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Rice straw management through biofuel,biochar,mushroom cultivation,and paper production to overcome environmental pollution in North India

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Waste Disposal and Sustainable Energy 2023年第4期5卷 483-510页

作者： Vikram Kumar Pooja Singh jyoti sharma Sakshi Saini Priyanka sharma Asha sharma Department of Botany Maharshi Dayanand UniversityRohtakHaryana124001India

Rice is the prominent food grain required by more than half of the world's population to fulfill their nutritional *** the continuous growth in the population at the global level,rice production has also been ***,high rice production also creates a new problem in waste management *** straw,generated after rice harvest,possesses meager nutritional value,due to which it is less preferred as fodder and burned in the *** burning is one of the major causes of air pollution,leading to lung,heart,eye,and skin-related diseases and even premature *** stubble burning also decreases soil *** this review article,we have discussed the various economic uses of paddy straw which will help to reduce air pollution through the decline in paddy straw *** is produced from paddy straw,which can be mixed into the soil to restore fertility and reduce toxic metals'*** generation of biofuels such as biobutanol,bioethanol,and biogas from rice straw with their mechanism of synthesis is also discussed in this *** straw can also be utilized in the preparation of solid *** with this,mushroom cultivation in paddy straw houses is also *** straw can be used for the pulp and paper industries,which will help to reduce the tree dependence of these *** from this,a bibliometric analysis of the Scopus database on rice straw uses for the last 20 years was done,including a bibliographic keyword analysis to show published documents'*** review will give an elaborated overview of the alternative uses of rice straw with a quantitative analysis of air pollution caused by paddy straw *** review will also help to improve the current uses of paddy straw for industrial and commercial benefits to make it more economical.

关键词： Rice straw Environment pollution Biochar Biofuels Mushroom cultivation Paper and pulp

Genetics on early onset inflammatory bowel disease:An update

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Genes & Diseases 2020年第1期7卷 93-106页

作者： Johnson Nameirakpam Rashmi Rikhi Sanjay Singh Rawat jyoti sharma Deepti Suri Pediatric Allergy and Immunology Unit Department of PediatricsAdvanced Pediatrics CentrePostgraduate Institute of Medical Education and ResearchChandigarhIndia

Inflammatory bowel disease(IBD)is more common in adults than in *** of IBD before 17 years of age is referred as pediatric onset IBD and is further categorized as very early onset IBD(VEO-IBD)for children who are diagnosed before 6 years of age,infantile IBD who had the disease before 2 years of age and neonatal onset IBD for children less than 28 days of *** presenting with early onset disease may have a monogenic *** and awareness of the clinical manifestations facilitates early evaluation and *** generation sequencing is helpful in making the genetic *** of childhood IBD is difficult;targeted therapies and hematopoietic stem cell transplantation form the *** this review we aim to summarize the genetic defects associated with IBD *** describe genetic location and functions of various genetic defect associated with VEO-IBD with their key clinical *** also provide clinical clues to suspect these conditions and approaches to the diagnosis of these disorders and suitable treatment options.

关键词： Il-10 signalling defect IPEX Next generation sequencing Targeted therapy Very early onset inflammatory bowel disease

Preoperative therapy in locally advanced esophageal cancer

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World Journal of Gastroenterology 2016年第39期22卷 8750-8759页

作者： Pankaj Kumar Garg jyoti sharma Ashish Jakhetiya Aakanksha Goel Manish Kumar Gaur Department of Surgery University College of Medical Sciences and Guru Teg Bahadur Hospital University of Delhi Department of Surgical Oncology Sawai Man Singh Medical College Department of Surgical Oncology Dr BRA Institute Rotary Cancer Hospital All India Institute of Medical Sciences

