检索结果-南通市图书馆

Structural features of substituted triazole-linked chalcone derivatives as antimalarial activities against D_(10) strains of Plasmodium falciparum: A QSAR approach

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2015年第10期22卷 3738-3744页

作者： Mukesh C.sharma Division of Drug Design & Medicinal Chemistry Research Lab School of Pharmacy Devi Ahilya University Takshila Campus

A quantitative structure–activity relationship(QSAR) was performed to analyze antimalarial activities against the D10 strains of Plasmodium falciparum of triazole-linked chalcone and dienone hybrid derivatives using partial least squares regression coupled with stepwise forward–backward variable selection method. QSAR analyses were performed on the available IC50 D10 strains of Plasmodium falciparum data based on theoretical molecular descriptors. The QSAR model developed gave good predictive correlation coefficient(r2) of 0.8994, significant cross validated correlation coefficient(q2) of 0.7689, r2 for external test set)(2predr of 0.8256, coefficient of correlation of predicted data set)(2sepred,r of 0.3276. The model shows that antimalarial activity is greatly affected by donor and electron-withdrawing substituents. The study implicates that chalcone and dienone rings should have strong donor and electron-withdrawing substituents as they increase the activity of chalcone. Results show that the predictive ability of the model is satisfactory, and it can be used for designing similar group of antimalarial compounds. The findings derived from this analysis along with other molecular modeling studies will be helpful in designing of the new potent antimalarial activity of clinical utility.

关键词： quantitative structure–activity relationship(QSAR) chalcone antimalarial Plasmodium falciparum stepwise forward–backward partial least squares

Antioxidant and modulatory role of Chlorophytum borivilianum against arsenic induced testicular impairment

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2012年第12期24卷 2159-2165页

作者： Garima sharma Madhu Kumar Cell and Molecular Biology Laboratory Department of ZoologyCentre for Advanced studiesUniversity of RajasthanJaipur 302055India

Arsenic has a suppressive influence on spermatogenesis and induces impairment in male reproductive system due to oxidative stress. The present study was aimed to test the arsenic induced toxicity and protection by Chlorophytum borivilianum. The effect of sodium arsenite （4 mg/（kg body weight （bw）.day）） via double distilled water without or with C. borivilianum （800 mg/（kg ***）） was evaluated in Swiss albino mice for 30 days. The radical scavenging activity of the aqueous C. borivilianum root extract was measured using DPPH （1,1-diphenyl-2-picryl hydrayzyl） radical. Qualitative assessment of various cell types in the testis, sperm count and motility, testicular activity of lipid peroxidation （LPO）, reduced glutathione （GSH）, acid and alkaline phosphatase, cholesterol and serum testosterone were monitored. Arsenic treatment showed a significant increase in LPO, acid and alkaline phosphatase, cholesterol and decrease in sperm count, sperm motility, GSH and serum testosterone. Combined treatment showed significant decrease in LPO, acid and alkaline phosphatase, cholesterol and elevation in sperm count, sperm motility, GSH and serum testosterone. Testicular histopathology showed that C. borivilianum had reduced degeneration of germ cell in the seminiferous tubules and loss of sperms induced by arsenic intoxication. The results thus led us to conclude that administration of C. borivilianum root extract is found to be protective against arsenic induced toxicity.

关键词： DPPH radical assay Chlorophytum borivilianum reduced glutathione lipid peroxidation arsenic testosterone

Mechanical, electrical, and thermal expansion properties of carbon nanotube-based silver and silver–palladium alloy composites

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2014年第11期21卷 1132-1140页

作者： Hemant Pal Vimal sharma Department of Physics National Institute of Technology Department of Physics Govt. Post graduate College

The mechanical, electrical, and thermal expansion properties of carbon nanotube（CNT）-based silver and silver–palladium（10：1, w/w） alloy nanocomposites are reported. To tailor the properties of silver, CNTs were incorporated into a silver matrix by a modified molecular level-mixing process. CNTs interact weakly with silver because of their non-reactive nature and lack of mutual solubility. Therefore, palladium was utilized as an alloying element to improve interfacial adhesion. Comparative microstructural characterizations and property evaluations of the nanocomposites were performed. The structural characterizations revealed that decorated type-CNTs were dispersed, embedded, and anchored into the silver matrix. The experimental results indicated that the modification of the silver and silver–palladium nanocomposite with CNT resulted in increases in the hardness and Young＇s modulus along with concomitant decreases in the electrical conductivity and the coefficient of thermal expansion（CTE）. The hardness and Young＇s modulus of the nanocomposites were increased by 30%？40% whereas the CTE was decreased to 50%-60% of the CTE of silver. The significantly improved CTE and the mechanical properties of the CNT-reinforced silver and silver–palladium nanocomposites are correlated with the intriguing properties of CNTs and with good interfacial adhesion between the CNTs and silver as a result of the fabrication process and the contact action of palladium as an alloying element.

