiology) West Bengal University of Animal&Fishery SciencesKolkata700037India Directorate of Research Extension&Farms West Bengal University of Animal&Fishery SciencesKolkata700037India Department of Orthopaedics Calcutta National Medical College&HospitalKolkata700014India School of Bio-Science&Engineering Jadavpur UniversityKolkata734432India

A multi-barrier antibiotics loaded biodegradable composite bone cement for resolving chronic osteomyelitis has been studied to understand the physico-mechanical properties,drug loading/eluting efficiency,and different merits and demerits prior to clinical *** successful induction of bone infection in 28 rabbits using methicillin-resistant Staphylococcus aureus(MRSA)strains,calcium sulfate/bioactive glass based composite cement was implanted in 12 defects to assess its performance over parenteral therapy with microscopic and radiological examination for 90 *** composite cement revealed acceptable physico-mechanical properties and controlled drug elution ***,the antibiotics concentrations in bone up to 42 days were sufficient to kill MRSA without eliciting adverse drug *** striking feature of platelets aggregation by composite cement could assist bone *** controlled degradation with simultaneous entrapment of composite cement within the osteoid tissues and complete repair of infected cortical defects(holes)in rabbit tibia at 6 weeks indicated the excellent anti-infective and osteoconductive properties of composite ***,the animal study demonstrated the superiority of composite over injectable antibiotic therapy based on infection resolution and bone *** thereby conclude that the composite cement can be effectively applied in the treatment of resistant cases of chronic osteomyelitis.

关键词： Antibiotics Biodegradable composite Osteomyelitis MRSA strains Osteoconduction

Dynamical study of a predator-prey system with Michaelis-Menten type predator-harvesting

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生物数学学报:英文版 2023年第8期16卷 121-153页

作者： Ankur jyoti Kashyap Quanxin Zhu Hemanta Kumar Sarmah Debasish Bhattacharjee Department of Mathematics Gauhati University AssamIndia Department of Mathematics Assam Royal Global University GuwahatiIndia School of Mathematical Sciences and Statistics Hunan Normal University Changsha410081P.R.China Sajkashyap.maths@***

The predation process plays a significant role in advancing life evolution and the maintenance of ecological balance and *** cooperation in predators is one of the most remarkable features of the predation process,which benefits the predators by developing fear upon their *** study investigates the dynamical behavior of a modified LV-type predator-prey system with Michaelis-Menten-type harvesting of predators where predators adopt cooperation strategy during *** ecologically feasible steady states of the system and their asymptotic stabilities are *** local codimension one bifurcations,***,saddle-node and Hopf bifurcations,that emerge in the system are *** approach is utilized to show the appearance of transcritical bifurcation and saddle-node bifurcation.A backward Hopfbifurcation is detected when the harvesting effort is increased,which destabilizes the system by generating periodic *** stability nature of the Hopf-bifurcating periodic orbits is determined by computing the first Lyapunov *** analyses revealed that above a threshold value of the harvesting effort promotes the coexistence of both *** periodic solutions of the system are also observed when the conversion efficiency rate or the hunting cooperation rate is *** have also explored codimension two bifurcations *** generalized Hopf and the Bogdanov-Takens bifurcation exhibit by the *** visualize the dynamical behavior of the system,numerical simulations are conducted using an ecologically plausible parameter *** existence of the bionomic equilibrium of the model is ***,an optimal harvesting policy for the proposed model is derived by considering harvesting effort as a control parameter with the help of Pontryagins maximum principle.

关键词： Hunting cooperation Michaelis-Menten-type harvesting transcritical and saddle-node bifurcation Hopf bifurcation optimal harvesting policy