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Photonic properties of novel Yb3＋ doped germanium-lead oxyfluoride glass-ceramics for laser cooling applications

Frontiers of Optoelectronics 2018年第2期11卷 189-198页

作者： Lauro J. Q. MAIA jyothis thomas Yannick LEDEMI Kummara V. KRISHNAIAH Denis SELETSKIY Younes MESSADDEQ Raman KASHYAP Instituto de Fisica Universidade Federal de Goias Av. Esperanga 1533 Campus Samambaia Goiania GO 74690-900 Brazil Department of Electrical Engineering Ecole Polytechnique de Montrral P.O. Box 6079 Station Centre-ville Montreal QC H3C 3A7 Canada Department of Engineering Physics Ecole Polytechnique de Montrral P.O. Box 6079 Station Centre-ville Montreal QC H3C 3A7 Canada Centre d'Optique Photonique et Laser 2375 Rue de la Terrasse Universite Laval Qurbec QC G1V 0A6 Canada

Abstract In recent years, our research group has developed and studied new rare-earth doped materials for the promising technology of solid-state laser cooling, which is based on anti-stokes fluorescence. To the best of our knowledge, our group is the only one in Canada leading the research into the properties of nanoparticles, glasses and glass-ceramics for optical refrigeration appli- cations. In the present work, optical properties of 50GeO2- 30PbF2-18PbO-2YbF3 glass-ceramics for laser cooling are presented and discussed as a function of crystallization temperature. Spectroscopic results show that samples have near infrared photoluminescence emission due to the 2F5/2 - 2F7/2 Yb3＋ transition, centered at -1016 nm with an excitation wavelength of 920 nm or 1011 nm, and the highest photoluminescence emission efficiency occurs for heat-treatment for 5 h at 350℃. The internal photolumi- nescence quantum yield varies between 99% and 80%, depending on the temperature of heat-treatment, being the most efficient under 1011 nm excitation. The 2F5/2 lifetime increases from 1.472 to 1.970 ms for heat treatments at 330℃ to 350℃, respectively, due to energy trapping and the low phonon energy of the nanocrystals. The sample temperature dependence was measured with a fiber Bragg grating sensor, as a function of input pump laser wavelength and processing temperature. These measure- ments show that the heating process approaches near zero for an excitation wavelength between 1020 and 1030 nm, which is an indication that phonons are removed effectivelly from the glass-ceramic materials, and they can be used for optical laser cooling applications. On theother hand, the temperature increase as a function of input laser power into samples remains constant between 920 and 980 nm wavelength excitation, a temperature variation of 36 K/W （temperature of 58℃/W） was attained under excitation at 950 nm, showing a possible use for biomedical applications to be explored.

关键词： optical refrigeration oxyfluoride glass-cera-mics Yb3+ doping quantum yield infrared emission lifetime

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Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 199-200页

作者： Srishti Chawla Mikael Molin thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Department of Life Sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and *** biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate *** calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B shows 54%identity with calcineurin B from Saccharomyces cerevisiae.

关键词： activation dinuclear conserved

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An in vitro and in silico study of anti-dermatophytic activity of gossypol from fruits of Thespesia populnea(L.)*** Correa

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Asian Pacific Journal of Tropical Biomedicine 2021年第12期11卷 543-552页

作者： Anuthara R Sebastian Jose Midhun jyothis Mathew Microbiology Research Lab School of BiosciencesMahatma Gandhi UniversityKottayamKeralaIndia

Objective:To isolate,purify,and characterize gossypol from the fruits of Thespesia populnea(L)*** Correa,test its antidermatophytic activity,identify its targets on the dermatophyte,and confirm the binding of gossypol with the fungal target by molecular docking ***:Gossypol from Thespesia populnea was characterized by high performance liquid chromatography,liquid chromatographmass spectrometry,Fourier transform infrared spectroscopy,and nuclear magnetic *** anti-dermatophytic activity of gossypol was tested against four different dermatophytes,*** mentagrophytes,Trichophyton rubrum,Microsporum canis,and Microsporum *** mentagrophytes was selected for further *** inhibitory mode of action of gossypol on Trichophyton mentagrophytes was determined by analyzing the modulation of gene expression in various pathways of the ***:Gossypol inhibited all the *** minimum inhibitory concentrations were 12.5μg/mL for Trichophyton mentagrophytes and Microsporum canis and 25μg/mL for Trichophyton rubrum and Microsporum *** minimum fungicidal concentrations were 50μg/mL for Trichophyton mentagrophytes,100μg/mL for Microsporum canis and Trichophyton rubrum,and 200μg/mL for Microsporum *** inhibited the mRNA expression of metalloprotease(MEP4)and isocitrate lyase(ICL).The binding of gossypol with the enzymes was confirmed by molecular docking *** best docking poses were found and the low binding energies were recorded with the two target ***:Gossypol is a potential antifungal agent and can be further explored as an anti-dermatophytic drug.