关键词： metal matrix composites carbon nanotubes mechanical properties coefficient of thermal expansion electrical conductivity

Biodiverse rotifer assemblage (Rotifera： Eurotatoria) of floodplain lakes of the Brahmaputra basin of lower Assam, northeast India： composition and ecosystem diversity

在线全文

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2018年第2期36卷 362-375页

作者： bhushan kumar sharma shaikhul islam khan sumita sharma Freshwater Biology Laboratory Department of Zoology North-Eastern Hill University Shillong-793 022 Meghalaya Indi

The study aims to ascertain the hypothesis on the rich rotifer biodiversity of the floodplain lakes （beels） of the Brahmaputra river basin and to use these metazoans to assess trophic status or to characterize habitat variations of wetlands. The plankton samples collected from four beels of lower Assam revealed 160 Rotifera species belonging to 35 genera and 19 families. The richness is of biodiversity value as -38.0% and -57.0% of the rotifer species known till date from India and northeast India （NEI）, respectively. One species each is new to the Oriental region and NEI, and three species are new to Assam; 23 species merit global biogeography interest and several exhibit distribution values in the Indian sub-region. The diverse Lecanidae 〉 Brachionidae 〉 Lepadellidae 〉 Trichocercidae and speciose littoral-periphytic Lecane〉 Lepadella〉Trichocerca, and richness of Brachionus spp. following removal of aquatic macrophytes are noteworthy. Overall rotifer composition showed homogeneity amongst beels while lower monthly richness and community similarities affirmed heterogeneity within individual beels. We propose L/B quotient based on Lecane： Brachionus species ratios to characterize habitat variations of the sampled wetlands. Slfide^ek＇s B/T quotient based on Brachionus： Trichocerca species ratios affirmed general ＇meso-trophic＇ status of different beels. Our results provided little insight on the influence of individual abiotic factors but the canonical correspondence analyses asserted higher cumulative influence of ten abiotic parameters on Rotifera richness in each beel.

关键词： B/T quotient L/B quotient intensive fishing habitat disturbance interesting taxa richness tropical beels

China–India collaborative opportunities on science and technology for sustainable development of the Hindu Kush Himalaya

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2017年第10期62卷 673-674页

作者： Eklabya sharma International Centre for Integrated Mountain Development (ICIMOD) GPO Box 3226 Kathmandu Nepal

China and India have a long historical relationship dating back to the 7th century when Xuanzang(玄奘;Hsüan Tsang)first traveled to India for *** followed the old silk route from China,across central Asia,to ***,China is promoting the‘‘Belt and Road Initiative,'a programme that could reinvigorate the historical connection between the two countries,and provide golden opportunity for collaboration.

关键词：可持续发展印度中国喜马拉雅合作技术科学历史关系

Thermogram Adaptive Efficient Model for Breast Cancer Detection Using Fractional Derivative Mask and Hybrid Feature Set in the IoT Environment

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2022年第2期130卷 923-947页

作者： Ritam sharma JankiBallabh sharma Ranjan Maheshwari Praveen Agarwal Rajasthan Technical University KotaRajasthan324010India Anand International College of Engineering Jaipur303012India Nonlinear Dynamics Research Center(NDRC) Ajman UniversityAjman20550United Arab Emirates International Center for Basic and Applied Sciences Jaipur302029India Institute of MathematicalModeling Almaty050000Kazakhstan