Esophageal cancer is an aggressive malignancy associated with dismal treatment outcomes. Presence of two distinct histopathological types distinguishes it from other gastrointestinal tract malignancies. Surgery is the cornerstone of treatment in locally advanced esophageal cancer(T2 or greater or node positive); however, a high rate of disease recurrence(systemic and loco-regional) and poor survival justifies a continued search for optimal therapy. Various combinations of multimodality treatment(preoperative/perioperative, or postoperative; radiotherapy, chemotherapy, or chemoradiotherapy) are being explored to lower disease recurrence and improve survival. Preoperative therapy followed by surgery is presently considered the standard of care in resectable locally advanced esophageal cancer as postoperative treatment may not be feasible for all the patients due to the morbidity of esophagectomy and prolonged recovery time limiting the tolerance of patient. There are wide variations in the preoperative therapy practiced across the centres depending upon the institutional practices, availability of facilities and personal experiences. There is paucity of literature to standardize the preoperative therapy. Broadly, chemoradiotherapy is the preferred neo-adjuvant modality in western countries whereas chemotherapy alone is considered optimal in the far East. The present review highlights the significant studies to assist in opting for the best evidence based preoperative therapy(radiotherapy, chemotherapy or chemoradiotherapy) for locally advanced esophageal cancer.

关键词： Esophageal cancer Preoperative therapy Multimodality treatment Chemotherapy Radiotherapy Chemoradiotherapy

Recent advances in chronic granulomatous disease

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Genes & Diseases 2020年第1期7卷 84-92页

作者： Gummadi Anjani Pandiarajan Vignesh Vibhu Joshi Jitendra Kumar Shandilya Dharmagat Bhattarai jyoti sharma Amit Rawat Allergy Immunology Unit Department of PediatricsAdvanced Pediatrics CentrePostgraduate Institute of Medical Education and ResearchChandigarhIndia

Chronic granulomatous disease(CGD)is an inherited defect of phagocyte function due to defective NADPH *** with CGD are not able to effectively clear the infections because of the defect in the phagocyte production of oxygen free radicals and are prone to recurrent bacterial and fungal *** complications are also noted in CGD such as colitis,non-infective granulomas causing gastrointestinal or urinary tract obstruction,hemophagocytic lymphohistiocytosis,and *** on toll-like receptor pathways and neutrophil extracellular traps in CGD have shed light on the role of NADPH oxidase in the innate immunity and pathogenesis of infections in *** reports also indicate a reduction of memory B cells and defective production of functional antibodies in *** the exact mechanisms for non-infective inflammatory complications in CGD are not yet clear,studies on efferocytosis and defective autophagy with inflammasome activation have made a substantial contribution to our understanding of the pathogenesis of inflammation in *** also discuss the clinical and molecular features of p40phox defects and a newer genetic defect,*** phenotypes of X-linked carriers of CYBB are also discussed.

关键词： Chronic granulomatous disease Colitis EROS Genetics Infections Inflammation p40phox

Assessment of reproductive health service utilization in urban slums: Evidence from Western Rajasthan

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Asian pacific Journal of Reproduction 2023年第2期12卷 52-57页

作者： jyoti sharma Nitin Kumar Joshi Yogesh Kumar Jain Kuldeep Singh Pankaj Bhardwaj School of Public Health All India Institute of Medical SciencesJodhpurIndia Department of Community Medicine and Family Medicine and School of Public Health All India Institute of Medical SciencesJodhpurIndia