关键词： Thespesia populnea Gossypol Anti-dermatophytic activity Trichophyton mentagrophytes Mechanism of action Gene expression Molecular docking Metalloprotease MEP4 Isocitrate lyase ICL

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Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

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Rotula aquatica Lour. inhibits growth and biofilm formation of clinically isolated uropathogenic Escherichia coli

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Asian Pacific Journal of Tropical Biomedicine 2020年第12期10卷 547-554页

作者： A.Vysakh Sebastian Jose Midhun Ninan Jisha Kuriakose Jayesh V.Vijeesh Mathew jyothis MS Latha School of Biosciences Mahatma Gandhi UniversityPriyadarshini HillsKottayamKeralaIndia

Objective:To evaluate the anti-bacterial and anti-biofilm activity of ethyl acetate fraction of Rotula aquatica Lour.(EFRA)against clinically isolated uropathogenic Escherichia ***:In vitro antibacterial and anti-biofilm studies were *** antimicrobial activity of EFRA was assayed by the well diffusion *** minimum inhibitory concentration(MIC)and minimum bactericidal concentration(MBC)of the active fraction were determined by Resazurin *** time-kill kinetic assay,acridine orange-ethidium bromide staining,propidium iodide uptake assay,and scanning electron microscopic(SEM)analysis were done to evaluate the efficacy of EFRA in killing uropathogenic Escherichia *** anti-biofilm activity was determined by 3-[4,5-dimethyl-2-thiazolyl]-2,5-diphenyl-2 H-tetrazolium-bromide(MTT)assay and specific biofilm formation ***:The well diffusion assay of EFRA showed a very clear zone of inhibition against Escherichia coli *** MIC and MBC of EFRA were 2.5 mg/m L and 5 mg/m L,*** time-kill kinetic assay,fluorescence microscopic analysis,propidium iodide uptake assay,and SEM analysis displayed the effect of EFRA in killing the *** MTT assay and specific biofilm formation assay showed that EFRA prevented the formation of ***:The results of the present study confirm that EFRA could prevent bacterial growth and inhibit its biofilm formation.

关键词： Rotula aquatica Escherichia coli Urinary tract infections Anti-bacterial activity

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Valencene-rich fraction from Vetiveria zizanioides exerts immunostimulatory effects in vitro and in mice

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Asian Pacific Journal of Tropical Biomedicine 2021年第8期11卷 335-343页

作者： V.S.Sunitha Sebastian Jose Midhun M.A.Sunil E.K.Radhakrishnan jyothis Mathew School of Biosciences Mahatma Gandhi UniversityKottayamIndia

Objective:To decipher the responsible compound present in the aqueous root extract of Vetiveria zizanioides which has tremendous immunomodulatory ***:Different fractions of the water extract were collected and analyzed for immunomodulatory activity by analyzing in vitro phagocytic activity and nitric oxide *** fraction VF3 was selected and further analyzed for possible compounds by high performance liquid chromatography and gas chromatography coupled with a mass *** in vitro immunomodulatory parameters such as phagocytic index,nitrite content,and tumor necrosis factor-α production in murine macrophages were *** vivo studies,sheep red blood cell induced haemagglutination titer,the number of antibody-producing cells,and sheep red blood cell induced delayed-type hypersensitivity were *** studies in L929 normal fibroblasts were also ***:One of the fractions,VF3,was selected and confirmed the presence of an active compound *** in vitro immunomodulatory parameters were significantly(P<0.05)increased by valencene *** vivo studies in Swiss albino mice showed that valencene could significantly(P<0.05)increase haemagglutination titer,the number of antibody-producing cells,and delayed-type *** studies also showed that valencene did not cause any morphological changes and DNA damage in normal ***:Valencene possesses immunomodulatory activities and can be commercially exploited for its immunostimulatory potentials.