In this paper,a novel hybrid texture feature set and fractional derivative filter-based breast cancer detection model is *** paper also introduces the application of a histogram of linear bipolar pattern features(HLBP)for breast thermogram ***,breast tissues are separated by masking operation and filtered by Gr¨umwald–Letnikov fractional derivative-based Sobel mask to enhance the texture and rectify the noise.A novel hybrid feature set usingHLBP and other statistical feature sets is derived and reduced by principal component *** basis function kernel-based support vector machine is employed for detecting the abnormality in the *** performance parameters are calculated using five-fold cross-validation scheme using MATLAB 2015a simulation *** proposedmodel achieves the classification accuracy,sensitivity,specificity,and area under the curve of 94.44%,95.55%,92.22%,96.11%,respectively.A comparative investigation of different texture features with respect to fractional orderαto classify the breast malignancy is also *** proposed model is also compared with a few existing state-of-art schemes which verifies the efficacy of the *** orderαoffers extra adaptability in overcoming the limitations of thermal imaging techniques and assists radiologists in prior breast cancer *** proposed model is more generalized which can be used with different thermal image acquisition protocols and IoT based applications.

关键词： Thermal image breast cancer fractional derivative mask image texture analysis feature extraction radial basis function machine learning

Cosmology using long gamma-ray bursts: statistical analysis of errors in calibrated data

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2019年第2期19卷 143-150页

作者： Meghendra Singh Shashikant Gupta Amit sharma Satendra sharma Dr.A.P.J.Abdul Kalam Technical University G.D.Goenka University Amity University Haryana Yobe State University

We investigate direction dependence and non-Gaussian features in high-z cosmological data using ?_(χ~2) and ?_χ statistics and the Kolmogorov-Smirnov test. These techniques are applied on a set of calibrated long gamma-ray bursts(GRBs) and its combination with recent Type Ia supernovae data(Union2). Our statistical analysis shows a weak but consistent direction dependence in both the data *** analysis also indicates a non-Gaussian nature of errors in both data sets.

关键词： gamma-ray bursts observational cosmology cosmological parameters Gaussian distribution supernovae

Systematic study of kinematic and dynamic moments of inertia of superdeformed bands with NpNn scheme

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2017年第8期41卷 101-107页

作者： Honey sharma Neha sharma H.M.Mittal Dr.B.R.Ambedkar National Institute of Technology Jalandhar144011India CT Institute of Engineering Management and Technology Jalandhar144020India

The systematics of kinematic moment of inertia J and dynamic moment of inertia J of superdeformed（SD） bands in A -130, 150, 190 mass regions have been studied. We have obtained the values of J^（1） and J^（2）for all the SD bands observed in the A-130, 150, 190 mass regions by using the experimental intraband E2 transition energies. The result of this work includes the variation of J with the product of valence proton and neutron numbers（NpNn）. The phenomenon of band mixing has been observed in the A -130, 150 mass regions and band crossing has been observed in the A-190 mass region. The systematics also includes the variation of J with the product of valence proton and neutron numbers（NpNn）. Evidence of staggering behaviour has been observed in all three A-130, 150 and 190 mass regions. We present for the first time the variation of J^（1）and J^（2）of SD bands in the A-130, 150, 190 mass regions with NpNn.

关键词： kinematic moment of inertia j dynamic moment of inertia j NpYn scheme

Self-Management of Low Back Pain Using Neural Network

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2021年第1期66卷 885-901页

作者： Purushottam sharma Mohammed Alshehri Richa sharma Osama Alfarraj ASET Amity University Uttar PradeshNoida201301India Department of Information Technology College of Computer and Information SciencesMajmaah UniversityMajmaah11952Saudi Arabia Computer Science Department Community CollegeKing Saud UniversityRiyadhSaudi Arabia

Low back pain(LBP)is a morbid condition that has afflicted several citizens in *** has negatively impacted the European economy due to several man-days lost,with bed rest and forced inactivity being the usual LBP care and management *** models,which incorporate various regression analyses,have been executed for the investigation of this premise due to the simplicity of ***,such straight models fail to completely consider the impact of association brought about by a mix of nonlinear connections and autonomous *** this paper,we discuss a system that aids decision-making regarding the best-suited support system for LBP,allowing the individual to avail of reinforcement and improvement in its *** activities are monitored with the help of a wearable sensor that helps in their detection and their classification as those that soothe or aggravate LBP and hence,should or should not be *** system helps the patients set their own boundaries and milestones with respect to suitable *** system also does windowing and feature *** present study is an empirical and comparative analysis of the most suitable activities that patients suffering from low back pain can *** evaluation shows that the system can distinguish between nine common daily activities effectively and helps self-monitor these activities for the efficient management of LBP.

关键词： Low back pain neural networks sensor classification time series