Objective:To assess the utilization of reproductive health services in urban slum of Jodhpur city,***:A community based cross-sectional study was conducted in an urban slums of Jodhpur city amongst 300 married women of reproductive age between March and June ***-structured questionnaire was used to gather demographic data and information about utilization of antenatal care(ANC)services,delivery and post-partum ***:The majority of females were aged less than 25 years(n=195;65.0%),married after 18 years(n=240;80%),living in extended families(n=265;88.3%)and with monthly family income less than 10000 rupees(n=182;60.7%).Statistically significant associations were found between≥4 ANC visits and educational level of secondary and above(OR 2.47,95%CI 1.03–6.28;P=0.04),older age(OR 15.70,95%CI 14.87–16.54 for women aged 26-35 years,OR 16.14,95%CI 12.12–20.01 for women aged≥36 years;P<0.01),and backward and general castes(OR 15.91,95%CI 13.57–17.85 for backward caste and OR 8.11,95%CI 8.07–8.26 for general category of caste;P<0.01).Seven percent of females had undergone *** age was associated with higher risks of postpartum complications(OR 1.06,95%CI 1.01–1.57 for women aged 26-35 years,OR 3.56,95%CI 1.29–4.69 for women aged≥36 years;P<0.01).In addition,risks of postpartum complications were associated with backward and general castes(OR 1.69,95%CI 1.34–2.13 for backward classes and OR 5.01,95%CI 4.29–5.31 for general category castes;P<0.01),and more than 4 ANC visits(OR 0.20,95%CI 0.09–0.34;P<0.01).Conclusions:More frequent ANC visits are associated with a lower risk of postpartum ***,a high utilization of reproductive health services represents good implementation of reproductive and child health programme at the peripheral level resulting in a stark rise in maternal health indicators in the state of Rajasthan.

关键词： Female Pregnancy Maternal health Maternal health services Prenatal care Postpartum period Facilities and services utilization Health services accessibility

Enhanced dielectric and optical properties of nanoscale barium hexaferrites for optoelectronics and high frequency application

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Chinese Physics B 2018年第12期27卷 517-525页

作者： J Mohammed A B Suleiman Tchouank Tekou Carol T H Y Hafeez jyoti sharma Pradip K Maji Sachin Godara Kumar A K Srivastava Department of Physics School of Chemical Engineering and Physical Sciences Lovely Professional University Department of Physics Faculty of Science Federal University Dutse SRM Research Institute SRM University Department of Polymer and Processing Engineering Indian Institute of Technology Roorkee Department of Chemistry Guru Nanak Dev University

M-type barium hexaferrites with chemical composition Ba1-xDyxFe12-yCryO19(x = 0.0, 0.1, 0.2, and y =0.0, 0.4, 0.5) were synthesized via sol–gel auto-combustion method. The samples were pre-sintered at 400℃ for 3 h and sintered at 950℃ for 5 h. The changes in the structural, dielectric, and optical properties were studied after the substitution of Dy3+and Cr3+ions. X-ray diffraction(XRD) analysis confirms the formation of single phase hexaferrites with the absence of secondary phase. FTIR analysis gives an idea of the formation of hexaferrites with the appearance of two peaks at 438 cm-1and 589 cm-1. The field emission scanning electron micrographs(FESEM) show a combination of crystallites with large shapes close to hexagonal platelet-like shape and others with rice or rod-like shapes, whereas EDX and elemental analysis confirm the stoichiometry of prepared samples. The calculated band gap from UV-vis NIR spectroscopy spectra was found to decreases with increase in Dy3+–Cr3+substitution. The dielectric properties were explained on the basis of Maxwell–Wagner model. Enhancement of dielectric constant at higher frequencies was observed in all the samples. Low dielectric loss is also observed in all the samples and Cole–Cole plot shows that grain boundary resistance(Rgb) contribute most to the dielectric properties. The prepared samples exhibit properties that could be useful for optoelectronics and high frequency application.

关键词： Maxwell–Wagner model dielectric constant Cole–Cole plot optical band-gap

EON Therapy Ameliorates Cachexia and Quality of Life in Cancer Patients

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Journal of Cancer Therapy 2022年第7期13卷 379-396页

作者： Abhiram Kumar jyoti sharma Raktim Chattopadhyay Shrikant Charde Anubhab Mukherjee Esperer Onco Nutrition Pvt Ltd. Mumbai India