关键词： GC-MS Immunomodulation Valencene Vetiveria zizanioides Thirst quencher

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Machine learning in solid organ transplantation:Charting the evolving landscape

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World Journal of Transplantation 2025年第1期15卷 165-177页

作者： Badi Rawashdeh Haneen Al-abdallat Emre Arpali Beje thomas Ty B Dunn Matthew Cooper Division of Transplant Surgery Medical College of WisconsinMilwaukeeWI 53202United States Department of Medicine Jordan University HospitalAmman 11263Jordan Department of Nephrology Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND Machine learning(ML),a major branch of artificial intelligence,has not only demonstrated the potential to significantly improve numerous sectors of healthcare but has also made significant contributions to the field of solid organ *** provides revolutionary opportunities in areas such as donorrecipient matching,post-transplant monitoring,and patient care by automatically analyzing large amounts of data,identifying patterns,and forecasting *** To conduct a comprehensive bibliometric analysis of publications on the use of ML in transplantation to understand current research trends and their *** On July 18,a thorough search strategy was used with the Web of Science *** and transplantation-related keywords were *** the aid of the VOS viewer application,the identified articles were subjected to bibliometric variable analysis in order to determine publication counts,citation counts,contributing countries,and institutions,among other *** Of the 529 articles that were first identified,427 were deemed relevant for bibliometric analysis.A surge in publications was observed over the last four years,especially after 2018,signifying growing interest in this *** 209 publications,the United States emerged as the top ***,the"Journal of Heart and Lung Transplantation"and the"American Journal of Transplantation"emerged as the leading journals,publishing the highest number of relevant *** keyword searches revealed that patient survival,mortality,outcomes,allocation,and risk assessment were significant themes of *** The growing body of pertinent publications highlights ML's growing presence in the field of solid organ *** bibliometric analysis highlights the growing importance of ML in transplant research and highlights its exciting potential to change medical practices and enhance patient *** collaboration between signific

关键词： Machine learning Artificial Intelligence Solid organ transplantation Bibliometric analysis

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Development of Tea Whitener Using Concentrated Whey and Milk Solids

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Food and Nutrition Sciences 2013年第2期4卷 215-221页

作者： jyothis Joy Mazhuvanchery Satish Kulkarni National Dairy Research Institute Bangalore India.

Whey and toned milk was effectively used for the development of tea whitener. Cheese whey was concentrated to 12% solids in a vacuum evaporator, pasteurized at 72℃±2℃ for 15 s, diluted back to 11.5% solids and was cold blended with toned milk of 11.5% solids in three ratios viz. 25:75, 50:50 and 75:25 and selected blends were homogenized at 1200-1500 psi. Tea was prepared by adding 80 mL whitener to 100 mL decoction and addition of sugar at 8% (w/v). The tea whitener was selected based on the sensory attributes of tea beverages. The colour of the beverages, tea whiteners and decoction were analyzed by reflectance meter and computer vision image analysis technique. The viscosity of the beverage was tested using a Brookfield viscometer. Coffee stability test was done to assess the stability of tea whitener under acidic conditions. Standard plate count, Coliform count and Presumptive Coliform test were done to assess the microbiological quality of the whitener. Homogenization had a positive impact on the viscosity and colour. The reflectance value of tea prepared from 25% homogenised whey milk blend and toned milk were in the range of 43-46 and 45-49, respectively. The viscosity of tea was found to increase with homogenization and whey levels. The sedimentation values of 25% whey blends and toned milk were 1.25 mL and 1 mL respectively. The shelf life of the blends was 2 days under refrigerated conditions. It can be concluded that a satisfactory tea whitener can be prepared by blending whey with toned milk in 25:75 proportion followed by homogenization.

关键词： Concentrated Whey Homogenization Sensory Evaluation Toned Milk Tea Tea Whitener

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Development of German-Ukrainian cooperations for education and research in photogrammetry and laser scanning

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Geo-Spatial Information Science 2021年第1期24卷 152-159,I0016页

作者： thomas Luhmann Institute for Applied Sciences and Geoinformatics Jade University of Applied Sciences OldenburgOldenburgGermany

Since 2011 an intensive international cooperation has been in place between the Institute for Applied Photogrammetry and Geoinformatics(IAPG)at the Jade University of Applied Sciences in Oldenburg,Germany,and various Ukrainian *** an initial contact by *** Konecny,the first visit was organized,and was followed by many *** subsequent years an intensive cooperation was established particularly with the National University for Construction and Architecture(KNUCA)in *** addition to architects and civil engineers,KNUCA also trains geodesists,geo-information scientists and landscape *** cooperation today includes the reciprocal exchange of scientists and students,research projects,courses and cooperation at many other *** addition,a commercial company has been established,SPM3D LLC,which now employs more than 14 engineers in the field of 3D acquisition,point cloud processing and *** article summarizes the history of the cooperation and presents the results of associated student *** addition,results of joint work on the development of a virtual laser scanner are presented,part of a German-Ukrainian initiative to digitize teaching.

关键词： Internationalization technology transfer curricula reform photogrammetry laser scanning e-learning

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