Cancer induced cachexia, a gross loss of skeletal muscle with or without adipose tissue wasting, remains a clinical impasse resulting in poor prognosis and Quality of Life (QoL). It is characterized by an inflammation driven anorexia and aberrant energy and protein balance. Indubitably, nutritional rehabilitation is required to address various daunting challenges of this multifactorial syndrome. Esperer Onco Nutrition has come up with an optimal clinical nutrition formulation with promising anti-cachexia effects. Towards validating the efficacy and ensuring the safety of EON Therapy (Es-Invigour plus Es-Fortitude-Protect) under clinical settings, a phase IV post marketing surveillance (PMS) study with 63 patients from various hospitals across India was undertaken. This multi-nutrient and multi-targeted nutritional intervention, being concurrent with mainstream therapy, demonstrated potential to ameliorate the cachectic condition which was measured by body weight of the volunteers at each visit. Biochemical parameters improved or remained same. Overall QoL assessment was performed by using ECOG Scale and Malnutrition Screening Tool (MST) which showed significant improvement in physical wellness and nutritional status of the volunteers. No adverse effect was observed during the entire period. These observations reinforce the need of research based nutritional intervention for clinical use in cachectic cancer patients.

关键词： Cancer Cachexia Nutritional Intervention EON Therapy Quality of Life

Lymphadenectomy in gastric cancer: Contentious issues

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World Journal of Gastrointestinal Surgery 2016年第4期8卷 294-300页

作者： Pankaj Kumar Garg Ashish Jakhetiya jyoti sharma Mukur Dipi Ray Durgatosh Pandey Department of Surgical Oncology Dr BRA Institute Rotary Cancer Hospital All India Institute of Medical Sciences Department of Surgery University College of Medical Sciences and Guru Teg Bahadur Hospital

The stomach is the sixth most common cause of cancer worldwide. Surgery is an important component of the multi-modality treatment of the gastric cancer. The extent of lymphadenectomy has been a controversial issue in the surgical management of gastric cancer. The East-Asian surgeons believe that quality-controlled extended lymphadenectomy resulting in better locoregional control leads to survival benefit in the gastric cancer; contrary to that, many western surgeons believe that extended lymphadenectomy adds to only postoperative morbidity and mortality without significantly enhancing the overall survival. We present a comprehensive review of the lymphadenectomy in the gastric cancer based on the previously published randomized controlled trials.

关键词： Gastric neoplasms Lymphadenectomy Gastrectomy Survival Disease recurrence

Targeted therapy of gastrointestinal stromal tumours

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World Journal of Gastrointestinal Surgery 2016年第5期8卷 345-352页

作者： Ashish Jakhetiya Pankaj Kumar Garg Gaurav Prakash jyoti sharma Rambha Pandey Durgatosh Pandey Department of Surgical Oncology Dr BRA Institute Rotary Cancer HospitalAll India Institute of Medical Sciences Department of Surgery University College of Medical Sciences and Guru Teg Bahadur HospitalUniversity of Delhi Clinical Hematology and Bone Marrow Transplant Unit Department of Internal MedicinePost-Graduate Institute of Medical Education and Research Department of Radiation Oncology Dr BRA Institute Rotary Cancer HospitalAll India Institute of Medical Sciences

Gastrointestinal stromal tumours(GISTs) are mesen-chymal neoplasms originating in the gastrointestinal tract, usually in the stomach or the small intestine, and rarely elsewhere in the abdomen. The malignant potential of GISTs is variable ranging from small lesions with a benign behaviour to fatal sarcomas. The majo-rity of the tumours stain positively for the CD-117(KIT) and discovered on GIST-1(DOG-1 or anoctamin 1) expression, and they are characterized by the presence of a driver kinase-activating mutation in either KIT or platelet-derived growth factor receptor α. Although surgery is the primary modality of treatment, almost half of the patients have disease recurrence following surgery, which highlights the need for an effective adjuvant therapy. Traditionally, GISTs are considered chemotherapy and radiotherapy resistant. With the advent of targeted therapy(tyrosine kinase inhibitors), there has been a paradigm shift in the management of GISTs in the last decade. We present a comprehensive review of targeted therapy in the management of GISTs.

关键词： Gastrointestinal tumors Molecular targeted therapy Protein kinase inhibitors Imatinib Survival